Analysis of the Broad’s Avana CRISPR (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017) and the Broad and Dana-Farber Cancer Institite’s Achilles shRNA (MacFarland et al. 2018, Data Science 2018).

The Avana screen produced results using CERES (Meyers et al. 2017) (GitHub), which generates gene dependency scores from sgRNA depletion scores from gene essentiality screens and eliminates bias arising from the effect of copy number variation on Cas9 DNA cleavage. The lower the CERES score, the higher the likelihood that the gene is essential in the associated cell line. Scores are scaled per cell line such that a score of 0 is the median effect of nonessential genes and -1 is the median effect of common core essential genes.

In a previous version of the shRNA screen, DEMETER (GitHub) was used to compute a dependency score for each gene by using the depletion values from each shRNA to infer the effect of target knockdown (on-target) and of expressing a given miRNA seed (off-target) in each cell line. More negative values indicate increased dependency, while more positive values indicate lower dependency. Zero represents the avergae dependency across all cell lines.

In the new data release, DEMETER2 (GitHub repository), developed by McFarland et al. (2018) was used to analyze the Achilles screen. DEMETER2 expands on DEMETER by including parameters for cell-line-specific screen effects and noisy data, correcting for global differences in shRNA levels across cell lines, pooling data acorss cell lines via hierarchical modeling, and using Bayesian inference to compute uncertainty estimates. Now, a score of zero represents no dependency.

All annotation files (copy number, mutation status, and gene expression) (Consortium and Consortium 2015, Barretina et al. 2012) were downloaded from the DepMap Data Portal.

1 Set up

Load libraries.

library(NMF)
library(ggpubr)
library(ggsignif)
library(rowr)
library(data.table)
library(CePa)
library(plyr)
library(tidyverse)
library(magrittr)
library(matrixStats)
library(parallel)
library(kableExtra)
library(gridExtra)
library(broom)
library(glmnet)
library(devtools)
library(reshape2)
library(caret)
library(bsselectR)
library(ComplexHeatmap)
library(circlize)

2 Functions

2.1 Significance thresholding

adj_signif <- function(df) {
  # Takes df from compare_means and creates a signif code column for adjusted p-vals
  df$p.signif <- ifelse(df$p.signif == "ns", NA, df$p.signif)
  df$p.signif.adj <- ifelse(df$p.adj <= 0.0001, "****",
                     ifelse(df$p.adj <= 0.001, "***",
                     ifelse(df$p.adj <= 0.01, "**",
                     ifelse(df$p.adj <= 0.05, "*", NA))))
  df$p.short <- formatC(df$p, format = "g", digits =  2)
  df$p.adj.short <- formatC(df$p.adj, format = "g", digits =  2)
  
  return(df)
}

2.2 Make CRISPR grobs

makeCRISPRgrob <- function(g) {
  
  gene <- filter(crispr_data, Hugo_Symbol == g)
  
  # Mutation status
  crispr_color <- as.character(gene$Color)
  names(crispr_color) <- gene$Mutation_Status
  sig <- filter(crispr_signif, Hugo_Symbol == g)
  plot_mut <- ggplot(data = gene, aes(x = Mutation_Status, y = Score, color = Mutation_Status)) +
    geom_boxplot(outlier.shape = NA) +
    geom_jitter(alpha = 0.3, size = 0.7, position = position_jitter(w = 0.05)) +
    scale_color_manual(values = crispr_color) +
    geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
    theme_light() +
    theme(legend.position = "none") +
    labs(x = paste0(g, " Mutation Status"), y = "CERES Score",
         title = "Mutation Status",
         subtitle = paste0("Wilcoxon test:\n- BH-corrected p-value: ", sig$p.adj.short, "\n- Uncorrected p-value: ", sig$p.short, "\nMutant lines harbor deleterious mutations."))
  
  # Copy number
  lo_cn <- range(gene$Copy_Number[!is.na(gene$Copy_Number)])[1]
  hi_cn <- range(gene$Copy_Number[!is.na(gene$Copy_Number)])[2]
  mid_cn <- (hi_cn - lo_cn) / 2
  plot_cn <- ggplot(data = gene, aes(x = Copy_Number, y = Score, color = Mutation_Status)) +
    geom_point(size = 0.5, alpha = 0.5) +
    geom_smooth(method = "lm", size = 0.5) +
    geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
    scale_color_manual(values = crispr_color) +
    stat_cor(method = "pearson", show.legend = FALSE, label.x = c((lo_cn + mid_cn) / 2, (hi_cn - mid_cn) / 2 + mid_cn), label.y = max(gene$Score)) +
    theme(legend.position = "none") +
    labs(y = "CERES Score", color = "Mutation Status",
         x = paste0(g, " Theoretical Copy number"), title = "Copy Number",
         subtitle = "r: Pearson correlation coeffcient")
  
  # Gene expression
  lo_ge <- range(gene$RPKM_log2[!is.na(gene$RPKM_log2)])[1]
  hi_ge <- range(gene$RPKM_log2[!is.na(gene$RPKM_log2)])[2]
  mid_ge <- (hi_ge - lo_ge) / 2
  plot_ge <- ggplot(data = gene, aes(x = RPKM_log2, y = Score, color = Mutation_Status)) +
    geom_point(size = 0.5, alpha = 0.5) +
    geom_smooth(method = "lm", size = 0.5) +
    geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
    scale_color_manual(values = crispr_color) +
    stat_cor(method = "pearson", show.legend = FALSE, label.x = c((lo_ge + mid_ge) / 2, (hi_ge - mid_ge) / 2 + mid_ge), label.y = max(gene$Score)) +
    theme(legend.position = "none") +
    labs(y = "CERES Score", color = "Mutation Status",
         x = paste0(g, " Gene Expression [log2(RPKM)]"),
         title = "Gene Expression",
         subtitle = "r: Pearson correlation coeffcient")
  
  # Cell line lineage
  plot_tissue <- ggplot(data = gene, aes(x = primary_tissue, y = Score, color = Mutation_Status)) +
    geom_point(alpha = 0.5) +
    scale_color_manual(values = crispr_color) +
    geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
    scale_y_continuous(sec.axis = sec_axis(~ .)) +
    coord_flip() +
    theme(legend.position = "none") +
    labs(y = "CERES Score", x = "Primary Tissue",
         color = "Mutation Status", title = g)
  
  # Arrange plots
  plot <- ggarrange(ggarrange(plot_tissue, nrow = 1, labels = c("A")),
                    ggarrange(plot_mut, plot_cn, plot_ge, nrow = 3,
                              labels = c("B", "C", "D"), heights = c(2, 3, 3)),
                    font.label = list(size = 30, face = "bold"),
                    nrow = 1, ncol = 2, widths = c(3, 2))
  return(plot)
}

2.3 Make lineage plot

makeCRISPRlinplot <- function(g) {
  sig <- filter(crispr_signif_lineage, Hugo_Symbol == g)
  if(nrow(sig) == 0) {
    return(NULL)
  }
  else {
    gene <- filter(crispr_data, Hugo_Symbol == g)
    gene <- merge(gene, sig, by = c("Hugo_Symbol", "group_general_lineage_name"))
    gene <- mutate(gene, group_general_lineage_name = reorder(group_general_lineage_name, p, mean))
    crispr_color <- as.character(gene$Color)
    names(crispr_color) <- gene$Mutation_Status
    score_range <- abs(range(gene$Score)[2] - range(gene$Score)[1])
    round_accuracy <- ifelse(score_range <= 2, 0.25,
                             ifelse(score_range <= 3, 0.5, 1.0))
    
    plot <- ggplot(data = gene, aes(x = group_general_lineage_name, y = Score)) +
      geom_point(alpha = 0.5, mapping = aes(color = Mutation_Status)) +
      scale_color_manual(values = crispr_color) +
      coord_cartesian(y = c(min(gene$Score), round_any(x = max(gene$Score), accuracy = round_accuracy, f = ceiling))) +
      geom_signif(data = gene, mapping = aes(xmin = group_general_lineage_name, xmax = group_general_lineage_name, annotations = paste(p.short, "\n", p.adj.short), y_position = max(gene$Score)), manual = TRUE, tip_length   = 0, size = 0, textsize = 3) +
      theme(legend.position = "top", axis.text.x = element_text(angle = 70, hjust = 1, size = 10)) +
      labs(y = "CERES Score",
           x = "Lineage",
           color = "Mutation Status",
           title = paste0(g, ": CERES score by cell line lineage"),
           subtitle = "Lineages sorted by increasing p-value; labels indicate unadjusted p-value / BH-corrected p-value.\nMutant lines harbor deleterious mutations.")
    return(plot)
  }
}

2.4 Make tissue plot

makeCRISPRtissueplot <- function(g) {
  sig <- filter(crispr_signif_tissue, Hugo_Symbol == g)
  if(nrow(sig) == 0) {
    return(NULL)
  }
  else {
    gene <- filter(crispr_data, Hugo_Symbol == g)
    gene <- merge(gene, sig, by = c("Hugo_Symbol", "primary_tissue"))
    gene <- mutate(gene, primary_tissue = reorder(primary_tissue, p, mean))
    crispr_color <- as.character(gene$Color)
    names(crispr_color) <- gene$Mutation_Status
    score_range <- abs(range(gene$Score)[2] - range(gene$Score)[1])
    round_accuracy <- ifelse(score_range <= 2, 0.25,
                             ifelse(score_range <= 3, 0.5, 1.0))
    
    plot <- ggplot(data = gene, aes(x = primary_tissue, y = Score)) +
      geom_point(alpha = 0.5, mapping = aes(color = Mutation_Status)) +
      scale_color_manual(values = crispr_color) +
      coord_cartesian(y = c(min(gene$Score), round_any(x = max(gene$Score), accuracy = round_accuracy, f = ceiling))) +
      geom_signif(data = gene, mapping = aes(xmin = primary_tissue, xmax = primary_tissue, annotations = paste(p.short, "\n", p.adj.short), y_position = max(gene$Score)), manual = TRUE, tip_length   = 0, size = 0, textsize = 3) +
      theme(legend.position = "top", axis.text.x = element_text(angle = 70, hjust = 1, size = 10)) +
      labs(y = "CERES Score",
           x = "Primary Tissue",
           color = "Mutation Status",
           title = paste0(g, ": CERES score by cell line primary tissue"),
           subtitle = "Primary tissues sorted by increasing p-value; labels indicate unadjusted p-value / BH-corrected p-value.\nMutant lines harbor deleterious mutations.")
    return(plot)
  }
}

3 Data management

3.1 D. Charytonowicz cell line converter

This comprehensive cancer cell line information curated by Daniel Charytonowicz.

ccl_converter <- read.delim("./data_munging/cell_line_database_v1_20180911.tsv", row.names = 1, sep = "\t", header = TRUE)

3.2 DepMap cell line metadata

ccl_info <- read.delim("./data_munging/DepMap-2018q3-celllines.csv", sep = ",", header = TRUE, na.strings = c("", NA))
ccl_info$Primary.Disease <- gsub("\\\\", "", ccl_info$Primary.Disease)
ccl_info$Primary.Disease <- gsub("Ewings", "Ewing's", ccl_info$Primary.Disease)

# From figshare
crispr_meta <- read.delim("./data_munging/sample_info_18Q3_crispr.csv", sep = ",", header = TRUE, na.strings = c("", NA))
colnames(crispr_meta)[7] <- "CCLE_Name"

3.3 CGC gene list

Select genes from the Cancer Gene Census (CGC). The list was pulled from the International Cancer Genome Consortium (ICGC) data portal (Advaced Search > Genes > Curated Gene Set > Cancer Gene Census).

cgc <- data_frame("Hugo_Symbol" = read.delim("./data_munging/gene-ids-for-set-Cancer Gene Census.tsv", header = FALSE, sep = "\t")[, 2])

3.4 CCLE MAF file

For mutation calling, get paired gene name and cell line fields in a data frame. For this analysis, we don’t care about how many mutations there are per gene or what type of mutations there are, so I didn’t save more information. I took unique gene-cell line combinations since we only cared about mutation presence/absence. Add a Mutation_Status column denoting all entries in MAF files as mutations present in the associated cell lines.

maf_raw <- read.delim("./data_munging/CCLE_DepMap_18q3_maf_20180718.txt.gz", header = TRUE, sep = "\t")
# Filter for cell lines in CRISPR screen
maf_raw <- filter(maf_raw, Broad_ID %in% unique(crispr_meta$Broad_ID))

# Select columns
maf_df <- subset(maf_raw, select = c("Hugo_Symbol", "Tumor_Sample_Barcode", "Broad_ID", "Variant_Classification", "isDeleterious", "Reference_Allele"))
colnames(maf_df)[colnames(maf_df) == "Tumor_Sample_Barcode"] <- "CCLE_Name"
maf_df$Var_Length <- nchar(as.character(maf_df$Reference_Allele))

# Add Mutation_Status column
maf_df$Mutation_Status_Deleterious <- ifelse(maf_df$isDeleterious == TRUE, "Mutant", "Other")
maf_df$Mutation_Status_Nonsilent <- ifelse(maf_df$Variant_Classification == "Silent", "Other", "Mutant")
maf_df$Mutation_Status_DeleteriousMissense <- ifelse(maf_df$isDeleterious == TRUE | maf_df$Variant_Classification == "Missense_Mutation", "Mutant", "Other")
maf_df <- unique(subset(maf_df, select = c("Hugo_Symbol", "CCLE_Name", "Broad_ID", "Mutation_Status_Deleterious", "Mutation_Status_Nonsilent", "Mutation_Status_DeleteriousMissense", "Var_Length")))

# Whole MAF summary table
maf_summ <- maf_raw[, c("Variant_Classification", "isDeleterious")] %>% group_by(Variant_Classification, isDeleterious) %>% tally()
maf_summ$Percent <- format(round(maf_summ$n / sum(maf_summ$n) * 100, 4), nsmall = 2)
maf_summ$isDeleterious <- ifelse(maf_summ$isDeleterious == "TRUE", "Yes", "No")

knitr::kable(maf_summ, caption = "Distribution of variant classifications in the MAF file") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive"))
Distribution of variant classifications in the MAF file
Variant_Classification isDeleterious n Percent
3’UTR No 1 0.0003
3’UTR Yes 30 0.0084
5’Flank No 8 0.0022
5’Flank Yes 34 0.0095
5’UTR No 2 0.0006
5’UTR Yes 15 0.0042
De_novo_Start_OutOfFrame Yes 2006 0.5595
Frame_Shift_Del Yes 12441 3.4698
Frame_Shift_Ins Yes 9215 2.5701
IGR No 6 0.0017
IGR Yes 44 0.0123
In_Frame_Del No 1747 0.4872
In_Frame_Ins No 442 0.1233
Intron No 9 0.0025
Intron Yes 187 0.0522
Missense_Mutation No 211359 58.9484
Nonsense_Mutation Yes 12711 3.5451
Nonstop_Mutation Yes 335 0.0934
Silent No 94225 26.2795
Splice_Site Yes 13180 3.6759
Start_Codon_Del Yes 25 0.0070
Start_Codon_Ins Yes 33 0.0092
Start_Codon_SNP No 402 0.1121
Stop_Codon_Del No 1 0.0003
Stop_Codon_Del Yes 52 0.0145
Stop_Codon_Ins Yes 39 0.0109 
max(nchar(as.character(maf_raw$Reference_Allele)))
## [1] 6494
maf_raw %>% group_by(Variant_Type, isTCGAhotspot) %>% tally()
## # A tibble: 9 x 3
## # Groups:   Variant_Type [?]
##   Variant_Type isTCGAhotspot      n
##   <fct>        <lgl>          <int>
## 1 DEL          FALSE          13940
## 2 DEL          TRUE            1453
## 3 DNP          FALSE           2411
## 4 DNP          TRUE              36
## 5 INS          FALSE          10000
## 6 INS          TRUE             364
## 7 SNP          FALSE         321337
## 8 SNP          TRUE            8978
## 9 TNP          FALSE             30
test <- filter(maf_raw, Hugo_Symbol == "KRAS")
test %>% group_by(isDeleterious) %>% tally()
## # A tibble: 2 x 2
##   isDeleterious     n
##   <lgl>         <int>
## 1 FALSE            95
## 2 TRUE              2

3.5 CCLE copy number file

cn <- read.delim("./data_munging/public_18Q3_gene_cn.csv.gz", sep = ",", check.names = FALSE, header = TRUE)

# Convert log2 ratios (log2(CN/2)) to CN
cn[2:ncol(cn)] <- lapply(cn[2:ncol(cn)], function(x) 2 * (2 ^ x))

# Remove Entrez gene IDs from colnames
colnames(cn) <- gsub(" .*", "", colnames(cn))
colnames(cn)[1] <- "Broad_ID"

# Melt
cn_melt <- melt(data = cn, id.vars = "Broad_ID", measure.vars = colnames(cn[2:ncol(cn)]), variable.name = "Hugo_Symbol", value.name = "Copy_Number")

saveRDS(cn_melt, "./data_munging/rds/cn_melt_18Q3.rds", compress = "xz")
cn_melt <- readRDS("./data_munging/rds/cn_melt_18Q3.rds")

3.6 CCLE gene expression file

Gene expression data (Reads Per Kilobase of transcript, per Million mapped reads, RPKM).

ge <- read.delim("./../crispr_lineages_giant_files/CCLE_DepMap_18q3_RNAseq_RPKM_20180718.gct.gz", skip = 2, header = TRUE, sep = "\t", check.names = FALSE)

# Edit columns
ge$Name <- NULL
colnames(ge)[1] <- "Hugo_Symbol"

# Melt
ge_melt <- melt(data = ge, id.vars = "Hugo_Symbol", measure.vars = colnames(ge[2:ncol(ge)]), value.name = "RPKM")
## Split variable column
ge_melt <- with(ge_melt, cbind(Hugo_Symbol, colsplit(variable, pattern = " ", names = c("CCLE_Name", "Broad_ID")), RPKM))
## Remove parentheses around Broad IDs
ge_melt$Broad_ID <- gsub("\\(|\\)", "", ge_melt$Broad_ID)

saveRDS(ge_melt, "./../crispr_lineages_giant_files/ge_melt_18Q3.rds", compress = "xz")
ge_melt <- readRDS("./../crispr_lineages_giant_files/ge_melt_18Q3.rds")

3.7 DepMap dependency probabilities

dep <- read.delim("./data_munging/gene_dependency_18Q3.csv.gz", sep = ",", header  = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(dep) <- gsub(" .*", "", colnames(dep))

3.8 Merge CRISPR data and annotations

The latest CRISPR CERES score data (18Q3, August 2018) was pulled from the DepMap Data Portal (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017).

crispr <- read.delim("./data_munging/gene_effect_18Q3.csv.gz", sep = ",", header  = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(crispr) <- gsub(" .*", "", colnames(crispr))

Merge annotation data:

# Melt CRISPR dataset for merging
crispr_melt <- melt(crispr, id.vars = "Broad_ID", measure.vars = colnames(crispr)[2:ncol(crispr)], variable.name = "Hugo_Symbol", value.name = "Score")

# Melt dependency probabilities dataset for merging
dep_melt <- melt(dep, id.vars = "Broad_ID", measure.vars = colnames(dep)[2:ncol(dep)], variable.name = "Hugo_Symbol", value.name = "Dep_Prob")

# Merge dependency probabilities
crispr_melt <- merge(crispr_melt, dep_melt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)

# Merge cell line metadata
crispr_melt <- merge(crispr_melt, ccl_info, by = "Broad_ID", all.x = TRUE)
crispr_melt <- merge(crispr_melt, crispr_meta, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)

# Merge mutation annotations
crispr_muts <- merge(crispr_melt, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
crispr_muts$Hugo_Symbol <- factor(crispr_muts$Hugo_Symbol)
crispr_muts <- crispr_muts %>% mutate(Mutation_Status_Deleterious = if_else(is.na(Mutation_Status_Deleterious), "Other", Mutation_Status_Deleterious), Mutation_Status_DeleteriousMissense = if_else(is.na(Mutation_Status_DeleteriousMissense), "Other", Mutation_Status_DeleteriousMissense), Mutation_Status_Nonsilent = if_else(is.na(Mutation_Status_Nonsilent), "Other", Mutation_Status_Nonsilent))

# Summarize number of mutant and Other cell lines
crispr_muts_summ <- crispr_muts %>% group_by(Hugo_Symbol) %>%
  summarize(N_Deleterious_Other = sum(Mutation_Status_Deleterious == "Other"),
            N_Deleterious_Mutant = sum(Mutation_Status_Deleterious == "Mutant"),
            N_DeleteriousMissense_Other = sum(Mutation_Status_DeleteriousMissense == "Other"),
            N_DeleteriousMissense_Mutant = sum(Mutation_Status_DeleteriousMissense == "Mutant"),
            N_Nonsilent_Other = sum(Mutation_Status_Nonsilent == "Other"),
            N_Nonsilent_Mutant = sum(Mutation_Status_Nonsilent == "Mutant"))

# Merge test results back into full dataset, which restores information lost in the summarization
crispr_data <- merge(crispr_muts_summ, crispr_muts, by = "Hugo_Symbol")

# Add Color columns
crispr_data$Color_Deleterious <- ifelse(crispr_data$Mutation_Status_Deleterious == "Other", "cyan3", "darkorchid")
crispr_data$Color_Deleterious <- factor(crispr_data$Color_Deleterious)
crispr_data$Color_DeleteriousMissense <- ifelse(crispr_data$Mutation_Status_DeleteriousMissense == "Other", "cyan3", "darkorchid")
crispr_data$Color_DeleteriousMissense <- factor(crispr_data$Color_DeleteriousMissense)
crispr_data$Color_Nonsilent <- ifelse(crispr_data$Mutation_Status_Nonsilent == "Other", "cyan3", "darkorchid")
crispr_data$Color_Nonsilent <- factor(crispr_data$Color_Nonsilent)

# Cell line lineages
crispr_data <- merge(crispr_data, ccl_converter, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
levels(crispr_data$lineage_name) <- sort(levels(crispr_data$lineage_name), decreasing = TRUE)

# Copy number
crispr_data <- merge(crispr_data, cn_melt, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)

# Gene expression (RPKM)
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))
crispr_data <- merge(crispr_data, ge_filt, by = c("Hugo_Symbol", "Broad_ID", "CCLE_Name"), all.x = TRUE)
crispr_data$RPKM_log2 <- log2(crispr_data$RPKM + 0.0001)

saveRDS(crispr_data, "./../crispr_lineages_giant_files/crispr_data_18Q3.rds", compress = "xz")
crispr_data <- readRDS("./../crispr_lineages_giant_files/crispr_data_18Q3.rds")
crispr_ccl <- data.frame("Broad_ID" = crispr_data$Broad_ID)
# write.table(crispr_data, file = "~/Desktop/crispr_data.tsv", quote = FALSE, sep = "\t")

4 Wilcoxon tests: Point mutations

Filter for point mutations:

crispr_data_ptmuts <- filter(crispr_data, Var_Length == 1)
test_ptmuts <- filter(crispr_data_ptmuts, is.na(group_general_lineage_name))
test_ptmuts <- filter(crispr_data_ptmuts, Hugo_Symbol == "KRAS")

4.1 Grouped by gene

4.1.1 Deleterious vs. Other

crispr_signif_del <- compare_means(Score ~ Mutation_Status_Deleterious, group.by = c("Hugo_Symbol"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_del <- adj_signif(crispr_signif_del)
crispr_signif_del <- crispr_signif_del[order(crispr_signif_del$p),]
saveRDS(crispr_signif_del, "./data_munging/rds/crispr_signif_ptmuts_deleterious_gene.rds")

# write.table(crispr_signif_del, file = "~/Desktop/crispr_signif_ptmuts_deleterious_gene.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_del <- readRDS("./data_munging/rds/crispr_signif_ptmuts_deleterious_gene.rds")

knitr::kable(filter(crispr_signif_del, p < 0.05)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing deleterious mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing deleterious mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol p p.adj p.format p.signif p.signif.adj
PTEN 0.0021089 1 0.0021 ** NA
SLC28A2 0.0026295 1 0.0026 ** NA
ZDHHC23 0.0032941 1 0.0033 ** NA
UTP20 0.0034834 1 0.0035 ** NA
C5orf42 0.0038672 1 0.0039 ** NA
AKAP13 0.0042868 1 0.0043 ** NA
KRT19 0.0044191 1 0.0044 ** NA
THEMIS 0.0046755 1 0.0047 ** NA
RINT1 0.0049652 1 0.0050 ** NA
BRD4 0.0050585 1 0.0051 ** NA
SSH3 0.0051775 1 0.0052 ** NA
CCDC135 0.0058036 1 0.0058 ** NA
AHR 0.0060268 1 0.0060 ** NA
ULK1 0.0063055 1 0.0063 ** NA
ABCB1 0.0067013 1 0.0067 ** NA
ABCD4 0.0067273 1 0.0067 ** NA
SEMA5A 0.0068162 1 0.0068 ** NA
PHLPP1 0.0070536 1 0.0071 ** NA
ARID1B 0.0071393 1 0.0071 ** NA
TUBGCP5 0.0074068 1 0.0074 ** NA
SPATA21 0.0078746 1 0.0079 ** NA
NUP188 0.0079638 1 0.0080 ** NA
DTX4 0.0084584 1 0.0085 ** NA
ATP8B4 0.0084882 1 0.0085 ** NA
GREB1 0.0085327 1 0.0085 ** NA
DHRS9 0.0089306 1 0.0089 ** NA
PLXNA1 0.0096965 1 0.0097 ** NA
UGT2A3 0.0097690 1 0.0098 ** NA
FPR1 0.0098014 1 0.0098 ** NA
SIN3A 0.0098748 1 0.0099 ** NA
KLHL17 0.0099584 1 0.0100 ** NA
ZC3H13 0.0099927 1 0.0100 ** NA
CR1 0.0100133 1 0.0100
NA
DENND1A 0.0101559 1 0.0102
NA
DMWD 0.0103569 1 0.0104
NA
ADRBK1 0.0104250 1 0.0104
NA
ST7 0.0107696 1 0.0108
NA
STRADA 0.0112806 1 0.0113
NA
ZBTB25 0.0115400 1 0.0115
NA
AMER2 0.0117726 1 0.0118
NA
OR4K1 0.0118838 1 0.0119
NA
NUP98 0.0122488 1 0.0122
NA
TTC22 0.0124718 1 0.0125
NA
DNAJC21 0.0127314 1 0.0127
NA
ARMC3 0.0127967 1 0.0128
NA
ATG2A 0.0131439 1 0.0131
NA
DENND6B 0.0131660 1 0.0132
NA
ESYT2 0.0134581 1 0.0135
NA
AGBL1 0.0137008 1 0.0137
NA
CHEK2 0.0142005 1 0.0142
NA
MTHFD1 0.0146665 1 0.0147
NA
CDH2 0.0148197 1 0.0148
NA
PLOD3 0.0148683 1 0.0149
NA
GOLIM4 0.0148715 1 0.0149
NA
PLEKHM1 0.0151720 1 0.0152
NA
TDRD7 0.0157211 1 0.0157
NA
SNX14 0.0160383 1 0.0160
NA
CENPN 0.0160926 1 0.0161
NA
GRXCR1 0.0161801 1 0.0162
NA
PRRX1 0.0162300 1 0.0162
NA
RRP12 0.0163072 1 0.0163
NA
NPSR1 0.0163159 1 0.0163
NA
ICA1 0.0165476 1 0.0165
NA
AJAP1 0.0167219 1 0.0167
NA
KIAA1107 0.0167220 1 0.0167
NA
SCN11A 0.0168208 1 0.0168
NA
SEC22A 0.0169247 1 0.0169
NA
ITGA10 0.0172436 1 0.0172
NA
ATP8A1 0.0176027 1 0.0176
NA
NPAT 0.0179484 1 0.0179
NA
NF2 0.0179509 1 0.0180
NA
VWA8 0.0180093 1 0.0180
NA
PIGR 0.0181195 1 0.0181
NA
GPR113 0.0181512 1 0.0182
NA
LMBR1L 0.0181630 1 0.0182
NA
HIP1R 0.0183228 1 0.0183
NA
OR5D14 0.0184355 1 0.0184
NA
RUNX2 0.0185804 1 0.0186
NA
ARID1A 0.0191886 1 0.0192
NA
KANK1 0.0197629 1 0.0198
NA
GLP1R 0.0202011 1 0.0202
NA
RIMBP3 0.0206112 1 0.0206
NA
ELL2 0.0207177 1 0.0207
NA
KIDINS220 0.0209368 1 0.0209
NA
RAPGEF4 0.0216312 1 0.0216
NA
TEK 0.0222037 1 0.0222
NA
SMURF1 0.0222802 1 0.0223
NA
RYR1 0.0224320 1 0.0224
NA
RBAK 0.0225161 1 0.0225
NA
CD4 0.0226405 1 0.0226
NA
MSANTD3 0.0226545 1 0.0227
NA
PPP1R3A 0.0227404 1 0.0227
NA
PRRT3 0.0230619 1 0.0231
NA
RNF4 0.0231629 1 0.0232
NA
MSH6 0.0232175 1 0.0232
NA
ARHGEF15 0.0232488 1 0.0232
NA
ZBTB41 0.0232746 1 0.0233
NA
NUP205 0.0233830 1 0.0234
NA
NHSL1 0.0234497 1 0.0234
NA
GSAP 0.0237385 1 0.0237
NA
TNRC6C 0.0244218 1 0.0244
NA
MYO1A 0.0244447 1 0.0244
NA
SKOR1 0.0246271 1 0.0246
NA
ANXA6 0.0248675 1 0.0249
NA
KMT2E 0.0251435 1 0.0251
NA
EPHX3 0.0252603 1 0.0253
NA
FAM73B 0.0253192 1 0.0253
NA
MICALCL 0.0257113 1 0.0257
NA
GATA6 0.0258595 1 0.0259
NA
ZNF804A 0.0260645 1 0.0261
NA
ELK3 0.0262196 1 0.0262
NA
ZNF571 0.0262242 1 0.0262
NA
CLEC3A 0.0265003 1 0.0265
NA
PAX5 0.0265720 1 0.0266
NA
POLR3E 0.0266110 1 0.0266
NA
ARID2 0.0268337 1 0.0268
NA
CSTF3 0.0272484 1 0.0272
NA
KRT31 0.0272562 1 0.0273
NA
DIDO1 0.0273407 1 0.0273
NA
CPVL 0.0273843 1 0.0274
NA
KIAA1755 0.0274942 1 0.0275
NA
NOC4L 0.0275531 1 0.0276
NA
CDH8 0.0276931 1 0.0277
NA
PTPRJ 0.0278970 1 0.0279
NA
ANGPTL3 0.0281858 1 0.0282
NA
TMEM206 0.0281858 1 0.0282
NA
C15orf41 0.0282035 1 0.0282
NA
TRMT44 0.0283870 1 0.0284
NA
SF3A2 0.0290951 1 0.0291
NA
SEC31B 0.0293458 1 0.0293
NA
BRD9 0.0293550 1 0.0294
NA
CMIP 0.0293550 1 0.0294
NA
PRPF40B 0.0293758 1 0.0294
NA
SLC37A1 0.0295080 1 0.0295
NA
PTPN22 0.0297220 1 0.0297
NA
C21orf33 0.0297581 1 0.0298
NA
CWF19L2 0.0298485 1 0.0298
NA
SREBF2 0.0298605 1 0.0299
NA
UTP3 0.0298676 1 0.0299
NA
SMARCA4 0.0299371 1 0.0299
NA
MGAT4C 0.0300872 1 0.0301
NA
ST3GAL5 0.0303828 1 0.0304
NA
CBX8 0.0303849 1 0.0304
NA
EPRS 0.0305970 1 0.0306
NA
OR5M1 0.0312294 1 0.0312
NA
ST5 0.0313517 1 0.0314
NA
CASC1 0.0313538 1 0.0314
NA
ARHGAP29 0.0315027 1 0.0315
NA
CHD6 0.0315125 1 0.0315
NA
TTI1 0.0315523 1 0.0316
NA
DPRX 0.0320887 1 0.0321
NA
EPHA5 0.0321478 1 0.0321
NA
MYO9A 0.0325995 1 0.0326
NA
MMP20 0.0327888 1 0.0328
NA
ATP8A2 0.0328064 1 0.0328
NA
ELTD1 0.0328536 1 0.0329
NA
TUBG2 0.0329052 1 0.0329
NA
ZNF208 0.0329272 1 0.0329
NA
FMN1 0.0330414 1 0.0330
NA
ST6GALNAC1 0.0335935 1 0.0336
NA
TMEM87A 0.0337522 1 0.0338
NA
TJP1 0.0338462 1 0.0338
NA
THSD7A 0.0341734 1 0.0342
NA
KIAA1467 0.0341902 1 0.0342
NA
BRIP1 0.0342696 1 0.0343
NA
BAI3 0.0345482 1 0.0345
NA
IGFALS 0.0345626 1 0.0346
NA
TMOD2 0.0346106 1 0.0346
NA
RPS6KC1 0.0349408 1 0.0349
NA
ZFYVE16 0.0349499 1 0.0349
NA
PHYKPL 0.0353082 1 0.0353
NA
LOXL3 0.0353190 1 0.0353
NA
IMMT 0.0357638 1 0.0358
NA
RNFT2 0.0357638 1 0.0358
NA
SLC25A47 0.0357638 1 0.0358
NA
POTEE 0.0360482 1 0.0360
NA
C2orf16 0.0360758 1 0.0361
NA
PPIP5K2 0.0362460 1 0.0362
NA
TANGO6 0.0364969 1 0.0365
NA
PIGB 0.0365460 1 0.0365
NA
KMT2D 0.0368033 1 0.0368
NA
ATAD5 0.0368596 1 0.0369
NA
ZNF74 0.0368841 1 0.0369
NA
TNFAIP8 0.0368884 1 0.0369
NA
ZMIZ2 0.0370443 1 0.0370
NA
RNF208 0.0372015 1 0.0372
NA
OR6C75 0.0372425 1 0.0372
NA
KAT8 0.0372425 1 0.0372
NA
GC 0.0379494 1 0.0379
NA
ACMSD 0.0382144 1 0.0382
NA
ATP6V1C1 0.0382144 1 0.0382
NA
DNTTIP2 0.0382144 1 0.0382
NA
IDI2 0.0382144 1 0.0382
NA
TMPRSS5 0.0382144 1 0.0382
NA
CYP26A1 0.0383496 1 0.0383
NA
VHL 0.0383864 1 0.0384
NA
ABCB9 0.0386096 1 0.0386
NA
CDC42BPA 0.0386978 1 0.0387
NA
DEPDC1 0.0387232 1 0.0387
NA
NPHP1 0.0387878 1 0.0388
NA
KCNJ6 0.0388645 1 0.0389
NA
WDR16 0.0389348 1 0.0389
NA
PDE1B 0.0389833 1 0.0390
NA
TIMD4 0.0391262 1 0.0391
NA
NUP210L 0.0393531 1 0.0394
NA
TRIM65 0.0393672 1 0.0394
NA
STK40 0.0394025 1 0.0394
NA
ARSB 0.0394890 1 0.0395
NA
TRIM33 0.0394890 1 0.0395
NA
ATP10D 0.0396888 1 0.0397
NA
UNC13B 0.0398774 1 0.0399
NA
VRTN 0.0401560 1 0.0402
NA
ZIC1 0.0401697 1 0.0402
NA
RB1 0.0402323 1 0.0402
NA
DBF4B 0.0402387 1 0.0402
NA
ADAR 0.0404928 1 0.0405
NA
C10orf76 0.0405689 1 0.0406
NA
BAZ1A 0.0409023 1 0.0409
NA
ADRB3 0.0409037 1 0.0409
NA
SPATA32 0.0409037 1 0.0409
NA
SUN5 0.0409037 1 0.0409
NA
HYOU1 0.0409286 1 0.0409
NA
DIP2A 0.0409688 1 0.0410
NA
FSCB 0.0409868 1 0.0410
NA
TP53BP2 0.0411750 1 0.0412
NA
ANKS4B 0.0412580 1 0.0413
NA
APOA1BP 0.0412580 1 0.0413
NA
BAIAP2 0.0412580 1 0.0413
NA
CAMKMT 0.0412580 1 0.0413
NA
GXYLT1 0.0412580 1 0.0413
NA
SERPINF1 0.0412580 1 0.0413
NA
SYNRG 0.0415762 1 0.0416
NA
HACE1 0.0416426 1 0.0416
NA
NBPF3 0.0416426 1 0.0416
NA
OR1E2 0.0416426 1 0.0416
NA
TTC3 0.0416676 1 0.0417
NA
CPXM2 0.0419858 1 0.0420
NA
PSMC2 0.0419967 1 0.0420
NA
LAX1 0.0420436 1 0.0420
NA
APAF1 0.0423314 1 0.0423
NA
AVL9 0.0427315 1 0.0427
NA
DLD 0.0427315 1 0.0427
NA
ZNF536 0.0429511 1 0.0430
NA
MS4A8 0.0429601 1 0.0430
NA
TIMM44 0.0429601 1 0.0430
NA
DZANK1 0.0430300 1 0.0430
NA
C20orf194 0.0432295 1 0.0432
NA
SLCO6A1 0.0432843 1 0.0433
NA
ITGAD 0.0432845 1 0.0433
NA
SULT1A1 0.0434349 1 0.0434
NA
BUB1 0.0435893 1 0.0436
NA
BOD1L1 0.0437266 1 0.0437
NA
ASAP1 0.0438204 1 0.0438
NA
TEX9 0.0440110 1 0.0440
NA
TXNDC16 0.0440110 1 0.0440
NA
DRD5 0.0440415 1 0.0440
NA
EGR3 0.0440415 1 0.0440
NA
MCM10 0.0441713 1 0.0442
NA
SQLE 0.0441713 1 0.0442
NA
ZNF878 0.0442851 1 0.0443
NA
BRD8 0.0443072 1 0.0443
NA
SLC3A1 0.0443072 1 0.0443
NA
SRPR 0.0443072 1 0.0443
NA
SCIN 0.0446501 1 0.0447
NA
PTPN3 0.0446853 1 0.0447
NA
ITGB7 0.0450993 1 0.0451
NA
MC2R 0.0451269 1 0.0451
NA
LPO 0.0452392 1 0.0452
NA
DDX46 0.0454011 1 0.0454
NA
RANBP3 0.0454640 1 0.0455
NA
PTPN23 0.0463589 1 0.0464
NA
FAM47E 0.0464111 1 0.0464
NA
GIGYF1 0.0465799 1 0.0466
NA
NLRP9 0.0467925 1 0.0468
NA
PTPRR 0.0468316 1 0.0468
NA
SLC17A2 0.0470143 1 0.0470
NA
DHX15 0.0471767 1 0.0472
NA
GPATCH4 0.0472209 1 0.0472
NA
NCAPG 0.0479872 1 0.0480
NA
UAP1L1 0.0480900 1 0.0481
NA
PAMR1 0.0481943 1 0.0482
NA
FOXN2 0.0482322 1 0.0482
NA
NLRP3 0.0482550 1 0.0483
NA
ITPKB 0.0483496 1 0.0483
NA
KLHL38 0.0488333 1 0.0488
NA
RASEF 0.0491408 1 0.0491
NA
GOLGA2 0.0492725 1 0.0493
NA
EDEM3 0.0493628 1 0.0494
NA
AADAT 0.0494912 1 0.0495
NA
BTNL3 0.0494912 1 0.0495
NA
KDM1A 0.0494912 1 0.0495
NA
LSS 0.0496091 1 0.0496
NA
SERPINB2 0.0497676 1 0.0498
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_gene_plot <- ggplot(data = crispr_signif_del) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_plot

4.1.2 Non-silent mutant vs. Other

crispr_signif_nonsilent <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_nonsilent <- adj_signif(crispr_signif_nonsilent)
crispr_signif_nonsilent <- crispr_signif_nonsilent[order(crispr_signif_nonsilent$p),]
saveRDS(crispr_signif_nonsilent, "./data_munging/rds/crispr_signif_ptmuts_nonsilent_gene.rds")

# write.table(crispr_signif_nonsilent, file = "~/Desktop/crispr_signif_ptmuts_nonsilent_gene.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_nonsilent <- readRDS("./data_munging/rds/crispr_signif_ptmuts_nonsilent_gene.rds")

knitr::kable(filter(crispr_signif_nonsilent, p < 0.05)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing non-silent mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol p p.adj p.format p.signif p.signif.adj
KMT2B 0.0001468 1 0.00015 *** NA
SLC12A3 0.0009262 1 0.00093 *** NA
HNRNPCL1 0.0015088 1 0.00151 ** NA
RGS12 0.0018901 1 0.00189 ** NA
EXOC3 0.0019090 1 0.00191 ** NA
TCERG1 0.0022235 1 0.00222 ** NA
ZNF560 0.0036554 1 0.00366 ** NA
EPHA5 0.0037993 1 0.00380 ** NA
C12orf4 0.0051890 1 0.00519 ** NA
VWCE 0.0063100 1 0.00631 ** NA
TJP3 0.0064667 1 0.00647 ** NA
FAM181B 0.0066551 1 0.00666 ** NA
IRS2 0.0068102 1 0.00681 ** NA
C2orf44 0.0069091 1 0.00691 ** NA
WFIKKN2 0.0077801 1 0.00778 ** NA
GPR152 0.0080099 1 0.00801 ** NA
CCM2L 0.0081382 1 0.00814 ** NA
NT5DC2 0.0083840 1 0.00838 ** NA
TOM1L1 0.0084748 1 0.00847 ** NA
FCGBP 0.0089536 1 0.00895 ** NA
KCNV2 0.0092945 1 0.00929 ** NA
MEF2C 0.0093314 1 0.00933 ** NA
EPS8L3 0.0097054 1 0.00971 ** NA
TSPAN12 0.0097565 1 0.00976 ** NA
NUP88 0.0103349 1 0.01033
NA
LRP12 0.0103961 1 0.01040
NA
C14orf39 0.0104695 1 0.01047
NA
CUL2 0.0104695 1 0.01047
NA
SCMH1 0.0105265 1 0.01053
NA
KRT19 0.0105337 1 0.01053
NA
SPATA4 0.0107334 1 0.01073
NA
MEX3B 0.0108964 1 0.01090
NA
SLC4A2 0.0109977 1 0.01100
NA
USP47 0.0110064 1 0.01101
NA
ZC3H4 0.0111545 1 0.01115
NA
FOXK2 0.0111590 1 0.01116
NA
RXRG 0.0112806 1 0.01128
NA
NXPE3 0.0112983 1 0.01130
NA
PGLYRP2 0.0112983 1 0.01130
NA
DLX5 0.0115400 1 0.01154
NA
NUP205 0.0118595 1 0.01186
NA
PTPRE 0.0121441 1 0.01214
NA
TUB 0.0124807 1 0.01248
NA
MKL2 0.0127073 1 0.01271
NA
CEP72 0.0132781 1 0.01328
NA
ZNF232 0.0137894 1 0.01379
NA
CHST8 0.0138833 1 0.01388
NA
STAM2 0.0140193 1 0.01402
NA
TBC1D10A 0.0140193 1 0.01402
NA
SOX9 0.0141779 1 0.01418
NA
FBXW4 0.0142140 1 0.01421
NA
HIST1H3G 0.0142140 1 0.01421
NA
PANK2 0.0142140 1 0.01421
NA
SHMT1 0.0142140 1 0.01421
NA
FAM161B 0.0142481 1 0.01425
NA
RNF133 0.0145321 1 0.01453
NA
CD4 0.0148355 1 0.01484
NA
PCK2 0.0149092 1 0.01491
NA
APBA1 0.0149172 1 0.01492
NA
MAML2 0.0149324 1 0.01493
NA
MEFV 0.0157143 1 0.01571
NA
PRKCZ 0.0157200 1 0.01572
NA
ZNF419 0.0157389 1 0.01574
NA
OR10J5 0.0157971 1 0.01580
NA
SLC16A14 0.0159858 1 0.01599
NA
SLC15A4 0.0160110 1 0.01601
NA
CNOT1 0.0163025 1 0.01630
NA
SPATA2 0.0163369 1 0.01634
NA
POU2F1 0.0164213 1 0.01642
NA
HIATL1 0.0166093 1 0.01661
NA
OR10C1 0.0167705 1 0.01677
NA
PHC2 0.0167890 1 0.01679
NA
PEAK1 0.0169258 1 0.01693
NA
C14orf37 0.0172588 1 0.01726
NA
CDH26 0.0172956 1 0.01730
NA
GSTM5 0.0173655 1 0.01737
NA
PINX1 0.0181630 1 0.01816
NA
AP2A1 0.0182644 1 0.01826
NA
ZEB2 0.0183165 1 0.01832
NA
SCUBE1 0.0185251 1 0.01853
NA
RBM33 0.0186071 1 0.01861
NA
ZNF568 0.0191481 1 0.01915
NA
CALCR 0.0192795 1 0.01928
NA
ARSJ 0.0196244 1 0.01962
NA
ZNF700 0.0196244 1 0.01962
NA
XPO1 0.0197345 1 0.01973
NA
CCNL1 0.0197808 1 0.01978
NA
ENAM 0.0197928 1 0.01979
NA
CR1 0.0198187 1 0.01982
NA
CD1B 0.0198735 1 0.01987
NA
ELK3 0.0199102 1 0.01991
NA
CD320 0.0199645 1 0.01996
NA
PARN 0.0201162 1 0.02012
NA
NRG2 0.0202011 1 0.02020
NA
TOX3 0.0202778 1 0.02028
NA
SPTBN4 0.0203213 1 0.02032
NA
DEPDC1 0.0204142 1 0.02041
NA
SPAST 0.0204637 1 0.02046
NA
CES2 0.0204680 1 0.02047
NA
PPP1R13L 0.0204924 1 0.02049
NA
ARMC3 0.0205423 1 0.02054
NA
VEGFB 0.0205964 1 0.02060
NA
PLXNB1 0.0207437 1 0.02074
NA
ERF 0.0213099 1 0.02131
NA
GPRIN2 0.0213871 1 0.02139
NA
TTC28 0.0214205 1 0.02142
NA
OR5B3 0.0218560 1 0.02186
NA
ROR1 0.0223731 1 0.02237
NA
CPNE9 0.0224789 1 0.02248
NA
RGS21 0.0224943 1 0.02249
NA
DPEP1 0.0226545 1 0.02265
NA
IL5RA 0.0226545 1 0.02265
NA
PLCD4 0.0226545 1 0.02265
NA
SNAP25 0.0226545 1 0.02265
NA
TIA1 0.0226545 1 0.02265
NA
DENND2A 0.0226895 1 0.02269
NA
HEATR5B 0.0226977 1 0.02270
NA
PEX6 0.0227903 1 0.02279
NA
KLF15 0.0230810 1 0.02308
NA
CNTNAP1 0.0231093 1 0.02311
NA
ARSB 0.0231629 1 0.02316
NA
MTF2 0.0232703 1 0.02327
NA
PIGO 0.0232906 1 0.02329
NA
KIAA1683 0.0233558 1 0.02336
NA
BCAR3 0.0234106 1 0.02341
NA
ORAI1 0.0234106 1 0.02341
NA
PRPF19 0.0234106 1 0.02341
NA
LCK 0.0234658 1 0.02347
NA
OR52I2 0.0238684 1 0.02387
NA
IMPG2 0.0240571 1 0.02406
NA
RP1L1 0.0241958 1 0.02420
NA
COG3 0.0242675 1 0.02427
NA
MORC2 0.0246516 1 0.02465
NA
CRLF3 0.0251815 1 0.02518
NA
NOLC1 0.0252007 1 0.02520
NA
PICK1 0.0252603 1 0.02526
NA
IRX3 0.0252712 1 0.02527
NA
TEKT3 0.0252712 1 0.02527
NA
TELO2 0.0252861 1 0.02529
NA
GPR141 0.0257358 1 0.02574
NA
FBXO30 0.0258965 1 0.02590
NA
PTCH1 0.0261041 1 0.02610
NA
FEM1B 0.0261845 1 0.02618
NA
ARMC2 0.0262242 1 0.02622
NA
FBXO34 0.0262602 1 0.02626
NA
CAMKMT 0.0265003 1 0.02650
NA
CEACAM6 0.0265003 1 0.02650
NA
REEP2 0.0265003 1 0.02650
NA
PCDHA3 0.0265116 1 0.02651
NA
CNGA3 0.0273471 1 0.02735
NA
DAAM1 0.0274105 1 0.02741
NA
KCNS3 0.0274686 1 0.02747
NA
ZNF470 0.0274686 1 0.02747
NA
LIPF 0.0275319 1 0.02753
NA
NEU2 0.0277377 1 0.02774
NA
PCNXL2 0.0277508 1 0.02775
NA
ARMC4 0.0278269 1 0.02783
NA
KIAA1279 0.0278923 1 0.02789
NA
ACD 0.0280601 1 0.02806
NA
ZFYVE1 0.0281001 1 0.02810
NA
TLE3 0.0281765 1 0.02818
NA
BSX 0.0281858 1 0.02819
NA
PPP1R8 0.0281858 1 0.02819
NA
RAB33B 0.0281858 1 0.02819
NA
SLC9C2 0.0283814 1 0.02838
NA
CACNA2D4 0.0283823 1 0.02838
NA
PIEZO1 0.0285905 1 0.02859
NA
CAPN11 0.0286576 1 0.02866
NA
F11R 0.0286881 1 0.02869
NA
COL9A2 0.0286949 1 0.02869
NA
OR4C3 0.0289870 1 0.02899
NA
BRD4 0.0290691 1 0.02907
NA
SLC24A1 0.0290963 1 0.02910
NA
GPR63 0.0292451 1 0.02925
NA
PQLC2 0.0297581 1 0.02976
NA
TPGS1 0.0297581 1 0.02976
NA
PMPCA 0.0298421 1 0.02984
NA
ADAMTSL3 0.0298966 1 0.02990
NA
RGPD2 0.0299488 1 0.02995
NA
GTF2H2C 0.0300279 1 0.03003
NA
MARK3 0.0301476 1 0.03015
NA
APBA2 0.0302173 1 0.03022
NA
SEL1L3 0.0302340 1 0.03023
NA
PURB 0.0304862 1 0.03049
NA
ST18 0.0305246 1 0.03052
NA
C8orf58 0.0305521 1 0.03055
NA
ACSBG2 0.0307039 1 0.03070
NA
RNF4 0.0307084 1 0.03071
NA
FAM171A1 0.0309508 1 0.03095
NA
PLK5 0.0312090 1 0.03121
NA
KLHL41 0.0312236 1 0.03122
NA
ZMYND15 0.0312236 1 0.03122
NA
RUFY3 0.0312294 1 0.03123
NA
SLC15A1 0.0313465 1 0.03135
NA
SLC7A1 0.0313598 1 0.03136
NA
FLT3 0.0314724 1 0.03147
NA
ZNF493 0.0315196 1 0.03152
NA
FIZ1 0.0315552 1 0.03156
NA
EEF2 0.0316232 1 0.03162
NA
TAS1R2 0.0317443 1 0.03174
NA
SMAD9 0.0320740 1 0.03207
NA
DDO 0.0320887 1 0.03209
NA
TBX20 0.0324262 1 0.03243
NA
MEF2A 0.0326119 1 0.03261
NA
TRAFD1 0.0327888 1 0.03279
NA
TRPM5 0.0327968 1 0.03280
NA
NUCB1 0.0328974 1 0.03290
NA
TRIOBP 0.0329216 1 0.03292
NA
ARFGAP1 0.0329694 1 0.03297
NA
ATMIN 0.0331389 1 0.03314
NA
MED15 0.0332413 1 0.03324
NA
CTNNB1 0.0333369 1 0.03334
NA
TLR1 0.0336042 1 0.03360
NA
MUS81 0.0336496 1 0.03365
NA
EPS8L2 0.0337362 1 0.03374
NA
ASB14 0.0337522 1 0.03375
NA
FANCC 0.0337522 1 0.03375
NA
KRT34 0.0337522 1 0.03375
NA
SLC22A9 0.0337522 1 0.03375
NA
RPUSD1 0.0337888 1 0.03379
NA
INPP5E 0.0338221 1 0.03382
NA
CCDC146 0.0340695 1 0.03407
NA
METTL17 0.0341540 1 0.03415
NA
SNX20 0.0342578 1 0.03426
NA
UPF1 0.0343090 1 0.03431
NA
CNTNAP3B 0.0343484 1 0.03435
NA
FCHO1 0.0344238 1 0.03442
NA
PARL 0.0344238 1 0.03442
NA
B3GAT3 0.0346106 1 0.03461
NA
CRNN 0.0346137 1 0.03461
NA
ARAP1 0.0346545 1 0.03465
NA
CKS1B 0.0348374 1 0.03484
NA
PATL1 0.0349959 1 0.03500
NA
ZNF808 0.0353176 1 0.03532
NA
HLCS 0.0353695 1 0.03537
NA
ATP5A1 0.0357638 1 0.03576
NA
CDC14B 0.0357638 1 0.03576
NA
PI16 0.0357638 1 0.03576
NA
TLX2 0.0357638 1 0.03576
NA
ATP6AP1L 0.0357701 1 0.03577
NA
UNKL 0.0358265 1 0.03583
NA
EIF4G3 0.0358452 1 0.03585
NA
COG7 0.0358888 1 0.03589
NA
GDF5 0.0359204 1 0.03592
NA
IFT140 0.0360521 1 0.03605
NA
OR51A4 0.0361966 1 0.03620
NA
NTN5 0.0363586 1 0.03636
NA
UMOD 0.0365375 1 0.03654
NA
ZNF229 0.0366794 1 0.03668
NA
XPO5 0.0367223 1 0.03672
NA
RCN1 0.0368884 1 0.03689
NA
UBE2Z 0.0368884 1 0.03689
NA
PEX14 0.0369043 1 0.03690
NA
OR2F1 0.0369820 1 0.03698
NA
HOXA5 0.0370407 1 0.03704
NA
ADCY8 0.0370802 1 0.03708
NA
MACC1 0.0371593 1 0.03716
NA
NFIC 0.0371667 1 0.03717
NA
DBX2 0.0372425 1 0.03724
NA
LDHAL6B 0.0372425 1 0.03724
NA
OR2L5 0.0373364 1 0.03734
NA
CSTF3 0.0376353 1 0.03764
NA
KIAA0355 0.0380751 1 0.03808
NA
GDF3 0.0382144 1 0.03821
NA
PIP5K1B 0.0382144 1 0.03821
NA
SPOCK3 0.0383702 1 0.03837
NA
CYP1A1 0.0385612 1 0.03856
NA
TG 0.0386297 1 0.03863
NA
ERC1 0.0388113 1 0.03881
NA
TRIM15 0.0388839 1 0.03888
NA
MAN2C1 0.0389628 1 0.03896
NA
SNX8 0.0389658 1 0.03897
NA
ACTA1 0.0390294 1 0.03903
NA
RELB 0.0392285 1 0.03923
NA
MFSD7 0.0392449 1 0.03924
NA
FASTKD3 0.0394025 1 0.03940
NA
L3MBTL4 0.0398326 1 0.03983
NA
SNX21 0.0400314 1 0.04003
NA
TMEM194A 0.0400314 1 0.04003
NA
AASDH 0.0400762 1 0.04008
NA
MPZL2 0.0402387 1 0.04024
NA
CACNB2 0.0402435 1 0.04024
NA
POU3F2 0.0403050 1 0.04030
NA
SLC52A2 0.0403050 1 0.04030
NA
AKNAD1 0.0405515 1 0.04055
NA
LRRCC1 0.0407213 1 0.04072
NA
ANKRD50 0.0410486 1 0.04105
NA
NAIF1 0.0411659 1 0.04117
NA
TCP10L2 0.0411842 1 0.04118
NA
CHPT1 0.0412580 1 0.04126
NA
CNBD2 0.0412580 1 0.04126
NA
KNSTRN 0.0412580 1 0.04126
NA
SERPINA5 0.0412580 1 0.04126
NA
SMG9 0.0412580 1 0.04126
NA
DCAF4 0.0414312 1 0.04143
NA
LPO 0.0415780 1 0.04158
NA
C2orf54 0.0416034 1 0.04160
NA
FAM205A 0.0416502 1 0.04165
NA
CCDC88A 0.0417383 1 0.04174
NA
ACLY 0.0419296 1 0.04193
NA
MCHR2 0.0419616 1 0.04196
NA
PKM 0.0419616 1 0.04196
NA
PADI3 0.0421983 1 0.04220
NA
PSAPL1 0.0422385 1 0.04224
NA
OR5D14 0.0426248 1 0.04262
NA
IQGAP3 0.0427033 1 0.04270
NA
KRT85 0.0427146 1 0.04271
NA
SNX30 0.0428256 1 0.04283
NA
CYP2J2 0.0429601 1 0.04296
NA
CORO7 0.0430141 1 0.04301
NA
ALDH9A1 0.0431214 1 0.04312
NA
ZFYVE27 0.0433081 1 0.04331
NA
SMC6 0.0434369 1 0.04344
NA
GARNL3 0.0435181 1 0.04352
NA
MFN1 0.0436613 1 0.04366
NA
GFRA1 0.0438890 1 0.04389
NA
GHR 0.0438890 1 0.04389
NA
ADRA2B 0.0439362 1 0.04394
NA
TET3 0.0441234 1 0.04412
NA
RALYL 0.0441713 1 0.04417
NA
NYNRIN 0.0441763 1 0.04418
NA
DTNB 0.0444785 1 0.04448
NA
ADSS 0.0446392 1 0.04464
NA
SLC22A16 0.0447106 1 0.04471
NA
ZNF814 0.0448920 1 0.04489
NA
FMNL2 0.0450476 1 0.04505
NA
MAP2K2 0.0451269 1 0.04513
NA
TBC1D7 0.0451269 1 0.04513
NA
IMMT 0.0453879 1 0.04539
NA
CHRM1 0.0454011 1 0.04540
NA
IBA57 0.0454360 1 0.04544
NA
SYDE1 0.0455892 1 0.04559
NA
YLPM1 0.0461029 1 0.04610
NA
MYOC 0.0464384 1 0.04644
NA
GRM1 0.0464874 1 0.04649
NA
ATG14 0.0465330 1 0.04653
NA
ECD 0.0468445 1 0.04684
NA
PPIL2 0.0472209 1 0.04722
NA
SEPT1 0.0472209 1 0.04722
NA
RABGAP1 0.0472391 1 0.04724
NA
WDR66 0.0473425 1 0.04734
NA
PAQR9 0.0474705 1 0.04747
NA
CDC37 0.0475369 1 0.04754
NA
LRRTM1 0.0476213 1 0.04762
NA
SLC22A15 0.0477173 1 0.04772
NA
ACTL8 0.0480388 1 0.04804
NA
ZNF395 0.0480598 1 0.04806
NA
SEMA7A 0.0480638 1 0.04806
NA
NSFL1C 0.0480802 1 0.04808
NA
ACMSD 0.0481324 1 0.04813
NA
FEZF2 0.0485396 1 0.04854
NA
TFR2 0.0485871 1 0.04859
NA
CATSPER1 0.0486717 1 0.04867
NA
EMR1 0.0488448 1 0.04884
NA
NOMO2 0.0489672 1 0.04897
NA
FKBP3 0.0490901 1 0.04909
NA
KRT83 0.0492535 1 0.04925
NA
PKNOX2 0.0494851 1 0.04949
NA
BCAN 0.0494941 1 0.04949
NA
ELMSAN1 0.0496272 1 0.04963
NA
PPFIBP2 0.0497165 1 0.04972
NA
DRC1 0.0498389 1 0.04984
NA
SEL1L2 0.0499043 1 0.04990
NA
SSH2 0.0499771 1 0.04998
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_gene_nonsilent_plot <- ggplot(data = crispr_signif_nonsilent) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_nonsilent_plot

4.1.3 Deleterious and missense mutant vs. Other

crispr_signif_delmis <- compare_means(Score ~ Mutation_Status_DeleteriousMissense, group.by = c("Hugo_Symbol"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_delmis <- adj_signif(crispr_signif_delmis)
crispr_signif_delmis <- crispr_signif_delmis[order(crispr_signif_delmis$p),]
saveRDS(crispr_signif_delmis, "./data_munging/rds/crispr_signif_ptmuts_deleteriousmissense_gene.rds")

# write.table(crispr_signif_delmis, file = "~/Desktop/crispr_signif_ptmuts_deleteriousmissense_gene.csv", quote = FALSE, sep = ",", row.names = FALSE)
compare_means(Score ~ Mutation_Status_DeleteriousMissense, group.by = c("Hugo_Symbol"), data = crispr_data_ptmuts[which(crispr_data_ptmuts$Hugo_Symbol == "KRAS"),], method = "wilcox.test", p.adjust.method = "BH")
## # A tibble: 1 x 9
##   Hugo_Symbol .y.   group1 group2     p p.adj p.format p.signif method  
##   <fct>       <chr> <chr>  <chr>  <dbl> <dbl> <chr>    <chr>    <chr>   
## 1 KRAS        Score Mutant Other  0.113 0.113 0.11     ns       Wilcoxon
crispr_signif_delmis <- readRDS("./data_munging/rds/crispr_signif_ptmuts_deleteriousmissense_gene.rds")

knitr::kable(filter(crispr_signif_delmis, p < 0.05)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing deleterious and missense mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing deleterious and missense mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol p p.adj p.format p.signif p.signif.adj
KMT2B 0.0001468 1 0.00015 *** NA
SLC12A3 0.0009262 1 0.00093 *** NA
HNRNPCL1 0.0015088 1 0.00151 ** NA
RGS12 0.0018901 1 0.00189 ** NA
EXOC3 0.0019090 1 0.00191 ** NA
TCERG1 0.0022235 1 0.00222 ** NA
NT5DC2 0.0034482 1 0.00345 ** NA
ZNF560 0.0036554 1 0.00366 ** NA
EPHA5 0.0037993 1 0.00380 ** NA
C12orf4 0.0051890 1 0.00519 ** NA
VWCE 0.0063100 1 0.00631 ** NA
TJP3 0.0064667 1 0.00647 ** NA
FAM181B 0.0066551 1 0.00666 ** NA
IRS2 0.0068102 1 0.00681 ** NA
C2orf44 0.0069091 1 0.00691 ** NA
WFIKKN2 0.0077801 1 0.00778 ** NA
GPR152 0.0080099 1 0.00801 ** NA
TOM1L1 0.0084748 1 0.00847 ** NA
FCGBP 0.0089536 1 0.00895 ** NA
KCNV2 0.0092945 1 0.00929 ** NA
MEF2C 0.0093314 1 0.00933 ** NA
CCM2L 0.0093630 1 0.00936 ** NA
EPS8L3 0.0097054 1 0.00971 ** NA
TSPAN12 0.0097565 1 0.00976 ** NA
NUP88 0.0103349 1 0.01033
NA
LRP12 0.0103961 1 0.01040
NA
C14orf39 0.0104695 1 0.01047
NA
CUL2 0.0104695 1 0.01047
NA
IQGAP3 0.0104805 1 0.01048
NA
SCMH1 0.0105265 1 0.01053
NA
KRT19 0.0105337 1 0.01053
NA
SPATA4 0.0107334 1 0.01073
NA
MEX3B 0.0108964 1 0.01090
NA
SLC4A2 0.0109977 1 0.01100
NA
USP47 0.0110064 1 0.01101
NA
ZC3H4 0.0111545 1 0.01115
NA
FOXK2 0.0111590 1 0.01116
NA
RXRG 0.0112806 1 0.01128
NA
NXPE3 0.0112983 1 0.01130
NA
PGLYRP2 0.0112983 1 0.01130
NA
DLX5 0.0115400 1 0.01154
NA
PTPRE 0.0121441 1 0.01214
NA
TUB 0.0124807 1 0.01248
NA
MKL2 0.0127073 1 0.01271
NA
NUP205 0.0128458 1 0.01285
NA
ZNF232 0.0137894 1 0.01379
NA
CHST8 0.0138833 1 0.01388
NA
STAM2 0.0140193 1 0.01402
NA
TBC1D10A 0.0140193 1 0.01402
NA
SOX9 0.0141779 1 0.01418
NA
HIST1H3G 0.0142140 1 0.01421
NA
PANK2 0.0142140 1 0.01421
NA
SHMT1 0.0142140 1 0.01421
NA
FAM161B 0.0142481 1 0.01425
NA
RNF133 0.0145321 1 0.01453
NA
CD4 0.0148355 1 0.01484
NA
PCK2 0.0149092 1 0.01491
NA
APBA1 0.0149172 1 0.01492
NA
ECD 0.0153927 1 0.01539
NA
MEFV 0.0157143 1 0.01571
NA
PRKCZ 0.0157200 1 0.01572
NA
ZNF419 0.0157389 1 0.01574
NA
OR10J5 0.0157971 1 0.01580
NA
SLC16A14 0.0159858 1 0.01599
NA
SLC15A4 0.0160110 1 0.01601
NA
CNOT1 0.0163025 1 0.01630
NA
SPATA2 0.0163369 1 0.01634
NA
POU2F1 0.0164213 1 0.01642
NA
HIATL1 0.0166093 1 0.01661
NA
OR10C1 0.0167705 1 0.01677
NA
PHC2 0.0167890 1 0.01679
NA
PEAK1 0.0169258 1 0.01693
NA
NOL7 0.0172390 1 0.01724
NA
C14orf37 0.0172588 1 0.01726
NA
CDH26 0.0172956 1 0.01730
NA
CEP72 0.0173561 1 0.01736
NA
GSTM5 0.0173655 1 0.01737
NA
PINX1 0.0181630 1 0.01816
NA
AP2A1 0.0182644 1 0.01826
NA
ZEB2 0.0183165 1 0.01832
NA
SCUBE1 0.0185251 1 0.01853
NA
RBM33 0.0186071 1 0.01861
NA
ZNF568 0.0191481 1 0.01915
NA
CALCR 0.0192795 1 0.01928
NA
ARSJ 0.0196244 1 0.01962
NA
ZNF700 0.0196244 1 0.01962
NA
XPO1 0.0197345 1 0.01973
NA
CCNL1 0.0197808 1 0.01978
NA
ENAM 0.0197928 1 0.01979
NA
CD1B 0.0198735 1 0.01987
NA
ELK3 0.0199102 1 0.01991
NA
CD320 0.0199645 1 0.01996
NA
PARN 0.0201162 1 0.02012
NA
NRG2 0.0202011 1 0.02020
NA
TOX3 0.0202778 1 0.02028
NA
SPTBN4 0.0203213 1 0.02032
NA
DEPDC1 0.0204142 1 0.02041
NA
SPAST 0.0204637 1 0.02046
NA
CES2 0.0204680 1 0.02047
NA
ARMC3 0.0205423 1 0.02054
NA
VEGFB 0.0205964 1 0.02060
NA
PLXNB1 0.0207437 1 0.02074
NA
ERF 0.0213099 1 0.02131
NA
GPRIN2 0.0213871 1 0.02139
NA
TTC28 0.0214205 1 0.02142
NA
OR5B3 0.0218560 1 0.02186
NA
ROR1 0.0223731 1 0.02237
NA
CPNE9 0.0224789 1 0.02248
NA
RGS21 0.0224943 1 0.02249
NA
DPEP1 0.0226545 1 0.02265
NA
IL5RA 0.0226545 1 0.02265
NA
PLCD4 0.0226545 1 0.02265
NA
SNAP25 0.0226545 1 0.02265
NA
TIA1 0.0226545 1 0.02265
NA
DENND2A 0.0226895 1 0.02269
NA
HEATR5B 0.0226977 1 0.02270
NA
PEX6 0.0227903 1 0.02279
NA
KLF15 0.0230810 1 0.02308
NA
CNTNAP1 0.0231093 1 0.02311
NA
ARSB 0.0231629 1 0.02316
NA
MTF2 0.0232703 1 0.02327
NA
PIGO 0.0232906 1 0.02329
NA
KIAA1683 0.0233558 1 0.02336
NA
BCAR3 0.0234106 1 0.02341
NA
ORAI1 0.0234106 1 0.02341
NA
PRPF19 0.0234106 1 0.02341
NA
LCK 0.0234658 1 0.02347
NA
OR52I2 0.0238684 1 0.02387
NA
IMPG2 0.0240571 1 0.02406
NA
COG3 0.0242675 1 0.02427
NA
MORC2 0.0246516 1 0.02465
NA
RP1L1 0.0247846 1 0.02478
NA
CRLF3 0.0251815 1 0.02518
NA
PICK1 0.0252603 1 0.02526
NA
IRX3 0.0252712 1 0.02527
NA
TEKT3 0.0252712 1 0.02527
NA
TELO2 0.0252861 1 0.02529
NA
GPR141 0.0257358 1 0.02574
NA
FBXO30 0.0258965 1 0.02590
NA
PTCH1 0.0261041 1 0.02610
NA
ARMC2 0.0262242 1 0.02622
NA
FBXO34 0.0262602 1 0.02626
NA
CAMKMT 0.0265003 1 0.02650
NA
CEACAM6 0.0265003 1 0.02650
NA
REEP2 0.0265003 1 0.02650
NA
PCDHA3 0.0265116 1 0.02651
NA
HMX3 0.0268091 1 0.02681
NA
C21orf58 0.0272754 1 0.02728
NA
CNGA3 0.0273471 1 0.02735
NA
DAAM1 0.0274105 1 0.02741
NA
KCNS3 0.0274686 1 0.02747
NA
ZNF470 0.0274686 1 0.02747
NA
LIPF 0.0275319 1 0.02753
NA
NEU2 0.0277377 1 0.02774
NA
PPP1R13L 0.0277440 1 0.02774
NA
PCNXL2 0.0277508 1 0.02775
NA
ARMC4 0.0278269 1 0.02783
NA
KIAA1279 0.0278923 1 0.02789
NA
ZFYVE1 0.0281001 1 0.02810
NA
TLE3 0.0281765 1 0.02818
NA
BSX 0.0281858 1 0.02819
NA
PPP1R8 0.0281858 1 0.02819
NA
RAB33B 0.0281858 1 0.02819
NA
SLC9C2 0.0283814 1 0.02838
NA
CACNA2D4 0.0283823 1 0.02838
NA
PIEZO1 0.0285905 1 0.02859
NA
CAPN11 0.0286576 1 0.02866
NA
COL9A2 0.0286949 1 0.02869
NA
OR4C3 0.0289870 1 0.02899
NA
BRD4 0.0290691 1 0.02907
NA
SLC24A1 0.0290963 1 0.02910
NA
GPR63 0.0292451 1 0.02925
NA
PQLC2 0.0297581 1 0.02976
NA
TPGS1 0.0297581 1 0.02976
NA
PMPCA 0.0298421 1 0.02984
NA
ADAMTSL3 0.0298966 1 0.02990
NA
KRT85 0.0299423 1 0.02994
NA
RGPD2 0.0299488 1 0.02995
NA
GTF2H2C 0.0300279 1 0.03003
NA
MARK3 0.0301476 1 0.03015
NA
APBA2 0.0302173 1 0.03022
NA
SEL1L3 0.0302340 1 0.03023
NA
SEL1L2 0.0304107 1 0.03041
NA
PURB 0.0304862 1 0.03049
NA
ST18 0.0305246 1 0.03052
NA
C8orf58 0.0305521 1 0.03055
NA
ACSBG2 0.0307039 1 0.03070
NA
RNF4 0.0307084 1 0.03071
NA
FAM171A1 0.0309508 1 0.03095
NA
PLK5 0.0312090 1 0.03121
NA
KLHL41 0.0312236 1 0.03122
NA
ZMYND15 0.0312236 1 0.03122
NA
SLC15A1 0.0313465 1 0.03135
NA
SLC7A1 0.0313598 1 0.03136
NA
FLT3 0.0314724 1 0.03147
NA
FIZ1 0.0315552 1 0.03156
NA
EEF2 0.0316232 1 0.03162
NA
TAS1R2 0.0317443 1 0.03174
NA
FAM131A 0.0319353 1 0.03194
NA
SMAD9 0.0320740 1 0.03207
NA
DDO 0.0320887 1 0.03209
NA
TBX20 0.0324262 1 0.03243
NA
MEF2A 0.0326119 1 0.03261
NA
TRAFD1 0.0327888 1 0.03279
NA
TRPM5 0.0327968 1 0.03280
NA
NUCB1 0.0328974 1 0.03290
NA
TRIOBP 0.0329216 1 0.03292
NA
ARFGAP1 0.0329694 1 0.03297
NA
ATMIN 0.0331389 1 0.03314
NA
MED15 0.0332413 1 0.03324
NA
CTNNB1 0.0333369 1 0.03334
NA
TLR1 0.0336042 1 0.03360
NA
MUS81 0.0336496 1 0.03365
NA
EPS8L2 0.0337362 1 0.03374
NA
ASB14 0.0337522 1 0.03375
NA
FANCC 0.0337522 1 0.03375
NA
KRT34 0.0337522 1 0.03375
NA
SLC22A9 0.0337522 1 0.03375
NA
ZNF80 0.0337522 1 0.03375
NA
RPUSD1 0.0337888 1 0.03379
NA
INPP5E 0.0338221 1 0.03382
NA
CCDC146 0.0340695 1 0.03407
NA
METTL17 0.0341540 1 0.03415
NA
SNX20 0.0342578 1 0.03426
NA
CNTNAP3B 0.0343484 1 0.03435
NA
FCHO1 0.0344238 1 0.03442
NA
PARL 0.0344238 1 0.03442
NA
B3GAT3 0.0346106 1 0.03461
NA
CRNN 0.0346137 1 0.03461
NA
ARAP1 0.0346545 1 0.03465
NA
CKS1B 0.0348374 1 0.03484
NA
ISM2 0.0349838 1 0.03498
NA
PATL1 0.0349959 1 0.03500
NA
ZNF808 0.0353176 1 0.03532
NA
HLCS 0.0353695 1 0.03537
NA
ATP5A1 0.0357638 1 0.03576
NA
CDC14B 0.0357638 1 0.03576
NA
PI16 0.0357638 1 0.03576
NA
TLX2 0.0357638 1 0.03576
NA
ATP6AP1L 0.0357701 1 0.03577
NA
UNKL 0.0358265 1 0.03583
NA
EIF4G3 0.0358452 1 0.03585
NA
COG7 0.0358888 1 0.03589
NA
GDF5 0.0359204 1 0.03592
NA
IFT140 0.0360521 1 0.03605
NA
OR51A4 0.0361966 1 0.03620
NA
NTN5 0.0363586 1 0.03636
NA
UMOD 0.0365375 1 0.03654
NA
TRA2B 0.0365460 1 0.03655
NA
ZNF229 0.0366794 1 0.03668
NA
XPO5 0.0367223 1 0.03672
NA
UBE2Z 0.0368884 1 0.03689
NA
OR2F1 0.0369820 1 0.03698
NA
HOXA5 0.0370407 1 0.03704
NA
ADCY8 0.0370802 1 0.03708
NA
MACC1 0.0371593 1 0.03716
NA
NFIC 0.0371667 1 0.03717
NA
DBX2 0.0372425 1 0.03724
NA
LDHAL6B 0.0372425 1 0.03724
NA
SLC30A4 0.0372599 1 0.03726
NA
OR2L5 0.0373364 1 0.03734
NA
F11R 0.0374740 1 0.03747
NA
CSTF3 0.0376353 1 0.03764
NA
KIAA0355 0.0380751 1 0.03808
NA
GDF3 0.0382144 1 0.03821
NA
SPOCK3 0.0383702 1 0.03837
NA
CYP1A1 0.0385612 1 0.03856
NA
TG 0.0386297 1 0.03863
NA
ERC1 0.0388113 1 0.03881
NA
TRIM15 0.0388839 1 0.03888
NA
MAN2C1 0.0389628 1 0.03896
NA
SNX8 0.0389658 1 0.03897
NA
ACTA1 0.0390294 1 0.03903
NA
RELB 0.0392285 1 0.03923
NA
MFSD7 0.0392449 1 0.03924
NA
FASTKD3 0.0394025 1 0.03940
NA
L3MBTL4 0.0398326 1 0.03983
NA
SNX21 0.0400314 1 0.04003
NA
TMEM194A 0.0400314 1 0.04003
NA
AASDH 0.0400762 1 0.04008
NA
MPZL2 0.0402387 1 0.04024
NA
CACNB2 0.0402435 1 0.04024
NA
POU3F2 0.0403050 1 0.04030
NA
SLC52A2 0.0403050 1 0.04030
NA
AKNAD1 0.0405515 1 0.04055
NA
LRRCC1 0.0407213 1 0.04072
NA
ANKRD50 0.0410486 1 0.04105
NA
NAIF1 0.0411659 1 0.04117
NA
CHPT1 0.0412580 1 0.04126
NA
CNBD2 0.0412580 1 0.04126
NA
KNSTRN 0.0412580 1 0.04126
NA
SMG9 0.0412580 1 0.04126
NA
DCAF4 0.0414312 1 0.04143
NA
ACD 0.0414779 1 0.04148
NA
LPO 0.0415780 1 0.04158
NA
C2orf54 0.0416034 1 0.04160
NA
FAM205A 0.0416502 1 0.04165
NA
CCDC88A 0.0417383 1 0.04174
NA
ACLY 0.0419296 1 0.04193
NA
MCHR2 0.0419616 1 0.04196
NA
PKM 0.0419616 1 0.04196
NA
SERPINA5 0.0419616 1 0.04196
NA
PADI3 0.0421983 1 0.04220
NA
PSAPL1 0.0422385 1 0.04224
NA
OR5D14 0.0426248 1 0.04262
NA
SNX30 0.0428256 1 0.04283
NA
FEM1B 0.0429241 1 0.04292
NA
CYP2J2 0.0429601 1 0.04296
NA
CORO7 0.0430141 1 0.04301
NA
ALDH9A1 0.0431214 1 0.04312
NA
ZFYVE27 0.0433081 1 0.04331
NA
SMC6 0.0434369 1 0.04344
NA
GARNL3 0.0435181 1 0.04352
NA
MFN1 0.0436613 1 0.04366
NA
GFRA1 0.0438890 1 0.04389
NA
GHR 0.0438890 1 0.04389
NA
ADRA2B 0.0439362 1 0.04394
NA
TET3 0.0441234 1 0.04412
NA
RALYL 0.0441713 1 0.04417
NA
NYNRIN 0.0441763 1 0.04418
NA
DTNB 0.0444785 1 0.04448
NA
ADSS 0.0446392 1 0.04464
NA
SLC22A16 0.0447106 1 0.04471
NA
BRCA1 0.0450320 1 0.04503
NA
FMNL2 0.0450476 1 0.04505
NA
MAP2K2 0.0451269 1 0.04513
NA
TBC1D7 0.0451269 1 0.04513
NA
IMMT 0.0453879 1 0.04539
NA
CHRM1 0.0454011 1 0.04540
NA
IBA57 0.0454360 1 0.04544
NA
SYDE1 0.0455892 1 0.04559
NA
CR1 0.0460075 1 0.04601
NA
YLPM1 0.0461029 1 0.04610
NA
MYOC 0.0464384 1 0.04644
NA
GRM1 0.0464874 1 0.04649
NA
ATG14 0.0465330 1 0.04653
NA
PPIL2 0.0472209 1 0.04722
NA
SEPT1 0.0472209 1 0.04722
NA
RABGAP1 0.0472391 1 0.04724
NA
WDR66 0.0473425 1 0.04734
NA
PAQR9 0.0474705 1 0.04747
NA
CDC37 0.0475369 1 0.04754
NA
LRRTM1 0.0476213 1 0.04762
NA
SLC22A15 0.0477173 1 0.04772
NA
ACTL8 0.0480388 1 0.04804
NA
ZNF395 0.0480598 1 0.04806
NA
SEMA7A 0.0480638 1 0.04806
NA
NSFL1C 0.0480802 1 0.04808
NA
PRUNE2 0.0480863 1 0.04809
NA
ACMSD 0.0481324 1 0.04813
NA
FEZF2 0.0485396 1 0.04854
NA
TFR2 0.0485871 1 0.04859
NA
CATSPER1 0.0486717 1 0.04867
NA
UPF1 0.0487801 1 0.04878
NA
EMR1 0.0488448 1 0.04884
NA
NOMO2 0.0489672 1 0.04897
NA
FKBP3 0.0490901 1 0.04909
NA
KRT83 0.0492535 1 0.04925
NA
PKNOX2 0.0494851 1 0.04949
NA
BCAN 0.0494941 1 0.04949
NA
PPFIBP2 0.0497165 1 0.04972
NA
DRC1 0.0498389 1 0.04984
NA
SSH2 0.0499771 1 0.04998
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_gene_delmis_plot <- ggplot(data = crispr_signif_delmis) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_delmis_plot

4.2 Grouped by gene and lineage

4.2.1 Deleterious vs. Other

crispr_signif_del_lineage <- compare_means(Score ~ Mutation_Status_Deleterious, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_del_lineage <- adj_signif(crispr_signif_del_lineage)
crispr_signif_del_lineage <- crispr_signif_del_lineage[order(crispr_signif_del_lineage$p),]
saveRDS(crispr_signif_del_lineage, "./data_munging/rds/crispr_signif_ptmuts_deleterious_lineage.rds")

# write.table(crispr_signif_del_lineage, file = "~/Desktop/crispr_signif_ptmuts_deleterious_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_del_lineage <- readRDS("./data_munging/rds/crispr_signif_ptmuts_deleterious_lineage.rds")

knitr::kable(filter(crispr_signif_del_lineage, p < 0.05)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing deleterious mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing deleterious mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol group_general_lineage_name p p.adj p.format p.signif p.signif.adj
PTEN central nervous system cancer 0.0073526 1 0.0074 ** NA
DCAF8 lung cancer 0.0127807 1 0.0128
NA
KMT2D lung cancer 0.0155311 1 0.0155
NA
RERE colorectal cancer 0.0199645 1 0.0200
NA
COL15A1 uterine cancer 0.0222455 1 0.0222
NA
BAZ2B lung cancer 0.0230287 1 0.0230
NA
SCN10A uterine cancer 0.0325499 1 0.0325
NA
RUNX2 uterine cancer 0.0368884 1 0.0369
NA
FRMD4A uterine cancer 0.0408331 1 0.0408
NA
TP53 lung cancer 0.0420128 1 0.0420
NA
TP53 skin cancer 0.0428256 1 0.0428
NA
MED12L lung cancer 0.0446392 1 0.0446
NA
RALGAPB uterine cancer 0.0457185 1 0.0457
NA
SMARCA4 lung cancer 0.0475939 1 0.0476
NA
ASXL3 colorectal cancer 0.0487981 1 0.0488
NA
BRD4 uterine cancer 0.0487981 1 0.0488
NA
ST5 uterine cancer 0.0488846 1 0.0489
NA
KNOP1 uterine cancer 0.0497460 1 0.0497
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_lineage_plot <- ggplot(data = crispr_signif_del_lineage) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_lineage_plot

4.2.2 Non-silent mutant vs. Other

crispr_signif_nonsilent_lineage <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_nonsilent_lineage <- adj_signif(crispr_signif_nonsilent_lineage)
crispr_signif_nonsilent_lineage <- crispr_signif_nonsilent_lineage[order(crispr_signif_nonsilent_lineage$p),]
saveRDS(crispr_signif_nonsilent_lineage, "./data_munging/rds/crispr_signif_ptmuts_nonsilent_lineage.rds")

# write.table(crispr_signif_nonsilent_lineage, file = "~/Desktop/crispr_signif_ptmuts_nonsilent_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_nonsilent_lineage <- readRDS("./data_munging/rds/crispr_signif_ptmuts_nonsilent_lineage.rds")

knitr::kable(filter(crispr_signif_nonsilent_lineage, p < 0.05)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing non-silent mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol group_general_lineage_name p p.adj p.format p.signif p.signif.adj
SYNE1 lung cancer 0.0140032 1 0.014
NA
PKHD1 lung cancer 0.0154975 1 0.015
NA
RP1L1 lung cancer 0.0163009 1 0.016
NA
BIRC6 lung cancer 0.0187768 1 0.019
NA
NOS1 lung cancer 0.0224943 1 0.022
NA
KMT2B breast cancer 0.0265187 1 0.027
NA
KMT2D ovarian cancer 0.0273481 1 0.027
NA
TRPA1 lung cancer 0.0281858 1 0.028
NA
PLEC kidney cancer 0.0303828 1 0.030
NA
TENM4 skin cancer 0.0349263 1 0.035
NA
NEBL uterine cancer 0.0362034 1 0.036
NA
ADAM11 lung cancer 0.0368884 1 0.037
NA
TJP1 uterine cancer 0.0372492 1 0.037
NA
XYLT2 uterine cancer 0.0372492 1 0.037
NA
LPHN3 lung cancer 0.0375182 1 0.038
NA
SALL4 lung cancer 0.0380559 1 0.038
NA
MMP16 lung cancer 0.0382144 1 0.038
NA
BMPER lung cancer 0.0396348 1 0.040
NA
POLE uterine cancer 0.0398748 1 0.040
NA
CMYA5 lung cancer 0.0412580 1 0.041
NA
HCN1 lung cancer 0.0419663 1 0.042
NA
TBC1D9 colorectal cancer 0.0419967 1 0.042
NA
KIAA0100 uterine cancer 0.0420664 1 0.042
NA
CHD5 colorectal cancer 0.0428256 1 0.043
NA
GLI3 colorectal cancer 0.0458662 1 0.046
NA
RRBP1 uterine cancer 0.0491854 1 0.049
NA
ARMC4 uterine cancer 0.0497460 1 0.050
NA
BRINP2 skin cancer 0.0497460 1 0.050
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_lineage_nonsilent_plot <- ggplot(data = crispr_signif_nonsilent_lineage) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_lineage_nonsilent_plot

4.2.3 Deleterious and missense mutant vs. Other

crispr_signif_delmis_lineage <- compare_means(Score ~ Mutation_Status_DeleteriousMissense, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_delmis_lineage <- adj_signif(crispr_signif_delmis_lineage)
crispr_signif_delmis_lineage <- crispr_signif_delmis_lineage[order(crispr_signif_delmis_lineage$p),]
saveRDS(crispr_signif_delmis_lineage, "./data_munging/rds/crispr_signif_ptmuts_deleteriousmissense_lineage.rds")

# write.table(crispr_signif_delmis_lineage, file = "~/Desktop/crispr_signif_ptmuts_deleteriousmissense_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_delmis_lineage <- readRDS("./data_munging/rds/crispr_signif_ptmuts_deleteriousmissense_lineage.rds")

knitr::kable(filter(crispr_signif_delmis_lineage, p < 0.05)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing deleterious and missense mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing deleterious and missense mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol group_general_lineage_name p p.adj p.format p.signif p.signif.adj
SYNE1 lung cancer 0.0140032 1 0.014
NA
PKHD1 lung cancer 0.0154975 1 0.015
NA
RP1L1 lung cancer 0.0163009 1 0.016
NA
BIRC6 lung cancer 0.0187768 1 0.019
NA
NOS1 lung cancer 0.0224943 1 0.022
NA
KMT2B breast cancer 0.0265187 1 0.027
NA
KMT2D ovarian cancer 0.0273481 1 0.027
NA
TRPA1 lung cancer 0.0281858 1 0.028
NA
PLEC kidney cancer 0.0303828 1 0.030
NA
TENM4 skin cancer 0.0349263 1 0.035
NA
NEBL uterine cancer 0.0362034 1 0.036
NA
ADAM11 lung cancer 0.0368884 1 0.037
NA
TJP1 uterine cancer 0.0372492 1 0.037
NA
XYLT2 uterine cancer 0.0372492 1 0.037
NA
LPHN3 lung cancer 0.0375182 1 0.038
NA
SALL4 lung cancer 0.0380559 1 0.038
NA
MMP16 lung cancer 0.0382144 1 0.038
NA
BMPER lung cancer 0.0396348 1 0.040
NA
POLE uterine cancer 0.0398748 1 0.040
NA
CMYA5 lung cancer 0.0412580 1 0.041
NA
HCN1 lung cancer 0.0419663 1 0.042
NA
TBC1D9 colorectal cancer 0.0419967 1 0.042
NA
KIAA0100 uterine cancer 0.0420664 1 0.042
NA
CHD5 colorectal cancer 0.0428256 1 0.043
NA
GLI3 colorectal cancer 0.0458662 1 0.046
NA
RRBP1 uterine cancer 0.0491854 1 0.049
NA
ARMC4 uterine cancer 0.0497460 1 0.050
NA
BRINP2 skin cancer 0.0497460 1 0.050
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_gene_delmis_lineage_plot <- ggplot(data = crispr_signif_delmis_lineage) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_delmis_lineage_plot

5 Wilcoxon tests: All mutations

5.1 Grouped by gene

5.1.1 Deleterious vs. Other

crispr_signif_allmut_del <- compare_means(Score ~ Mutation_Status_Deleterious, group.by = c("Hugo_Symbol"), data = crispr_data, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_allmut_del <- adj_signif(crispr_signif_allmut_del)
crispr_signif_allmut_del <- crispr_signif_allmut_del[order(crispr_signif_allmut_del$p),]
saveRDS(crispr_signif_allmut_del, "./data_munging/rds/crispr_signif_allmut_deleterious_gene.rds")

# write.table(crispr_signif_allmut_del, file = "~/Desktop/crispr_signif_allmut_deleterious_gene.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_allmut_del <- readRDS("./data_munging/rds/crispr_signif_allmut_deleterious_gene.rds")

knitr::kable(filter(crispr_signif_allmut_del, p < 0.05)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing deleterious mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing deleterious mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol p p.adj p.format p.signif p.signif.adj
PTEN 0.0000000 0.0000000 2.9e-13 **** ****
TP53 0.0000002 0.0016540 2.5e-07 **** **
ARID1A 0.0000011 0.0047700 1.1e-06 **** **
VHL 0.0000016 0.0053734 1.6e-06 **** **
UTP20 0.0000301 0.0802533 3.0e-05 **** NA
KRT19 0.0000705 0.1566873 7.0e-05 **** NA
ZC3H13 0.0009557 0.7440112 0.00096 *** NA
ARID1B 0.0010200 0.7440112 0.00102 ** NA
ABCD4 0.0012457 0.7440112 0.00125 ** NA
TCERG1 0.0012735 0.7440112 0.00127 ** NA
NPSR1 0.0013941 0.7440112 0.00139 ** NA
KRTAP10-6 0.0015323 0.7440112 0.00153 ** NA
PLXNA1 0.0016291 0.7440112 0.00163 ** NA
LILRB2 0.0016968 0.7440112 0.00170 ** NA
RNF208 0.0019385 0.7440112 0.00194 ** NA
AJAP1 0.0021018 0.7440112 0.00210 ** NA
HAX1 0.0022315 0.7440112 0.00223 ** NA
TIMD4 0.0022527 0.7440112 0.00225 ** NA
PIGR 0.0028924 0.7440112 0.00289 ** NA
TP53BP2 0.0029507 0.7440112 0.00295 ** NA
MSH6 0.0031226 0.7440112 0.00312 ** NA
KLHL17 0.0038240 0.7440112 0.00382 ** NA
TUBGCP5 0.0038993 0.7440112 0.00390 ** NA
FMN1 0.0039763 0.7440112 0.00398 ** NA
AKAP13 0.0040426 0.7440112 0.00404 ** NA
UGT2A3 0.0041569 0.7440112 0.00416 ** NA
BRD4 0.0042237 0.7440112 0.00422 ** NA
RB1 0.0042661 0.7440112 0.00427 ** NA
NIPBL 0.0042726 0.7440112 0.00427 ** NA
ATAD5 0.0045229 0.7440112 0.00452 ** NA
CR1 0.0047742 0.7440112 0.00477 ** NA
PPIL4 0.0047926 0.7440112 0.00479 ** NA
RINT1 0.0048906 0.7440112 0.00489 ** NA
SIN3A 0.0049114 0.7440112 0.00491 ** NA
PIK3R1 0.0052016 0.7440112 0.00520 ** NA
TPR 0.0052404 0.7440112 0.00524 ** NA
DLD 0.0053697 0.7440112 0.00537 ** NA
PTPRR 0.0055220 0.7440112 0.00552 ** NA
CSTF3 0.0055891 0.7440112 0.00559 ** NA
OLFML2B 0.0058315 0.7440112 0.00583 ** NA
GSTM5 0.0058384 0.7440112 0.00584 ** NA
NOC4L 0.0061581 0.7440112 0.00616 ** NA
KIAA1107 0.0061991 0.7440112 0.00620 ** NA
RTN3 0.0062371 0.7440112 0.00624 ** NA
PLOD3 0.0062880 0.7440112 0.00629 ** NA
ZNF439 0.0063457 0.7440112 0.00635 ** NA
DMKN 0.0063484 0.7440112 0.00635 ** NA
EDNRB 0.0063517 0.7440112 0.00635 ** NA
UTP3 0.0065359 0.7440112 0.00654 ** NA
IQCH 0.0067700 0.7440112 0.00677 ** NA
ST7 0.0068047 0.7440112 0.00680 ** NA
ZNF177 0.0068619 0.7440112 0.00686 ** NA
ENAH 0.0069381 0.7440112 0.00694 ** NA
RTF1 0.0070416 0.7440112 0.00704 ** NA
UTS2B 0.0072533 0.7440112 0.00725 ** NA
TRIM13 0.0073672 0.7440112 0.00737 ** NA
KLHL1 0.0073975 0.7440112 0.00740 ** NA
AMER2 0.0076915 0.7440112 0.00769 ** NA
DMWD 0.0077073 0.7440112 0.00771 ** NA
ATG2A 0.0077283 0.7440112 0.00773 ** NA
NPAT 0.0078418 0.7440112 0.00784 ** NA
SMARCB1 0.0081997 0.7440112 0.00820 ** NA
PAQR3 0.0082276 0.7440112 0.00823 ** NA
SF3B2 0.0084940 0.7440112 0.00849 ** NA
NGRN 0.0085338 0.7440112 0.00853 ** NA
SKOR1 0.0085338 0.7440112 0.00853 ** NA
PHLPP1 0.0085991 0.7440112 0.00860 ** NA
ZBTB25 0.0086381 0.7440112 0.00864 ** NA
ZFR 0.0087353 0.7440112 0.00874 ** NA
ZNF124 0.0089578 0.7440112 0.00896 ** NA
TOP1MT 0.0089680 0.7440112 0.00897 ** NA
NUP98 0.0091458 0.7440112 0.00915 ** NA
THEMIS 0.0092069 0.7440112 0.00921 ** NA
ESYT2 0.0092528 0.7440112 0.00925 ** NA
DZANK1 0.0092793 0.7440112 0.00928 ** NA
SRPR 0.0092882 0.7440112 0.00929 ** NA
PAX5 0.0093106 0.7440112 0.00931 ** NA
ST5 0.0094802 0.7440112 0.00948 ** NA
TTC22 0.0094965 0.7440112 0.00950 ** NA
BUB1 0.0095144 0.7440112 0.00951 ** NA
RIMBP3 0.0096462 0.7440112 0.00965 ** NA
ORC3 0.0101460 0.7440112 0.01015
NA
ANK2 0.0102526 0.7440112 0.01025
NA
NUP188 0.0102849 0.7440112 0.01028
NA
VLDLR 0.0103143 0.7440112 0.01031
NA
CENPN 0.0103696 0.7440112 0.01037
NA
TIMM44 0.0104690 0.7440112 0.01047
NA
SLITRK1 0.0105878 0.7440112 0.01059
NA
DPP7 0.0107060 0.7440112 0.01071
NA
DENND6B 0.0111415 0.7440112 0.01114
NA
RNF34 0.0113109 0.7440112 0.01131
NA
KIAA0319L 0.0115810 0.7440112 0.01158
NA
LPO 0.0116102 0.7440112 0.01161
NA
ANGPTL3 0.0116442 0.7440112 0.01164
NA
CDH2 0.0118805 0.7440112 0.01188
NA
OR5D14 0.0119207 0.7440112 0.01192
NA
SLC4A8 0.0119350 0.7440112 0.01193
NA
RFC1 0.0120450 0.7440112 0.01205
NA
ZNF571 0.0122030 0.7440112 0.01220
NA
TTC1 0.0123463 0.7440112 0.01235
NA
ELK3 0.0124923 0.7440112 0.01249
NA
ZFYVE16 0.0127670 0.7440112 0.01277
NA
CWH43 0.0128962 0.7440112 0.01290
NA
ZNF536 0.0129168 0.7440112 0.01292
NA
ARMC3 0.0130830 0.7440112 0.01308
NA
ELTD1 0.0133559 0.7440112 0.01336
NA
OR4K1 0.0133924 0.7440112 0.01339
NA
PLEKHM1 0.0134758 0.7440112 0.01348
NA
PRODH2 0.0135312 0.7440112 0.01353
NA
MTHFD1 0.0141191 0.7440112 0.01412
NA
MYOC 0.0141485 0.7440112 0.01415
NA
TTI1 0.0141895 0.7440112 0.01419
NA
PHYKPL 0.0145159 0.7440112 0.01452
NA
NF1 0.0145228 0.7440112 0.01452
NA
C15orf41 0.0145458 0.7440112 0.01455
NA
VPS13D 0.0145537 0.7440112 0.01455
NA
METTL17 0.0146362 0.7440112 0.01464
NA
PLCH1 0.0146973 0.7440112 0.01470
NA
ARHGEF15 0.0148093 0.7440112 0.01481
NA
MCM10 0.0148519 0.7440112 0.01485
NA
ZBTB41 0.0151996 0.7440112 0.01520
NA
FAM193B 0.0152532 0.7440112 0.01525
NA
SNX14 0.0152641 0.7440112 0.01526
NA
CHEK2 0.0153426 0.7440112 0.01534
NA
SUGP1 0.0154425 0.7440112 0.01544
NA
KIAA1731 0.0155107 0.7440112 0.01551
NA
CAMK2B 0.0155438 0.7440112 0.01554
NA
BAP1 0.0157521 0.7440112 0.01575
NA
PLCH2 0.0158874 0.7440112 0.01589
NA
MS4A8 0.0159011 0.7440112 0.01590
NA
INTS4 0.0159428 0.7440112 0.01594
NA
PPIG 0.0159689 0.7440112 0.01597
NA
SREK1IP1 0.0159901 0.7440112 0.01599
NA
NHSL1 0.0160609 0.7440112 0.01606
NA
NCAPG 0.0162126 0.7440112 0.01621
NA
TYMS 0.0162168 0.7440112 0.01622
NA
HIP1R 0.0162733 0.7440112 0.01627
NA
C2orf16 0.0163209 0.7440112 0.01632
NA
CACYBP 0.0164377 0.7440112 0.01644
NA
FAM133B 0.0164486 0.7440112 0.01645
NA
PRKCZ 0.0164498 0.7440112 0.01645
NA
TCF19 0.0164498 0.7440112 0.01645
NA
KMT2E 0.0165564 0.7440112 0.01656
NA
DDX46 0.0166289 0.7440112 0.01663
NA
LOXL3 0.0166388 0.7440112 0.01664
NA
KDM5B 0.0167711 0.7440112 0.01677
NA
UNC13B 0.0167873 0.7440112 0.01679
NA
HS6ST1 0.0171234 0.7440112 0.01712
NA
SRL 0.0173728 0.7440112 0.01737
NA
RBAK 0.0175357 0.7440112 0.01754
NA
KIDINS220 0.0175972 0.7440112 0.01760
NA
GATS 0.0176183 0.7440112 0.01762
NA
SEMA5A 0.0176624 0.7440112 0.01766
NA
ARID5B 0.0176670 0.7440112 0.01767
NA
SRSF11 0.0177257 0.7440112 0.01773
NA
UAP1L1 0.0177257 0.7440112 0.01773
NA
ACSM2B 0.0177775 0.7440112 0.01778
NA
THSD7A 0.0178267 0.7440112 0.01783
NA
DPRX 0.0181967 0.7440112 0.01820
NA
NDC80 0.0181967 0.7440112 0.01820
NA
ST6GALNAC1 0.0183398 0.7440112 0.01834
NA
PDE1B 0.0184191 0.7440112 0.01842
NA
TMEM41B 0.0184648 0.7440112 0.01846
NA
THAP8 0.0184776 0.7440112 0.01848
NA
SSH3 0.0184807 0.7440112 0.01848
NA
MYBPC2 0.0185554 0.7440112 0.01856
NA
KDM1A 0.0185906 0.7440112 0.01859
NA
ARSB 0.0186005 0.7440112 0.01860
NA
ZNF585A 0.0187860 0.7440112 0.01879
NA
LRRC37A3 0.0187890 0.7440112 0.01879
NA
POLR3E 0.0188444 0.7440112 0.01884
NA
CYP4F3 0.0189552 0.7440112 0.01896
NA
EIF3M 0.0190178 0.7440112 0.01902
NA
ZNF581 0.0191124 0.7440112 0.01911
NA
ATP8B4 0.0194207 0.7440112 0.01942
NA
TANGO6 0.0194580 0.7440112 0.01946
NA
SAMM50 0.0194922 0.7440112 0.01949
NA
TIMM50 0.0194922 0.7440112 0.01949
NA
CLEC9A 0.0196115 0.7440112 0.01961
NA
XIRP1 0.0197014 0.7440112 0.01970
NA
DHX57 0.0197101 0.7440112 0.01971
NA
FNTA 0.0199034 0.7440112 0.01990
NA
IMP3 0.0199034 0.7440112 0.01990
NA
SRSF6 0.0199034 0.7440112 0.01990
NA
TOMM40 0.0199034 0.7440112 0.01990
NA
BANK1 0.0200489 0.7440112 0.02005
NA
C5orf42 0.0200703 0.7440112 0.02007
NA
CD1E 0.0201041 0.7440112 0.02010
NA
ZCCHC11 0.0201479 0.7440112 0.02015
NA
USF1 0.0201733 0.7440112 0.02017
NA
RAD54B 0.0202809 0.7440112 0.02028
NA
PI4K2A 0.0202952 0.7440112 0.02030
NA
MPHOSPH10 0.0203621 0.7440112 0.02036
NA
OPRL1 0.0204465 0.7440112 0.02045
NA
GOLIM4 0.0204740 0.7440112 0.02047
NA
TNFAIP8 0.0205509 0.7440112 0.02055
NA
TEK 0.0206927 0.7440112 0.02069
NA
DENND1A 0.0207496 0.7440112 0.02075
NA
C11orf24 0.0208130 0.7440112 0.02081
NA
SSH1 0.0209270 0.7440112 0.02093
NA
RAPGEF4 0.0209862 0.7440112 0.02099
NA
HMGB1 0.0210024 0.7440112 0.02100
NA
ULK1 0.0210253 0.7440112 0.02103
NA
MAPK15 0.0212485 0.7440112 0.02125
NA
WDR16 0.0212725 0.7440112 0.02127
NA
TAS2R13 0.0212853 0.7440112 0.02129
NA
ZC3HC1 0.0212853 0.7440112 0.02129
NA
IHH 0.0213193 0.7440112 0.02132
NA
FIP1L1 0.0213221 0.7440112 0.02132
NA
ELL2 0.0214238 0.7440112 0.02142
NA
SURF6 0.0215360 0.7440112 0.02154
NA
RAE1 0.0217615 0.7440112 0.02176
NA
ATR 0.0217885 0.7440112 0.02179
NA
KCNA5 0.0218055 0.7440112 0.02181
NA
ATP6V0A2 0.0218056 0.7440112 0.02181
NA
NAA15 0.0218557 0.7440112 0.02186
NA
ZNF878 0.0218941 0.7440112 0.02189
NA
SLC22A3 0.0219157 0.7440112 0.02192
NA
CALCR 0.0221211 0.7440112 0.02212
NA
CD320 0.0221539 0.7440112 0.02215
NA
KPNA6 0.0221836 0.7440112 0.02218
NA
BAI3 0.0222061 0.7440112 0.02221
NA
COL11A1 0.0222203 0.7440112 0.02222
NA
PKP3 0.0222621 0.7440112 0.02226
NA
SLC17A1 0.0222818 0.7440112 0.02228
NA
ZNF74 0.0223389 0.7440112 0.02234
NA
TMEM63C 0.0223767 0.7440112 0.02238
NA
CEACAM1 0.0223857 0.7440112 0.02239
NA
ZNF207 0.0224145 0.7440112 0.02241
NA
CD302 0.0224258 0.7440112 0.02243
NA
SLC37A1 0.0224762 0.7440112 0.02248
NA
RRP12 0.0225550 0.7440112 0.02256
NA
COL1A1 0.0226218 0.7440112 0.02262
NA
SYCP2L 0.0227500 0.7440112 0.02275
NA
LNPEP 0.0228276 0.7440112 0.02283
NA
SPAG17 0.0230011 0.7440112 0.02300
NA
PTPN22 0.0230120 0.7440112 0.02301
NA
DENND4C 0.0232757 0.7440112 0.02328
NA
APOA1BP 0.0233600 0.7440112 0.02336
NA
EVI2B 0.0233600 0.7440112 0.02336
NA
RAD50 0.0234163 0.7440112 0.02342
NA
KCNJ6 0.0234914 0.7440112 0.02349
NA
RPS6KA2 0.0235958 0.7440112 0.02360
NA
SRSF7 0.0236703 0.7440112 0.02367
NA
GIGYF1 0.0238378 0.7440112 0.02384
NA
CDC6 0.0239032 0.7440112 0.02390
NA
PIK3R2 0.0239841 0.7440112 0.02398
NA
THADA 0.0240031 0.7440112 0.02400
NA
WRNIP1 0.0240827 0.7440112 0.02408
NA
CMYA5 0.0242763 0.7440112 0.02428
NA
PRRT3 0.0242853 0.7440112 0.02429
NA
CDK5RAP2 0.0242967 0.7440112 0.02430
NA
PRMT8 0.0243497 0.7440112 0.02435
NA
KIAA1467 0.0245131 0.7440112 0.02451
NA
DLX5 0.0245836 0.7440112 0.02458
NA
SLC25A4 0.0245960 0.7440112 0.02460
NA
KIAA1324L 0.0246190 0.7440112 0.02462
NA
BAIAP2 0.0246226 0.7440112 0.02462
NA
KIAA1755 0.0248485 0.7440112 0.02485
NA
DIP2A 0.0251488 0.7440112 0.02515
NA
NFASC 0.0251569 0.7440112 0.02516
NA
GRWD1 0.0252188 0.7440112 0.02522
NA
WDR27 0.0252324 0.7440112 0.02523
NA
PCDH12 0.0252450 0.7440112 0.02525
NA
SGK1 0.0252595 0.7440112 0.02526
NA
CEP192 0.0252892 0.7440112 0.02529
NA
NRD1 0.0253277 0.7440112 0.02533
NA
SF3A2 0.0254511 0.7440112 0.02545
NA
C14orf39 0.0254571 0.7440112 0.02546
NA
MUS81 0.0254783 0.7440112 0.02548
NA
MEI1 0.0255356 0.7440112 0.02554
NA
DENR 0.0256080 0.7440112 0.02561
NA
IMMT 0.0256080 0.7440112 0.02561
NA
RYR1 0.0257094 0.7440112 0.02571
NA
ATP8A1 0.0258844 0.7440112 0.02588
NA
ARL16 0.0260661 0.7440112 0.02607
NA
TJP3 0.0261039 0.7440112 0.02610
NA
ALDH16A1 0.0261587 0.7440112 0.02616
NA
PPP1R12B 0.0262521 0.7440112 0.02625
NA
STEAP3 0.0262837 0.7440112 0.02628
NA
ARID2 0.0265889 0.7440112 0.02659
NA
IDI2 0.0266273 0.7440112 0.02663
NA
DSCAM 0.0267708 0.7440112 0.02677
NA
AVL9 0.0267977 0.7440112 0.02680
NA
GRXCR1 0.0267977 0.7440112 0.02680
NA
PROB1 0.0269397 0.7440112 0.02694
NA
AGBL1 0.0269699 0.7440112 0.02697
NA
CAMKMT 0.0269748 0.7440112 0.02697
NA
TMPO 0.0271515 0.7440112 0.02715
NA
DNAH11 0.0272393 0.7440112 0.02724
NA
SKAP1 0.0272913 0.7440112 0.02729
NA
LAX1 0.0273444 0.7440112 0.02734
NA
SPAG6 0.0274579 0.7440112 0.02746
NA
IQSEC1 0.0274935 0.7440112 0.02749
NA
SLC7A5 0.0276455 0.7440112 0.02765
NA
SDAD1 0.0276596 0.7440112 0.02766
NA
SMARCA4 0.0276732 0.7440112 0.02767
NA
SYNE2 0.0277609 0.7440112 0.02776
NA
COX17 0.0277763 0.7440112 0.02778
NA
RPL21 0.0277763 0.7440112 0.02778
NA
STAT5A 0.0280036 0.7440112 0.02800
NA
SMURF1 0.0280333 0.7440112 0.02803
NA
GOLGA2 0.0280390 0.7440112 0.02804
NA
DEFB131 0.0280408 0.7440112 0.02804
NA
GTF2A1 0.0280408 0.7440112 0.02804
NA
RNASEH1 0.0280408 0.7440112 0.02804
NA
TMEM87A 0.0280408 0.7440112 0.02804
NA
UTP14C 0.0280686 0.7440112 0.02807
NA
STK17B 0.0280705 0.7440112 0.02807
NA
IRGQ 0.0281842 0.7440112 0.02818
NA
SDHD 0.0284041 0.7440112 0.02840
NA
BRD9 0.0287319 0.7440112 0.02873
NA
RNFT2 0.0287715 0.7440112 0.02877
NA
RCHY1 0.0289694 0.7440112 0.02897
NA
FUT4 0.0290213 0.7440112 0.02902
NA
TPRN 0.0290616 0.7440112 0.02906
NA
OSR1 0.0290711 0.7440112 0.02907
NA
EPRS 0.0290841 0.7440112 0.02908
NA
DHX33 0.0291429 0.7440112 0.02914
NA
OARD1 0.0291429 0.7440112 0.02914
NA
STAR 0.0291429 0.7440112 0.02914
NA
GRHL1 0.0294521 0.7440112 0.02945
NA
BMF 0.0295185 0.7440112 0.02952
NA
RALGPS2 0.0295185 0.7440112 0.02952
NA
ACAD8 0.0295823 0.7440112 0.02958
NA
RNF144B 0.0297642 0.7440112 0.02976
NA
ALG8 0.0298929 0.7440112 0.02989
NA
PLEKHB1 0.0298929 0.7440112 0.02989
NA
SLC3A1 0.0298929 0.7440112 0.02989
NA
BAG2 0.0298982 0.7440112 0.02990
NA
DHRS9 0.0299865 0.7440112 0.02999
NA
FAM65C 0.0300893 0.7440112 0.03009
NA
GINS3 0.0302821 0.7440112 0.03028
NA
GTPBP4 0.0304299 0.7440112 0.03043
NA
FBXO46 0.0305521 0.7440112 0.03055
NA
MYCBP 0.0306703 0.7440112 0.03067
NA
SCTR 0.0306703 0.7440112 0.03067
NA
STOML2 0.0306703 0.7440112 0.03067
NA
SYNRG 0.0307273 0.7440112 0.03073
NA
CTSO 0.0308986 0.7440112 0.03090
NA
GLP1R 0.0309671 0.7440112 0.03097
NA
ITGAD 0.0310012 0.7440112 0.03100
NA
RNF182 0.0310275 0.7440112 0.03103
NA
TRIM16 0.0310527 0.7440112 0.03105
NA
PPFIBP2 0.0313148 0.7440112 0.03131
NA
CMIP 0.0314109 0.7440112 0.03141
NA
AHR 0.0314700 0.7440112 0.03147
NA
DNTTIP2 0.0318604 0.7440112 0.03186
NA
SARS2 0.0318604 0.7440112 0.03186
NA
TRAPPC12 0.0321131 0.7440112 0.03211
NA
IFRD1 0.0321468 0.7440112 0.03215
NA
ZNF117 0.0321940 0.7440112 0.03219
NA
C2orf71 0.0322411 0.7440112 0.03224
NA
CHID1 0.0322611 0.7440112 0.03226
NA
FKBP2 0.0322658 0.7440112 0.03227
NA
TXNIP 0.0322658 0.7440112 0.03227
NA
VWA3B 0.0323842 0.7440112 0.03238
NA
ZMYND11 0.0325036 0.7440112 0.03250
NA
RECK 0.0325066 0.7440112 0.03251
NA
ZC3H6 0.0325252 0.7440112 0.03253
NA
ADRBK1 0.0326005 0.7440112 0.03260
NA
ACBD6 0.0326756 0.7440112 0.03268
NA
KLHL23 0.0328289 0.7440112 0.03283
NA
CPVL 0.0328339 0.7440112 0.03283
NA
REV3L 0.0329328 0.7440112 0.03293
NA
CHD6 0.0330817 0.7440112 0.03308
NA
ALDH3B2 0.0330899 0.7440112 0.03309
NA
C11orf21 0.0330899 0.7440112 0.03309
NA
ERP44 0.0330899 0.7440112 0.03309
NA
PRPF40A 0.0332227 0.7440112 0.03322
NA
BAZ1A 0.0332629 0.7440112 0.03326
NA
IL31RA 0.0333880 0.7440112 0.03339
NA
SALL4 0.0334874 0.7440112 0.03349
NA
INPP5F 0.0334990 0.7440112 0.03350
NA
SNRPA1 0.0335087 0.7440112 0.03351
NA
DUSP22 0.0336636 0.7440112 0.03366
NA
TCFL5 0.0336636 0.7440112 0.03366
NA
GON4L 0.0337522 0.7440112 0.03375
NA
TNIK 0.0337624 0.7440112 0.03376
NA
SORCS1 0.0338045 0.7440112 0.03380
NA
GREB1 0.0338290 0.7440112 0.03383
NA
ZNF469 0.0338750 0.7440112 0.03387
NA
ARHGEF39 0.0339320 0.7440112 0.03393
NA
C19orf60 0.0339320 0.7440112 0.03393
NA
OR1E2 0.0339320 0.7440112 0.03393
NA
CUL5 0.0340399 0.7440112 0.03404
NA
INPP4B 0.0340955 0.7440112 0.03410
NA
DENND1B 0.0341606 0.7440112 0.03416
NA
AATF 0.0343598 0.7440112 0.03436
NA
ATP6V1C1 0.0343598 0.7440112 0.03436
NA
APAF1 0.0346080 0.7440112 0.03461
NA
SLC28A2 0.0346976 0.7440112 0.03470
NA
FBXL20 0.0347923 0.7440112 0.03479
NA
HIST1H2BC 0.0347923 0.7440112 0.03479
NA
TCN1 0.0347923 0.7440112 0.03479
NA
PRRX1 0.0348995 0.7440112 0.03490
NA
RASEF 0.0348995 0.7440112 0.03490
NA
SGSM2 0.0349384 0.7440112 0.03494
NA
TJP1 0.0349735 0.7440112 0.03497
NA
ZNF496 0.0351164 0.7440112 0.03512
NA
FRMD4B 0.0351679 0.7440112 0.03517
NA
UGT1A6 0.0351679 0.7440112 0.03517
NA
C1orf159 0.0353139 0.7440112 0.03531
NA
GIMAP7 0.0353874 0.7440112 0.03539
NA
NOL6 0.0354282 0.7440112 0.03543
NA
WDR47 0.0354830 0.7440112 0.03548
NA
THBS3 0.0357025 0.7440112 0.03570
NA
RBBP8 0.0357101 0.7440112 0.03571
NA
KCNJ5 0.0358180 0.7440112 0.03582
NA
TULP1 0.0358602 0.7440112 0.03586
NA
AKR1C2 0.0359515 0.7440112 0.03595
NA
GPR126 0.0359515 0.7440112 0.03595
NA
MOG 0.0359719 0.7440112 0.03597
NA
NEK7 0.0359825 0.7440112 0.03598
NA
UBXN4 0.0359887 0.7440112 0.03599
NA
BTNL3 0.0360530 0.7440112 0.03605
NA
SPHAR 0.0361177 0.7440112 0.03612
NA
POTEH 0.0361769 0.7440112 0.03618
NA
ECT2L 0.0362229 0.7440112 0.03622
NA
AGT 0.0363134 0.7440112 0.03631
NA
SEC31B 0.0365899 0.7440112 0.03659
NA
SLC12A6 0.0366283 0.7440112 0.03663
NA
TMOD2 0.0367203 0.7440112 0.03672
NA
MMP20 0.0367531 0.7440112 0.03675
NA
NSFL1C 0.0367785 0.7440112 0.03678
NA
CYP26A1 0.0368908 0.7440112 0.03689
NA
BRMS1 0.0369352 0.7440112 0.03694
NA
MYT1L 0.0369915 0.7440112 0.03699
NA
NRM 0.0370249 0.7440112 0.03702
NA
UPF3A 0.0371226 0.7440112 0.03712
NA
FGFRL1 0.0371412 0.7440112 0.03714
NA
PGLS 0.0372379 0.7440112 0.03724
NA
STK40 0.0373470 0.7440112 0.03735
NA
COL7A1 0.0373540 0.7440112 0.03735
NA
MPHOSPH9 0.0374137 0.7440112 0.03741
NA
ZNF3 0.0374162 0.7440112 0.03742
NA
NCF1 0.0374858 0.7440112 0.03749
NA
PDZD3 0.0374861 0.7440112 0.03749
NA
PIGB 0.0377961 0.7440112 0.03780
NA
SLCO6A1 0.0378338 0.7440112 0.03783
NA
NECAB1 0.0378656 0.7440112 0.03787
NA
RPLP1 0.0379516 0.7440112 0.03795
NA
SLC25A47 0.0379516 0.7440112 0.03795
NA
PGM5 0.0380424 0.7440112 0.03804
NA
CEL 0.0381779 0.7440112 0.03818
NA
MAP2K3 0.0382766 0.7440112 0.03828
NA
ADCY10 0.0383591 0.7440112 0.03836
NA
CACNG4 0.0384222 0.7440112 0.03842
NA
TMOD3 0.0384222 0.7440112 0.03842
NA
C20orf194 0.0385032 0.7440112 0.03850
NA
BRPF1 0.0386345 0.7440112 0.03863
NA
TRPC4 0.0388235 0.7440112 0.03882
NA
HS3ST3B1 0.0388978 0.7440112 0.03890
NA
KAT8 0.0389009 0.7440112 0.03890
NA
CTNNA1 0.0389275 0.7440112 0.03893
NA
DAG1 0.0389866 0.7440112 0.03899
NA
SYBU 0.0390619 0.7440112 0.03906
NA
HIST1H2AG 0.0393784 0.7440112 0.03938
NA
FPR1 0.0394048 0.7440112 0.03940
NA
TMEM151A 0.0395432 0.7440112 0.03954
NA
PTPRG 0.0396227 0.7440112 0.03962
NA
USP13 0.0396274 0.7440112 0.03963
NA
CLGN 0.0397013 0.7440112 0.03970
NA
KDR 0.0397901 0.7440112 0.03979
NA
LSP1 0.0398448 0.7440112 0.03984
NA
HSD3B7 0.0398641 0.7440112 0.03986
NA
KCNU1 0.0402531 0.7440112 0.04025
NA
IPPK 0.0403548 0.7440112 0.04035
NA
SMIM8 0.0403548 0.7440112 0.04035
NA
SPOP 0.0404230 0.7440112 0.04042
NA
RPRD1B 0.0406221 0.7440112 0.04062
NA
AKAP10 0.0406245 0.7440112 0.04062
NA
SNIP1 0.0406870 0.7440112 0.04069
NA
SLC38A1 0.0407686 0.7440112 0.04077
NA
SAMD14 0.0408506 0.7440112 0.04085
NA
QARS 0.0410123 0.7440112 0.04101
NA
H2AFY2 0.0410175 0.7440112 0.04102
NA
CCT4 0.0410211 0.7440112 0.04102
NA
GNAL 0.0410211 0.7440112 0.04102
NA
HYOU1 0.0411063 0.7440112 0.04111
NA
NOL10 0.0411696 0.7440112 0.04117
NA
DTX4 0.0411937 0.7440112 0.04119
NA
MAP4K3 0.0411937 0.7440112 0.04119
NA
MAST2 0.0412532 0.7440112 0.04125
NA
PIGG 0.0413516 0.7440112 0.04135
NA
PYGM 0.0413516 0.7440112 0.04135
NA
SETDB1 0.0415700 0.7440112 0.04157
NA
C6orf165 0.0415872 0.7440112 0.04159
NA
FASTKD5 0.0417557 0.7440112 0.04176
NA
DPPA4 0.0418439 0.7440112 0.04184
NA
ANXA11 0.0418512 0.7440112 0.04185
NA
SREBF2 0.0418512 0.7440112 0.04185
NA
ACMSD 0.0418578 0.7440112 0.04186
NA
TTPAL 0.0418578 0.7440112 0.04186
NA
UBTD1 0.0418578 0.7440112 0.04186
NA
INTS12 0.0422541 0.7440112 0.04225
NA
PGS1 0.0422606 0.7440112 0.04226
NA
SIGLEC7 0.0423692 0.7440112 0.04237
NA
TTF1 0.0424560 0.7440112 0.04246
NA
GTF3C1 0.0425019 0.7440112 0.04250
NA
NABP2 0.0426779 0.7440112 0.04268
NA
CDHR4 0.0427824 0.7440112 0.04278
NA
GALNT5 0.0428754 0.7440112 0.04288
NA
NBPF3 0.0428921 0.7440112 0.04289
NA
GCNT2 0.0429066 0.7440112 0.04291
NA
COL3A1 0.0430315 0.7440112 0.04303
NA
BMPR1A 0.0430554 0.7440112 0.04306
NA
RASGRP1 0.0430554 0.7440112 0.04306
NA
PPIP5K2 0.0431887 0.7440112 0.04319
NA
NLRP6 0.0432152 0.7440112 0.04322
NA
ADAR 0.0433161 0.7440112 0.04332
NA
MAP9 0.0433431 0.7440112 0.04334
NA
VAMP4 0.0434078 0.7440112 0.04341
NA
ZCWPW2 0.0434078 0.7440112 0.04341
NA
SLAMF9 0.0434745 0.7440112 0.04347
NA
ZNF521 0.0435209 0.7440112 0.04352
NA
TFPI 0.0435222 0.7440112 0.04352
NA
FUBP1 0.0435315 0.7440112 0.04353
NA
HSPD1 0.0435780 0.7440112 0.04358
NA
DDX18 0.0435838 0.7440112 0.04358
NA
PRSS3 0.0436285 0.7440112 0.04363
NA
EMILIN3 0.0437424 0.7440112 0.04374
NA
PCDHA2 0.0437481 0.7440112 0.04375
NA
ECD 0.0437989 0.7440112 0.04380
NA
HAND2 0.0438089 0.7440112 0.04381
NA
LMBR1L 0.0438962 0.7440112 0.04390
NA
SUN3 0.0439352 0.7440112 0.04394
NA
HSF4 0.0441790 0.7440112 0.04418
NA
RUNX2 0.0441844 0.7440112 0.04418
NA
KRT83 0.0442061 0.7440112 0.04421
NA
CCDC54 0.0443944 0.7440112 0.04439
NA
USP6 0.0443973 0.7440112 0.04440
NA
SRRT 0.0444011 0.7440112 0.04440
NA
ENG 0.0444679 0.7440112 0.04447
NA
LRRK2 0.0445023 0.7440112 0.04450
NA
CSNK1G2 0.0445094 0.7440112 0.04451
NA
SLC30A9 0.0447128 0.7440112 0.04471
NA
SERPINB2 0.0447140 0.7440112 0.04471
NA
RANBP3 0.0447140 0.7440112 0.04471
NA
TAF6 0.0447140 0.7440112 0.04471
NA
RFX6 0.0447354 0.7440112 0.04474
NA
CREBBP 0.0447559 0.7440112 0.04476
NA
CD4 0.0447956 0.7440112 0.04480
NA
XCR1 0.0448251 0.7440112 0.04483
NA
CNGA1 0.0448333 0.7440112 0.04483
NA
EBF4 0.0448346 0.7440112 0.04483
NA
NUP205 0.0448814 0.7440112 0.04488
NA
MAML2 0.0448847 0.7440112 0.04488
NA
TMEM173 0.0449082 0.7440112 0.04491
NA
VWA8 0.0449979 0.7440112 0.04500
NA
CPEB1 0.0450061 0.7440112 0.04501
NA
FGF21 0.0450061 0.7440112 0.04501
NA
NME9 0.0450061 0.7440112 0.04501
NA
TWF1 0.0450061 0.7440112 0.04501
NA
WDR77 0.0450061 0.7440112 0.04501
NA
NEDD4 0.0450568 0.7440112 0.04506
NA
CFDP1 0.0452758 0.7440112 0.04528
NA
KRTAP17-1 0.0452758 0.7440112 0.04528
NA
COL9A3 0.0452762 0.7440112 0.04528
NA
GC 0.0454497 0.7440112 0.04545
NA
OR5M1 0.0454984 0.7440112 0.04550
NA
CAPN11 0.0455498 0.7440112 0.04555
NA
SFXN3 0.0455498 0.7440112 0.04555
NA
KIAA1211L 0.0456220 0.7440112 0.04562
NA
MYO9A 0.0456487 0.7440112 0.04565
NA
KRTAP5-1 0.0457215 0.7440112 0.04572
NA
ACTA2 0.0457226 0.7440112 0.04572
NA
DUSP27 0.0457692 0.7440112 0.04577
NA
SBNO1 0.0458868 0.7440112 0.04589
NA
EAPP 0.0460990 0.7440112 0.04610
NA
PMPCA 0.0460990 0.7440112 0.04610
NA
CMC2 0.0461719 0.7440112 0.04617
NA
ERCC3 0.0461719 0.7440112 0.04617
NA
ALDOC 0.0463963 0.7440112 0.04640
NA
MIB2 0.0464456 0.7440112 0.04645
NA
PAK2 0.0466255 0.7440112 0.04663
NA
MME 0.0466326 0.7440112 0.04663
NA
CELF5 0.0466538 0.7440112 0.04665
NA
DLEC1 0.0467871 0.7440112 0.04679
NA
SH3PXD2A 0.0468962 0.7440112 0.04690
NA
RBM39 0.0469049 0.7440112 0.04690
NA
ERCC2 0.0470448 0.7440112 0.04704
NA
DCLRE1C 0.0470829 0.7440112 0.04708
NA
DNAJC8 0.0472436 0.7440112 0.04724
NA
ALDH5A1 0.0473887 0.7440112 0.04739
NA
FGFR1 0.0473887 0.7440112 0.04739
NA
DUS2 0.0475440 0.7440112 0.04754
NA
FKBP10 0.0477327 0.7440112 0.04773
NA
PCYT1A 0.0477712 0.7440112 0.04777
NA
SCO2 0.0477802 0.7440112 0.04778
NA
GABRG1 0.0478264 0.7440112 0.04783
NA
KNOP1 0.0481347 0.7440112 0.04813
NA
ACADL 0.0482407 0.7440112 0.04824
NA
TOP1 0.0484651 0.7440112 0.04847
NA
PLD3 0.0485912 0.7440112 0.04859
NA
UBXN1 0.0486065 0.7440112 0.04861
NA
TAF1B 0.0487066 0.7440112 0.04871
NA
FBXW7 0.0487981 0.7440112 0.04880
NA
PRKAA2 0.0488957 0.7440112 0.04890
NA
ESR2 0.0489293 0.7440112 0.04893
NA
CACNB2 0.0491393 0.7440112 0.04914
NA
STAT3 0.0493968 0.7440112 0.04940
NA
GIMAP5 0.0494266 0.7440112 0.04943
NA
EXT1 0.0494783 0.7440112 0.04948
NA
GEMIN2 0.0495125 0.7440112 0.04951
NA
HACE1 0.0495125 0.7440112 0.04951
NA
KLHL33 0.0495125 0.7440112 0.04951
NA
MAPK4 0.0495125 0.7440112 0.04951
NA
CENPJ 0.0495338 0.7440112 0.04953
NA
PARP4 0.0496821 0.7440112 0.04968
NA
RLN2 0.0498459 0.7440112 0.04985
NA
PTPN3 0.0498521 0.7440112 0.04985
NA
GDI2 0.0498660 0.7440112 0.04987
NA
C7orf63 0.0499705 0.7440112 0.04997
NA
DHH 0.0499834 0.7440112 0.04998
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_gene_allmut_plot <- ggplot(data = crispr_signif_allmut_del) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_allmut_plot

# ggsave(filename = "./plots_18Q3/crispr/pvals_genes.pdf", plot = wilcox_gene_plot, width = 8, height = 4, device = "pdf")

5.1.2 Non-silent mutant vs. Other

crispr_signif_allmut_nonsilent <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol"), data = crispr_data, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_allmut_nonsilent <- adj_signif(crispr_signif_allmut_nonsilent)
crispr_signif_allmut_nonsilent <- crispr_signif_allmut_nonsilent[order(crispr_signif_allmut_nonsilent$p),]
saveRDS(crispr_signif_allmut_nonsilent, "./data_munging/rds/crispr_signif_allmut_nonsilent_gene.rds")

# write.table(crispr_signif_allmut_nonsilent, file = "~/Desktop/crispr_signif_allmut_nonsilent_gene.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_allmut_nonsilent <- readRDS("./data_munging/rds/crispr_signif_allmut_nonsilent_gene.rds")

knitr::kable(filter(crispr_signif_allmut_nonsilent, p < 0.05)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing non-silent mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol p p.adj p.format p.signif p.signif.adj
TP53 0.0000000 0.0000000 < 2e-16 **** ****
KRAS 0.0000000 0.0000000 < 2e-16 **** ****
NRAS 0.0000000 0.0000000 < 2e-16 **** ****
BRAF 0.0000000 0.0000000 < 2e-16 **** ****
PTEN 0.0000000 0.0000000 < 2e-16 **** ****
PIK3CA 0.0000000 0.0000000 1.0e-13 **** ****
PIK3R1 0.0000001 0.0003379 1.4e-07 **** ***
CTNNB1 0.0000023 0.0050434 2.3e-06 **** **
TCERG1 0.0000055 0.0104819 5.5e-06 ****
ARID1A 0.0000065 0.0111737 6.5e-06 ****
TPR 0.0000510 0.0797535 5.1e-05 **** NA
VHL 0.0000665 0.0952975 6.7e-05 **** NA
FCGBP 0.0000895 0.1184104 9.0e-05 **** NA
ZNF177 0.0001226 0.1505314 0.00012 *** NA
C14orf39 0.0002001 0.2293087 0.00020 *** NA
SLC22A9 0.0002503 0.2677702 0.00025 *** NA
GSTM5 0.0002648 0.2677702 0.00026 *** NA
NIPBL 0.0003016 0.2880836 0.00030 *** NA
PIGW 0.0003638 0.3291939 0.00036 *** NA
TLX2 0.0004787 0.4114775 0.00048 *** NA
ARFGAP1 0.0005157 0.4159808 0.00052 *** NA
ZNF808 0.0005323 0.4159808 0.00053 *** NA
CD320 0.0005816 0.4347206 0.00058 *** NA
ING2 0.0006989 0.4568910 0.00070 *** NA
MAT2B 0.0007184 0.4568910 0.00072 *** NA
SYNPO2L 0.0007699 0.4568910 0.00077 *** NA
UTP20 0.0007718 0.4568910 0.00077 *** NA
HRAS 0.0008408 0.4568910 0.00084 *** NA
TAOK2 0.0008437 0.4568910 0.00084 *** NA
CPSF1 0.0008505 0.4568910 0.00085 *** NA
UTP3 0.0008549 0.4568910 0.00085 *** NA
RFC1 0.0008787 0.4568910 0.00088 *** NA
RNF208 0.0008907 0.4568910 0.00089 *** NA
KHSRP 0.0009036 0.4568910 0.00090 *** NA
KCNIP4 0.0009472 0.4652404 0.00095 *** NA
GOLGA3 0.0010340 0.4841935 0.00103 ** NA
PROM1 0.0010485 0.4841935 0.00105 ** NA
PMPCA 0.0010990 0.4841935 0.00110 ** NA
MDN1 0.0011415 0.4841935 0.00114 ** NA
PCDHA8 0.0012404 0.4841935 0.00124 ** NA
OR13C4 0.0012702 0.4841935 0.00127 ** NA
FASTKD2 0.0012728 0.4841935 0.00127 ** NA
TELO2 0.0012922 0.4841935 0.00129 ** NA
TAS1R2 0.0013163 0.4841935 0.00132 ** NA
ZNF439 0.0013227 0.4841935 0.00132 ** NA
KRT19 0.0013501 0.4841935 0.00135 ** NA
AVEN 0.0013562 0.4841935 0.00136 ** NA
MTMR2 0.0014414 0.4841935 0.00144 ** NA
E2F1 0.0014486 0.4841935 0.00145 ** NA
IQCH 0.0014602 0.4841935 0.00146 ** NA
LPO 0.0014636 0.4841935 0.00146 ** NA
FRMD4B 0.0014758 0.4841935 0.00148 ** NA
PLA2G4F 0.0014997 0.4841935 0.00150 ** NA
DSEL 0.0015209 0.4841935 0.00152 ** NA
HSD3B7 0.0015616 0.4880853 0.00156 ** NA
PCDHB15 0.0016370 0.4937603 0.00164 ** NA
TAAR1 0.0016765 0.4937603 0.00168 ** NA
MYH13 0.0016962 0.4937603 0.00170 ** NA
ACSM2B 0.0017107 0.4937603 0.00171 ** NA
OR8D1 0.0017233 0.4937603 0.00172 ** NA
KIAA1211L 0.0019402 0.5370893 0.00194 ** NA
SENP8 0.0019559 0.5370893 0.00196 ** NA
RUVBL1 0.0019950 0.5370893 0.00200 ** NA
OR52E8 0.0020406 0.5370893 0.00204 ** NA
CNOT1 0.0020488 0.5370893 0.00205 ** NA
PI4K2A 0.0020961 0.5370893 0.00210 ** NA
KPNA6 0.0021334 0.5370893 0.00213 ** NA
ST6GALNAC1 0.0022068 0.5370893 0.00221 ** NA
POU2F1 0.0022102 0.5370893 0.00221 ** NA
BTBD11 0.0022318 0.5370893 0.00223 ** NA
LPCAT4 0.0022875 0.5370893 0.00229 ** NA
LILRB2 0.0023004 0.5370893 0.00230 ** NA
ANKRD31 0.0023475 0.5370893 0.00235 ** NA
OR51T1 0.0023614 0.5370893 0.00236 ** NA
METTL17 0.0023923 0.5370893 0.00239 ** NA
POLG 0.0024034 0.5370893 0.00240 ** NA
CIITA 0.0024057 0.5370893 0.00241 ** NA
ADAM15 0.0024806 0.5467237 0.00248 ** NA
RAB43 0.0025433 0.5500972 0.00254 ** NA
EZH2 0.0025733 0.5500972 0.00257 ** NA
ZDHHC24 0.0025919 0.5500972 0.00259 ** NA
NFE2L2 0.0026889 0.5525281 0.00269 ** NA
SURF6 0.0027361 0.5525281 0.00274 ** NA
KIF11 0.0027512 0.5525281 0.00275 ** NA
SDHD 0.0027619 0.5525281 0.00276 ** NA
GRM7 0.0027641 0.5525281 0.00276 ** NA
NXPH4 0.0028292 0.5590491 0.00283 ** NA
DENND4C 0.0028765 0.5604565 0.00288 ** NA
LRGUK 0.0029016 0.5604565 0.00290 ** NA
SAMM50 0.0030102 0.5719308 0.00301 ** NA
ACTA1 0.0030465 0.5719308 0.00305 ** NA
SPAG17 0.0030697 0.5719308 0.00307 ** NA
SLC26A2 0.0030940 0.5719308 0.00309 ** NA
MAP2K3 0.0032831 0.5896613 0.00328 ** NA
DIS3L2 0.0032847 0.5896613 0.00328 ** NA
PTPRE 0.0032929 0.5896613 0.00329 ** NA
SCG2 0.0034839 0.6121167 0.00348 ** NA
TRIM8 0.0034895 0.6121167 0.00349 ** NA
CAMK2B 0.0035496 0.6128833 0.00355 ** NA
SLC38A7 0.0036411 0.6128833 0.00364 ** NA
MMRN2 0.0036540 0.6128833 0.00365 ** NA
MAML2 0.0037079 0.6128833 0.00371 ** NA
SGCD 0.0037645 0.6128833 0.00376 ** NA
FBXW7 0.0037715 0.6128833 0.00377 ** NA
ATXN2 0.0037776 0.6128833 0.00378 ** NA
VPS13D 0.0037846 0.6128833 0.00378 ** NA
KRT83 0.0038147 0.6128833 0.00381 ** NA
SUSD5 0.0039261 0.6249422 0.00393 ** NA
ATR 0.0040408 0.6288252 0.00404 ** NA
ATXN2L 0.0041364 0.6288252 0.00414 ** NA
CD83 0.0041819 0.6288252 0.00418 ** NA
ZNF135 0.0042047 0.6288252 0.00420 ** NA
CREBBP 0.0042381 0.6288252 0.00424 ** NA
TOP1MT 0.0042412 0.6288252 0.00424 ** NA
EMILIN3 0.0042659 0.6288252 0.00427 ** NA
SPTBN4 0.0042799 0.6288252 0.00428 ** NA
SPHK2 0.0043100 0.6288252 0.00431 ** NA
GNAI2 0.0043171 0.6288252 0.00432 ** NA
PSMB4 0.0043587 0.6288252 0.00436 ** NA
TPP1 0.0046001 0.6288252 0.00460 ** NA
NFE2L1 0.0046446 0.6288252 0.00464 ** NA
PIGP 0.0046922 0.6288252 0.00469 ** NA
PPP1R1C 0.0047398 0.6288252 0.00474 ** NA
CDC37 0.0047810 0.6288252 0.00478 ** NA
TFAP2A 0.0048201 0.6288252 0.00482 ** NA
CD200R1 0.0048862 0.6288252 0.00489 ** NA
CWH43 0.0048913 0.6288252 0.00489 ** NA
FOXRED1 0.0049144 0.6288252 0.00491 ** NA
HCRTR1 0.0049160 0.6288252 0.00492 ** NA
CACNA1I 0.0050408 0.6288252 0.00504 ** NA
RBBP9 0.0050826 0.6288252 0.00508 ** NA
OGFOD3 0.0051338 0.6288252 0.00513 ** NA
AKR1C1 0.0051682 0.6288252 0.00517 ** NA
TBC1D22A 0.0052429 0.6288252 0.00524 ** NA
APOBEC1 0.0052779 0.6288252 0.00528 ** NA
OR56A3 0.0052916 0.6288252 0.00529 ** NA
SLC46A2 0.0053108 0.6288252 0.00531 ** NA
STK17B 0.0053176 0.6288252 0.00532 ** NA
C6orf15 0.0053410 0.6288252 0.00534 ** NA
SMPD1 0.0053513 0.6288252 0.00535 ** NA
FBXW12 0.0053691 0.6288252 0.00537 ** NA
MGA 0.0053870 0.6288252 0.00539 ** NA
RSPH6A 0.0053903 0.6288252 0.00539 ** NA
EEF2 0.0054341 0.6288252 0.00543 ** NA
CD5L 0.0054356 0.6288252 0.00544 ** NA
AKR1B15 0.0054791 0.6288252 0.00548 ** NA
THADA 0.0055256 0.6288252 0.00553 ** NA
MYOC 0.0055382 0.6288252 0.00554 ** NA
SLC12A4 0.0056227 0.6288252 0.00562 ** NA
DNAJC5B 0.0057016 0.6288252 0.00570 ** NA
TAS2R60 0.0057034 0.6288252 0.00570 ** NA
IBA57 0.0057420 0.6288252 0.00574 ** NA
HDGFRP2 0.0057596 0.6288252 0.00576 ** NA
MRPS34 0.0057928 0.6288252 0.00579 ** NA
AP5B1 0.0057997 0.6288252 0.00580 ** NA
KIF3B 0.0058153 0.6288252 0.00582 ** NA
SSH2 0.0058405 0.6288252 0.00584 ** NA
MBD3L2 0.0058844 0.6288252 0.00588 ** NA
COPS2 0.0059315 0.6288252 0.00593 ** NA
WDR75 0.0059969 0.6288252 0.00600 ** NA
FRYL 0.0060235 0.6288252 0.00602 ** NA
ZNF438 0.0060372 0.6288252 0.00604 ** NA
ELK3 0.0061135 0.6288252 0.00611 ** NA
MUS81 0.0061273 0.6288252 0.00613 ** NA
PRRC1 0.0061280 0.6288252 0.00613 ** NA
CLEC9A 0.0062087 0.6288252 0.00621 ** NA
LMX1A 0.0062097 0.6288252 0.00621 ** NA
SFXN3 0.0062354 0.6288252 0.00624 ** NA
FAM181B 0.0062849 0.6288252 0.00628 ** NA
SMARCB1 0.0062993 0.6288252 0.00630 ** NA
ACBD6 0.0063036 0.6288252 0.00630 ** NA
SUPT7L 0.0063204 0.6288252 0.00632 ** NA
CYP19A1 0.0063281 0.6288252 0.00633 ** NA
FBXL20 0.0064106 0.6333572 0.00641 ** NA
OR4N2 0.0065455 0.6387591 0.00655 ** NA
MIIP 0.0066145 0.6387591 0.00661 ** NA
FCN3 0.0066248 0.6387591 0.00662 ** NA
ZNF107 0.0066752 0.6387591 0.00668 ** NA
MLST8 0.0067360 0.6387591 0.00674 ** NA
TSPAN13 0.0067540 0.6387591 0.00675 ** NA
DPP7 0.0067839 0.6387591 0.00678 ** NA
KDM5B 0.0068837 0.6387591 0.00688 ** NA
IFFO2 0.0068857 0.6387591 0.00689 ** NA
COG3 0.0069083 0.6387591 0.00691 ** NA
DHX35 0.0069214 0.6387591 0.00692 ** NA
PPM1A 0.0069353 0.6387591 0.00694 ** NA
MSGN1 0.0069483 0.6387591 0.00695 ** NA
ANKRD32 0.0071033 0.6427900 0.00710 ** NA
TLN1 0.0071319 0.6427900 0.00713 ** NA
POC1A 0.0071368 0.6427900 0.00714 ** NA
CLDN5 0.0071709 0.6427900 0.00717 ** NA
PRKCZ 0.0072554 0.6427900 0.00726 ** NA
ACTL8 0.0072969 0.6427900 0.00730 ** NA
KRTAP10-6 0.0072992 0.6427900 0.00730 ** NA
SMCR8 0.0073359 0.6427900 0.00734 ** NA
OLFML2B 0.0073612 0.6427900 0.00736 ** NA
HSPB2 0.0073660 0.6427900 0.00737 ** NA
INTS12 0.0075473 0.6534174 0.00755 ** NA
NAA15 0.0075638 0.6534174 0.00756 ** NA
ARSB 0.0076069 0.6538525 0.00761 ** NA
VPS37B 0.0076704 0.6545014 0.00767 ** NA
CCDC159 0.0077369 0.6545014 0.00774 ** NA
SSH1 0.0077665 0.6545014 0.00777 ** NA
NCR3LG1 0.0078580 0.6545014 0.00786 ** NA
ACYP2 0.0079841 0.6545014 0.00798 ** NA
XPO5 0.0080510 0.6545014 0.00805 ** NA
GTF3C1 0.0080700 0.6545014 0.00807 ** NA
OR4S2 0.0081035 0.6545014 0.00810 ** NA
BTAF1 0.0081559 0.6545014 0.00816 ** NA
TACSTD2 0.0081791 0.6545014 0.00818 ** NA
MED30 0.0082419 0.6545014 0.00824 ** NA
ADAM32 0.0082522 0.6545014 0.00825 ** NA
LY9 0.0083045 0.6545014 0.00830 ** NA
H2AFY2 0.0083475 0.6545014 0.00835 ** NA
MRPL13 0.0083762 0.6545014 0.00838 ** NA
PAQR3 0.0084147 0.6545014 0.00841 ** NA
GHITM 0.0084474 0.6545014 0.00845 ** NA
SGK2 0.0084586 0.6545014 0.00846 ** NA
ADO 0.0085378 0.6545014 0.00854 ** NA
ZNF17 0.0085562 0.6545014 0.00856 ** NA
MFAP4 0.0085654 0.6545014 0.00857 ** NA
CD163 0.0085663 0.6545014 0.00857 ** NA
COL7A1 0.0085733 0.6545014 0.00857 ** NA
CD80 0.0085983 0.6545014 0.00860 ** NA
ARMC7 0.0085988 0.6545014 0.00860 ** NA
COL8A1 0.0086043 0.6545014 0.00860 ** NA
KHDC1L 0.0086562 0.6546529 0.00866 ** NA
CHD2 0.0086825 0.6546529 0.00868 ** NA
PLCH2 0.0088368 0.6560317 0.00884 ** NA
OR13C3 0.0088398 0.6560317 0.00884 ** NA
C1orf141 0.0089498 0.6560317 0.00895 ** NA
ARHGEF17 0.0089894 0.6560317 0.00899 ** NA
ARID1B 0.0090009 0.6560317 0.00900 ** NA
COL9A2 0.0090078 0.6560317 0.00901 ** NA
ZC3H4 0.0091088 0.6560317 0.00911 ** NA
SUPT6H 0.0091374 0.6560317 0.00914 ** NA
CCNL1 0.0091597 0.6560317 0.00916 ** NA
TMEM258 0.0091769 0.6560317 0.00918 ** NA
USP32 0.0092096 0.6560317 0.00921 ** NA
DNAJC8 0.0093058 0.6560317 0.00931 ** NA
C20orf26 0.0093466 0.6560317 0.00935 ** NA
KRTAP4-4 0.0093494 0.6560317 0.00935 ** NA
ACHE 0.0093636 0.6560317 0.00936 ** NA
LCTL 0.0093837 0.6560317 0.00938 ** NA
ELMSAN1 0.0093954 0.6560317 0.00940 ** NA
SLC25A4 0.0094344 0.6560317 0.00943 ** NA
F11R 0.0094708 0.6560317 0.00947 ** NA
LY6G6F 0.0095144 0.6560317 0.00951 ** NA
ZNF330 0.0095171 0.6560317 0.00952 ** NA
NECAB1 0.0095689 0.6560317 0.00957 ** NA
GMCL1 0.0096195 0.6560317 0.00962 ** NA
C16orf58 0.0096729 0.6560317 0.00967 ** NA
ZBTB44 0.0096904 0.6560317 0.00969 ** NA
INHBA 0.0097282 0.6560317 0.00973 ** NA
CLEC4C 0.0097545 0.6560317 0.00975 ** NA
GLG1 0.0097693 0.6560317 0.00977 ** NA
RNF31 0.0098119 0.6563315 0.00981 ** NA
COPS3 0.0098996 0.6577057 0.00990 ** NA
NOL6 0.0099717 0.6577057 0.00997 ** NA
WDR77 0.0099778 0.6577057 0.00998 ** NA
RB1 0.0100036 0.6577057 0.01000
NA
MYO19 0.0100325 0.6577057 0.01003
NA
RASL10A 0.0101963 0.6577057 0.01020
NA
CAMKMT 0.0102403 0.6577057 0.01024
NA
DOCK10 0.0103184 0.6577057 0.01032
NA
MTMR3 0.0103229 0.6577057 0.01032
NA
TNS3 0.0103275 0.6577057 0.01033
NA
PROK2 0.0103717 0.6577057 0.01037
NA
TSC2 0.0105293 0.6577057 0.01053
NA
RSPRY1 0.0105428 0.6577057 0.01054
NA
GUCA1A 0.0105465 0.6577057 0.01055
NA
MEMO1 0.0105878 0.6577057 0.01059
NA
ALG2 0.0106228 0.6577057 0.01062
NA
ADPRHL2 0.0106256 0.6577057 0.01063
NA
PGLYRP2 0.0106515 0.6577057 0.01065
NA
NXPE3 0.0106737 0.6577057 0.01067
NA
RAD54B 0.0106800 0.6577057 0.01068
NA
C11orf80 0.0106863 0.6577057 0.01069
NA
NCBP2 0.0106973 0.6577057 0.01070
NA
BEND3 0.0107124 0.6577057 0.01071
NA
PIKFYVE 0.0108785 0.6655226 0.01088
NA
RGS12 0.0109744 0.6687125 0.01097
NA
SAR1B 0.0110318 0.6687125 0.01103
NA
PCK2 0.0110473 0.6687125 0.01105
NA
SLC39A3 0.0110919 0.6690574 0.01109
NA
RBKS 0.0112277 0.6698280 0.01123
NA
NPHP3 0.0112387 0.6698280 0.01124
NA
MEF2C 0.0112579 0.6698280 0.01126
NA
EML5 0.0112606 0.6698280 0.01126
NA
EXTL3 0.0113170 0.6708666 0.01132
NA
KRT34 0.0114533 0.6717006 0.01145
NA
C2CD5 0.0114844 0.6717006 0.01148
NA
BAG2 0.0115080 0.6717006 0.01151
NA
ZNF124 0.0115109 0.6717006 0.01151
NA
KLHL12 0.0115898 0.6717006 0.01159
NA
LRRC37A2 0.0116352 0.6717006 0.01164
NA
ENG 0.0117491 0.6717006 0.01175
NA
TMBIM6 0.0117817 0.6717006 0.01178
NA
PARN 0.0117847 0.6717006 0.01178
NA
ZNF493 0.0118075 0.6717006 0.01181
NA
PPP4R1 0.0118118 0.6717006 0.01181
NA
KLF15 0.0118404 0.6717006 0.01184
NA
LINGO1 0.0118947 0.6717006 0.01189
NA
CTTN 0.0119113 0.6717006 0.01191
NA
NPTXR 0.0119683 0.6717006 0.01197
NA
ATAD5 0.0119901 0.6717006 0.01199
NA
OR4K15 0.0120265 0.6717006 0.01203
NA
MFSD7 0.0120692 0.6717006 0.01207
NA
GPR152 0.0120735 0.6717006 0.01207
NA
SLC10A7 0.0121841 0.6756673 0.01218
NA
HOXC8 0.0123116 0.6789278 0.01231
NA
CABP5 0.0123463 0.6789278 0.01235
NA
PHTF2 0.0123776 0.6789278 0.01238
NA
BCAR3 0.0124058 0.6789278 0.01241
NA
KRTAP5-1 0.0124797 0.6789278 0.01248
NA
ABCB1 0.0124799 0.6789278 0.01248
NA
IQGAP3 0.0125501 0.6800432 0.01255
NA
LPA 0.0125795 0.6800432 0.01258
NA
FMO5 0.0126220 0.6802009 0.01262
NA
HIGD1A 0.0127101 0.6828095 0.01271
NA
TDRD5 0.0129101 0.6913926 0.01291
NA
SRSF7 0.0129839 0.6921675 0.01298
NA
IL32 0.0130858 0.6921675 0.01309
NA
MGME1 0.0130858 0.6921675 0.01309
NA
SMARCAD1 0.0132080 0.6921675 0.01321
NA
BNC2 0.0132235 0.6921675 0.01322
NA
CPNE9 0.0133390 0.6921675 0.01334
NA
TRIM54 0.0133390 0.6921675 0.01334
NA
TIGD6 0.0133873 0.6921675 0.01339
NA
UNC13A 0.0133962 0.6921675 0.01340
NA
VSIG8 0.0134000 0.6921675 0.01340
NA
NOC4L 0.0134073 0.6921675 0.01341
NA
CDK5RAP2 0.0135336 0.6921675 0.01353
NA
SYTL1 0.0135425 0.6921675 0.01354
NA
CCDC104 0.0135614 0.6921675 0.01356
NA
GINS4 0.0135805 0.6921675 0.01358
NA
CHRNA1 0.0135920 0.6921675 0.01359
NA
EML1 0.0137085 0.6921675 0.01371
NA
NBPF15 0.0137804 0.6921675 0.01378
NA
ANTXRL 0.0138763 0.6921675 0.01388
NA
SKIV2L 0.0138944 0.6921675 0.01389
NA
IL20RA 0.0139102 0.6921675 0.01391
NA
AMER2 0.0139939 0.6921675 0.01399
NA
DTYMK 0.0140606 0.6921675 0.01406
NA
SRPR 0.0141785 0.6921675 0.01418
NA
TOPORS 0.0141999 0.6921675 0.01420
NA
OR10J5 0.0142591 0.6921675 0.01426
NA
CNTROB 0.0142899 0.6921675 0.01429
NA
TPGS1 0.0143284 0.6921675 0.01433
NA
CLEC4F 0.0143425 0.6921675 0.01434
NA
FUBP1 0.0144614 0.6921675 0.01446
NA
IL11RA 0.0144784 0.6921675 0.01448
NA
SLC4A2 0.0145053 0.6921675 0.01451
NA
OR2K2 0.0145176 0.6921675 0.01452
NA
WHSC1 0.0145819 0.6921675 0.01458
NA
ZNHIT2 0.0146341 0.6921675 0.01463
NA
CORO7 0.0146560 0.6921675 0.01466
NA
HMBOX1 0.0147521 0.6921675 0.01475
NA
FBXO34 0.0148001 0.6921675 0.01480
NA
SOX9 0.0148412 0.6921675 0.01484
NA
RRP36 0.0148669 0.6921675 0.01487
NA
MDFIC 0.0149717 0.6921675 0.01497
NA
TOM1 0.0150225 0.6921675 0.01502
NA
KCNE4 0.0151121 0.6921675 0.01511
NA
WDR48 0.0151289 0.6921675 0.01513
NA
LRRN3 0.0151951 0.6921675 0.01520
NA
FAM129C 0.0152365 0.6921675 0.01524
NA
MAFG 0.0152463 0.6921675 0.01525
NA
MTSS1L 0.0152551 0.6921675 0.01526
NA
STK11 0.0152640 0.6921675 0.01526
NA
SURF1 0.0152678 0.6921675 0.01527
NA
UBE2U 0.0153184 0.6921675 0.01532
NA
POU6F1 0.0153816 0.6921675 0.01538
NA
CILP2 0.0154408 0.6921675 0.01544
NA
CCDC152 0.0155180 0.6921675 0.01552
NA
TMEM18 0.0155180 0.6921675 0.01552
NA
UBE2D2 0.0155253 0.6921675 0.01553
NA
HOXB4 0.0155534 0.6921675 0.01555
NA
SLC16A6 0.0157270 0.6921675 0.01573
NA
MSANTD2 0.0157897 0.6921675 0.01579
NA
EPS8L3 0.0157909 0.6921675 0.01579
NA
OR51A2 0.0157938 0.6921675 0.01579
NA
ERI1 0.0159894 0.6921675 0.01599
NA
TBC1D3B 0.0159902 0.6921675 0.01599
NA
SYBU 0.0159985 0.6921675 0.01600
NA
BRD1 0.0160256 0.6921675 0.01603
NA
THBS3 0.0160463 0.6921675 0.01605
NA
OR2L5 0.0160740 0.6921675 0.01607
NA
FNTA 0.0160949 0.6921675 0.01609
NA
RTP1 0.0160949 0.6921675 0.01609
NA
SPDL1 0.0161551 0.6921675 0.01616
NA
TYMS 0.0162168 0.6921675 0.01622
NA
ASB15 0.0162606 0.6921675 0.01626
NA
GMFB 0.0162651 0.6921675 0.01627
NA
PRRC2A 0.0162959 0.6921675 0.01630
NA
BPHL 0.0163018 0.6921675 0.01630
NA
TTC27 0.0163108 0.6921675 0.01631
NA
MMS22L 0.0163488 0.6921675 0.01635
NA
ENTPD7 0.0163744 0.6921675 0.01637
NA
ADAMTS7 0.0163920 0.6921675 0.01639
NA
SH3GLB2 0.0164302 0.6921675 0.01643
NA
KLF13 0.0165159 0.6921675 0.01652
NA
KIAA0355 0.0165390 0.6921675 0.01654
NA
NAT2 0.0165798 0.6921675 0.01658
NA
C2CD4A 0.0166163 0.6921675 0.01662
NA
ZC3H18 0.0166232 0.6921675 0.01662
NA
C6orf165 0.0166669 0.6921675 0.01667
NA
FAM110A 0.0167391 0.6921675 0.01674
NA
NBEA 0.0167455 0.6921675 0.01675
NA
VSIG2 0.0168247 0.6921675 0.01682
NA
PCBP3 0.0168344 0.6921675 0.01683
NA
AASDH 0.0168355 0.6921675 0.01684
NA
NGRN 0.0168506 0.6921675 0.01685
NA
ART3 0.0169259 0.6921675 0.01693
NA
RNF144B 0.0169947 0.6921675 0.01699
NA
COL9A3 0.0170529 0.6921675 0.01705
NA
SDC3 0.0170624 0.6921675 0.01706
NA
RABGAP1 0.0170759 0.6921675 0.01708
NA
PRKACA 0.0171054 0.6921675 0.01711
NA
CHAC1 0.0171297 0.6921675 0.01713
NA
ZNF536 0.0171495 0.6921675 0.01715
NA
NAA16 0.0171651 0.6921675 0.01717
NA
YLPM1 0.0172817 0.6921675 0.01728
NA
SNX30 0.0173795 0.6921675 0.01738
NA
DTHD1 0.0174060 0.6921675 0.01741
NA
KIRREL2 0.0174171 0.6921675 0.01742
NA
PRPF40A 0.0174654 0.6921675 0.01747
NA
DLG4 0.0174967 0.6921675 0.01750
NA
ZNF2 0.0175390 0.6921675 0.01754
NA
RPL23A 0.0175416 0.6921675 0.01754
NA
SIMC1 0.0175548 0.6921675 0.01755
NA
SNX11 0.0175972 0.6921675 0.01760
NA
PENK 0.0176291 0.6921675 0.01763
NA
ETNK1 0.0176578 0.6921675 0.01766
NA
KCNN4 0.0176578 0.6921675 0.01766
NA
SERPINA1 0.0176578 0.6921675 0.01766
NA
AARS 0.0176892 0.6921675 0.01769
NA
BEAN1 0.0176914 0.6921675 0.01769
NA
NPLOC4 0.0176914 0.6921675 0.01769
NA
WBSCR28 0.0177446 0.6921675 0.01774
NA
KIAA1586 0.0177561 0.6921675 0.01776
NA
RPS2 0.0178488 0.6923213 0.01785
NA
IL15RA 0.0178620 0.6923213 0.01786
NA
H3F3A 0.0179365 0.6923213 0.01794
NA
MRI1 0.0179740 0.6923213 0.01797
NA
C12orf4 0.0179744 0.6923213 0.01797
NA
TRIM29 0.0180076 0.6923213 0.01801
NA
RBM39 0.0180840 0.6923213 0.01808
NA
IL17D 0.0181006 0.6923213 0.01810
NA
ECT2L 0.0181225 0.6923213 0.01812
NA
DIRAS3 0.0181967 0.6924997 0.01820
NA
ADCY7 0.0182881 0.6924997 0.01829
NA
GSPT1 0.0182933 0.6924997 0.01829
NA
ZCCHC17 0.0183005 0.6924997 0.01830
NA
HABP4 0.0184450 0.6924997 0.01844
NA
GBP1 0.0186314 0.6924997 0.01863
NA
CCDC171 0.0186758 0.6924997 0.01868
NA
SHARPIN 0.0186795 0.6924997 0.01868
NA
ALDOC 0.0187003 0.6924997 0.01870
NA
SCN3B 0.0187606 0.6924997 0.01876
NA
RNLS 0.0188141 0.6924997 0.01881
NA
OS9 0.0189468 0.6924997 0.01895
NA
GPR39 0.0189755 0.6924997 0.01898
NA
PTPN9 0.0189755 0.6924997 0.01898
NA
PCDHA11 0.0189862 0.6924997 0.01899
NA
LGI2 0.0190765 0.6924997 0.01908
NA
CHRM1 0.0191150 0.6924997 0.01911
NA
ATP6V0C 0.0191253 0.6924997 0.01913
NA
CCDC142 0.0191303 0.6924997 0.01913
NA
MKX 0.0191818 0.6924997 0.01918
NA
SLC12A6 0.0191872 0.6924997 0.01919
NA
ASPHD1 0.0192611 0.6924997 0.01926
NA
CRYGA 0.0192775 0.6924997 0.01928
NA
ARHGEF35 0.0193343 0.6924997 0.01933
NA
BARD1 0.0193381 0.6924997 0.01934
NA
HSF4 0.0193619 0.6924997 0.01936
NA
PINX1 0.0194107 0.6924997 0.01941
NA
RALGAPA1 0.0194692 0.6924997 0.01947
NA
SLC2A5 0.0195109 0.6924997 0.01951
NA
TMPRSS13 0.0195287 0.6924997 0.01953
NA
ZNF205 0.0195474 0.6924997 0.01955
NA
C2orf88 0.0196004 0.6924997 0.01960
NA
C2orf50 0.0196262 0.6924997 0.01963
NA
SF3B4 0.0196658 0.6924997 0.01967
NA
C2orf78 0.0196756 0.6924997 0.01968
NA
LIAS 0.0196947 0.6924997 0.01969
NA
PLEKHB1 0.0196947 0.6924997 0.01969
NA
DAPP1 0.0197368 0.6924997 0.01974
NA
JAK2 0.0198294 0.6924997 0.01983
NA
CCDC115 0.0198380 0.6924997 0.01984
NA
MZT2B 0.0198839 0.6924997 0.01988
NA
PANX1 0.0199144 0.6924997 0.01991
NA
OR8A1 0.0199787 0.6924997 0.01998
NA
FCHO1 0.0201035 0.6924997 0.02010
NA
ACTR5 0.0202362 0.6924997 0.02024
NA
GUCY2D 0.0202823 0.6924997 0.02028
NA
PLOD1 0.0202894 0.6924997 0.02029
NA
RPS13 0.0204465 0.6924997 0.02045
NA
NEDD1 0.0204533 0.6924997 0.02045
NA
TAF2 0.0204635 0.6924997 0.02046
NA
BMPR1A 0.0204701 0.6924997 0.02047
NA
FGD4 0.0205429 0.6924997 0.02054
NA
FBXO41 0.0205706 0.6924997 0.02057
NA
MAP7D1 0.0205964 0.6924997 0.02060
NA
MOG 0.0206161 0.6924997 0.02062
NA
ASB7 0.0206561 0.6924997 0.02066
NA
KCNK2 0.0206735 0.6924997 0.02067
NA
KMT2C 0.0207089 0.6924997 0.02071
NA
TUBB6 0.0207161 0.6924997 0.02072
NA
MDH2 0.0207490 0.6924997 0.02075
NA
CHCHD1 0.0207775 0.6924997 0.02078
NA
PI3 0.0207775 0.6924997 0.02078
NA
RAB11A 0.0207775 0.6924997 0.02078
NA
PPP1R10 0.0207943 0.6924997 0.02079
NA
ZNF207 0.0208075 0.6924997 0.02081
NA
ITPKA 0.0208317 0.6924997 0.02083
NA
FHOD1 0.0208348 0.6924997 0.02083
NA
SEPT1 0.0208670 0.6924997 0.02087
NA
PIGV 0.0209067 0.6924997 0.02091
NA
ABHD10 0.0210063 0.6932629 0.02101
NA
CST5 0.0210104 0.6932629 0.02101
NA
PIK3R2 0.0211318 0.6956730 0.02113
NA
GTF3A 0.0211896 0.6956730 0.02119
NA
PRSS3 0.0212668 0.6956730 0.02127
NA
ZZZ3 0.0213127 0.6956730 0.02131
NA
RNF43 0.0213163 0.6956730 0.02132
NA
GPR37 0.0213263 0.6956730 0.02133
NA
TMEM41B 0.0214180 0.6957514 0.02142
NA
IQUB 0.0214313 0.6957514 0.02143
NA
AKAP12 0.0214914 0.6957514 0.02149
NA
MS4A8 0.0214997 0.6957514 0.02150
NA
IFNL1 0.0215715 0.6957514 0.02157
NA
ORAOV1 0.0215715 0.6957514 0.02157
NA
TBRG4 0.0216575 0.6970525 0.02166
NA
ZMPSTE24 0.0216929 0.6970525 0.02169
NA
TMEM129 0.0217350 0.6971014 0.02173
NA
TJP3 0.0219082 0.6981323 0.02191
NA
NEUROD2 0.0219195 0.6981323 0.02192
NA
DCAF13 0.0220082 0.6981323 0.02201
NA
MPHOSPH9 0.0220179 0.6981323 0.02202
NA
LDHAL6A 0.0221759 0.6981323 0.02218
NA
SLC45A4 0.0222470 0.6981323 0.02225
NA
ANGPTL6 0.0222522 0.6981323 0.02225
NA
LCE1F 0.0222746 0.6981323 0.02227
NA
TMEM61 0.0222926 0.6981323 0.02229
NA
PTPN13 0.0223570 0.6981323 0.02236
NA
C8orf76 0.0224110 0.6981323 0.02241
NA
RGS9BP 0.0224503 0.6981323 0.02245
NA
ASUN 0.0224525 0.6981323 0.02245
NA
METTL21A 0.0224812 0.6981323 0.02248
NA
HHATL 0.0224814 0.6981323 0.02248
NA
KBTBD7 0.0225386 0.6981323 0.02254
NA
TRIM58 0.0226236 0.6981323 0.02262
NA
MICAL2 0.0226366 0.6981323 0.02264
NA
R3HDML 0.0226712 0.6981323 0.02267
NA
DHODH 0.0227793 0.6981323 0.02278
NA
CCDC71 0.0228105 0.6981323 0.02281
NA
ATP2A2 0.0228138 0.6981323 0.02281
NA
DONSON 0.0228465 0.6981323 0.02285
NA
CLVS1 0.0229019 0.6981323 0.02290
NA
PCF11 0.0229787 0.6981323 0.02298
NA
KLHL7 0.0230358 0.6981323 0.02304
NA
C1orf159 0.0230406 0.6981323 0.02304
NA
PCDHB4 0.0231162 0.6981323 0.02312
NA
POLR2C 0.0232298 0.6981323 0.02323
NA
NDUFC2 0.0232423 0.6981323 0.02324
NA
CLN3 0.0233589 0.6981323 0.02336
NA
OR2T8 0.0235046 0.6981323 0.02350
NA
SEL1L3 0.0235259 0.6981323 0.02353
NA
KCTD9 0.0235572 0.6981323 0.02356
NA
EBF1 0.0236453 0.6981323 0.02365
NA
RBBP8 0.0236694 0.6981323 0.02367
NA
GOLPH3L 0.0237947 0.6981323 0.02379
NA
POU3F3 0.0238157 0.6981323 0.02382
NA
LILRA6 0.0238221 0.6981323 0.02382
NA
EGLN1 0.0238408 0.6981323 0.02384
NA
FAM173A 0.0238408 0.6981323 0.02384
NA
TCN1 0.0238408 0.6981323 0.02384
NA
MS4A13 0.0239032 0.6981323 0.02390
NA
KCNJ4 0.0239513 0.6981323 0.02395
NA
RRAD 0.0240674 0.6981323 0.02407
NA
TYRP1 0.0241193 0.6981323 0.02412
NA
RAB13 0.0241332 0.6981323 0.02413
NA
KLHL1 0.0241352 0.6981323 0.02414
NA
CCK 0.0241866 0.6981323 0.02419
NA
SPARC 0.0241876 0.6981323 0.02419
NA
COL11A1 0.0241951 0.6981323 0.02420
NA
CORO2B 0.0242628 0.6981323 0.02426
NA
DBH 0.0243035 0.6981323 0.02430
NA
SULT1C4 0.0244477 0.6981323 0.02445
NA
FAM3C 0.0244543 0.6981323 0.02445
NA
TIMM50 0.0245092 0.6981323 0.02451
NA
OLIG2 0.0245804 0.6981323 0.02458
NA
KLF6 0.0246163 0.6981323 0.02462
NA
PPFIBP2 0.0246379 0.6981323 0.02464
NA
MTRF1L 0.0246493 0.6981323 0.02465
NA
NUP62 0.0247392 0.6981323 0.02474
NA
KLHL23 0.0248002 0.6981323 0.02480
NA
TTC9B 0.0248097 0.6981323 0.02481
NA
WDR46 0.0248504 0.6981323 0.02485
NA
IFT172 0.0249357 0.6981323 0.02494
NA
DIABLO 0.0249474 0.6981323 0.02495
NA
EAF1 0.0249772 0.6981323 0.02498
NA
SPATA5 0.0249872 0.6981323 0.02499
NA
ISCA1 0.0250831 0.6981323 0.02508
NA
DEGS1 0.0251069 0.6981323 0.02511
NA
KCNS3 0.0251441 0.6981323 0.02514
NA
EID2 0.0252457 0.6981323 0.02525
NA
MYO1C 0.0253569 0.6981323 0.02536
NA
DYNC1LI2 0.0254202 0.6981323 0.02542
NA
EPS8L2 0.0254243 0.6981323 0.02542
NA
TAOK1 0.0254296 0.6981323 0.02543
NA
MAD1L1 0.0255079 0.6981323 0.02551
NA
OR2AP1 0.0255091 0.6981323 0.02551
NA
TAF11 0.0255166 0.6981323 0.02552
NA
MCTP1 0.0255261 0.6981323 0.02553
NA
C15orf43 0.0256080 0.6981323 0.02561
NA
DENR 0.0256080 0.6981323 0.02561
NA
MRPL33 0.0256080 0.6981323 0.02561
NA
DPPA2 0.0256158 0.6981323 0.02562
NA
TEX10 0.0256828 0.6981323 0.02568
NA
TOM1L1 0.0257763 0.6981323 0.02578
NA
OPN4 0.0258199 0.6981323 0.02582
NA
MAPK15 0.0258235 0.6981323 0.02582
NA
CCDC96 0.0258427 0.6981323 0.02584
NA
MEI1 0.0258727 0.6981323 0.02587
NA
GLUD1 0.0259200 0.6981323 0.02592
NA
PTP4A2 0.0259440 0.6981323 0.02594
NA
NCAPG2 0.0259475 0.6981323 0.02595
NA
B4GALNT1 0.0261147 0.6981323 0.02611
NA
OR52N5 0.0261163 0.6981323 0.02612
NA
NUDCD3 0.0261301 0.6981323 0.02613
NA
RBM42 0.0261515 0.6981323 0.02615
NA
CD1E 0.0262158 0.6981323 0.02622
NA
PCDHA3 0.0262240 0.6981323 0.02622
NA
ANPEP 0.0262478 0.6981323 0.02625
NA
CKS1B 0.0264513 0.6981323 0.02645
NA
OR52I2 0.0264602 0.6981323 0.02646
NA
CYP2J2 0.0265156 0.6981323 0.02652
NA
TTF1 0.0265210 0.6981323 0.02652
NA
FAM43A 0.0265534 0.6981323 0.02655
NA
SKIV2L2 0.0265706 0.6981323 0.02657
NA
TTLL12 0.0265763 0.6981323 0.02658
NA
XRCC4 0.0265979 0.6981323 0.02660
NA
PLEKHG3 0.0266061 0.6981323 0.02661
NA
MDFI 0.0266258 0.6981323 0.02663
NA
INPP4A 0.0267730 0.6981323 0.02677
NA
FAM204A 0.0268079 0.6981323 0.02681
NA
TNFAIP8L2 0.0269397 0.6981323 0.02694
NA
DDX31 0.0269587 0.6981323 0.02696
NA
GTF2A1 0.0269590 0.6981323 0.02696
NA
HAS3 0.0269634 0.6981323 0.02696
NA
TAL2 0.0269748 0.6981323 0.02697
NA
CEP76 0.0269937 0.6981323 0.02699
NA
CD69 0.0271125 0.6981323 0.02711
NA
KRTCAP3 0.0271141 0.6981323 0.02711
NA
SLC35G5 0.0271141 0.6981323 0.02711
NA
KIAA1462 0.0271815 0.6981323 0.02718
NA
NPC2 0.0271958 0.6981323 0.02720
NA
RBM19 0.0273147 0.6981323 0.02731
NA
LRP12 0.0273147 0.6981323 0.02731
NA
SUCLA2 0.0273370 0.6981323 0.02734
NA
SLC19A1 0.0273534 0.6981323 0.02735
NA
LNPEP 0.0273579 0.6981323 0.02736
NA
C17orf80 0.0274189 0.6981323 0.02742
NA
TNFSF11 0.0274431 0.6981323 0.02744
NA
C6orf163 0.0274476 0.6981323 0.02745
NA
SNX29 0.0275222 0.6981323 0.02752
NA
BUD13 0.0275706 0.6981323 0.02757
NA
NFE2 0.0276008 0.6981323 0.02760
NA
CDKL2 0.0276823 0.6981323 0.02768
NA
GORASP2 0.0276849 0.6981323 0.02768
NA
NICN1 0.0276849 0.6981323 0.02768
NA
CSNK1G2 0.0276950 0.6981323 0.02770
NA
EPB41 0.0277433 0.6981323 0.02774
NA
COL6A2 0.0277462 0.6981323 0.02775
NA
ZFHX4 0.0277710 0.6981323 0.02777
NA
C4orf27 0.0277763 0.6981323 0.02778
NA
COX17 0.0277763 0.6981323 0.02778
NA
USP17L10 0.0277763 0.6981323 0.02778
NA
DNAJC2 0.0278627 0.6981323 0.02786
NA
TDP1 0.0278750 0.6981323 0.02788
NA
EIF3J 0.0279121 0.6981323 0.02791
NA
SMG9 0.0280395 0.6981323 0.02804
NA
DEFB131 0.0280408 0.6981323 0.02804
NA
MCCD1 0.0280705 0.6981323 0.02807
NA
C14orf37 0.0280815 0.6981323 0.02808
NA
FBXO31 0.0281623 0.6981323 0.02816
NA
OR10A3 0.0282028 0.6981323 0.02820
NA
GJA10 0.0282031 0.6981323 0.02820
NA
BET1L 0.0282211 0.6981323 0.02822
NA
PIGO 0.0282639 0.6981323 0.02826
NA
SASH1 0.0282777 0.6981323 0.02828
NA
ACD 0.0283109 0.6981323 0.02831
NA
DGKA 0.0283559 0.6981323 0.02836
NA
MMP1 0.0284373 0.6981323 0.02844
NA
TRIM16 0.0284413 0.6981323 0.02844
NA
GAS2L2 0.0284850 0.6981323 0.02848
NA
SLC45A2 0.0284990 0.6981323 0.02850
NA
URGCP 0.0286375 0.6981323 0.02864
NA
TMEM200A 0.0286464 0.6981323 0.02865
NA
LRIT3 0.0286486 0.6981323 0.02865
NA
NDST4 0.0286959 0.6981323 0.02870
NA
KIF7 0.0287984 0.6981323 0.02880
NA
DECR2 0.0288239 0.6981323 0.02882
NA
TMEM87A 0.0288644 0.6981323 0.02886
NA
RRAS2 0.0289694 0.6981323 0.02897
NA
TIMM22 0.0289694 0.6981323 0.02897
NA
LIPA 0.0290000 0.6981323 0.02900
NA
OR52I1 0.0290000 0.6981323 0.02900
NA
HMGCR 0.0290163 0.6981323 0.02902
NA
CPN2 0.0290290 0.6981323 0.02903
NA
DSPP 0.0290518 0.6981323 0.02905
NA
KRT76 0.0291641 0.6981323 0.02916
NA
BMP1 0.0291723 0.6981323 0.02917
NA
RHO 0.0291851 0.6981323 0.02919
NA
ERCC6L2 0.0292121 0.6981323 0.02921
NA
TP53BP2 0.0293445 0.6981323 0.02934
NA
ZNF266 0.0294360 0.6981323 0.02944
NA
OPA3 0.0294553 0.6981323 0.02946
NA
C3orf27 0.0295303 0.6981323 0.02953
NA
ZNF843 0.0295336 0.6981323 0.02953
NA
PARD3 0.0295550 0.6981323 0.02955
NA
ZSCAN25 0.0295558 0.6981323 0.02956
NA
ENAH 0.0295627 0.6981323 0.02956
NA
ATP13A2 0.0295809 0.6981323 0.02958
NA
LAMTOR4 0.0295823 0.6981323 0.02958
NA
CR1 0.0296106 0.6981323 0.02961
NA
YAF2 0.0296928 0.6981323 0.02969
NA
CSTF3 0.0297008 0.6981323 0.02970
NA
RSPH3 0.0297048 0.6981323 0.02970
NA
SLC30A5 0.0297500 0.6981323 0.02975
NA
VPS9D1 0.0298015 0.6981323 0.02980
NA
MX1 0.0298423 0.6981323 0.02984
NA
MCHR2 0.0298947 0.6981323 0.02989
NA
NMT1 0.0298947 0.6981323 0.02989
NA
PDXDC1 0.0299298 0.6981323 0.02993
NA
CPS1 0.0300319 0.6983849 0.03003
NA
ITCH 0.0301951 0.6983849 0.03020
NA
PRAME 0.0302442 0.6983849 0.03024
NA
REEP1 0.0302821 0.6983849 0.03028
NA
PRPSAP2 0.0303133 0.6983849 0.03031
NA
MVB12B 0.0303463 0.6983849 0.03035
NA
IFNL2 0.0303577 0.6983849 0.03036
NA
ATAD1 0.0305058 0.6983849 0.03051
NA
KRTAP21-1 0.0305058 0.6983849 0.03051
NA
PRB4 0.0305082 0.6983849 0.03051
NA
TBC1D2B 0.0305442 0.6983849 0.03054
NA
DMTF1 0.0305680 0.6983849 0.03057
NA
OR1M1 0.0305828 0.6983849 0.03058
NA
PARS2 0.0305828 0.6983849 0.03058
NA
ADCY3 0.0305934 0.6983849 0.03059
NA
GREM2 0.0306275 0.6983849 0.03063
NA
SPATA31A6 0.0306337 0.6983849 0.03063
NA
SPO11 0.0306963 0.6983849 0.03070
NA
ZNF777 0.0307455 0.6983849 0.03075
NA
C22orf31 0.0307531 0.6983849 0.03075
NA
SEPT9 0.0308830 0.6993916 0.03088
NA
PCDHA5 0.0308930 0.6993916 0.03089
NA
GSTT2 0.0309556 0.6993916 0.03096
NA
MYBPC2 0.0310240 0.6993916 0.03102
NA
MAPK1IP1L 0.0310627 0.6993916 0.03106
NA
C6orf223 0.0310995 0.6993916 0.03110
NA
PRKAA2 0.0311335 0.6993916 0.03113
NA
STIL 0.0311479 0.6993916 0.03115
NA
OSTM1 0.0311636 0.6993916 0.03116
NA
DMTN 0.0312326 0.7000258 0.03123
NA
PAK7 0.0313634 0.7014545 0.03136
NA
ACSS1 0.0314160 0.7014545 0.03142
NA
FNIP1 0.0314274 0.7014545 0.03143
NA
RBM48 0.0314596 0.7014545 0.03146
NA
ACY1 0.0316459 0.7021250 0.03165
NA
NOS2 0.0316928 0.7021250 0.03169
NA
NLRP2 0.0317326 0.7021250 0.03173
NA
DPH6 0.0317433 0.7021250 0.03174
NA
OR4M2 0.0317477 0.7021250 0.03175
NA
CADM4 0.0317957 0.7021250 0.03180
NA
PALB2 0.0318584 0.7021250 0.03186
NA
GOLT1B 0.0318604 0.7021250 0.03186
NA
NNT 0.0319110 0.7021250 0.03191
NA
ZNF117 0.0320044 0.7021250 0.03200
NA
C19orf70 0.0320157 0.7021250 0.03202
NA
INO80E 0.0320157 0.7021250 0.03202
NA
CDKN2A 0.0320307 0.7021250 0.03203
NA
TEFM 0.0320974 0.7021250 0.03210
NA
ALG1 0.0321116 0.7021250 0.03211
NA
MRPL30 0.0321468 0.7021250 0.03215
NA
SPEN 0.0322268 0.7021250 0.03223
NA
DCTN2 0.0322611 0.7021250 0.03226
NA
FKBP2 0.0322658 0.7021250 0.03227
NA
RAD9B 0.0323115 0.7021250 0.03231
NA
PLD5 0.0323473 0.7021250 0.03235
NA
OR4C46 0.0323905 0.7021758 0.03239
NA
STX5 0.0325330 0.7034903 0.03253
NA
WRAP73 0.0325330 0.7034903 0.03253
NA
CDPF1 0.0326756 0.7044985 0.03268
NA
KLHL10 0.0327225 0.7044985 0.03272
NA
ADAMDEC1 0.0328669 0.7044985 0.03287
NA
P2RX2 0.0328669 0.7044985 0.03287
NA
CCDC28A 0.0329804 0.7044985 0.03298
NA
DUSP14 0.0330575 0.7044985 0.03306
NA
GALNT2 0.0330885 0.7044985 0.03309
NA
C11orf21 0.0330899 0.7044985 0.03309
NA
PRSS22 0.0331003 0.7044985 0.03310
NA
ACOT6 0.0331565 0.7044985 0.03316
NA
KIAA0100 0.0331653 0.7044985 0.03317
NA
RDH16 0.0331950 0.7044985 0.03320
NA
CCAR2 0.0332750 0.7044985 0.03327
NA
USF2 0.0333059 0.7044985 0.03331
NA
ZFYVE26 0.0333603 0.7044985 0.03336
NA
CERKL 0.0334875 0.7044985 0.03349
NA
APH1B 0.0334921 0.7044985 0.03349
NA
GPX8 0.0334990 0.7044985 0.03350
NA
CXCL17 0.0335087 0.7044985 0.03351
NA
NIP7 0.0335087 0.7044985 0.03351
NA
MBTD1 0.0335846 0.7044985 0.03358
NA
C9orf152 0.0335891 0.7044985 0.03359
NA
FARSB 0.0337024 0.7044985 0.03370
NA
CHD9 0.0337543 0.7044985 0.03375
NA
OSBPL1A 0.0337660 0.7044985 0.03377
NA
CRLF3 0.0337765 0.7044985 0.03378
NA
HRASLS2 0.0338287 0.7044985 0.03383
NA
PRM2 0.0338577 0.7044985 0.03386
NA
CLN6 0.0338681 0.7044985 0.03387
NA
PIGC 0.0338801 0.7044985 0.03388
NA
APBA2 0.0339173 0.7044985 0.03392
NA
BUB3 0.0339320 0.7044985 0.03393
NA
C19orf60 0.0339320 0.7044985 0.03393
NA
TRPC1 0.0339915 0.7048829 0.03399
NA
ZYG11B 0.0340597 0.7051640 0.03406
NA
NCAPG 0.0340874 0.7051640 0.03409
NA
RERG 0.0341281 0.7051640 0.03413
NA
SRP54 0.0342653 0.7068243 0.03427
NA
RCE1 0.0343970 0.7068243 0.03440
NA
STAR 0.0344475 0.7068243 0.03445
NA
GNL1 0.0345269 0.7068243 0.03453
NA
USP53 0.0345322 0.7068243 0.03453
NA
IL31 0.0345448 0.7068243 0.03454
NA
NOTCH2 0.0345931 0.7068243 0.03459
NA
QPCTL 0.0346745 0.7068243 0.03467
NA
FAM131B 0.0347063 0.7068243 0.03471
NA
SLC35F5 0.0347263 0.7068243 0.03473
NA
NUDT1 0.0347923 0.7068243 0.03479
NA
IL21R 0.0348186 0.7068243 0.03482
NA
MAS1 0.0348574 0.7068243 0.03486
NA
LIMA1 0.0348857 0.7068243 0.03489
NA
TSPAN12 0.0348876 0.7068243 0.03489
NA
LRRC25 0.0348995 0.7068243 0.03490
NA
MSR1 0.0349074 0.7068243 0.03491
NA
ATP6V0E2 0.0349504 0.7068622 0.03495
NA
INTS7 0.0350081 0.7071956 0.03501
NA
ETAA1 0.0351634 0.7092355 0.03516
NA
C11orf86 0.0353227 0.7092355 0.03532
NA
HAUS1 0.0353227 0.7092355 0.03532
NA
CERS3 0.0353508 0.7092355 0.03535
NA
GXYLT2 0.0353557 0.7092355 0.03536
NA
ZNF354B 0.0353566 0.7092355 0.03536
NA
HSPG2 0.0354373 0.7100269 0.03544
NA
MTX2 0.0355682 0.7118192 0.03557
NA
NOL7 0.0356827 0.7120055 0.03568
NA
PRR23A 0.0357211 0.7120055 0.03572
NA
STT3A 0.0357945 0.7120055 0.03579
NA
USP15 0.0359354 0.7120055 0.03594
NA
DPY30 0.0359515 0.7120055 0.03595
NA
MARK3 0.0359740 0.7120055 0.03597
NA
PDE6D 0.0359825 0.7120055 0.03598
NA
LRRC37A3 0.0359877 0.7120055 0.03599
NA
C3orf14 0.0360183 0.7120055 0.03602
NA
ABCC5 0.0360750 0.7120055 0.03607
NA
FAM160B1 0.0361241 0.7120055 0.03612
NA
TRPM5 0.0361241 0.7120055 0.03612
NA
ADORA2B 0.0361933 0.7120055 0.03619
NA
ZBTB9 0.0362123 0.7120055 0.03621
NA
CSF1 0.0362861 0.7120055 0.03629
NA
LRRC32 0.0363299 0.7120055 0.03633
NA
NEBL 0.0363515 0.7120055 0.03635
NA
ARHGAP12 0.0363757 0.7120055 0.03638
NA
ADIPOR2 0.0364959 0.7120055 0.03650
NA
PHIP 0.0365065 0.7120055 0.03651
NA
IRAK1BP1 0.0365899 0.7120055 0.03659
NA
KCNC2 0.0366278 0.7120055 0.03663
NA
C16orf54 0.0366459 0.7120055 0.03665
NA
CA14 0.0366459 0.7120055 0.03665
NA
ZMYND15 0.0366858 0.7120055 0.03669
NA
CLPB 0.0367008 0.7120055 0.03670
NA
CUL5 0.0367173 0.7120055 0.03672
NA
PPP1R12B 0.0368777 0.7120055 0.03688
NA
GNLY 0.0370249 0.7120055 0.03702
NA
MYADM 0.0371412 0.7120055 0.03714
NA
SMAP2 0.0371812 0.7120055 0.03718
NA
MMS19 0.0372272 0.7120055 0.03723
NA
OXCT1 0.0373375 0.7120055 0.03734
NA
CNTNAP5 0.0373406 0.7120055 0.03734
NA
CYP11B1 0.0373528 0.7120055 0.03735
NA
DGKZ 0.0374261 0.7120055 0.03743
NA
LMF2 0.0374407 0.7120055 0.03744
NA
SLC4A8 0.0374443 0.7120055 0.03744
NA
AIMP2 0.0374709 0.7120055 0.03747
NA
ATP5I 0.0375615 0.7120055 0.03756
NA
CSF3 0.0375656 0.7120055 0.03757
NA
SNX33 0.0375727 0.7120055 0.03757
NA
LGALS3BP 0.0375877 0.7120055 0.03759
NA
ZFAND3 0.0376203 0.7120055 0.03762
NA
MANEAL 0.0376931 0.7120055 0.03769
NA
TAF1A 0.0377764 0.7120055 0.03778
NA
TOX3 0.0377824 0.7120055 0.03778
NA
CCL13 0.0378511 0.7120055 0.03785
NA
RMND1 0.0378511 0.7120055 0.03785
NA
GTF2E1 0.0378819 0.7120055 0.03788
NA
DYNLL2 0.0378957 0.7120055 0.03790
NA
EXOSC1 0.0378957 0.7120055 0.03790
NA
SLIRP 0.0378957 0.7120055 0.03790
NA
RBBP4 0.0379938 0.7120055 0.03799
NA
ZNF451 0.0380083 0.7120055 0.03801
NA
ZNF850 0.0380102 0.7120055 0.03801
NA
CTNS 0.0380423 0.7120055 0.03804
NA
TIGD2 0.0380474 0.7120055 0.03805
NA
PET112 0.0381029 0.7120055 0.03810
NA
RXRG 0.0381855 0.7120055 0.03819
NA
NFIC 0.0381982 0.7120055 0.03820
NA
LIPT1 0.0383279 0.7120055 0.03833
NA
C16orf62 0.0383964 0.7120055 0.03840
NA
ACAP1 0.0384069 0.7120055 0.03841
NA
HIGD1C 0.0384222 0.7120055 0.03842
NA
RNF123 0.0384721 0.7120055 0.03847
NA
CNNM2 0.0384829 0.7120055 0.03848
NA
ADCY10 0.0385573 0.7120055 0.03856
NA
HMX1 0.0385633 0.7120055 0.03856
NA
FAM217B 0.0385789 0.7120055 0.03858
NA
BAZ2B 0.0386349 0.7120055 0.03863
NA
C2orf54 0.0386821 0.7120055 0.03868
NA
TMEM2 0.0386878 0.7120055 0.03869
NA
OR5B21 0.0388010 0.7120055 0.03880
NA
NCAPD3 0.0388398 0.7120055 0.03884
NA
EREG 0.0388978 0.7120055 0.03890
NA
PPM1H 0.0389034 0.7120055 0.03890
NA
WFIKKN2 0.0389068 0.7120055 0.03891
NA
ACOX3 0.0389509 0.7120055 0.03895
NA
CCHCR1 0.0389641 0.7120055 0.03896
NA
CRKL 0.0390113 0.7120055 0.03901
NA
BCAT2 0.0390151 0.7120055 0.03902
NA
RNASEH1 0.0390151 0.7120055 0.03902
NA
ZNF609 0.0393834 0.7165056 0.03938
NA
ZNF213 0.0393860 0.7165056 0.03939
NA
KCNJ5 0.0395030 0.7165056 0.03950
NA
DPYD 0.0395906 0.7165056 0.03959
NA
SLK 0.0396132 0.7165056 0.03961
NA
BEND6 0.0396274 0.7165056 0.03963
NA
E2F2 0.0397669 0.7165056 0.03977
NA
GIMAP6 0.0397956 0.7165056 0.03980
NA
KIAA1598 0.0398110 0.7165056 0.03981
NA
SGMS1 0.0398226 0.7165056 0.03982
NA
GOLGA8H 0.0398371 0.7165056 0.03984
NA
LZTR1 0.0398585 0.7165056 0.03986
NA
ASCL3 0.0398641 0.7165056 0.03986
NA
ODF4 0.0398641 0.7165056 0.03986
NA
PTH2R 0.0399054 0.7165056 0.03991
NA
PRR18 0.0399286 0.7165056 0.03993
NA
ATM 0.0400264 0.7167587 0.04003
NA
PTPN21 0.0400716 0.7167587 0.04007
NA
TBC1D20 0.0401391 0.7167587 0.04014
NA
KIAA1324L 0.0401580 0.7167587 0.04016
NA
GRPEL1 0.0402017 0.7167587 0.04020
NA
KLF4 0.0402283 0.7167587 0.04023
NA
C19orf48 0.0402762 0.7167587 0.04028
NA
TSNAX 0.0402762 0.7167587 0.04028
NA
IL12RB1 0.0404010 0.7173396 0.04040
NA
AGK 0.0404578 0.7173396 0.04046
NA
PROKR1 0.0404705 0.7173396 0.04047
NA
RBM33 0.0404758 0.7173396 0.04048
NA
FBXL14 0.0405536 0.7174632 0.04055
NA
PLLP 0.0406221 0.7174632 0.04062
NA
NCDN 0.0406410 0.7174632 0.04064
NA
PTGIR 0.0406723 0.7174632 0.04067
NA
SNX5 0.0406914 0.7174632 0.04069
NA
PPEF2 0.0408167 0.7183772 0.04082
NA
C5orf47 0.0408506 0.7183772 0.04085
NA
MDM4 0.0408966 0.7183772 0.04090
NA
MYOCD 0.0410464 0.7183772 0.04105
NA
G3BP2 0.0410671 0.7183772 0.04107
NA
ARHGAP5 0.0411052 0.7183772 0.04111
NA
CNNM1 0.0411505 0.7183772 0.04115
NA
CC2D1A 0.0411785 0.7183772 0.04118
NA
IGLON5 0.0412008 0.7183772 0.04120
NA
FAM105A 0.0412062 0.7183772 0.04121
NA
LINGO2 0.0412668 0.7183772 0.04127
NA
COX14 0.0413516 0.7183772 0.04135
NA
STRA6 0.0414147 0.7183772 0.04141
NA
PFDN5 0.0414227 0.7183772 0.04142
NA
MRPL1 0.0414756 0.7183772 0.04148
NA
FAM65C 0.0415897 0.7183772 0.04159
NA
COL19A1 0.0416157 0.7183772 0.04162
NA
DES 0.0416363 0.7183772 0.04164
NA
KHDC3L 0.0417259 0.7183772 0.04173
NA
OR8B3 0.0417488 0.7183772 0.04175
NA
S1PR2 0.0417725 0.7183772 0.04177
NA
KLK1 0.0417863 0.7183772 0.04179
NA
TMEM177 0.0417863 0.7183772 0.04179
NA
PDZD8 0.0418275 0.7183772 0.04183
NA
SAMD3 0.0418914 0.7183772 0.04189
NA
CCND3 0.0419359 0.7183772 0.04194
NA
UGT8 0.0419667 0.7183772 0.04197
NA
TTF2 0.0420543 0.7183772 0.04205
NA
HRH3 0.0420709 0.7183772 0.04207
NA
OGDHL 0.0421482 0.7183772 0.04215
NA
DCUN1D4 0.0421585 0.7183772 0.04216
NA
OR2B6 0.0422113 0.7183772 0.04221
NA
HOGA1 0.0422392 0.7183772 0.04224
NA
IRX6 0.0422711 0.7183772 0.04227
NA
SETD6 0.0423132 0.7183772 0.04231
NA
AARS2 0.0423233 0.7183772 0.04232
NA
ALKBH6 0.0423692 0.7183772 0.04237
NA
EMX2 0.0423730 0.7183772 0.04237
NA
PSMF1 0.0423730 0.7183772 0.04237
NA
ALKBH4 0.0426779 0.7227043 0.04268
NA
RAC3 0.0428858 0.7227043 0.04289
NA
KIAA0319L 0.0429048 0.7227043 0.04290
NA
SNX8 0.0429372 0.7227043 0.04294
NA
CACNA2D4 0.0430041 0.7227043 0.04300
NA
GBX1 0.0431017 0.7227043 0.04310
NA
KLRC1 0.0431316 0.7227043 0.04313
NA
C21orf59 0.0431423 0.7227043 0.04314
NA
FAM120A 0.0431508 0.7227043 0.04315
NA
AGT 0.0431603 0.7227043 0.04316
NA
ZNF559 0.0431660 0.7227043 0.04317
NA
TESPA1 0.0432436 0.7227043 0.04324
NA
FUT1 0.0433427 0.7227043 0.04334
NA
CHST10 0.0433590 0.7227043 0.04336
NA
HCN3 0.0433972 0.7227043 0.04340
NA
SPPL2C 0.0435456 0.7227043 0.04355
NA
KHDRBS1 0.0435889 0.7227043 0.04359
NA
DZANK1 0.0435957 0.7227043 0.04360
NA
ATP6V1B1 0.0437134 0.7227043 0.04371
NA
TRIM15 0.0437755 0.7227043 0.04378
NA
CYCS 0.0438414 0.7227043 0.04384
NA
WDR62 0.0439460 0.7227043 0.04395
NA
CAV2 0.0439592 0.7227043 0.04396
NA
WFDC8 0.0439741 0.7227043 0.04397
NA
KDM2A 0.0440131 0.7227043 0.04401
NA
TUBA3D 0.0440466 0.7227043 0.04405
NA
PIWIL3 0.0440555 0.7227043 0.04406
NA
DPP10 0.0441750 0.7227043 0.04418
NA
SEC61A2 0.0441996 0.7227043 0.04420
NA
ALKBH5 0.0442464 0.7227043 0.04425
NA
TGFBRAP1 0.0443459 0.7227043 0.04435
NA
HNF1B 0.0443600 0.7227043 0.04436
NA
EGLN3 0.0443944 0.7227043 0.04439
NA
CTNNA2 0.0445720 0.7227043 0.04457
NA
SETD1B 0.0446135 0.7227043 0.04461
NA
ERP44 0.0446187 0.7227043 0.04462
NA
LIMD1 0.0446187 0.7227043 0.04462
NA
C19orf73 0.0446522 0.7227043 0.04465
NA
TBC1D10A 0.0446814 0.7227043 0.04468
NA
HMGXB4 0.0446975 0.7227043 0.04470
NA
ZC3H13 0.0447369 0.7227043 0.04474
NA
CPLX2 0.0448210 0.7227043 0.04482
NA
S100B 0.0448333 0.7227043 0.04483
NA
IL5RA 0.0448419 0.7227043 0.04484
NA
MED20 0.0448419 0.7227043 0.04484
NA
HEPACAM2 0.0448533 0.7227043 0.04485
NA
ALKBH3 0.0448876 0.7227043 0.04489
NA
GLT8D2 0.0449398 0.7227043 0.04494
NA
MAP3K1 0.0449558 0.7227043 0.04496
NA
PFKFB4 0.0449608 0.7227043 0.04496
NA
PROK1 0.0450061 0.7227043 0.04501
NA
TRIM37 0.0450664 0.7227043 0.04507
NA
MYH10 0.0450962 0.7227043 0.04510
NA
ZNF814 0.0452059 0.7227043 0.04521
NA
CTRL 0.0452758 0.7227043 0.04528
NA
RAX 0.0452758 0.7227043 0.04528
NA
FURIN 0.0453413 0.7227043 0.04534
NA
CHST8 0.0453527 0.7227043 0.04535
NA
DEAF1 0.0453686 0.7227043 0.04537
NA
SPATC1 0.0453780 0.7227043 0.04538
NA
FZD6 0.0453946 0.7227043 0.04539
NA
OR51I2 0.0454940 0.7227043 0.04549
NA
ZDHHC4 0.0455498 0.7227043 0.04555
NA
THSD7A 0.0455987 0.7227043 0.04560
NA
GLRA3 0.0456039 0.7227043 0.04560
NA
DDX39A 0.0456316 0.7227043 0.04563
NA
KMT2B 0.0456850 0.7227043 0.04568
NA
HLA-E 0.0457183 0.7227043 0.04572
NA
IPPK 0.0457183 0.7227043 0.04572
NA
C8B 0.0457888 0.7227043 0.04579
NA
TNFRSF10A 0.0458385 0.7227043 0.04584
NA
AP1G2 0.0458399 0.7227043 0.04584
NA
TNFRSF14 0.0458677 0.7227043 0.04587
NA
FAM186B 0.0459061 0.7227043 0.04591
NA
ATP1B1 0.0459617 0.7227043 0.04596
NA
C4orf22 0.0459836 0.7227043 0.04598
NA
PHF3 0.0460203 0.7227043 0.04602
NA
RHBDF2 0.0460464 0.7227043 0.04605
NA
MIS18A 0.0460990 0.7227043 0.04610
NA
TBC1D9 0.0461894 0.7227043 0.04619
NA
PPIL4 0.0462020 0.7227043 0.04620
NA
LRRC10 0.0462742 0.7227043 0.04627
NA
LIPJ 0.0464341 0.7227043 0.04643
NA
CAPN11 0.0465031 0.7227043 0.04650
NA
NUP88 0.0466791 0.7227043 0.04668
NA
ERICH1 0.0466984 0.7227043 0.04670
NA
SLC22A3 0.0467229 0.7227043 0.04672
NA
ZNF326 0.0467262 0.7227043 0.04673
NA
RPS6KA2 0.0467548 0.7227043 0.04675
NA
NFIB 0.0467702 0.7227043 0.04677
NA
NPSR1 0.0467775 0.7227043 0.04678
NA
ROM1 0.0468214 0.7227043 0.04682
NA
SH2D2A 0.0468513 0.7227043 0.04685
NA
PCDHB13 0.0468548 0.7227043 0.04685
NA
NELFE 0.0468560 0.7227043 0.04686
NA
C1orf185 0.0469092 0.7227043 0.04691
NA
GNAL 0.0469154 0.7227043 0.04692
NA
MIEF1 0.0470635 0.7227043 0.04706
NA
PTCD1 0.0470762 0.7227043 0.04708
NA
CORIN 0.0471720 0.7227043 0.04717
NA
S100A6 0.0472141 0.7227043 0.04721
NA
ABCA9 0.0473710 0.7227043 0.04737
NA
SLC22A13 0.0474283 0.7227043 0.04743
NA
MEF2A 0.0474528 0.7227043 0.04745
NA
KRCC1 0.0474879 0.7227043 0.04749
NA
BRMS1 0.0474991 0.7227043 0.04750
NA
ARHGAP25 0.0475079 0.7227043 0.04751
NA
RPRD1B 0.0475144 0.7227043 0.04751
NA
LYSMD1 0.0476325 0.7227043 0.04763
NA
TEX29 0.0476325 0.7227043 0.04763
NA
SMYD1 0.0476620 0.7227043 0.04766
NA
SYT17 0.0476719 0.7227043 0.04767
NA
PRLH 0.0477090 0.7227043 0.04771
NA
XIRP1 0.0477339 0.7227043 0.04773
NA
KRT84 0.0477744 0.7227043 0.04777
NA
BPIFA2 0.0477871 0.7227043 0.04779
NA
LRRC18 0.0477871 0.7227043 0.04779
NA
SFRP2 0.0477871 0.7227043 0.04779
NA
SH2D3C 0.0478068 0.7227043 0.04781
NA
ATP4A 0.0478112 0.7227043 0.04781
NA
CORO1C 0.0478195 0.7227043 0.04782
NA
GPR155 0.0478422 0.7227043 0.04784
NA
HJURP 0.0478596 0.7227043 0.04786
NA
ATRNL1 0.0478614 0.7227043 0.04786
NA
ADCY5 0.0478832 0.7227043 0.04788
NA
ZNF568 0.0479824 0.7235667 0.04798
NA
HTR1B 0.0480911 0.7240150 0.04809
NA
SPRN 0.0481290 0.7240150 0.04813
NA
KCNH4 0.0481783 0.7240150 0.04818
NA
ZNF189 0.0481806 0.7240150 0.04818
NA
EHHADH 0.0482318 0.7241507 0.04823
NA
RASA3 0.0482897 0.7243879 0.04829
NA
PDLIM2 0.0483754 0.7247845 0.04838
NA
TAS2R1 0.0484254 0.7247845 0.04843
NA
RMDN2 0.0484570 0.7247845 0.04846
NA
TBC1D24 0.0485074 0.7247845 0.04851
NA
AXDND1 0.0485270 0.7247845 0.04853
NA
RALGPS2 0.0487816 0.7264119 0.04878
NA
BRPF1 0.0488381 0.7264119 0.04884
NA
SPOCK2 0.0488578 0.7264119 0.04886
NA
ZNF600 0.0488773 0.7264119 0.04888
NA
HILPDA 0.0489293 0.7264119 0.04893
NA
PGM2 0.0489831 0.7264119 0.04898
NA
TMEM9 0.0490056 0.7264119 0.04901
NA
KLRC2 0.0490094 0.7264119 0.04901
NA
MTA2 0.0490162 0.7264119 0.04902
NA
VPS72 0.0490591 0.7264124 0.04906
NA
ZNF34 0.0491384 0.7264124 0.04914
NA
USP6 0.0491430 0.7264124 0.04914
NA
REV3L 0.0492101 0.7267785 0.04921
NA
DTNBP1 0.0493800 0.7273627 0.04938
NA
CIR1 0.0494156 0.7273627 0.04942
NA
PRPF38A 0.0494226 0.7273627 0.04942
NA
TMEM116 0.0494266 0.7273627 0.04943
NA
C10orf113 0.0494612 0.7273627 0.04946
NA
RAB27A 0.0495125 0.7274958 0.04951
NA
TCF3 0.0498558 0.7307291 0.04986
NA
TRAM1L1 0.0498947 0.7307291 0.04989
NA
SNRNP40 0.0499070 0.7307291 0.04991
NA
TPTE2 0.0499226 0.7307291 0.04992
NA
BCL2 0.0499451 0.7307291 0.04995
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_gene_allmut_nonsilent_plot <- ggplot(data = crispr_signif_allmut_nonsilent) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_allmut_nonsilent_plot

5.1.3 Deleterious and missense mutant vs. Other

crispr_signif_allmut_delmis <- compare_means(Score ~ Mutation_Status_DeleteriousMissense, group.by = c("Hugo_Symbol"), data = crispr_data, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_allmut_delmis <- adj_signif(crispr_signif_allmut_delmis)
crispr_signif_allmut_delmis <- crispr_signif_allmut_delmis[order(crispr_signif_allmut_delmis$p),]
saveRDS(crispr_signif_allmut_delmis, "./data_munging/rds/crispr_signif_allmut_deleteriousmissense_gene.rds")

# write.table(crispr_signif_allmut_delmis, file = "~/Desktop/crispr_signif_allmut_deleteriousmissense_gene.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_allmut_delmis <- readRDS("./data_munging/rds/crispr_signif_allmut_deleteriousmissense_gene.rds")

knitr::kable(filter(crispr_signif_allmut_delmis, p < 0.05)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing deleterious and missense mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing deleterious and missense mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol p p.adj p.format p.signif p.signif.adj
KRAS 0.0000000 0.0000000 < 2e-16 **** ****
TP53 0.0000000 0.0000000 < 2e-16 **** ****
BRAF 0.0000000 0.0000000 < 2e-16 **** ****
NRAS 0.0000000 0.0000000 < 2e-16 **** ****
PTEN 0.0000000 0.0000000 5.1e-16 **** ****
PIK3CA 0.0000000 0.0000000 9.7e-14 **** ****
CTNNB1 0.0000023 0.0057622 2.3e-06 **** **
TCERG1 0.0000043 0.0092556 4.3e-06 **** **
ARID1A 0.0000077 0.0146617 7.7e-06 ****
TPR 0.0000436 0.0749151 4.4e-05 **** NA
FCGBP 0.0000695 0.1085679 6.9e-05 **** NA
VHL 0.0001029 0.1473663 0.00010 *** NA
ZNF177 0.0001226 0.1620635 0.00012 *** NA
C14orf39 0.0002001 0.2456164 0.00020 *** NA
SLC22A9 0.0002503 0.2844231 0.00025 *** NA
GSTM5 0.0002648 0.2844231 0.00026 *** NA
PIGW 0.0003638 0.3678156 0.00036 *** NA
TLX2 0.0004787 0.4570643 0.00048 *** NA
ARFGAP1 0.0005157 0.4574458 0.00052 *** NA
ZNF808 0.0005323 0.4574458 0.00053 *** NA
CD320 0.0005816 0.4759840 0.00058 *** NA
ING2 0.0006989 0.4783606 0.00070 *** NA
NIPBL 0.0007160 0.4783606 0.00072 *** NA
MAT2B 0.0007184 0.4783606 0.00072 *** NA
SYNPO2L 0.0007699 0.4783606 0.00077 *** NA
UTP20 0.0007718 0.4783606 0.00077 *** NA
HRAS 0.0008408 0.4783606 0.00084 *** NA
CPSF1 0.0008505 0.4783606 0.00085 *** NA
UTP3 0.0008549 0.4783606 0.00085 *** NA
FBXW7 0.0008732 0.4783606 0.00087 *** NA
RFC1 0.0008787 0.4783606 0.00088 *** NA
RNF208 0.0008907 0.4783606 0.00089 *** NA
KCNIP4 0.0009472 0.4932932 0.00095 *** NA
GOLGA3 0.0010340 0.5125264 0.00103 ** NA
PROM1 0.0010485 0.5125264 0.00105 ** NA
PMPCA 0.0010990 0.5125264 0.00110 ** NA
PIK3R1 0.0011525 0.5125264 0.00115 ** NA
PCDHA8 0.0012404 0.5125264 0.00124 ** NA
OR13C4 0.0012702 0.5125264 0.00127 ** NA
MDN1 0.0012746 0.5125264 0.00127 ** NA
TELO2 0.0012922 0.5125264 0.00129 ** NA
TAS1R2 0.0013163 0.5125264 0.00132 ** NA
ZNF439 0.0013227 0.5125264 0.00132 ** NA
KRT19 0.0013501 0.5125264 0.00135 ** NA
MTMR2 0.0014414 0.5125264 0.00144 ** NA
E2F1 0.0014486 0.5125264 0.00145 ** NA
IQCH 0.0014602 0.5125264 0.00146 ** NA
LPO 0.0014636 0.5125264 0.00146 ** NA
FRMD4B 0.0014758 0.5125264 0.00148 ** NA
PLA2G4F 0.0014997 0.5125264 0.00150 ** NA
DSEL 0.0015209 0.5125264 0.00152 ** NA
HSD3B7 0.0015616 0.5160939 0.00156 ** NA
PCDHB15 0.0016370 0.5195965 0.00164 ** NA
TAAR1 0.0016765 0.5195965 0.00168 ** NA
MYH13 0.0016962 0.5195965 0.00170 ** NA
ACSM2B 0.0017107 0.5195965 0.00171 ** NA
OR8D1 0.0017233 0.5195965 0.00172 ** NA
KIAA1211L 0.0019402 0.5430002 0.00194 ** NA
SENP8 0.0019559 0.5430002 0.00196 ** NA
AVEN 0.0019832 0.5430002 0.00198 ** NA
TAOK2 0.0019841 0.5430002 0.00198 ** NA
RUVBL1 0.0019950 0.5430002 0.00200 ** NA
CLEC4C 0.0020406 0.5430002 0.00204 ** NA
OR52E8 0.0020406 0.5430002 0.00204 ** NA
PI4K2A 0.0020961 0.5430002 0.00210 ** NA
KPNA6 0.0021334 0.5430002 0.00213 ** NA
ST6GALNAC1 0.0022068 0.5430002 0.00221 ** NA
POU2F1 0.0022102 0.5430002 0.00221 ** NA
EZH2 0.0022226 0.5430002 0.00222 ** NA
BTBD11 0.0022318 0.5430002 0.00223 ** NA
LPCAT4 0.0022875 0.5430002 0.00229 ** NA
ANKRD31 0.0023475 0.5430002 0.00235 ** NA
OR51T1 0.0023614 0.5430002 0.00236 ** NA
METTL17 0.0023923 0.5430002 0.00239 ** NA
KHSRP 0.0023925 0.5430002 0.00239 ** NA
CIITA 0.0024057 0.5430002 0.00241 ** NA
TUBB2A 0.0024329 0.5430002 0.00243 ** NA
ADAM15 0.0024806 0.5465647 0.00248 ** NA
ZDHHC24 0.0025919 0.5638596 0.00259 ** NA
SURF6 0.0027361 0.5723325 0.00274 ** NA
KIF11 0.0027512 0.5723325 0.00275 ** NA
SDHD 0.0027619 0.5723325 0.00276 ** NA
GRM7 0.0027641 0.5723325 0.00276 ** NA
NXPH4 0.0028292 0.5788467 0.00283 ** NA
SAMM50 0.0030102 0.6042511 0.00301 ** NA
ACTA1 0.0030465 0.6042511 0.00305 ** NA
SPAG17 0.0030697 0.6042511 0.00307 ** NA
SLC26A2 0.0030940 0.6042511 0.00309 ** NA
DENND4C 0.0031465 0.6075857 0.00315 ** NA
ATXN2 0.0032463 0.6085056 0.00325 ** NA
MAP2K3 0.0032831 0.6085056 0.00328 ** NA
DIS3L2 0.0032847 0.6085056 0.00328 ** NA
PTPRE 0.0032929 0.6085056 0.00329 ** NA
CNOT1 0.0034549 0.6246874 0.00345 ** NA
SCG2 0.0034839 0.6246874 0.00348 ** NA
TRIM8 0.0034895 0.6246874 0.00349 ** NA
CAMK2B 0.0035496 0.6288942 0.00355 ** NA
SLC38A7 0.0036411 0.6335632 0.00364 ** NA
MMRN2 0.0036540 0.6335632 0.00365 ** NA
SGCD 0.0037645 0.6335632 0.00376 ** NA
VPS13D 0.0037846 0.6335632 0.00378 ** NA
KRT83 0.0038147 0.6335632 0.00381 ** NA
EEF2 0.0038279 0.6335632 0.00383 ** NA
LILRB2 0.0038340 0.6335632 0.00383 ** NA
SUSD5 0.0039261 0.6376846 0.00393 ** NA
NOL7 0.0039331 0.6376846 0.00393 ** NA
ATR 0.0040408 0.6473519 0.00404 ** NA
ATXN2L 0.0041364 0.6473519 0.00414 ** NA
CD83 0.0041819 0.6473519 0.00418 ** NA
ZNF135 0.0042047 0.6473519 0.00420 ** NA
TOP1MT 0.0042412 0.6473519 0.00424 ** NA
EMILIN3 0.0042659 0.6473519 0.00427 ** NA
SPTBN4 0.0042799 0.6473519 0.00428 ** NA
SPHK2 0.0043100 0.6473519 0.00431 ** NA
PSMB4 0.0043587 0.6473519 0.00436 ** NA
IQGAP3 0.0045407 0.6473519 0.00454 ** NA
TPP1 0.0046001 0.6473519 0.00460 ** NA
NFE2L1 0.0046446 0.6473519 0.00464 ** NA
PIGP 0.0046922 0.6473519 0.00469 ** NA
PPP1R1C 0.0047398 0.6473519 0.00474 ** NA
CDC37 0.0047810 0.6473519 0.00478 ** NA
TFAP2A 0.0048201 0.6473519 0.00482 ** NA
CD200R1 0.0048862 0.6473519 0.00489 ** NA
CWH43 0.0048913 0.6473519 0.00489 ** NA
FOXRED1 0.0049144 0.6473519 0.00491 ** NA
HCRTR1 0.0049160 0.6473519 0.00492 ** NA
RBBP9 0.0050826 0.6473519 0.00508 ** NA
OGFOD3 0.0051338 0.6473519 0.00513 ** NA
AKR1C1 0.0051682 0.6473519 0.00517 ** NA
TBC1D22A 0.0052429 0.6473519 0.00524 ** NA
APOBEC1 0.0052779 0.6473519 0.00528 ** NA
OR56A3 0.0052916 0.6473519 0.00529 ** NA
SLC46A2 0.0053108 0.6473519 0.00531 ** NA
C6orf15 0.0053410 0.6473519 0.00534 ** NA
SMPD1 0.0053513 0.6473519 0.00535 ** NA
FBXW12 0.0053691 0.6473519 0.00537 ** NA
MGA 0.0053870 0.6473519 0.00539 ** NA
RSPH6A 0.0053903 0.6473519 0.00539 ** NA
THADA 0.0055256 0.6473519 0.00553 ** NA
MYOC 0.0055382 0.6473519 0.00554 ** NA
LRGUK 0.0056014 0.6473519 0.00560 ** NA
SLC12A4 0.0056227 0.6473519 0.00562 ** NA
DNAJC5B 0.0057016 0.6473519 0.00570 ** NA
TAS2R60 0.0057034 0.6473519 0.00570 ** NA
IBA57 0.0057420 0.6473519 0.00574 ** NA
HDGFRP2 0.0057596 0.6473519 0.00576 ** NA
MRPS34 0.0057928 0.6473519 0.00579 ** NA
KIF3B 0.0058153 0.6473519 0.00582 ** NA
SSH2 0.0058405 0.6473519 0.00584 ** NA
MBD3L2 0.0058844 0.6473519 0.00588 ** NA
COPS2 0.0059315 0.6473519 0.00593 ** NA
WDR75 0.0059969 0.6473519 0.00600 ** NA
FRYL 0.0060235 0.6473519 0.00602 ** NA
ZNF438 0.0060372 0.6473519 0.00604 ** NA
MMS22L 0.0060571 0.6473519 0.00606 ** NA
ELK3 0.0061135 0.6473519 0.00611 ** NA
MUS81 0.0061273 0.6473519 0.00613 ** NA
PRRC1 0.0061280 0.6473519 0.00613 ** NA
CD5L 0.0061987 0.6473519 0.00620 ** NA
CLEC9A 0.0062087 0.6473519 0.00621 ** NA
LMX1A 0.0062097 0.6473519 0.00621 ** NA
SFXN3 0.0062354 0.6473519 0.00624 ** NA
RAB43 0.0062666 0.6473519 0.00627 ** NA
FAM181B 0.0062849 0.6473519 0.00628 ** NA
SMARCB1 0.0062993 0.6473519 0.00630 ** NA
ACBD6 0.0063036 0.6473519 0.00630 ** NA
SUPT7L 0.0063204 0.6473519 0.00632 ** NA
CYP19A1 0.0063281 0.6473519 0.00633 ** NA
FBXL20 0.0064106 0.6511943 0.00641 ** NA
CEP76 0.0064716 0.6511943 0.00647 ** NA
DPP7 0.0064794 0.6511943 0.00648 ** NA
OR4N2 0.0065455 0.6540139 0.00655 ** NA
MIIP 0.0066145 0.6543288 0.00661 ** NA
FCN3 0.0066248 0.6543288 0.00662 ** NA
ZNF107 0.0066752 0.6555409 0.00668 ** NA
TSPAN13 0.0067540 0.6595153 0.00675 ** NA
KDM5B 0.0068837 0.6597415 0.00688 ** NA
IFFO2 0.0068857 0.6597415 0.00689 ** NA
COG3 0.0069083 0.6597415 0.00691 ** NA
DHX35 0.0069214 0.6597415 0.00692 ** NA
MSGN1 0.0069483 0.6597415 0.00695 ** NA
ANKRD32 0.0071033 0.6599783 0.00710 ** NA
RB1 0.0071617 0.6599783 0.00716 ** NA
CLDN5 0.0071709 0.6599783 0.00717 ** NA
PRKCZ 0.0072554 0.6599783 0.00726 ** NA
ARID1B 0.0072590 0.6599783 0.00726 ** NA
ACTL8 0.0072969 0.6599783 0.00730 ** NA
KRTAP10-6 0.0072992 0.6599783 0.00730 ** NA
EML1 0.0073078 0.6599783 0.00731 ** NA
SMCR8 0.0073359 0.6599783 0.00734 ** NA
OLFML2B 0.0073612 0.6599783 0.00736 ** NA
CREBBP 0.0073732 0.6599783 0.00737 ** NA
F11R 0.0075268 0.6631134 0.00753 ** NA
INTS12 0.0075473 0.6631134 0.00755 ** NA
NAA15 0.0075638 0.6631134 0.00756 ** NA
ARSB 0.0076069 0.6631134 0.00761 ** NA
VPS37B 0.0076704 0.6631134 0.00767 ** NA
CCDC159 0.0077369 0.6631134 0.00774 ** NA
SSH1 0.0077665 0.6631134 0.00777 ** NA
NCR3LG1 0.0078580 0.6631134 0.00786 ** NA
PLOD1 0.0078951 0.6631134 0.00790 ** NA
ACYP2 0.0079841 0.6631134 0.00798 ** NA
XPO5 0.0080510 0.6631134 0.00805 ** NA
AP5B1 0.0080810 0.6631134 0.00808 ** NA
OR4S2 0.0081035 0.6631134 0.00810 ** NA
BTAF1 0.0081559 0.6631134 0.00816 ** NA
TACSTD2 0.0081791 0.6631134 0.00818 ** NA
MED30 0.0082419 0.6631134 0.00824 ** NA
ADAM32 0.0082522 0.6631134 0.00825 ** NA
LY9 0.0083045 0.6631134 0.00830 ** NA
H2AFY2 0.0083475 0.6631134 0.00835 ** NA
MRPL13 0.0083762 0.6631134 0.00838 ** NA
PAQR3 0.0084147 0.6631134 0.00841 ** NA
YLPM1 0.0084185 0.6631134 0.00842 ** NA
GHITM 0.0084474 0.6631134 0.00845 ** NA
SGK2 0.0084586 0.6631134 0.00846 ** NA
ADO 0.0085378 0.6631134 0.00854 ** NA
ZNF17 0.0085562 0.6631134 0.00856 ** NA
MFAP4 0.0085654 0.6631134 0.00857 ** NA
CD163 0.0085663 0.6631134 0.00857 ** NA
COL7A1 0.0085733 0.6631134 0.00857 ** NA
ARMC7 0.0085988 0.6631134 0.00860 ** NA
COL8A1 0.0086043 0.6631134 0.00860 ** NA
KHDC1L 0.0086562 0.6641352 0.00866 ** NA
PLCH2 0.0088368 0.6679256 0.00884 ** NA
OR13C3 0.0088398 0.6679256 0.00884 ** NA
C1orf141 0.0089498 0.6679256 0.00895 ** NA
ARHGEF17 0.0089894 0.6679256 0.00899 ** NA
COL9A2 0.0090078 0.6679256 0.00901 ** NA
H3F3A 0.0090755 0.6679256 0.00908 ** NA
ZC3H4 0.0091088 0.6679256 0.00911 ** NA
SUPT6H 0.0091374 0.6679256 0.00914 ** NA
CCNL1 0.0091597 0.6679256 0.00916 ** NA
MAML2 0.0091672 0.6679256 0.00917 ** NA
TMEM258 0.0091769 0.6679256 0.00918 ** NA
USP32 0.0092096 0.6679256 0.00921 ** NA
DNAJC8 0.0093058 0.6679256 0.00931 ** NA
C20orf26 0.0093466 0.6679256 0.00935 ** NA
KRTAP4-4 0.0093494 0.6679256 0.00935 ** NA
ACHE 0.0093636 0.6679256 0.00936 ** NA
LCTL 0.0093837 0.6679256 0.00938 ** NA
SLC25A4 0.0094344 0.6679256 0.00943 ** NA
LY6G6F 0.0095144 0.6679256 0.00951 ** NA
ZNF330 0.0095171 0.6679256 0.00952 ** NA
NECAB1 0.0095689 0.6679256 0.00957 ** NA
PPM1A 0.0095782 0.6679256 0.00958 ** NA
GMCL1 0.0096195 0.6679256 0.00962 ** NA
C16orf58 0.0096729 0.6679256 0.00967 ** NA
ZBTB44 0.0096904 0.6679256 0.00969 ** NA
INHBA 0.0097282 0.6679256 0.00973 ** NA
GLG1 0.0097693 0.6679256 0.00977 ** NA
RNF31 0.0098119 0.6679256 0.00981 ** NA
COPS3 0.0098996 0.6679256 0.00990 ** NA
NOL6 0.0099717 0.6679256 0.00997 ** NA
WDR77 0.0099778 0.6679256 0.00998 ** NA
RASL10A 0.0101963 0.6679256 0.01020
NA
CAMKMT 0.0102403 0.6679256 0.01024
NA
TSC2 0.0103123 0.6679256 0.01031
NA
DOCK10 0.0103184 0.6679256 0.01032
NA
MTMR3 0.0103229 0.6679256 0.01032
NA
TNS3 0.0103275 0.6679256 0.01033
NA
EXTL3 0.0103845 0.6679256 0.01038
NA
CACNA1I 0.0104317 0.6679256 0.01043
NA
RSPRY1 0.0105428 0.6679256 0.01054
NA
GUCA1A 0.0105465 0.6679256 0.01055
NA
MEMO1 0.0105878 0.6679256 0.01059
NA
ALG2 0.0106228 0.6679256 0.01062
NA
ADPRHL2 0.0106256 0.6679256 0.01063
NA
PGLYRP2 0.0106515 0.6679256 0.01065
NA
TLN1 0.0106651 0.6679256 0.01067
NA
NXPE3 0.0106737 0.6679256 0.01067
NA
RAD54B 0.0106800 0.6679256 0.01068
NA
C11orf80 0.0106863 0.6679256 0.01069
NA
NCBP2 0.0106973 0.6679256 0.01070
NA
BEND3 0.0107124 0.6679256 0.01071
NA
GTF3C1 0.0107266 0.6679256 0.01073
NA
PIKFYVE 0.0108785 0.6732593 0.01088
NA
RGS12 0.0109744 0.6732593 0.01097
NA
SAR1B 0.0110318 0.6732593 0.01103
NA
NFE2L2 0.0110341 0.6732593 0.01103
NA
ETAA1 0.0110432 0.6732593 0.01104
NA
PCK2 0.0110473 0.6732593 0.01105
NA
SLC39A3 0.0110919 0.6735898 0.01109
NA
RBKS 0.0112277 0.6742997 0.01123
NA
NPHP3 0.0112387 0.6742997 0.01124
NA
MEF2C 0.0112579 0.6742997 0.01126
NA
EML5 0.0112606 0.6742997 0.01126
NA
KRT34 0.0114533 0.6755085 0.01145
NA
C2CD5 0.0114844 0.6755085 0.01148
NA
BAG2 0.0115080 0.6755085 0.01151
NA
ZNF124 0.0115109 0.6755085 0.01151
NA
KLHL12 0.0115898 0.6755085 0.01159
NA
LRRC37A2 0.0116352 0.6755085 0.01164
NA
ENG 0.0117491 0.6755085 0.01175
NA
MYO19 0.0117687 0.6755085 0.01177
NA
TMBIM6 0.0117817 0.6755085 0.01178
NA
PARN 0.0117847 0.6755085 0.01178
NA
PPP4R1 0.0118118 0.6755085 0.01181
NA
KLF15 0.0118404 0.6755085 0.01184
NA
LINGO1 0.0118947 0.6755085 0.01189
NA
CTTN 0.0119113 0.6755085 0.01191
NA
NPTXR 0.0119683 0.6755085 0.01197
NA
ATAD5 0.0119901 0.6755085 0.01199
NA
OR4K15 0.0120265 0.6755085 0.01203
NA
MFSD7 0.0120692 0.6755085 0.01207
NA
GPR152 0.0120735 0.6755085 0.01207
NA
STIL 0.0121403 0.6755085 0.01214
NA
FASTKD2 0.0121423 0.6755085 0.01214
NA
SLC10A7 0.0121841 0.6755085 0.01218
NA
TAOK1 0.0121848 0.6755085 0.01218
NA
HOXC8 0.0123116 0.6787303 0.01231
NA
SMARCAD1 0.0123644 0.6787303 0.01236
NA
PHTF2 0.0123776 0.6787303 0.01238
NA
BCAR3 0.0124058 0.6787303 0.01241
NA
KRTAP5-1 0.0124797 0.6787303 0.01248
NA
ABCB1 0.0124799 0.6787303 0.01248
NA
ZC3H18 0.0125608 0.6798454 0.01256
NA
LPA 0.0125795 0.6798454 0.01258
NA
FMO5 0.0126220 0.6800031 0.01262
NA
HIGD1A 0.0127101 0.6826109 0.01271
NA
TDRD5 0.0129101 0.6908413 0.01291
NA
NBPF15 0.0129638 0.6908413 0.01296
NA
SRSF7 0.0129839 0.6908413 0.01298
NA
IL32 0.0130858 0.6911024 0.01309
NA
MGME1 0.0130858 0.6911024 0.01309
NA
BNC2 0.0132235 0.6911024 0.01322
NA
STK17B 0.0132543 0.6911024 0.01325
NA
CPNE9 0.0133390 0.6911024 0.01334
NA
TRIM54 0.0133390 0.6911024 0.01334
NA
TIGD6 0.0133873 0.6911024 0.01339
NA
VSIG8 0.0134000 0.6911024 0.01340
NA
NOC4L 0.0134073 0.6911024 0.01341
NA
CD80 0.0134654 0.6911024 0.01347
NA
CDK5RAP2 0.0135336 0.6911024 0.01353
NA
SYTL1 0.0135425 0.6911024 0.01354
NA
CCDC104 0.0135614 0.6911024 0.01356
NA
GINS4 0.0135805 0.6911024 0.01358
NA
CHRNA1 0.0135920 0.6911024 0.01359
NA
SOX9 0.0138196 0.6918571 0.01382
NA
ANTXRL 0.0138763 0.6918571 0.01388
NA
IL20RA 0.0139102 0.6918571 0.01391
NA
SASH1 0.0139155 0.6918571 0.01392
NA
AMER2 0.0139939 0.6918571 0.01399
NA
DTYMK 0.0140606 0.6918571 0.01406
NA
SRPR 0.0141785 0.6918571 0.01418
NA
TOPORS 0.0141999 0.6918571 0.01420
NA
OR10J5 0.0142591 0.6918571 0.01426
NA
CNTROB 0.0142899 0.6918571 0.01429
NA
TPGS1 0.0143284 0.6918571 0.01433
NA
CLEC4F 0.0143425 0.6918571 0.01434
NA
FUBP1 0.0144614 0.6918571 0.01446
NA
IL11RA 0.0144784 0.6918571 0.01448
NA
SLC4A2 0.0145053 0.6918571 0.01451
NA
OR2K2 0.0145176 0.6918571 0.01452
NA
WHSC1 0.0145819 0.6918571 0.01458
NA
ZNHIT2 0.0146341 0.6918571 0.01463
NA
CORO7 0.0146560 0.6918571 0.01466
NA
UNC13A 0.0146599 0.6918571 0.01466
NA
GNAI2 0.0147521 0.6918571 0.01475
NA
HMBOX1 0.0147521 0.6918571 0.01475
NA
FBXO34 0.0148001 0.6918571 0.01480
NA
RRP36 0.0148669 0.6918571 0.01487
NA
MDFIC 0.0149717 0.6918571 0.01497
NA
ELMSAN1 0.0150028 0.6918571 0.01500
NA
TOM1 0.0150225 0.6918571 0.01502
NA
KCNE4 0.0151121 0.6918571 0.01511
NA
WDR48 0.0151289 0.6918571 0.01513
NA
LRRN3 0.0151951 0.6918571 0.01520
NA
FAM129C 0.0152365 0.6918571 0.01524
NA
MAFG 0.0152463 0.6918571 0.01525
NA
MTSS1L 0.0152551 0.6918571 0.01526
NA
STK11 0.0152640 0.6918571 0.01526
NA
SURF1 0.0152678 0.6918571 0.01527
NA
UBE2U 0.0153184 0.6918571 0.01532
NA
POU6F1 0.0153816 0.6918571 0.01538
NA
CILP2 0.0154408 0.6918571 0.01544
NA
IFT172 0.0154572 0.6918571 0.01546
NA
CCDC152 0.0155180 0.6918571 0.01552
NA
TMEM18 0.0155180 0.6918571 0.01552
NA
UBE2D2 0.0155253 0.6918571 0.01553
NA
HOXB4 0.0155534 0.6918571 0.01555
NA
MLST8 0.0156118 0.6918571 0.01561
NA
SLC16A6 0.0157270 0.6918571 0.01573
NA
MSANTD2 0.0157897 0.6918571 0.01579
NA
EPS8L3 0.0157909 0.6918571 0.01579
NA
OR51A2 0.0157938 0.6918571 0.01579
NA
ERI1 0.0159894 0.6918571 0.01599
NA
TBC1D3B 0.0159902 0.6918571 0.01599
NA
SYBU 0.0159985 0.6918571 0.01600
NA
BRD1 0.0160256 0.6918571 0.01603
NA
THBS3 0.0160463 0.6918571 0.01605
NA
FNTA 0.0160949 0.6918571 0.01609
NA
RTP1 0.0160949 0.6918571 0.01609
NA
SPDL1 0.0161551 0.6918571 0.01616
NA
TYMS 0.0162168 0.6918571 0.01622
NA
ASB15 0.0162606 0.6918571 0.01626
NA
GMFB 0.0162651 0.6918571 0.01627
NA
PRRC2A 0.0162959 0.6918571 0.01630
NA
BPHL 0.0163018 0.6918571 0.01630
NA
TTC27 0.0163108 0.6918571 0.01631
NA
ENTPD7 0.0163744 0.6918571 0.01637
NA
ADAMTS7 0.0163920 0.6918571 0.01639
NA
SH3GLB2 0.0164302 0.6918571 0.01643
NA
KLF13 0.0165159 0.6918571 0.01652
NA
KIAA0355 0.0165390 0.6918571 0.01654
NA
NAT2 0.0165798 0.6918571 0.01658
NA
PANX1 0.0166012 0.6918571 0.01660
NA
C2CD4A 0.0166163 0.6918571 0.01662
NA
POC1A 0.0166190 0.6918571 0.01662
NA
C6orf165 0.0166669 0.6918571 0.01667
NA
FAM110A 0.0167391 0.6918571 0.01674
NA
NBEA 0.0167455 0.6918571 0.01675
NA
GBP1 0.0167884 0.6918571 0.01679
NA
VSIG2 0.0168247 0.6918571 0.01682
NA
PCBP3 0.0168344 0.6918571 0.01683
NA
AASDH 0.0168355 0.6918571 0.01684
NA
NGRN 0.0168506 0.6918571 0.01685
NA
ART3 0.0169259 0.6918571 0.01693
NA
RNF144B 0.0169947 0.6918571 0.01699
NA
COL9A3 0.0170529 0.6918571 0.01705
NA
SDC3 0.0170624 0.6918571 0.01706
NA
RABGAP1 0.0170759 0.6918571 0.01708
NA
PRKACA 0.0171054 0.6918571 0.01711
NA
CHAC1 0.0171297 0.6918571 0.01713
NA
C9orf43 0.0171383 0.6918571 0.01714
NA
ZNF536 0.0171495 0.6918571 0.01715
NA
SNX30 0.0173795 0.6919662 0.01738
NA
DTHD1 0.0174060 0.6919662 0.01741
NA
KIRREL2 0.0174171 0.6919662 0.01742
NA
PRPF40A 0.0174654 0.6919662 0.01747
NA
DLG4 0.0174967 0.6919662 0.01750
NA
ZNF2 0.0175390 0.6919662 0.01754
NA
SNX11 0.0175972 0.6919662 0.01760
NA
PENK 0.0176291 0.6919662 0.01763
NA
KCNN4 0.0176578 0.6919662 0.01766
NA
SERPINA1 0.0176578 0.6919662 0.01766
NA
AARS 0.0176892 0.6919662 0.01769
NA
BEAN1 0.0176914 0.6919662 0.01769
NA
NPLOC4 0.0176914 0.6919662 0.01769
NA
WBSCR28 0.0177446 0.6919662 0.01774
NA
KIAA1586 0.0177561 0.6919662 0.01776
NA
RPS2 0.0178488 0.6921200 0.01785
NA
IL15RA 0.0178620 0.6921200 0.01786
NA
MYO1C 0.0179626 0.6921200 0.01796
NA
MRI1 0.0179740 0.6921200 0.01797
NA
C12orf4 0.0179744 0.6921200 0.01797
NA
TRIM29 0.0180076 0.6921200 0.01801
NA
RBM39 0.0180840 0.6921200 0.01808
NA
IL17D 0.0181006 0.6921200 0.01810
NA
ECT2L 0.0181225 0.6921200 0.01812
NA
DIRAS3 0.0181967 0.6927583 0.01820
NA
POLG 0.0182402 0.6927583 0.01824
NA
GSPT1 0.0182933 0.6927583 0.01829
NA
ZCCHC17 0.0183005 0.6927583 0.01830
NA
HABP4 0.0184450 0.6966922 0.01844
NA
SERHL2 0.0185025 0.6973331 0.01850
NA
CCDC171 0.0186758 0.6976753 0.01868
NA
SHARPIN 0.0186795 0.6976753 0.01868
NA
ALDOC 0.0187003 0.6976753 0.01870
NA
SCN3B 0.0187606 0.6976753 0.01876
NA
RNLS 0.0188141 0.6976753 0.01881
NA
GPR39 0.0189755 0.6976753 0.01898
NA
PTPN9 0.0189755 0.6976753 0.01898
NA
PCDHA11 0.0189862 0.6976753 0.01899
NA
LGI2 0.0190765 0.6976753 0.01908
NA
CHRM1 0.0191150 0.6976753 0.01911
NA
ATP6V0C 0.0191253 0.6976753 0.01913
NA
CCDC142 0.0191303 0.6976753 0.01913
NA
MKX 0.0191818 0.6976753 0.01918
NA
SLC12A6 0.0191872 0.6976753 0.01919
NA
ASPHD1 0.0192611 0.6976753 0.01926
NA
CRYGA 0.0192775 0.6976753 0.01928
NA
ARHGEF35 0.0193343 0.6976753 0.01933
NA
HSF4 0.0193619 0.6976753 0.01936
NA
PINX1 0.0194107 0.6976753 0.01941
NA
RALGAPA1 0.0194692 0.6976753 0.01947
NA
SLC2A5 0.0195109 0.6976753 0.01951
NA
TMPRSS13 0.0195287 0.6976753 0.01953
NA
ZNF205 0.0195474 0.6976753 0.01955
NA
C2orf88 0.0196004 0.6976753 0.01960
NA
C2orf50 0.0196262 0.6976753 0.01963
NA
C2orf78 0.0196756 0.6976753 0.01968
NA
LIAS 0.0196947 0.6976753 0.01969
NA
PLEKHB1 0.0196947 0.6976753 0.01969
NA
DAPP1 0.0197368 0.6976753 0.01974
NA
JAK2 0.0198294 0.6976753 0.01983
NA
CCDC115 0.0198380 0.6976753 0.01984
NA
MZT2B 0.0198839 0.6976753 0.01988
NA
OR8A1 0.0199787 0.6976753 0.01998
NA
PDZD2 0.0200597 0.6976753 0.02006
NA
ADCY7 0.0200630 0.6976753 0.02006
NA
FCHO1 0.0201035 0.6976753 0.02010
NA
SKIV2L 0.0201353 0.6976753 0.02014
NA
CHD2 0.0201529 0.6976753 0.02015
NA
ACTR5 0.0202362 0.6976753 0.02024
NA
GUCY2D 0.0202823 0.6976753 0.02028
NA
RPS13 0.0204465 0.6976753 0.02045
NA
NEDD1 0.0204533 0.6976753 0.02045
NA
TAF2 0.0204635 0.6976753 0.02046
NA
BMPR1A 0.0204701 0.6976753 0.02047
NA
FBXO41 0.0205706 0.6976753 0.02057
NA
HMGCR 0.0205957 0.6976753 0.02060
NA
MAP7D1 0.0205964 0.6976753 0.02060
NA
MOG 0.0206161 0.6976753 0.02062
NA
ASB7 0.0206561 0.6976753 0.02066
NA
KCNK2 0.0206735 0.6976753 0.02067
NA
MDH2 0.0207490 0.6976753 0.02075
NA
PI3 0.0207775 0.6976753 0.02078
NA
RAB11A 0.0207775 0.6976753 0.02078
NA
PPP1R10 0.0207943 0.6976753 0.02079
NA
ZNF207 0.0208075 0.6976753 0.02081
NA
ITPKA 0.0208317 0.6976753 0.02083
NA
SEPT1 0.0208670 0.6976753 0.02087
NA
KMT2C 0.0209043 0.6976753 0.02090
NA
PIGV 0.0209067 0.6976753 0.02091
NA
ABHD10 0.0210063 0.6984235 0.02101
NA
CST5 0.0210104 0.6984235 0.02101
NA
PIK3R2 0.0211318 0.7007898 0.02113
NA
GTF3A 0.0211896 0.7007898 0.02119
NA
PRSS3 0.0212668 0.7007898 0.02127
NA
ZZZ3 0.0213127 0.7007898 0.02131
NA
RNF43 0.0213163 0.7007898 0.02132
NA
GPR37 0.0213263 0.7007898 0.02133
NA
TMEM41B 0.0214180 0.7008084 0.02142
NA
IQUB 0.0214313 0.7008084 0.02143
NA
AKAP12 0.0214914 0.7008084 0.02149
NA
MS4A8 0.0214997 0.7008084 0.02150
NA
IFNL1 0.0215715 0.7008084 0.02157
NA
ORAOV1 0.0215715 0.7008084 0.02157
NA
TBRG4 0.0216575 0.7020991 0.02166
NA
ZMPSTE24 0.0216929 0.7020991 0.02169
NA
TMEM129 0.0217350 0.7021385 0.02173
NA
TJP3 0.0219082 0.7045712 0.02191
NA
NEUROD2 0.0219195 0.7045712 0.02192
NA
FHOD1 0.0220033 0.7045712 0.02200
NA
DCAF13 0.0220082 0.7045712 0.02201
NA
MPHOSPH9 0.0220179 0.7045712 0.02202
NA
LDHAL6A 0.0221759 0.7045712 0.02218
NA
SLC45A4 0.0222470 0.7045712 0.02225
NA
ANGPTL6 0.0222522 0.7045712 0.02225
NA
LCE1F 0.0222746 0.7045712 0.02227
NA
TMEM61 0.0222926 0.7045712 0.02229
NA
PTPN13 0.0223570 0.7045712 0.02236
NA
C8orf76 0.0224110 0.7045712 0.02241
NA
RGS9BP 0.0224503 0.7045712 0.02245
NA
ASUN 0.0224525 0.7045712 0.02245
NA
METTL21A 0.0224812 0.7045712 0.02248
NA
HHATL 0.0224814 0.7045712 0.02248
NA
KBTBD7 0.0225386 0.7045712 0.02254
NA
MPHOSPH10 0.0225617 0.7045712 0.02256
NA
TRIM58 0.0226236 0.7045712 0.02262
NA
MICAL2 0.0226366 0.7045712 0.02264
NA
R3HDML 0.0226712 0.7045712 0.02267
NA
DHODH 0.0227793 0.7051149 0.02278
NA
ATP2A2 0.0228138 0.7051149 0.02281
NA
CCAR2 0.0228701 0.7051149 0.02287
NA
CAPN11 0.0228966 0.7051149 0.02290
NA
CLVS1 0.0229019 0.7051149 0.02290
NA
PCF11 0.0229787 0.7051149 0.02298
NA
KLHL7 0.0230358 0.7051149 0.02304
NA
C1orf159 0.0230406 0.7051149 0.02304
NA
PCDHB4 0.0231162 0.7051149 0.02312
NA
POLR2C 0.0232298 0.7051149 0.02323
NA
NDUFC2 0.0232423 0.7051149 0.02324
NA
SEL1L3 0.0235259 0.7051149 0.02353
NA
KCTD9 0.0235572 0.7051149 0.02356
NA
POU3F3 0.0235617 0.7051149 0.02356
NA
KIAA1522 0.0236147 0.7051149 0.02361
NA
EBF1 0.0236453 0.7051149 0.02365
NA
RBBP8 0.0236694 0.7051149 0.02367
NA
GOLPH3L 0.0237947 0.7051149 0.02379
NA
LILRA6 0.0238221 0.7051149 0.02382
NA
EGLN1 0.0238408 0.7051149 0.02384
NA
FAM173A 0.0238408 0.7051149 0.02384
NA
TCN1 0.0238408 0.7051149 0.02384
NA
MS4A13 0.0239032 0.7051149 0.02390
NA
KCNJ4 0.0239513 0.7051149 0.02395
NA
RRAD 0.0240674 0.7051149 0.02407
NA
TYRP1 0.0241193 0.7051149 0.02412
NA
RAB13 0.0241332 0.7051149 0.02413
NA
CCK 0.0241866 0.7051149 0.02419
NA
SPARC 0.0241876 0.7051149 0.02419
NA
COL11A1 0.0241951 0.7051149 0.02420
NA
CORO2B 0.0242628 0.7051149 0.02426
NA
DBH 0.0243035 0.7051149 0.02430
NA
SULT1C4 0.0244477 0.7051149 0.02445
NA
FAM3C 0.0244543 0.7051149 0.02445
NA
TIMM50 0.0245092 0.7051149 0.02451
NA
GNAL 0.0245319 0.7051149 0.02453
NA
OLIG2 0.0245804 0.7051149 0.02458
NA
KLF6 0.0246163 0.7051149 0.02462
NA
PPFIBP2 0.0246379 0.7051149 0.02464
NA
MTRF1L 0.0246493 0.7051149 0.02465
NA
NUP62 0.0247392 0.7051149 0.02474
NA
KLHL23 0.0248002 0.7051149 0.02480
NA
TTC9B 0.0248097 0.7051149 0.02481
NA
WDR46 0.0248504 0.7051149 0.02485
NA
ECD 0.0248946 0.7051149 0.02489
NA
DIABLO 0.0249474 0.7051149 0.02495
NA
EAF1 0.0249772 0.7051149 0.02498
NA
SPATA5 0.0249872 0.7051149 0.02499
NA
ZNF493 0.0249974 0.7051149 0.02500
NA
ISCA1 0.0250831 0.7051149 0.02508
NA
DEGS1 0.0251069 0.7051149 0.02511
NA
KCNS3 0.0251441 0.7051149 0.02514
NA
EID2 0.0252457 0.7051149 0.02525
NA
ETNK1 0.0252712 0.7051149 0.02527
NA
DMTF1 0.0253905 0.7051149 0.02539
NA
DYNC1LI2 0.0254202 0.7051149 0.02542
NA
EPS8L2 0.0254243 0.7051149 0.02542
NA
MAD1L1 0.0255079 0.7051149 0.02551
NA
OR2AP1 0.0255091 0.7051149 0.02551
NA
TAF11 0.0255166 0.7051149 0.02552
NA
MCTP1 0.0255261 0.7051149 0.02553
NA
STK33 0.0255982 0.7051149 0.02560
NA
C15orf43 0.0256080 0.7051149 0.02561
NA
DENR 0.0256080 0.7051149 0.02561
NA
MRPL33 0.0256080 0.7051149 0.02561
NA
DPPA2 0.0256158 0.7051149 0.02562
NA
TEX10 0.0256828 0.7051149 0.02568
NA
TOM1L1 0.0257763 0.7051149 0.02578
NA
OPN4 0.0258199 0.7051149 0.02582
NA
MEI1 0.0258727 0.7051149 0.02587
NA
GLUD1 0.0259200 0.7051149 0.02592
NA
PTP4A2 0.0259440 0.7051149 0.02594
NA
NCAPG2 0.0259475 0.7051149 0.02595
NA
B4GALNT1 0.0261147 0.7051149 0.02611
NA
OR52N5 0.0261163 0.7051149 0.02612
NA
NUDCD3 0.0261301 0.7051149 0.02613
NA
RBM42 0.0261515 0.7051149 0.02615
NA
CD1E 0.0262158 0.7051149 0.02622
NA
PCDHA3 0.0262240 0.7051149 0.02622
NA
ANPEP 0.0262478 0.7051149 0.02625
NA
SIMC1 0.0262942 0.7051149 0.02629
NA
OR52I2 0.0264602 0.7051149 0.02646
NA
CYP2J2 0.0265156 0.7051149 0.02652
NA
TTF1 0.0265210 0.7051149 0.02652
NA
FAM43A 0.0265534 0.7051149 0.02655
NA
SKIV2L2 0.0265706 0.7051149 0.02657
NA
XRCC4 0.0265979 0.7051149 0.02660
NA
PLEKHG3 0.0266061 0.7051149 0.02661
NA
MDFI 0.0266258 0.7051149 0.02663
NA
INPP4A 0.0267730 0.7051149 0.02677
NA
FAM204A 0.0268079 0.7051149 0.02681
NA
TNFAIP8L2 0.0269397 0.7051149 0.02694
NA
DDX31 0.0269587 0.7051149 0.02696
NA
GTF2A1 0.0269590 0.7051149 0.02696
NA
HAS3 0.0269634 0.7051149 0.02696
NA
TAL2 0.0269748 0.7051149 0.02697
NA
CD69 0.0271125 0.7051149 0.02711
NA
KRTCAP3 0.0271141 0.7051149 0.02711
NA
SLC35G5 0.0271141 0.7051149 0.02711
NA
NPC2 0.0271958 0.7051149 0.02720
NA
RPL23A 0.0271958 0.7051149 0.02720
NA
HSPB2 0.0272041 0.7051149 0.02720
NA
RBM19 0.0273147 0.7051149 0.02731
NA
LRP12 0.0273147 0.7051149 0.02731
NA
SUCLA2 0.0273370 0.7051149 0.02734
NA
SLC19A1 0.0273534 0.7051149 0.02735
NA
LNPEP 0.0273579 0.7051149 0.02736
NA
C17orf80 0.0274189 0.7051149 0.02742
NA
TNFSF11 0.0274431 0.7051149 0.02744
NA
C6orf163 0.0274476 0.7051149 0.02745
NA
SNX29 0.0275222 0.7051149 0.02752
NA
BUD13 0.0275706 0.7051149 0.02757
NA
ENAH 0.0275762 0.7051149 0.02758
NA
NFE2 0.0276008 0.7051149 0.02760
NA
CDKL2 0.0276823 0.7051149 0.02768
NA
GORASP2 0.0276849 0.7051149 0.02768
NA
NICN1 0.0276849 0.7051149 0.02768
NA
CSNK1G2 0.0276950 0.7051149 0.02770
NA
EPB41 0.0277433 0.7051149 0.02774
NA
COL6A2 0.0277462 0.7051149 0.02775
NA
ZFHX4 0.0277710 0.7051149 0.02777
NA
C4orf27 0.0277763 0.7051149 0.02778
NA
COX17 0.0277763 0.7051149 0.02778
NA
USP17L10 0.0277763 0.7051149 0.02778
NA
DNAJC2 0.0278627 0.7055376 0.02786
NA
TDP1 0.0278750 0.7055376 0.02788
NA
SMG9 0.0280395 0.7070083 0.02804
NA
DEFB131 0.0280408 0.7070083 0.02804
NA
MCCD1 0.0280705 0.7070083 0.02807
NA
FBXO31 0.0281623 0.7070083 0.02816
NA
OR10A3 0.0282028 0.7070083 0.02820
NA
GJA10 0.0282031 0.7070083 0.02820
NA
BET1L 0.0282211 0.7070083 0.02822
NA
PIGO 0.0282639 0.7070508 0.02826
NA
DGKA 0.0283559 0.7070974 0.02836
NA
MMP1 0.0284373 0.7070974 0.02844
NA
TRIM16 0.0284413 0.7070974 0.02844
NA
GAS2L2 0.0284850 0.7070974 0.02848
NA
SLC45A2 0.0284990 0.7070974 0.02850
NA
CHD9 0.0286130 0.7070974 0.02861
NA
URGCP 0.0286375 0.7070974 0.02864
NA
LRIT3 0.0286486 0.7070974 0.02865
NA
NELFE 0.0286932 0.7070974 0.02869
NA
NDST4 0.0286959 0.7070974 0.02870
NA
CHCHD1 0.0287715 0.7070974 0.02877
NA
DECR2 0.0288239 0.7070974 0.02882
NA
TMEM87A 0.0288644 0.7070974 0.02886
NA
RRAS2 0.0289694 0.7070974 0.02897
NA
TIMM22 0.0289694 0.7070974 0.02897
NA
LIPA 0.0290000 0.7070974 0.02900
NA
OR52I1 0.0290000 0.7070974 0.02900
NA
CPN2 0.0290290 0.7070974 0.02903
NA
VGLL2 0.0290908 0.7070974 0.02909
NA
KRT76 0.0291641 0.7070974 0.02916
NA
BMP1 0.0291723 0.7070974 0.02917
NA
RHO 0.0291851 0.7070974 0.02919
NA
ERCC6L2 0.0292121 0.7070974 0.02921
NA
ZNF266 0.0294360 0.7080544 0.02944
NA
OPA3 0.0294553 0.7080544 0.02946
NA
C3orf27 0.0295303 0.7080544 0.02953
NA
ZNF843 0.0295336 0.7080544 0.02953
NA
PARD3 0.0295550 0.7080544 0.02955
NA
ZSCAN25 0.0295558 0.7080544 0.02956
NA
ATP13A2 0.0295809 0.7080544 0.02958
NA
LAMTOR4 0.0295823 0.7080544 0.02958
NA
YAF2 0.0296928 0.7080544 0.02969
NA
CSTF3 0.0297008 0.7080544 0.02970
NA
RSPH3 0.0297048 0.7080544 0.02970
NA
SLC30A5 0.0297500 0.7081489 0.02975
NA
MX1 0.0298423 0.7083555 0.02984
NA
MCHR2 0.0298947 0.7083555 0.02989
NA
NMT1 0.0298947 0.7083555 0.02989
NA
PDXDC1 0.0299298 0.7083555 0.02993
NA
XPO4 0.0299648 0.7083555 0.02996
NA
CPS1 0.0300319 0.7089677 0.03003
NA
ITCH 0.0301951 0.7093850 0.03020
NA
PRAME 0.0302442 0.7093850 0.03024
NA
REEP1 0.0302821 0.7093850 0.03028
NA
PRPSAP2 0.0303133 0.7093850 0.03031
NA
MVB12B 0.0303463 0.7093850 0.03035
NA
IFNL2 0.0303577 0.7093850 0.03036
NA
ATAD1 0.0305058 0.7093850 0.03051
NA
KRTAP21-1 0.0305058 0.7093850 0.03051
NA
PRB4 0.0305082 0.7093850 0.03051
NA
TBC1D2B 0.0305442 0.7093850 0.03054
NA
OR1M1 0.0305828 0.7093850 0.03058
NA
PARS2 0.0305828 0.7093850 0.03058
NA
ADCY3 0.0305934 0.7093850 0.03059
NA
GREM2 0.0306275 0.7093850 0.03063
NA
SPO11 0.0306963 0.7094276 0.03070
NA
ZNF777 0.0307455 0.7094276 0.03075
NA
C22orf31 0.0307531 0.7094276 0.03075
NA
PCDHA5 0.0308930 0.7116981 0.03089
NA
GSTT2 0.0309556 0.7121850 0.03096
NA
MYBPC2 0.0310240 0.7122049 0.03102
NA
MAPK1IP1L 0.0310627 0.7122049 0.03106
NA
C6orf223 0.0310995 0.7122049 0.03110
NA
PRKAA2 0.0311335 0.7122049 0.03113
NA
OSTM1 0.0311636 0.7122049 0.03116
NA
DMTN 0.0312326 0.7128335 0.03123
NA
ACSS1 0.0314160 0.7151642 0.03142
NA
FNIP1 0.0314274 0.7151642 0.03143
NA
RBM48 0.0314596 0.7151642 0.03146
NA
ACY1 0.0316459 0.7165696 0.03165
NA
NOS2 0.0316928 0.7165696 0.03169
NA
NLRP2 0.0317326 0.7165696 0.03173
NA
DPH6 0.0317433 0.7165696 0.03174
NA
CADM4 0.0317957 0.7165696 0.03180
NA
PALB2 0.0318584 0.7165696 0.03186
NA
GOLT1B 0.0318604 0.7165696 0.03186
NA
NNT 0.0319110 0.7165696 0.03191
NA
ZNF117 0.0320044 0.7165696 0.03200
NA
C19orf70 0.0320157 0.7165696 0.03202
NA
INO80E 0.0320157 0.7165696 0.03202
NA
CDKN2A 0.0320307 0.7165696 0.03203
NA
TEFM 0.0320974 0.7165696 0.03210
NA
ALG1 0.0321116 0.7165696 0.03211
NA
MRPL30 0.0321468 0.7165696 0.03215
NA
DCTN2 0.0322611 0.7173177 0.03226
NA
FKBP2 0.0322658 0.7173177 0.03227
NA
RAD9B 0.0323115 0.7173177 0.03231
NA
PLD5 0.0323473 0.7173177 0.03235
NA
OR4C46 0.0323905 0.7173499 0.03239
NA
WRAP73 0.0325330 0.7195780 0.03253
NA
CDPF1 0.0326756 0.7218043 0.03268
NA
KLHL10 0.0327225 0.7219122 0.03272
NA
P2RX2 0.0328669 0.7219245 0.03287
NA
CCDC28A 0.0329804 0.7219245 0.03298
NA
PISD 0.0329829 0.7219245 0.03298
NA
DUSP14 0.0330575 0.7219245 0.03306
NA
GALNT2 0.0330885 0.7219245 0.03309
NA
C11orf21 0.0330899 0.7219245 0.03309
NA
PRSS22 0.0331003 0.7219245 0.03310
NA
KIAA0100 0.0331653 0.7219245 0.03317
NA
RDH16 0.0331950 0.7219245 0.03320
NA
USF2 0.0333059 0.7219245 0.03331
NA
ZFYVE26 0.0333603 0.7219245 0.03336
NA
APH1B 0.0334921 0.7219245 0.03349
NA
GPX8 0.0334990 0.7219245 0.03350
NA
CXCL17 0.0335087 0.7219245 0.03351
NA
NIP7 0.0335087 0.7219245 0.03351
NA
MBTD1 0.0335846 0.7219245 0.03358
NA
C9orf152 0.0335891 0.7219245 0.03359
NA
FARSB 0.0337024 0.7219245 0.03370
NA
OSBPL1A 0.0337660 0.7219245 0.03377
NA
CRLF3 0.0337765 0.7219245 0.03378
NA
OR2L5 0.0337914 0.7219245 0.03379
NA
HRASLS2 0.0338287 0.7219245 0.03383
NA
PRM2 0.0338577 0.7219245 0.03386
NA
CLN6 0.0338681 0.7219245 0.03387
NA
PIGC 0.0338801 0.7219245 0.03388
NA
APBA2 0.0339173 0.7219245 0.03392
NA
BUB3 0.0339320 0.7219245 0.03393
NA
C19orf60 0.0339320 0.7219245 0.03393
NA
TRPC1 0.0339915 0.7219245 0.03399
NA
ZYG11B 0.0340597 0.7219245 0.03406
NA
NCAPG 0.0340874 0.7219245 0.03409
NA
RERG 0.0341281 0.7219245 0.03413
NA
SRP54 0.0342653 0.7219245 0.03427
NA
HJURP 0.0343092 0.7219245 0.03431
NA
TP53BP2 0.0343442 0.7219245 0.03434
NA
RCE1 0.0343970 0.7219245 0.03440
NA
STAR 0.0344475 0.7219245 0.03445
NA
GNL1 0.0345269 0.7219245 0.03453
NA
USP53 0.0345322 0.7219245 0.03453
NA
IL31 0.0345448 0.7219245 0.03454
NA
NOTCH2 0.0345931 0.7219245 0.03459
NA
QPCTL 0.0346745 0.7219245 0.03467
NA
FAM131B 0.0347063 0.7219245 0.03471
NA
SLC35F5 0.0347263 0.7219245 0.03473
NA
NUDT1 0.0347923 0.7219245 0.03479
NA
IL21R 0.0348186 0.7219245 0.03482
NA
MAS1 0.0348574 0.7219245 0.03486
NA
LIMA1 0.0348857 0.7219245 0.03489
NA
TSPAN12 0.0348876 0.7219245 0.03489
NA
CCDC71 0.0348995 0.7219245 0.03490
NA
LRRC25 0.0348995 0.7219245 0.03490
NA
MSR1 0.0349074 0.7219245 0.03491
NA
INTS7 0.0350081 0.7231351 0.03501
NA
C11orf86 0.0353227 0.7259713 0.03532
NA
HAUS1 0.0353227 0.7259713 0.03532
NA
CERS3 0.0353508 0.7259713 0.03535
NA
GXYLT2 0.0353557 0.7259713 0.03536
NA
ZNF354B 0.0353566 0.7259713 0.03536
NA
HSPG2 0.0354373 0.7267612 0.03544
NA
ACD 0.0355361 0.7277082 0.03554
NA
MTX2 0.0355682 0.7277082 0.03557
NA
PRR23A 0.0357211 0.7288197 0.03572
NA
TUBB6 0.0357912 0.7288197 0.03579
NA
STT3A 0.0357945 0.7288197 0.03579
NA
USP15 0.0359354 0.7288197 0.03594
NA
DPY30 0.0359515 0.7288197 0.03595
NA
MARK3 0.0359740 0.7288197 0.03597
NA
PDE6D 0.0359825 0.7288197 0.03598
NA
LRRC37A3 0.0359877 0.7288197 0.03599
NA
C3orf14 0.0360183 0.7288197 0.03602
NA
TRPM5 0.0361241 0.7288197 0.03612
NA
ADORA2B 0.0361933 0.7288197 0.03619
NA
ZBTB9 0.0362123 0.7288197 0.03621
NA
CSF1 0.0362861 0.7288197 0.03629
NA
LRRC32 0.0363299 0.7288197 0.03633
NA
NEBL 0.0363515 0.7288197 0.03635
NA
ARHGAP12 0.0363757 0.7288197 0.03638
NA
ADIPOR2 0.0364959 0.7288197 0.03650
NA
PHIP 0.0365065 0.7288197 0.03651
NA
TMEM200A 0.0365199 0.7288197 0.03652
NA
IRAK1BP1 0.0365899 0.7288197 0.03659
NA
KCNC2 0.0366278 0.7288197 0.03663
NA
C16orf54 0.0366459 0.7288197 0.03665
NA
CA14 0.0366459 0.7288197 0.03665
NA
CLN3 0.0366482 0.7288197 0.03665
NA
CUL5 0.0367173 0.7288197 0.03672
NA
PPP1R12B 0.0368777 0.7288197 0.03688
NA
GNLY 0.0370249 0.7288197 0.03702
NA
MYADM 0.0371412 0.7288197 0.03714
NA
SMAP2 0.0371812 0.7288197 0.03718
NA
MMS19 0.0372272 0.7288197 0.03723
NA
OXCT1 0.0373375 0.7288197 0.03734
NA
CYP11B1 0.0373528 0.7288197 0.03735
NA
DGKZ 0.0374261 0.7288197 0.03743
NA
LMF2 0.0374407 0.7288197 0.03744
NA
SLC4A8 0.0374443 0.7288197 0.03744
NA
AIMP2 0.0374709 0.7288197 0.03747
NA
SF3B4 0.0374858 0.7288197 0.03749
NA
ATP5I 0.0375615 0.7288197 0.03756
NA
CSF3 0.0375656 0.7288197 0.03757
NA
SNX33 0.0375727 0.7288197 0.03757
NA
LGALS3BP 0.0375877 0.7288197 0.03759
NA
ZFAND3 0.0376203 0.7288197 0.03762
NA
MANEAL 0.0376931 0.7288197 0.03769
NA
TAF1A 0.0377764 0.7288197 0.03778
NA
TOX3 0.0377824 0.7288197 0.03778
NA
CCL13 0.0378511 0.7288197 0.03785
NA
RMND1 0.0378511 0.7288197 0.03785
NA
GTF2E1 0.0378819 0.7288197 0.03788
NA
EXOSC1 0.0378957 0.7288197 0.03790
NA
SLIRP 0.0378957 0.7288197 0.03790
NA
RBBP4 0.0379938 0.7288197 0.03799
NA
ZNF451 0.0380083 0.7288197 0.03801
NA
ZNF850 0.0380102 0.7288197 0.03801
NA
TIGD2 0.0380474 0.7288197 0.03805
NA
PET112 0.0381029 0.7288197 0.03810
NA
RXRG 0.0381855 0.7288197 0.03819
NA
NFIC 0.0381982 0.7288197 0.03820
NA
LIPT1 0.0383279 0.7288197 0.03833
NA
C16orf62 0.0383964 0.7288197 0.03840
NA
ACAP1 0.0384069 0.7288197 0.03841
NA
OR4M2 0.0384121 0.7288197 0.03841
NA
HIGD1C 0.0384222 0.7288197 0.03842
NA
RNF123 0.0384721 0.7288197 0.03847
NA
CNNM2 0.0384829 0.7288197 0.03848
NA
ADCY10 0.0385573 0.7288197 0.03856
NA
HMX1 0.0385633 0.7288197 0.03856
NA
FAM217B 0.0385789 0.7288197 0.03858
NA
BAZ2B 0.0386349 0.7288197 0.03863
NA
C2orf54 0.0386821 0.7288197 0.03868
NA
TMEM2 0.0386878 0.7288197 0.03869
NA
OR5B21 0.0388010 0.7288197 0.03880
NA
EREG 0.0388978 0.7288197 0.03890
NA
EIF5AL1 0.0389009 0.7288197 0.03890
NA
PPM1H 0.0389034 0.7288197 0.03890
NA
WFIKKN2 0.0389068 0.7288197 0.03891
NA
ACOX3 0.0389509 0.7288197 0.03895
NA
CCHCR1 0.0389641 0.7288197 0.03896
NA
PROK2 0.0390113 0.7288197 0.03901
NA
BCAT2 0.0390151 0.7288197 0.03902
NA
RNASEH1 0.0390151 0.7288197 0.03902
NA
ZNF609 0.0393834 0.7301870 0.03938
NA
ZNF213 0.0393860 0.7301870 0.03939
NA
KCNJ5 0.0395030 0.7301870 0.03950
NA
AHNAK 0.0395607 0.7301870 0.03956
NA
NCAPD3 0.0395778 0.7301870 0.03958
NA
DPYD 0.0395906 0.7301870 0.03959
NA
SLK 0.0396132 0.7301870 0.03961
NA
BEND6 0.0396274 0.7301870 0.03963
NA
GIMAP6 0.0397956 0.7301870 0.03980
NA
KIAA1598 0.0398110 0.7301870 0.03981
NA
SGMS1 0.0398226 0.7301870 0.03982
NA
GOLGA8H 0.0398371 0.7301870 0.03984
NA
NAA16 0.0398371 0.7301870 0.03984
NA
LZTR1 0.0398585 0.7301870 0.03986
NA
ASCL3 0.0398641 0.7301870 0.03986
NA
ODF4 0.0398641 0.7301870 0.03986
NA
PTH2R 0.0399054 0.7301870 0.03991
NA
PRR18 0.0399286 0.7301870 0.03993
NA
ZC3H13 0.0400231 0.7301870 0.04002
NA
ATM 0.0400264 0.7301870 0.04003
NA
TBC1D20 0.0401391 0.7301870 0.04014
NA
KIAA1324L 0.0401580 0.7301870 0.04016
NA
GRPEL1 0.0402017 0.7301870 0.04020
NA
KLF4 0.0402283 0.7301870 0.04023
NA
C19orf48 0.0402762 0.7301870 0.04028
NA
TSNAX 0.0402762 0.7301870 0.04028
NA
IL12RB1 0.0404010 0.7301870 0.04040
NA
AGK 0.0404578 0.7301870 0.04046
NA
PROKR1 0.0404705 0.7301870 0.04047
NA
RBM33 0.0404758 0.7301870 0.04048
NA
PLLP 0.0406221 0.7301870 0.04062
NA
NCDN 0.0406410 0.7301870 0.04064
NA
PTGIR 0.0406723 0.7301870 0.04067
NA
SNX5 0.0406914 0.7301870 0.04069
NA
PPEF2 0.0408167 0.7301870 0.04082
NA
C5orf47 0.0408506 0.7301870 0.04085
NA
MDM4 0.0408966 0.7301870 0.04090
NA
MYOCD 0.0410464 0.7301870 0.04105
NA
G3BP2 0.0410671 0.7301870 0.04107
NA
ARHGAP5 0.0411052 0.7301870 0.04111
NA
CNNM1 0.0411505 0.7301870 0.04115
NA
CC2D1A 0.0411785 0.7301870 0.04118
NA
IGLON5 0.0412008 0.7301870 0.04120
NA
FAM105A 0.0412062 0.7301870 0.04121
NA
LINGO2 0.0412668 0.7301870 0.04127
NA
COX14 0.0413516 0.7301870 0.04135
NA
STRA6 0.0414147 0.7301870 0.04141
NA
PFDN5 0.0414227 0.7301870 0.04142
NA
MRPL1 0.0414756 0.7301870 0.04148
NA
FAM65C 0.0415897 0.7301870 0.04159
NA
COL19A1 0.0416157 0.7301870 0.04162
NA
DES 0.0416363 0.7301870 0.04164
NA
KHDC3L 0.0417259 0.7301870 0.04173
NA
OR8B3 0.0417488 0.7301870 0.04175
NA
PTH 0.0417488 0.7301870 0.04175
NA
S1PR2 0.0417725 0.7301870 0.04177
NA
TMEM177 0.0417863 0.7301870 0.04179
NA
PDZD8 0.0418275 0.7301870 0.04183
NA
SAMD3 0.0418914 0.7301870 0.04189
NA
CCND3 0.0419359 0.7301870 0.04194
NA
UGT8 0.0419667 0.7301870 0.04197
NA
STX5 0.0420533 0.7301870 0.04205
NA
TTF2 0.0420543 0.7301870 0.04205
NA
CR1 0.0420633 0.7301870 0.04206
NA
HRH3 0.0420709 0.7301870 0.04207
NA
OGDHL 0.0421482 0.7301870 0.04215
NA
DCUN1D4 0.0421585 0.7301870 0.04216
NA
OR2B6 0.0422113 0.7301870 0.04221
NA
HOGA1 0.0422392 0.7301870 0.04224
NA
IRX6 0.0422711 0.7301870 0.04227
NA
SETD6 0.0423132 0.7301870 0.04231
NA
AARS2 0.0423233 0.7301870 0.04232
NA
ALKBH6 0.0423692 0.7301870 0.04237
NA
EMX2 0.0423730 0.7301870 0.04237
NA
PSMF1 0.0423730 0.7301870 0.04237
NA
ALKBH4 0.0426779 0.7301870 0.04268
NA
YTHDC1 0.0428630 0.7301870 0.04286
NA
KIAA0319L 0.0429048 0.7301870 0.04290
NA
SNX8 0.0429372 0.7301870 0.04294
NA
CACNA2D4 0.0430041 0.7301870 0.04300
NA
CCDC96 0.0431017 0.7301870 0.04310
NA
GBX1 0.0431017 0.7301870 0.04310
NA
KIAA1462 0.0431147 0.7301870 0.04311
NA
KLRC1 0.0431316 0.7301870 0.04313
NA
C21orf59 0.0431423 0.7301870 0.04314
NA
FAM120A 0.0431508 0.7301870 0.04315
NA
AGT 0.0431603 0.7301870 0.04316
NA
ZNF559 0.0431660 0.7301870 0.04317
NA
TESPA1 0.0432436 0.7301870 0.04324
NA
FUT1 0.0433427 0.7301870 0.04334
NA
CHST10 0.0433590 0.7301870 0.04336
NA
HCN3 0.0433972 0.7301870 0.04340
NA
SLC30A4 0.0435311 0.7301870 0.04353
NA
SPPL2C 0.0435456 0.7301870 0.04355
NA
KHDRBS1 0.0435889 0.7301870 0.04359
NA
DZANK1 0.0435957 0.7301870 0.04360
NA
ATP6V1B1 0.0437134 0.7301870 0.04371
NA
EIF3J 0.0437157 0.7301870 0.04372
NA
FAM60A 0.0437157 0.7301870 0.04372
NA
BARD1 0.0437508 0.7301870 0.04375
NA
TRIM15 0.0437755 0.7301870 0.04378
NA
CCNB1 0.0438089 0.7301870 0.04381
NA
CYCS 0.0438414 0.7301870 0.04384
NA
ZEB1 0.0438519 0.7301870 0.04385
NA
WDR62 0.0439460 0.7301870 0.04395
NA
CAV2 0.0439592 0.7301870 0.04396
NA
WFDC8 0.0439741 0.7301870 0.04397
NA
LRRC27 0.0439907 0.7301870 0.04399
NA
KDM2A 0.0440131 0.7301870 0.04401
NA
TUBA3D 0.0440466 0.7301870 0.04405
NA
PIWIL3 0.0440555 0.7301870 0.04406
NA
SEPT9 0.0441130 0.7301870 0.04411
NA
DPP10 0.0441750 0.7301870 0.04418
NA
SEC61A2 0.0441996 0.7301870 0.04420
NA
ALKBH5 0.0442464 0.7301870 0.04425
NA
HMX3 0.0442500 0.7301870 0.04425
NA
TGFBRAP1 0.0443459 0.7301870 0.04435
NA
HNF1B 0.0443600 0.7301870 0.04436
NA
EGLN3 0.0443944 0.7301870 0.04439
NA
CTNNA2 0.0445720 0.7301870 0.04457
NA
SETD1B 0.0446135 0.7301870 0.04461
NA
ERP44 0.0446187 0.7301870 0.04462
NA
LIMD1 0.0446187 0.7301870 0.04462
NA
C19orf73 0.0446522 0.7301870 0.04465
NA
TBC1D10A 0.0446814 0.7301870 0.04468
NA
HMGXB4 0.0446975 0.7301870 0.04470
NA
CPLX2 0.0448210 0.7301870 0.04482
NA
S100B 0.0448333 0.7301870 0.04483
NA
IL5RA 0.0448419 0.7301870 0.04484
NA
MED20 0.0448419 0.7301870 0.04484
NA
HEPACAM2 0.0448533 0.7301870 0.04485
NA
PNKD 0.0448863 0.7301870 0.04489
NA
ALKBH3 0.0448876 0.7301870 0.04489
NA
GLT8D2 0.0449398 0.7301870 0.04494
NA
MAP3K1 0.0449558 0.7301870 0.04496
NA
PFKFB4 0.0449608 0.7301870 0.04496
NA
PROK1 0.0450061 0.7301870 0.04501
NA
TRIM37 0.0450664 0.7301870 0.04507
NA
MYH10 0.0450962 0.7301870 0.04510
NA
CTRL 0.0452758 0.7301870 0.04528
NA
RAX 0.0452758 0.7301870 0.04528
NA
FURIN 0.0453413 0.7301870 0.04534
NA
CHST8 0.0453527 0.7301870 0.04535
NA
DEAF1 0.0453686 0.7301870 0.04537
NA
SPATC1 0.0453780 0.7301870 0.04538
NA
FZD6 0.0453946 0.7301870 0.04539
NA
OR51I2 0.0454940 0.7301870 0.04549
NA
ZDHHC4 0.0455498 0.7301870 0.04555
NA
GLRA3 0.0456039 0.7301870 0.04560
NA
DDX39A 0.0456316 0.7301870 0.04563
NA
KMT2B 0.0456850 0.7301870 0.04568
NA
HLA-E 0.0457183 0.7301870 0.04572
NA
IPPK 0.0457183 0.7301870 0.04572
NA
HNRNPD 0.0457668 0.7301870 0.04577
NA
C8B 0.0457888 0.7301870 0.04579
NA
TNFRSF10A 0.0458385 0.7301870 0.04584
NA
AP1G2 0.0458399 0.7301870 0.04584
NA
TNFRSF14 0.0458677 0.7301870 0.04587
NA
FAM186B 0.0459061 0.7301870 0.04591
NA
ATP1B1 0.0459617 0.7301870 0.04596
NA
C4orf22 0.0459836 0.7301870 0.04598
NA
MIS18A 0.0460990 0.7301870 0.04610
NA
PPIL4 0.0462020 0.7301870 0.04620
NA
LRRC10 0.0462742 0.7301870 0.04627
NA
LIPJ 0.0464341 0.7301870 0.04643
NA
TBL1XR1 0.0464341 0.7301870 0.04643
NA
NUP88 0.0466791 0.7301870 0.04668
NA
ERICH1 0.0466984 0.7301870 0.04670
NA
SLC22A3 0.0467229 0.7301870 0.04672
NA
ZNF326 0.0467262 0.7301870 0.04673
NA
RPS6KA2 0.0467548 0.7301870 0.04675
NA
NFIB 0.0467702 0.7301870 0.04677
NA
NPSR1 0.0467775 0.7301870 0.04678
NA
ROM1 0.0468214 0.7301870 0.04682
NA
SH2D2A 0.0468513 0.7301870 0.04685
NA
PCDHB13 0.0468548 0.7301870 0.04685
NA
C1orf185 0.0469092 0.7301870 0.04691
NA
MIEF1 0.0470635 0.7301870 0.04706
NA
PTCD1 0.0470762 0.7301870 0.04708
NA
CORIN 0.0471720 0.7301870 0.04717
NA
S100A6 0.0472141 0.7301870 0.04721
NA
ATP6V0E2 0.0473854 0.7301870 0.04739
NA
SLC22A13 0.0474283 0.7301870 0.04743
NA
MEF2A 0.0474528 0.7301870 0.04745
NA
KRCC1 0.0474879 0.7301870 0.04749
NA
ALS2 0.0474973 0.7301870 0.04750
NA
BRMS1 0.0474991 0.7301870 0.04750
NA
ARHGAP25 0.0475079 0.7301870 0.04751
NA
TBC1D9 0.0475095 0.7301870 0.04751
NA
RPRD1B 0.0475144 0.7301870 0.04751
NA
PAK7 0.0475610 0.7301870 0.04756
NA
LYSMD1 0.0476325 0.7301870 0.04763
NA
TEX29 0.0476325 0.7301870 0.04763
NA
SMYD1 0.0476620 0.7301870 0.04766
NA
PRLH 0.0477090 0.7301870 0.04771
NA
XIRP1 0.0477339 0.7301870 0.04773
NA
OR2T8 0.0477685 0.7301870 0.04777
NA
KRT84 0.0477744 0.7301870 0.04777
NA
BPIFA2 0.0477871 0.7301870 0.04779
NA
LRRC18 0.0477871 0.7301870 0.04779
NA
SFRP2 0.0477871 0.7301870 0.04779
NA
SH2D3C 0.0478068 0.7301870 0.04781
NA
ATP4A 0.0478112 0.7301870 0.04781
NA
CORO1C 0.0478195 0.7301870 0.04782
NA
GPR155 0.0478422 0.7301870 0.04784
NA
ATRNL1 0.0478614 0.7301870 0.04786
NA
ADCY5 0.0478832 0.7301870 0.04788
NA
ELN 0.0479819 0.7304040 0.04798
NA
ZNF568 0.0479824 0.7304040 0.04798
NA
HTR1B 0.0480911 0.7314109 0.04809
NA
KCNH4 0.0481783 0.7314773 0.04818
NA
ZNF189 0.0481806 0.7314773 0.04818
NA
AMBRA1 0.0483222 0.7328509 0.04832
NA
PDLIM2 0.0483754 0.7328509 0.04838
NA
TAS2R1 0.0484254 0.7328509 0.04843
NA
RMDN2 0.0484570 0.7328509 0.04846
NA
TBC1D24 0.0485074 0.7328509 0.04851
NA
AXDND1 0.0485270 0.7328509 0.04853
NA
SPEN 0.0486899 0.7344104 0.04869
NA
RALGPS2 0.0487816 0.7344104 0.04878
NA
SPOCK2 0.0488578 0.7344104 0.04886
NA
ZNF600 0.0488773 0.7344104 0.04888
NA
HILPDA 0.0489293 0.7344104 0.04893
NA
PGM2 0.0489831 0.7344104 0.04898
NA
TMEM9 0.0490056 0.7344104 0.04901
NA
KLRC2 0.0490094 0.7344104 0.04901
NA
MTA2 0.0490162 0.7344104 0.04902
NA
VPS72 0.0490591 0.7344104 0.04906
NA
ZNF34 0.0491384 0.7344104 0.04914
NA
USP6 0.0491430 0.7344104 0.04914
NA
REV3L 0.0492101 0.7347733 0.04921
NA
DTNBP1 0.0493800 0.7348209 0.04938
NA
CIR1 0.0494156 0.7348209 0.04942
NA
PRPF38A 0.0494226 0.7348209 0.04942
NA
TMEM116 0.0494266 0.7348209 0.04943
NA
C10orf113 0.0494612 0.7348209 0.04946
NA
ACOT6 0.0495125 0.7348209 0.04951
NA
RAB27A 0.0495125 0.7348209 0.04951
NA
KIF7 0.0497607 0.7359083 0.04976
NA
TCF3 0.0498558 0.7359083 0.04986
NA
TRAM1L1 0.0498947 0.7359083 0.04989
NA
SNRNP40 0.0499070 0.7359083 0.04991
NA
TPTE2 0.0499226 0.7359083 0.04992
NA
BCL2 0.0499451 0.7359083 0.04995
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_gene_allmut_delmis_plot <- ggplot(data = crispr_signif_allmut_delmis) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_gene_allmut_delmis_plot

5.2 Grouped by gene and lineage

5.2.1 Deleterious vs. Other

crispr_signif_allmut_del_lineage <- compare_means(Score ~ Mutation_Status_Deleterious, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_allmut_del_lineage <- adj_signif(crispr_signif_allmut_del_lineage)
crispr_signif_allmut_del_lineage <- crispr_signif_allmut_del_lineage[order(crispr_signif_allmut_del_lineage$p),]
saveRDS(crispr_signif_allmut_del_lineage, "./data_munging/rds/crispr_signif_allmut_deleterious_lineage.rds")

# write.table(crispr_signif_allmut_del_lineage, file = "~/Desktop/crispr_signif_allmut_deleterious_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_allmut_del_lineage <- readRDS("./data_munging/rds/crispr_signif_allmut_deleterious_lineage.rds")

knitr::kable(filter(crispr_signif_allmut_del_lineage, p < 0.05)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing deleterious mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing deleterious mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol group_general_lineage_name p p.adj p.format p.signif p.signif.adj
PTEN central nervous system cancer 0.0006658 0.8331843 0.00067 *** NA
TP53 lung cancer 0.0006718 0.8331843 0.00067 *** NA
ZNF141 central nervous system cancer 0.0031757 0.8331843 0.00318 ** NA
DCAF8 lung cancer 0.0033009 0.8331843 0.00330 ** NA
PTEN ovarian cancer 0.0048168 0.8331843 0.00482 ** NA
ARID1B ovarian cancer 0.0054869 0.8331843 0.00549 ** NA
IFT122 lung cancer 0.0055037 0.8331843 0.00550 ** NA
SETD2 kidney cancer 0.0056647 0.8331843 0.00566 ** NA
KRT17 breast cancer 0.0063661 0.8331843 0.00637 ** NA
DVL2 uterine cancer 0.0067676 0.8331843 0.00677 ** NA
ARID1A pancreatic cancer 0.0076726 0.8331843 0.00767 ** NA
MCPH1 lung cancer 0.0077467 0.8331843 0.00775 ** NA
COX4I1 lung cancer 0.0091372 0.8331843 0.00914 ** NA
ZNF343 lung cancer 0.0098486 0.8331843 0.00985 ** NA
TPR lung cancer 0.0106211 0.8331843 0.01062
NA
PLOD3 colorectal cancer 0.0114716 0.8331843 0.01147
NA
SCN10A uterine cancer 0.0119017 0.8331843 0.01190
NA
DOPEY2 colorectal cancer 0.0120018 0.8331843 0.01200
NA
ALPPL2 ovarian cancer 0.0124948 0.8331843 0.01249
NA
RB1 central nervous system cancer 0.0126776 0.8331843 0.01268
NA
ATRNL1 lung cancer 0.0129054 0.8331843 0.01291
NA
KMT2B stomach cancer 0.0132674 0.8331843 0.01327
NA
PPP3R1 skin cancer 0.0134888 0.8331843 0.01349
NA
DDC uterine cancer 0.0137273 0.8331843 0.01373
NA
ST5 uterine cancer 0.0147587 0.8331843 0.01476
NA
JMJD1C kidney cancer 0.0155331 0.8331843 0.01553
NA
KRT19 urinary bladder cancer 0.0166681 0.8331843 0.01667
NA
DENND1B uterine cancer 0.0168725 0.8331843 0.01687
NA
FAT1 head and neck cancer 0.0169287 0.8331843 0.01693
NA
ZCCHC24 lung cancer 0.0173326 0.8331843 0.01733
NA
GATS ovarian cancer 0.0173464 0.8331843 0.01735
NA
C11orf57 uterine cancer 0.0178172 0.8331843 0.01782
NA
TIMD4 uterine cancer 0.0178172 0.8331843 0.01782
NA
HEATR5B leukemia 0.0181845 0.8331843 0.01818
NA
MEGF8 colorectal cancer 0.0183515 0.8331843 0.01835
NA
ATP13A5 lymphoma 0.0189035 0.8331843 0.01890
NA
KMT2D lung cancer 0.0190686 0.8331843 0.01907
NA
ANKRD11 central nervous system cancer 0.0191124 0.8331843 0.01911
NA
NCOR1 uterine cancer 0.0197808 0.8331843 0.01978
NA
ECT2L central nervous system cancer 0.0205456 0.8331843 0.02055
NA
PRDM2 colorectal cancer 0.0208898 0.8331843 0.02089
NA
AKR1C1 lung cancer 0.0210544 0.8331843 0.02105
NA
PDE1A lung cancer 0.0210544 0.8331843 0.02105
NA
DENND4B uterine cancer 0.0213185 0.8331843 0.02132
NA
ESRP1 uterine cancer 0.0213911 0.8331843 0.02139
NA
MAP3K2 central nervous system cancer 0.0218317 0.8331843 0.02183
NA
RALGAPB uterine cancer 0.0222505 0.8331843 0.02225
NA
THADA colorectal cancer 0.0226230 0.8331843 0.02262
NA
AXIN1 ovarian cancer 0.0226568 0.8331843 0.02266
NA
FER colorectal cancer 0.0228475 0.8331843 0.02285
NA
CALCRL lung cancer 0.0231325 0.8331843 0.02313
NA
UGT2A3 lung cancer 0.0231325 0.8331843 0.02313
NA
B4GALNT3 colorectal cancer 0.0233134 0.8331843 0.02331
NA
COG6 colorectal cancer 0.0233134 0.8331843 0.02331
NA
HAX1 colorectal cancer 0.0233134 0.8331843 0.02331
NA
TAF3 colorectal cancer 0.0233134 0.8331843 0.02331
NA
WDR46 colorectal cancer 0.0233134 0.8331843 0.02331
NA
DAZAP1 uterine cancer 0.0233796 0.8331843 0.02338
NA
ANXA4 breast cancer 0.0237414 0.8331843 0.02374
NA
FNIP1 ovarian cancer 0.0237603 0.8331843 0.02376
NA
NRG3 lung cancer 0.0240587 0.8331843 0.02406
NA
ABCC5 multiple myeloma 0.0240966 0.8331843 0.02410
NA
NUP205 uterine cancer 0.0243902 0.8331843 0.02439
NA
RYR2 colorectal cancer 0.0246475 0.8331843 0.02465
NA
PABPC1 pancreatic cancer 0.0246982 0.8331843 0.02470
NA
EGFR lung cancer 0.0248011 0.8331843 0.02480
NA
SMARCA4 lung cancer 0.0248724 0.8331843 0.02487
NA
EIF2AK3 kidney cancer 0.0252676 0.8331843 0.02527
NA
DLGAP5 uterine cancer 0.0252831 0.8331843 0.02528
NA
EPB41L5 uterine cancer 0.0252831 0.8331843 0.02528
NA
AJAP1 lung cancer 0.0253864 0.8331843 0.02539
NA
KIAA1755 lung cancer 0.0253864 0.8331843 0.02539
NA
ZNRF3 lung cancer 0.0253864 0.8331843 0.02539
NA
PPP1R12A central nervous system cancer 0.0257091 0.8331843 0.02571
NA
GSPT1 colorectal cancer 0.0257186 0.8331843 0.02572
NA
ZNF292 colorectal cancer 0.0257186 0.8331843 0.02572
NA
ERMAP leukemia 0.0266603 0.8331843 0.02666
NA
ZNF230 urinary bladder cancer 0.0266603 0.8331843 0.02666
NA
ZNF581 leukemia 0.0266603 0.8331843 0.02666
NA
EDNRB uterine cancer 0.0277385 0.8331843 0.02774
NA
REG1B lung cancer 0.0278279 0.8331843 0.02783
NA
GYPE skin cancer 0.0281858 0.8331843 0.02819
NA
CACYBP uterine cancer 0.0283176 0.8331843 0.02832
NA
KRTAP10-6 cancer 0.0283176 0.8331843 0.02832
NA
KRTAP10-6 uterine cancer 0.0283176 0.8331843 0.02832
NA
RPL14 uterine cancer 0.0283176 0.8331843 0.02832
NA
TEX10 ovarian cancer 0.0290244 0.8331843 0.02902
NA
DOPEY1 colorectal cancer 0.0293818 0.8331843 0.02938
NA
AGO4 uterine cancer 0.0294387 0.8331843 0.02944
NA
CCDC83 uterine cancer 0.0294387 0.8331843 0.02944
NA
CYP20A1 uterine cancer 0.0294387 0.8331843 0.02944
NA
DNAH10 cancer 0.0294387 0.8331843 0.02944
NA
MCM10 uterine cancer 0.0294387 0.8331843 0.02944
NA
PALB2 uterine cancer 0.0294387 0.8331843 0.02944
NA
RALGPS2 uterine cancer 0.0294387 0.8331843 0.02944
NA
TMEM87A uterine cancer 0.0294387 0.8331843 0.02944
NA
TRMT44 uterine cancer 0.0294387 0.8331843 0.02944
NA
ZNF124 uterine cancer 0.0294387 0.8331843 0.02944
NA
SEMA5A colorectal cancer 0.0295794 0.8331843 0.02958
NA
SORCS3 uterine cancer 0.0295834 0.8331843 0.02958
NA
DEPDC5 uterine cancer 0.0298871 0.8331843 0.02989
NA
SKAP1 lung cancer 0.0301543 0.8331843 0.03015
NA
MRPL22 ovarian cancer 0.0301937 0.8331843 0.03019
NA
PDXDC1 breast cancer 0.0302390 0.8331843 0.03024
NA
ARHGDIB lung cancer 0.0304692 0.8331843 0.03047
NA
SRPK2 lung cancer 0.0304692 0.8331843 0.03047
NA
TTF1 lung cancer 0.0304692 0.8331843 0.03047
NA
CTNND2 uterine cancer 0.0305459 0.8331843 0.03055
NA
RYR1 uterine cancer 0.0305459 0.8331843 0.03055
NA
KRT19 bone cancer 0.0305521 0.8331843 0.03055
NA
TMTC2 urinary bladder cancer 0.0307084 0.8331843 0.03071
NA
NBEAL2 leukemia 0.0310773 0.8331843 0.03108
NA
ZNF326 head and neck cancer 0.0312294 0.8331843 0.03123
NA
UTP14C uterine cancer 0.0314807 0.8331843 0.03148
NA
GUCY1A3 stomach cancer 0.0319476 0.8331843 0.03195
NA
ABCA13 leukemia 0.0328552 0.8331843 0.03286
NA
AP2A2 breast cancer 0.0331955 0.8331843 0.03320
NA
DZANK1 breast cancer 0.0331955 0.8331843 0.03320
NA
COL11A1 lung cancer 0.0332228 0.8331843 0.03322
NA
MCM3AP lung cancer 0.0333231 0.8331843 0.03332
NA
ZKSCAN3 lung cancer 0.0333231 0.8331843 0.03332
NA
ZNF90 lung cancer 0.0333231 0.8331843 0.03332
NA
SLC16A1 uterine cancer 0.0334693 0.8331843 0.03347
NA
ZNF454 uterine cancer 0.0334693 0.8331843 0.03347
NA
CAGE1 uterine cancer 0.0335702 0.8331843 0.03357
NA
INTS4 uterine cancer 0.0335702 0.8331843 0.03357
NA
PRSS3 esophageal cancer 0.0335935 0.8331843 0.03359
NA
PVRIG esophageal cancer 0.0335935 0.8331843 0.03359
NA
KIAA1211 stomach cancer 0.0337522 0.8331843 0.03375
NA
KIAA1107 colorectal cancer 0.0338654 0.8331843 0.03387
NA
MLH3 colorectal cancer 0.0338654 0.8331843 0.03387
NA
TMTC2 colorectal cancer 0.0338654 0.8331843 0.03387
NA
BRINP1 central nervous system cancer 0.0339701 0.8331843 0.03397
NA
ZNF804A central nervous system cancer 0.0339701 0.8331843 0.03397
NA
ZNF812 central nervous system cancer 0.0339701 0.8331843 0.03397
NA
IFITM1 skin cancer 0.0339779 0.8331843 0.03398
NA
JSRP1 skin cancer 0.0339779 0.8331843 0.03398
NA
SRRM2 skin cancer 0.0339779 0.8331843 0.03398
NA
GBA2 uterine cancer 0.0341228 0.8331843 0.03412
NA
UBN2 lung cancer 0.0341909 0.8331843 0.03419
NA
MSH6 colorectal cancer 0.0342415 0.8331843 0.03424
NA
ANKRD27 lung cancer 0.0342726 0.8331843 0.03427
NA
FAM160B1 ovarian cancer 0.0343251 0.8331843 0.03433
NA
MBD5 leukemia 0.0345626 0.8331843 0.03456
NA
RPL22 kidney cancer 0.0346137 0.8331843 0.03461
NA
SYNE1 kidney cancer 0.0346137 0.8331843 0.03461
NA
SIPA1L1 skin cancer 0.0349770 0.8331843 0.03498
NA
NF1 peripheral nervous system neoplasm 0.0353557 0.8331843 0.03536
NA
TNRC6A lung cancer 0.0355046 0.8331843 0.03550
NA
KIAA0586 colorectal cancer 0.0356243 0.8331843 0.03562
NA
CREBBP esophageal cancer 0.0357638 0.8331843 0.03576
NA
DOPEY2 esophageal cancer 0.0357638 0.8331843 0.03576
NA
OSBPL1A esophageal cancer 0.0357638 0.8331843 0.03576
NA
SCN9A esophageal cancer 0.0357638 0.8331843 0.03576
NA
VPS41 colorectal cancer 0.0360283 0.8331843 0.03603
NA
CELSR3 ovarian cancer 0.0360402 0.8331843 0.03604
NA
CMIP ovarian cancer 0.0360402 0.8331843 0.03604
NA
PRSS3 pancreatic cancer 0.0361401 0.8331843 0.03614
NA
BAP1 lung cancer 0.0364026 0.8331843 0.03640
NA
BRD8 lung cancer 0.0364026 0.8331843 0.03640
NA
PIK3R1 ovarian cancer 0.0366841 0.8331843 0.03668
NA
TPR colorectal cancer 0.0367990 0.8331843 0.03680
NA
RNF213 breast cancer 0.0372136 0.8331843 0.03721
NA
BCAS3 colorectal cancer 0.0372425 0.8331843 0.03724
NA
CNTN6 colorectal cancer 0.0372425 0.8331843 0.03724
NA
GFRA3 colorectal cancer 0.0372425 0.8331843 0.03724
NA
HIP1R colorectal cancer 0.0372425 0.8331843 0.03724
NA
NGRN colorectal cancer 0.0372425 0.8331843 0.03724
NA
PRSS1 colorectal cancer 0.0372425 0.8331843 0.03724
NA
TSC2 colorectal cancer 0.0372425 0.8331843 0.03724
NA
NEDD4 uterine cancer 0.0373482 0.8331843 0.03735
NA
TOP1 uterine cancer 0.0374917 0.8331843 0.03749
NA
CR1 colorectal cancer 0.0375189 0.8331843 0.03752
NA
KRT17 colorectal cancer 0.0375189 0.8331843 0.03752
NA
ZNF300 central nervous system cancer 0.0378333 0.8331843 0.03783
NA
DCAF17 peripheral nervous system neoplasm 0.0382144 0.8331843 0.03821
NA
LARS peripheral nervous system neoplasm 0.0382144 0.8331843 0.03821
NA
DNAJC2 uterine cancer 0.0383702 0.8331843 0.03837
NA
LRRC27 breast cancer 0.0385612 0.8331843 0.03856
NA
SUGP1 lung cancer 0.0386553 0.8331843 0.03866
NA
PARD3B uterine cancer 0.0388613 0.8331843 0.03886
NA
MCPH1 central nervous system cancer 0.0388899 0.8331843 0.03889
NA
NACA skin cancer 0.0390566 0.8331843 0.03906
NA
CAPN12 uterine cancer 0.0394025 0.8331843 0.03940
NA
KDM6B uterine cancer 0.0394025 0.8331843 0.03940
NA
RAPGEF5 uterine cancer 0.0394025 0.8331843 0.03940
NA
SMC4 kidney cancer 0.0396492 0.8331843 0.03965
NA
DSE lung cancer 0.0397214 0.8331843 0.03972
NA
DTHD1 lung cancer 0.0397214 0.8331843 0.03972
NA
ENTPD2 lung cancer 0.0397214 0.8331843 0.03972
NA
IPO4 lung cancer 0.0397214 0.8331843 0.03972
NA
PHLPP1 lung cancer 0.0397214 0.8331843 0.03972
NA
WDR87 leukemia 0.0397512 0.8331843 0.03975
NA
KNTC1 uterine cancer 0.0400927 0.8331843 0.04009
NA
TCHH kidney cancer 0.0401560 0.8331843 0.04016
NA
GTF2H2C colorectal cancer 0.0401697 0.8331843 0.04017
NA
LTF colorectal cancer 0.0401697 0.8331843 0.04017
NA
CAB39L uterine cancer 0.0402767 0.8331843 0.04028
NA
ZNF292 lung cancer 0.0406966 0.8331843 0.04070
NA
MYOM3 lung cancer 0.0408871 0.8331843 0.04089
NA
HAUS3 colorectal cancer 0.0409023 0.8331843 0.04090
NA
KANSL1L colorectal cancer 0.0409023 0.8331843 0.04090
NA
CADPS2 colorectal cancer 0.0410595 0.8331843 0.04106
NA
HYOU1 colorectal cancer 0.0410595 0.8331843 0.04106
NA
CLEC9A liver cancer 0.0412218 0.8331843 0.04122
NA
LILRB2 leukemia 0.0412359 0.8331843 0.04124
NA
FAM47E uterine cancer 0.0413827 0.8331843 0.04138
NA
FSIP2 ovarian cancer 0.0416058 0.8331843 0.04161
NA
BBX uterine cancer 0.0416426 0.8331843 0.04164
NA
CD302 uterine cancer 0.0416426 0.8331843 0.04164
NA
ECH1 uterine cancer 0.0416426 0.8331843 0.04164
NA
IMP3 uterine cancer 0.0416426 0.8331843 0.04164
NA
NOL7 uterine cancer 0.0416426 0.8331843 0.04164
NA
PGLS uterine cancer 0.0416426 0.8331843 0.04164
NA
PIGR uterine cancer 0.0416426 0.8331843 0.04164
NA
SPAG6 uterine cancer 0.0416426 0.8331843 0.04164
NA
SPHAR uterine cancer 0.0416426 0.8331843 0.04164
NA
VHL kidney cancer 0.0417890 0.8331843 0.04179
NA
TNN lung cancer 0.0420475 0.8331843 0.04205
NA
MAATS1 ovarian cancer 0.0428256 0.8331843 0.04283
NA
SF1 ovarian cancer 0.0428256 0.8331843 0.04283
NA
CDC6 skin cancer 0.0431187 0.8331843 0.04312
NA
PDGFA skin cancer 0.0431187 0.8331843 0.04312
NA
SPRYD3 skin cancer 0.0431187 0.8331843 0.04312
NA
KDM4D lung cancer 0.0432936 0.8331843 0.04329
NA
TENM4 lung cancer 0.0432936 0.8331843 0.04329
NA
BBOX1 head and neck cancer 0.0436525 0.8331843 0.04365
NA
TJP3 head and neck cancer 0.0436525 0.8331843 0.04365
NA
BANK1 uterine cancer 0.0436613 0.8331843 0.04366
NA
BMP1 uterine cancer 0.0436613 0.8331843 0.04366
NA
CHD8 liver cancer 0.0436906 0.8331843 0.04369
NA
ATF7IP lung cancer 0.0438441 0.8331843 0.04384
NA
CCDC110 uterine cancer 0.0440784 0.8331843 0.04408
NA
VCP uterine cancer 0.0441476 0.8331843 0.04415
NA
SLC26A8 colorectal cancer 0.0442803 0.8331843 0.04428
NA
AADAC central nervous system cancer 0.0444022 0.8331843 0.04440
NA
LYPLA2 central nervous system cancer 0.0444022 0.8331843 0.04440
NA
UBXN1 central nervous system cancer 0.0444022 0.8331843 0.04440
NA
FUBP1 lung cancer 0.0444926 0.8331843 0.04449
NA
ITGA8 lung cancer 0.0444926 0.8331843 0.04449
NA
TMEM194A breast cancer 0.0448103 0.8331843 0.04481
NA
LRRC37A3 breast cancer 0.0448181 0.8331843 0.04482
NA
SGK1 colorectal cancer 0.0448793 0.8331843 0.04488
NA
TNXB uterine cancer 0.0448968 0.8331843 0.04490
NA
INCENP lymphoma 0.0451269 0.8331843 0.04513
NA
DNAJC13 lung cancer 0.0456195 0.8331843 0.04562
NA
COL4A3 uterine cancer 0.0462058 0.8331843 0.04621
NA
KCNJ6 uterine cancer 0.0462058 0.8331843 0.04621
NA
NCAPD2 uterine cancer 0.0462058 0.8331843 0.04621
NA
NFASC uterine cancer 0.0462058 0.8331843 0.04621
NA
RMDN2 uterine cancer 0.0462058 0.8331843 0.04621
NA
TUBGCP5 uterine cancer 0.0462058 0.8331843 0.04621
NA
UTP20 uterine cancer 0.0464100 0.8331843 0.04641
NA
HS6ST1 esophageal cancer 0.0465278 0.8331843 0.04653
NA
ATP6V1C1 colorectal cancer 0.0465344 0.8331843 0.04653
NA
C11orf21 colorectal cancer 0.0465344 0.8331843 0.04653
NA
C11orf54 colorectal cancer 0.0465344 0.8331843 0.04653
NA
CUEDC1 colorectal cancer 0.0465344 0.8331843 0.04653
NA
KNOP1 colorectal cancer 0.0465344 0.8331843 0.04653
NA
PDGFD colorectal cancer 0.0465344 0.8331843 0.04653
NA
PLD1 colorectal cancer 0.0465344 0.8331843 0.04653
NA
PTGIS colorectal cancer 0.0465344 0.8331843 0.04653
NA
RFXANK colorectal cancer 0.0465344 0.8331843 0.04653
NA
TIE1 colorectal cancer 0.0465344 0.8331843 0.04653
NA
USP20 colorectal cancer 0.0465344 0.8331843 0.04653
NA
ZC3H13 colorectal cancer 0.0465344 0.8331843 0.04653
NA
HECTD1 lung cancer 0.0471334 0.8331843 0.04713
NA
DSG1 bone cancer 0.0471767 0.8331843 0.04718
NA
FRMPD2 liver cancer 0.0471767 0.8331843 0.04718
NA
MAP1B multiple myeloma 0.0471767 0.8331843 0.04718
NA
UNC5C central nervous system cancer 0.0477802 0.8331843 0.04778
NA
AK7 leukemia 0.0480598 0.8331843 0.04806
NA
CSTF3 urinary bladder cancer 0.0480598 0.8331843 0.04806
NA
GAB1 leukemia 0.0480598 0.8331843 0.04806
NA
KIAA0825 urinary bladder cancer 0.0480598 0.8331843 0.04806
NA
MAP4K3 urinary bladder cancer 0.0480598 0.8331843 0.04806
NA
SLC4A9 leukemia 0.0480598 0.8331843 0.04806
NA
GP1BA breast cancer 0.0485396 0.8331843 0.04854
NA
CELSR3 colorectal cancer 0.0487466 0.8331843 0.04875
NA
SGIP1 colorectal cancer 0.0491408 0.8331843 0.04914
NA
SH3D21 colorectal cancer 0.0491408 0.8331843 0.04914
NA
ALDH2 colorectal cancer 0.0496715 0.8331843 0.04967
NA
ARHGAP12 colorectal cancer 0.0496715 0.8331843 0.04967
NA
GRK7 colorectal cancer 0.0496715 0.8331843 0.04967
NA
MYO3B colorectal cancer 0.0496715 0.8331843 0.04967
NA
PPP1R3A colorectal cancer 0.0496715 0.8331843 0.04967
NA
ABCA5 uterine cancer 0.0497933 0.8331843 0.04979
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_lineage_allmut_plot <- ggplot(data = crispr_signif_allmut_del_lineage) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_lineage_allmut_plot

5.2.2 Non-silent mutant vs. Other

crispr_signif_allmut_nonsilent_lineage <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_allmut_nonsilent_lineage <- adj_signif(crispr_signif_allmut_nonsilent_lineage)
crispr_signif_allmut_nonsilent_lineage <- crispr_signif_allmut_nonsilent_lineage[order(crispr_signif_allmut_nonsilent_lineage$p),]
saveRDS(crispr_signif_allmut_nonsilent_lineage, "./data_munging/rds/crispr_signif_allmut_nonsilent_lineage.rds")

# write.table(crispr_signif_allmut_nonsilent_lineage, file = "~/Desktop/crispr_signif_allmut_nonsilent_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_allmut_nonsilent_lineage <- readRDS("./data_munging/rds/crispr_signif_allmut_nonsilent_lineage.rds")

knitr::kable(filter(crispr_signif_allmut_nonsilent_lineage, p < 0.05)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing non-silent mutant and other cell lines by lineage, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol group_general_lineage_name p p.adj p.format p.signif p.signif.adj
KRAS lung cancer 0.0000000 0.0000734 5.9e-10 **** ****
TP53 lung cancer 0.0000047 0.2961085 4.7e-06 **** NA
TP53 central nervous system cancer 0.0000302 0.8628420 3.0e-05 **** NA
TP53 ovarian cancer 0.0001395 0.8628420 0.00014 *** NA
KRAS ovarian cancer 0.0001488 0.8628420 0.00015 *** NA
NRAS leukemia 0.0005316 0.8628420 0.00053 *** NA
TP53 leukemia 0.0005388 0.8628420 0.00054 *** NA
NRAS skin cancer 0.0006117 0.8628420 0.00061 *** NA
TP53 skin cancer 0.0008277 0.8628420 0.00083 *** NA
PIK3CA ovarian cancer 0.0008371 0.8628420 0.00084 *** NA
DZANK1 breast cancer 0.0009819 0.8628420 0.00098 *** NA
PIK3CA breast cancer 0.0009842 0.8628420 0.00098 *** NA
KRAS colorectal cancer 0.0010547 0.8628420 0.00105 ** NA
UNC45B lung cancer 0.0011215 0.8628420 0.00112 ** NA
VHL kidney cancer 0.0011846 0.8628420 0.00118 ** NA
KRT17 breast cancer 0.0012972 0.8628420 0.00130 ** NA
PIK3R1 central nervous system cancer 0.0013246 0.8628420 0.00132 ** NA
GOLGA3 uterine cancer 0.0013666 0.8628420 0.00137 ** NA
NRAS multiple myeloma 0.0013756 0.8628420 0.00138 ** NA
GTF3C1 lung cancer 0.0013893 0.8628420 0.00139 ** NA
TICRR uterine cancer 0.0014839 0.8628420 0.00148 ** NA
ARID1A pancreatic cancer 0.0014920 0.8628420 0.00149 ** NA
TP53 kidney cancer 0.0016347 0.8628420 0.00163 ** NA
HYDIN colorectal cancer 0.0017600 0.8628420 0.00176 ** NA
PTEN ovarian cancer 0.0018079 0.8628420 0.00181 ** NA
HYOU1 colorectal cancer 0.0018107 0.8628420 0.00181 ** NA
USP34 breast cancer 0.0018820 0.8628420 0.00188 ** NA
MGA uterine cancer 0.0019495 0.8628420 0.00195 ** NA
SVOPL lung cancer 0.0019973 0.8628420 0.00200 ** NA
LILRB2 leukemia 0.0021670 0.8628420 0.00217 ** NA
PIK3R1 ovarian cancer 0.0021769 0.8628420 0.00218 ** NA
KMT2B stomach cancer 0.0022800 0.8628420 0.00228 ** NA
TNRC6A lung cancer 0.0023744 0.8628420 0.00237 ** NA
COX4I1 lung cancer 0.0023949 0.8628420 0.00239 ** NA
SNX29 uterine cancer 0.0026104 0.8628420 0.00261 ** NA
KIF3B ovarian cancer 0.0026230 0.8628420 0.00262 ** NA
KMT2B breast cancer 0.0026433 0.8628420 0.00264 ** NA
GSPT1 colorectal cancer 0.0028115 0.8628420 0.00281 ** NA
BRAF ovarian cancer 0.0028709 0.8628420 0.00287 ** NA
AP1G2 breast cancer 0.0029835 0.8628420 0.00298 ** NA
ZNF264 colorectal cancer 0.0029879 0.8628420 0.00299 ** NA
ZNF141 central nervous system cancer 0.0031757 0.8628420 0.00318 ** NA
KMT2B ovarian cancer 0.0032684 0.8628420 0.00327 ** NA
KIAA0586 colorectal cancer 0.0032838 0.8628420 0.00328 ** NA
ANK2 colorectal cancer 0.0033597 0.8628420 0.00336 ** NA
RPS19BP1 multiple myeloma 0.0034613 0.8628420 0.00346 ** NA
TGS1 uterine cancer 0.0035864 0.8628420 0.00359 ** NA
COL2A1 leukemia 0.0036054 0.8628420 0.00361 ** NA
SLIT3 leukemia 0.0036054 0.8628420 0.00361 ** NA
TP53 colorectal cancer 0.0036994 0.8628420 0.00370 ** NA
HTR7 lung cancer 0.0037248 0.8628420 0.00372 ** NA
PAPPA uterine cancer 0.0037971 0.8628420 0.00380 ** NA
ZNF292 lung cancer 0.0038193 0.8628420 0.00382 ** NA
PTEN central nervous system cancer 0.0038648 0.8628420 0.00386 ** NA
KRAS stomach cancer 0.0040001 0.8628420 0.00400 ** NA
MTMR3 lung cancer 0.0041192 0.8628420 0.00412 ** NA
TSKS uterine cancer 0.0042550 0.8628420 0.00425 ** NA
ARHGAP12 colorectal cancer 0.0042860 0.8628420 0.00429 ** NA
PAM uterine cancer 0.0043488 0.8628420 0.00435 ** NA
PDE10A uterine cancer 0.0043488 0.8628420 0.00435 ** NA
BRAF skin cancer 0.0043710 0.8628420 0.00437 ** NA
ECT2L central nervous system cancer 0.0044085 0.8628420 0.00441 ** NA
MAML2 uterine cancer 0.0044510 0.8628420 0.00445 ** NA
ARID1B ovarian cancer 0.0046380 0.8628420 0.00464 ** NA
NCOR2 colorectal cancer 0.0046575 0.8628420 0.00466 ** NA
NLRP9 lung cancer 0.0046872 0.8628420 0.00469 ** NA
LRP4 uterine cancer 0.0046963 0.8628420 0.00470 ** NA
VAV3 lung cancer 0.0047769 0.8628420 0.00478 ** NA
NUP88 uterine cancer 0.0048888 0.8628420 0.00489 ** NA
LRRIQ1 central nervous system cancer 0.0049271 0.8628420 0.00493 ** NA
PTEN uterine cancer 0.0050051 0.8628420 0.00501 ** NA
AXIN1 ovarian cancer 0.0050354 0.8628420 0.00504 ** NA
PIK3CA colorectal cancer 0.0050602 0.8628420 0.00506 ** NA
TNK2 uterine cancer 0.0050864 0.8628420 0.00509 ** NA
DIP2C kidney cancer 0.0052747 0.8628420 0.00527 ** NA
CTAGE15 lung cancer 0.0053375 0.8628420 0.00534 ** NA
LSP1 colorectal cancer 0.0053452 0.8628420 0.00535 ** NA
CORIN colorectal cancer 0.0054756 0.8628420 0.00548 ** NA
SETD2 kidney cancer 0.0056647 0.8628420 0.00566 ** NA
FNDC7 colorectal cancer 0.0057059 0.8628420 0.00571 ** NA
SKOR1 uterine cancer 0.0057795 0.8628420 0.00578 ** NA
PARD3B uterine cancer 0.0059302 0.8628420 0.00593 ** NA
FNIP1 ovarian cancer 0.0060557 0.8628420 0.00606 ** NA
AP2A2 breast cancer 0.0061570 0.8628420 0.00616 ** NA
ASXL1 colorectal cancer 0.0061648 0.8628420 0.00616 ** NA
CCT8L2 colorectal cancer 0.0061648 0.8628420 0.00616 ** NA
MTMR14 colorectal cancer 0.0061648 0.8628420 0.00616 ** NA
TTC32 uterine cancer 0.0062881 0.8628420 0.00629 ** NA
NR4A1 lung cancer 0.0064934 0.8628420 0.00649 ** NA
SLC22A17 lung cancer 0.0064934 0.8628420 0.00649 ** NA
FAM208B colorectal cancer 0.0065065 0.8628420 0.00651 ** NA
ROCK1 colorectal cancer 0.0066106 0.8628420 0.00661 ** NA
ZNF521 colorectal cancer 0.0066975 0.8628420 0.00670 ** NA
RFWD3 lung cancer 0.0067488 0.8628420 0.00675 ** NA
TYRP1 lung cancer 0.0067488 0.8628420 0.00675 ** NA
ADRBK2 uterine cancer 0.0067676 0.8628420 0.00677 ** NA
DVL2 uterine cancer 0.0067676 0.8628420 0.00677 ** NA
EXOC8 uterine cancer 0.0067676 0.8628420 0.00677 ** NA
VPS51 pancreatic cancer 0.0067999 0.8628420 0.00680 ** NA
ITSN1 colorectal cancer 0.0069403 0.8628420 0.00694 ** NA
ZNF292 colorectal cancer 0.0069403 0.8628420 0.00694 ** NA
OR5M8 colorectal cancer 0.0070184 0.8628420 0.00702 ** NA
C10orf76 ovarian cancer 0.0070773 0.8628420 0.00708 ** NA
DDX11 lung cancer 0.0070952 0.8628420 0.00710 ** NA
KMT2C multiple myeloma 0.0071541 0.8628420 0.00715 ** NA
MYH6 uterine cancer 0.0071786 0.8628420 0.00718 ** NA
SURF6 uterine cancer 0.0073058 0.8628420 0.00731 ** NA
GLP2R lung cancer 0.0073425 0.8628420 0.00734 ** NA
C1orf86 leukemia 0.0073710 0.8628420 0.00737 ** NA
TEX10 ovarian cancer 0.0075601 0.8628420 0.00756 ** NA
ALPK3 ovarian cancer 0.0076300 0.8628420 0.00763 ** NA
MYOM3 lung cancer 0.0076435 0.8628420 0.00764 ** NA
ALPPL2 ovarian cancer 0.0077480 0.8628420 0.00775 ** NA
PNPLA5 colorectal cancer 0.0077740 0.8628420 0.00777 ** NA
PTPRN2 colorectal cancer 0.0078299 0.8628420 0.00783 ** NA
PTGFRN lung cancer 0.0078691 0.8628420 0.00787 ** NA
PCDH10 uterine cancer 0.0078925 0.8628420 0.00789 ** NA
ANKRD23 colorectal cancer 0.0078965 0.8628420 0.00790 ** NA
RB1 central nervous system cancer 0.0079424 0.8628420 0.00794 ** NA
HERC1 skin cancer 0.0079501 0.8628420 0.00795 ** NA
RANBP2 colorectal cancer 0.0079744 0.8628420 0.00797 ** NA
SCFD1 colorectal cancer 0.0079828 0.8628420 0.00798 ** NA
C12orf4 uterine cancer 0.0080215 0.8628420 0.00802 ** NA
EGFLAM lung cancer 0.0081906 0.8628420 0.00819 ** NA
FAM160B1 ovarian cancer 0.0082030 0.8628420 0.00820 ** NA
SPRED1 lung cancer 0.0084512 0.8628420 0.00845 ** NA
MROH1 pancreatic cancer 0.0084519 0.8628420 0.00845 ** NA
SBF2 lung cancer 0.0084541 0.8628420 0.00845 ** NA
EFCAB5 ovarian cancer 0.0084624 0.8628420 0.00846 ** NA
THSD7A lung cancer 0.0085271 0.8628420 0.00853 ** NA
C6orf211 uterine cancer 0.0085754 0.8628420 0.00858 ** NA
CSNK1D uterine cancer 0.0085754 0.8628420 0.00858 ** NA
FAM110A uterine cancer 0.0085754 0.8628420 0.00858 ** NA
MICAL1 uterine cancer 0.0085754 0.8628420 0.00858 ** NA
MORF4L1 uterine cancer 0.0085754 0.8628420 0.00858 ** NA
RIOK2 uterine cancer 0.0085754 0.8628420 0.00858 ** NA
GAA colorectal cancer 0.0085960 0.8628420 0.00860 ** NA
KIAA1107 colorectal cancer 0.0085960 0.8628420 0.00860 ** NA
ZNF536 skin cancer 0.0086987 0.8628420 0.00870 ** NA
RPS6KA2 uterine cancer 0.0087779 0.8628420 0.00878 ** NA
NF1 peripheral nervous system neoplasm 0.0088143 0.8628420 0.00881 ** NA
TPR lung cancer 0.0088831 0.8628420 0.00888 ** NA
NFE2L2 esophageal cancer 0.0088890 0.8628420 0.00889 ** NA
TECRL lung cancer 0.0089331 0.8628420 0.00893 ** NA
CLEC9A liver cancer 0.0090085 0.8628420 0.00901 ** NA
SVEP1 skin cancer 0.0090238 0.8628420 0.00902 ** NA
DPYSL5 uterine cancer 0.0091517 0.8628420 0.00915 ** NA
FAM189A1 uterine cancer 0.0091517 0.8628420 0.00915 ** NA
HSPB2 uterine cancer 0.0091517 0.8628420 0.00915 ** NA
IRX6 uterine cancer 0.0091517 0.8628420 0.00915 ** NA
XKR9 uterine cancer 0.0091517 0.8628420 0.00915 ** NA
KIAA0922 lung cancer 0.0091532 0.8628420 0.00915 ** NA
STK17B lung cancer 0.0092125 0.8628420 0.00921 ** NA
TTF1 lung cancer 0.0092125 0.8628420 0.00921 ** NA
SYNE1 lung cancer 0.0092324 0.8628420 0.00923 ** NA
TBC1D10B uterine cancer 0.0092568 0.8628420 0.00926 ** NA
DNAJC8 uterine cancer 0.0092717 0.8628420 0.00927 ** NA
PKDCC uterine cancer 0.0092717 0.8628420 0.00927 ** NA
TCF3 uterine cancer 0.0092717 0.8628420 0.00927 ** NA
ZNF207 uterine cancer 0.0093098 0.8628420 0.00931 ** NA
RASIP1 colorectal cancer 0.0093199 0.8628420 0.00932 ** NA
AP5B1 uterine cancer 0.0093215 0.8628420 0.00932 ** NA
RAD50 leukemia 0.0094090 0.8628420 0.00941 ** NA
DNAH5 colorectal cancer 0.0095928 0.8628420 0.00959 ** NA
TJP3 head and neck cancer 0.0096224 0.8628420 0.00962 ** NA
NRP2 colorectal cancer 0.0096226 0.8628420 0.00962 ** NA
INTS4 uterine cancer 0.0096407 0.8628420 0.00964 ** NA
TCHH liver cancer 0.0096613 0.8628420 0.00966 ** NA
TTF1 leukemia 0.0097690 0.8628420 0.00977 ** NA
ZNF343 lung cancer 0.0098486 0.8628420 0.00985 ** NA
ZNF469 uterine cancer 0.0099581 0.8628420 0.00996 ** NA
IPO4 uterine cancer 0.0099688 0.8628420 0.00997 ** NA
TET3 ovarian cancer 0.0100008 0.8628420 0.01000
NA
USP21 ovarian cancer 0.0100008 0.8628420 0.01000
NA
SP140L lung cancer 0.0100344 0.8628420 0.01003
NA
TBC1D9 colorectal cancer 0.0100658 0.8628420 0.01007
NA
SPTBN5 central nervous system cancer 0.0100977 0.8628420 0.01010
NA
ELAC2 lung cancer 0.0102227 0.8628420 0.01022
NA
LGSN uterine cancer 0.0103804 0.8628420 0.01038
NA
ZNF581 leukemia 0.0103818 0.8628420 0.01038
NA
ARID1A skin cancer 0.0104238 0.8628420 0.01042
NA
SLC22A9 skin cancer 0.0104238 0.8628420 0.01042
NA
UNC13B skin cancer 0.0104238 0.8628420 0.01042
NA
B4GALNT3 colorectal cancer 0.0104834 0.8628420 0.01048
NA
SCN10A pancreatic cancer 0.0104889 0.8628420 0.01049
NA
SUGP1 lung cancer 0.0105193 0.8628420 0.01052
NA
DNAH11 uterine cancer 0.0107248 0.8628420 0.01072
NA
SEMA4G uterine cancer 0.0108615 0.8628420 0.01086
NA
CD180 lung cancer 0.0109209 0.8628420 0.01092
NA
GPR37L1 lung cancer 0.0109209 0.8628420 0.01092
NA
MYH13 central nervous system cancer 0.0112036 0.8628420 0.01120
NA
DDC uterine cancer 0.0112169 0.8628420 0.01122
NA
ITGB4 lung cancer 0.0112630 0.8628420 0.01126
NA
RBM39 uterine cancer 0.0113320 0.8628420 0.01133
NA
NPAS2 breast cancer 0.0115094 0.8628420 0.01151
NA
PIK3CA head and neck cancer 0.0115400 0.8628420 0.01154
NA
SLC22A17 stomach cancer 0.0115400 0.8628420 0.01154
NA
KLHL18 colorectal cancer 0.0115434 0.8628420 0.01154
NA
ZNF132 colorectal cancer 0.0115434 0.8628420 0.01154
NA
VPS13D colorectal cancer 0.0117450 0.8628420 0.01174
NA
KRR1 uterine cancer 0.0117559 0.8628420 0.01176
NA
ARHGEF10L ovarian cancer 0.0117835 0.8628420 0.01178
NA
DHX36 uterine cancer 0.0118194 0.8628420 0.01182
NA
EIF2D uterine cancer 0.0118466 0.8628420 0.01185
NA
LIG3 cancer 0.0118466 0.8628420 0.01185
NA
SLC24A5 uterine cancer 0.0118466 0.8628420 0.01185
NA
LRRC24 lung cancer 0.0118764 0.8628420 0.01188
NA
PFAS lung cancer 0.0118764 0.8628420 0.01188
NA
IL27RA esophageal cancer 0.0119719 0.8628420 0.01197
NA
ZNF785 leukemia 0.0120078 0.8628420 0.01201
NA
USP6NL bone cancer 0.0120377 0.8628420 0.01204
NA
UBASH3B uterine cancer 0.0121489 0.8628420 0.01215
NA
CLSPN colorectal cancer 0.0121613 0.8628420 0.01216
NA
COG6 colorectal cancer 0.0121613 0.8628420 0.01216
NA
KIAA0319L colorectal cancer 0.0121613 0.8628420 0.01216
NA
KLHL12 colorectal cancer 0.0121613 0.8628420 0.01216
NA
TSGA10 colorectal cancer 0.0121613 0.8628420 0.01216
NA
EXO1 lung cancer 0.0122948 0.8628420 0.01229
NA
ATP13A5 uterine cancer 0.0123809 0.8628420 0.01238
NA
MTMR12 uterine cancer 0.0123944 0.8628420 0.01239
NA
GRIN1 uterine cancer 0.0125718 0.8628420 0.01257
NA
HELB uterine cancer 0.0126206 0.8628420 0.01262
NA
ZNF454 uterine cancer 0.0126206 0.8628420 0.01262
NA
SCN4A colorectal cancer 0.0127308 0.8628420 0.01273
NA
ABCC3 skin cancer 0.0128117 0.8628420 0.01281
NA
ABCC6 lung cancer 0.0128413 0.8628420 0.01284
NA
ZNF827 lung cancer 0.0128413 0.8628420 0.01284
NA
C6orf223 uterine cancer 0.0128512 0.8628420 0.01285
NA
SRP68 uterine cancer 0.0128512 0.8628420 0.01285
NA
TMPPE uterine cancer 0.0128512 0.8628420 0.01285
NA
CHRM3 lung cancer 0.0129054 0.8628420 0.01291
NA
DGKQ lung cancer 0.0129054 0.8628420 0.01291
NA
PSKH2 lung cancer 0.0129054 0.8628420 0.01291
NA
HLA-G lung cancer 0.0129294 0.8628420 0.01293
NA
ECT2 lung cancer 0.0132161 0.8628420 0.01322
NA
SORCS3 uterine cancer 0.0132719 0.8628420 0.01327
NA
IQGAP1 skin cancer 0.0134888 0.8628420 0.01349
NA
PPP3R1 skin cancer 0.0134888 0.8628420 0.01349
NA
PCDHGA2 colorectal cancer 0.0136086 0.8628420 0.01361
NA
CLTC colorectal cancer 0.0136329 0.8628420 0.01363
NA
NOS3 colorectal cancer 0.0137107 0.8628420 0.01371
NA
HEATR1 lung cancer 0.0137738 0.8628420 0.01377
NA
UGGT2 leukemia 0.0137795 0.8628420 0.01378
NA
ATP2B4 leukemia 0.0138033 0.8628420 0.01380
NA
SETBP1 colorectal cancer 0.0138037 0.8628420 0.01380
NA
ZNF136 uterine cancer 0.0138645 0.8628420 0.01386
NA
KIF26A colorectal cancer 0.0139045 0.8628420 0.01390
NA
VPS41 colorectal cancer 0.0139045 0.8628420 0.01390
NA
RFPL4B central nervous system cancer 0.0139274 0.8628420 0.01393
NA
NEDD4L lung cancer 0.0140124 0.8628420 0.01401
NA
PDE1A lung cancer 0.0140124 0.8628420 0.01401
NA
SAMD11 lung cancer 0.0140124 0.8628420 0.01401
NA
SIGLEC7 lung cancer 0.0140124 0.8628420 0.01401
NA
OXCT1 uterine cancer 0.0140391 0.8628420 0.01404
NA
CAGE1 uterine cancer 0.0141081 0.8628420 0.01411
NA
IQUB uterine cancer 0.0142430 0.8628420 0.01424
NA
ZBTB41 colorectal cancer 0.0142761 0.8628420 0.01428
NA
ITIH1 uterine cancer 0.0143762 0.8628420 0.01438
NA
CD163L1 ovarian cancer 0.0144687 0.8628420 0.01447
NA
SMCR8 uterine cancer 0.0144732 0.8628420 0.01447
NA
TP53 urinary bladder cancer 0.0146235 0.8628420 0.01462
NA
SBF1 colorectal cancer 0.0148562 0.8628420 0.01486
NA
JAG2 central nervous system cancer 0.0149192 0.8628420 0.01492
NA
GFRA3 colorectal cancer 0.0150873 0.8628420 0.01509
NA
RFXANK colorectal cancer 0.0150873 0.8628420 0.01509
NA
SEC22A colorectal cancer 0.0150873 0.8628420 0.01509
NA
VASN colorectal cancer 0.0150873 0.8628420 0.01509
NA
IL17RD colorectal cancer 0.0151103 0.8628420 0.01511
NA
NOS1 lung cancer 0.0151398 0.8628420 0.01514
NA
SOX30 lung cancer 0.0152024 0.8628420 0.01520
NA
ZC3H18 uterine cancer 0.0152235 0.8628420 0.01522
NA
KIAA1731 ovarian cancer 0.0154482 0.8628420 0.01545
NA
KNDC1 liver cancer 0.0154514 0.8628420 0.01545
NA
OTUD4 urinary bladder cancer 0.0154565 0.8628420 0.01546
NA
NNT lung cancer 0.0154639 0.8628420 0.01546
NA
JMJD1C kidney cancer 0.0155331 0.8628420 0.01553
NA
CRISP3 lung cancer 0.0155759 0.8628420 0.01558
NA
WDR11 lung cancer 0.0156454 0.8628420 0.01565
NA
ANKRD55 colorectal cancer 0.0157625 0.8628420 0.01576
NA
ATP8A2 colorectal cancer 0.0157625 0.8628420 0.01576
NA
CARS colorectal cancer 0.0157625 0.8628420 0.01576
NA
PLEKHG4B uterine cancer 0.0158232 0.8628420 0.01582
NA
SLK uterine cancer 0.0158232 0.8628420 0.01582
NA
C14orf39 uterine cancer 0.0158941 0.8628420 0.01589
NA
PCDHGA3 uterine cancer 0.0158941 0.8628420 0.01589
NA
NTRK1 uterine cancer 0.0160319 0.8628420 0.01603
NA
PIK3CG uterine cancer 0.0160319 0.8628420 0.01603
NA
BRD4 lymphoma 0.0160440 0.8628420 0.01604
NA
DDX59 lymphoma 0.0160440 0.8628420 0.01604
NA
CEP290 colorectal cancer 0.0160938 0.8628420 0.01609
NA
BSDC1 uterine cancer 0.0161801 0.8628420 0.01618
NA
COMP uterine cancer 0.0161801 0.8628420 0.01618
NA
ACSBG1 lung cancer 0.0162285 0.8628420 0.01623
NA
ZZZ3 uterine cancer 0.0162966 0.8628420 0.01630
NA
SMG1 esophageal cancer 0.0163951 0.8628420 0.01640
NA
CFTR colorectal cancer 0.0164072 0.8628420 0.01641
NA
MIS18BP1 colorectal cancer 0.0164072 0.8628420 0.01641
NA
PTPRE colorectal cancer 0.0164072 0.8628420 0.01641
NA
SREK1 colorectal cancer 0.0164072 0.8628420 0.01641
NA
NBAS skin cancer 0.0164406 0.8628420 0.01644
NA
CYTH4 lung cancer 0.0164805 0.8628420 0.01648
NA
ITGA2 lung cancer 0.0164805 0.8628420 0.01648
NA
TP53 uterine cancer 0.0165330 0.8628420 0.01653
NA
PDGFRA colorectal cancer 0.0165448 0.8628420 0.01654
NA
TOP2A colorectal cancer 0.0165482 0.8628420 0.01655
NA
CLEC4F skin cancer 0.0165842 0.8628420 0.01658
NA
KRT19 urinary bladder cancer 0.0166681 0.8628420 0.01667
NA
PLEC head and neck cancer 0.0166707 0.8628420 0.01667
NA
ASAP2 uterine cancer 0.0166803 0.8628420 0.01668
NA
SLFN12L uterine cancer 0.0166803 0.8628420 0.01668
NA
KNTC1 uterine cancer 0.0166884 0.8628420 0.01669
NA
POLE uterine cancer 0.0166884 0.8628420 0.01669
NA
MPO leukemia 0.0167340 0.8628420 0.01673
NA
ZC3H13 urinary bladder cancer 0.0167340 0.8628420 0.01673
NA
CHD2 uterine cancer 0.0168725 0.8628420 0.01687
NA
TRAM1L1 central nervous system cancer 0.0169020 0.8628420 0.01690
NA
CCDC77 uterine cancer 0.0169268 0.8628420 0.01693
NA
HSF1 ovarian cancer 0.0170103 0.8628420 0.01701
NA
SMC1B ovarian cancer 0.0170103 0.8628420 0.01701
NA
ZNF592 head and neck cancer 0.0172390 0.8628420 0.01724
NA
ST5 uterine cancer 0.0172718 0.8628420 0.01727
NA
PHYH lung cancer 0.0173326 0.8628420 0.01733
NA
ZCCHC24 lung cancer 0.0173326 0.8628420 0.01733
NA
GATS ovarian cancer 0.0173464 0.8628420 0.01735
NA
PPP2R5B bone cancer 0.0173572 0.8628420 0.01736
NA
DNAH6 colorectal cancer 0.0173625 0.8628420 0.01736
NA
KRTAP19-6 lung cancer 0.0173813 0.8628420 0.01738
NA
RERGL lung cancer 0.0173813 0.8628420 0.01738
NA
SLC46A2 lung cancer 0.0173813 0.8628420 0.01738
NA
SLC6A18 lung cancer 0.0173813 0.8628420 0.01738
NA
TOMM40 lung cancer 0.0173813 0.8628420 0.01738
NA
GNL3 colorectal cancer 0.0174434 0.8628420 0.01744
NA
OR51I2 colorectal cancer 0.0174434 0.8628420 0.01744
NA
PUF60 colorectal cancer 0.0174434 0.8628420 0.01744
NA
ZBBX colorectal cancer 0.0174434 0.8628420 0.01744
NA
RYR3 central nervous system cancer 0.0175113 0.8628420 0.01751
NA
DCAF8 lung cancer 0.0175301 0.8628420 0.01753
NA
ATRNL1 lung cancer 0.0175487 0.8628420 0.01755
NA
DAGLA leukemia 0.0175662 0.8628420 0.01757
NA
SHANK1 central nervous system cancer 0.0176419 0.8628420 0.01764
NA
LRRC1 skin cancer 0.0176490 0.8628420 0.01765
NA
SEPT14 lung cancer 0.0176723 0.8628420 0.01767
NA
FCRL3 skin cancer 0.0177061 0.8628420 0.01771
NA
ADAM17 uterine cancer 0.0178172 0.8628420 0.01782
NA
BMPER uterine cancer 0.0178172 0.8628420 0.01782
NA
C11orf57 uterine cancer 0.0178172 0.8628420 0.01782
NA
DCUN1D4 uterine cancer 0.0178172 0.8628420 0.01782
NA
FRMD4B uterine cancer 0.0178172 0.8628420 0.01782
NA
GALK1 uterine cancer 0.0178172 0.8628420 0.01782
NA
HABP4 uterine cancer 0.0178172 0.8628420 0.01782
NA
SPHK2 uterine cancer 0.0178172 0.8628420 0.01782
NA
SRPR uterine cancer 0.0178172 0.8628420 0.01782
NA
TIMD4 uterine cancer 0.0178172 0.8628420 0.01782
NA
ARHGDIB lung cancer 0.0178521 0.8628420 0.01785
NA
LACRT lung cancer 0.0178521 0.8628420 0.01785
NA
TSHZ2 lung cancer 0.0178521 0.8628420 0.01785
NA
NAA60 skin cancer 0.0179741 0.8628420 0.01797
NA
IPCEF1 uterine cancer 0.0179937 0.8628420 0.01799
NA
STT3B uterine cancer 0.0179937 0.8628420 0.01799
NA
FBXO46 colorectal cancer 0.0180867 0.8628420 0.01809
NA
PHF3 colorectal cancer 0.0180867 0.8628420 0.01809
NA
MAN1B1 uterine cancer 0.0181827 0.8628420 0.01818
NA
NUP62 uterine cancer 0.0181827 0.8628420 0.01818
NA
TUBGCP5 uterine cancer 0.0181827 0.8628420 0.01818
NA
CEP192 leukemia 0.0181845 0.8628420 0.01818
NA
ERF leukemia 0.0181845 0.8628420 0.01818
NA
LY75 leukemia 0.0181845 0.8628420 0.01818
NA
NRAS lung cancer 0.0182610 0.8628420 0.01826
NA
TPR ovarian cancer 0.0183210 0.8628420 0.01832
NA
EXOC1 uterine cancer 0.0183476 0.8628420 0.01835
NA
TOPAZ1 uterine cancer 0.0184163 0.8628420 0.01842
NA
COMP colorectal cancer 0.0186163 0.8628420 0.01862
NA
ENTPD4 colorectal cancer 0.0186163 0.8628420 0.01862
NA
NLRP14 colorectal cancer 0.0186163 0.8628420 0.01862
NA
WDR3 colorectal cancer 0.0187002 0.8628420 0.01870
NA
OPTN uterine cancer 0.0187215 0.8628420 0.01872
NA
TMPRSS4 uterine cancer 0.0187215 0.8628420 0.01872
NA
CASZ1 skin cancer 0.0187389 0.8628420 0.01874
NA
LHX8 lung cancer 0.0187985 0.8628420 0.01880
NA
OR10W1 lung cancer 0.0187985 0.8628420 0.01880
NA
TXNDC16 lung cancer 0.0188103 0.8628420 0.01881
NA
CENPK uterine cancer 0.0188289 0.8628420 0.01883
NA
SPAG17 uterine cancer 0.0189001 0.8628420 0.01890
NA
ATP13A5 lymphoma 0.0189035 0.8628420 0.01890
NA
TCHH kidney cancer 0.0189394 0.8628420 0.01894
NA
ZBTB3 lung cancer 0.0189829 0.8628420 0.01898
NA
CDKN2A pancreatic cancer 0.0190032 0.8628420 0.01900
NA
MYO3B central nervous system cancer 0.0191124 0.8628420 0.01911
NA
LPCAT2 lung cancer 0.0191409 0.8628420 0.01914
NA
PIP5KL1 lung cancer 0.0191409 0.8628420 0.01914
NA
PLIN4 skin cancer 0.0191460 0.8628420 0.01915
NA
ABCB11 colorectal cancer 0.0191531 0.8628420 0.01915
NA
BAZ2B kidney cancer 0.0192345 0.8628420 0.01923
NA
ANGEL2 central nervous system cancer 0.0192461 0.8628420 0.01925
NA
ANKRD36 central nervous system cancer 0.0192461 0.8628420 0.01925
NA
DTNB central nervous system cancer 0.0192461 0.8628420 0.01925
NA
FLNB central nervous system cancer 0.0192461 0.8628420 0.01925
NA
SLC35A5 central nervous system cancer 0.0192461 0.8628420 0.01925
NA
SYNJ2 central nervous system cancer 0.0192461 0.8628420 0.01925
NA
LRGUK colorectal cancer 0.0192474 0.8628420 0.01925
NA
MRVI1 colorectal cancer 0.0192474 0.8628420 0.01925
NA
NFIA colorectal cancer 0.0192474 0.8628420 0.01925
NA
PLOD1 colorectal cancer 0.0192474 0.8628420 0.01925
NA
GOLGA6L9 central nervous system cancer 0.0192773 0.8628420 0.01928
NA
NCAPD2 colorectal cancer 0.0192795 0.8628420 0.01928
NA
UNC80 leukemia 0.0192996 0.8628420 0.01930
NA
OR4N2 lung cancer 0.0193226 0.8628420 0.01932
NA
SLC6A17 lung cancer 0.0193226 0.8628420 0.01932
NA
ZNF213 lung cancer 0.0193226 0.8628420 0.01932
NA
MKI67 skin cancer 0.0194253 0.8628420 0.01943
NA
FMN2 esophageal cancer 0.0195175 0.8628420 0.01952
NA
CEP250 esophageal cancer 0.0196244 0.8628420 0.01962
NA
ANKRD11 central nervous system cancer 0.0196394 0.8628420 0.01964
NA
PUS10 uterine cancer 0.0196882 0.8628420 0.01969
NA
PCDHGB1 liver cancer 0.0196896 0.8628420 0.01969
NA
FUT5 colorectal cancer 0.0198845 0.8628420 0.01988
NA
FAM135B uterine cancer 0.0199102 0.8628420 0.01991
NA
ABCA6 lung cancer 0.0199212 0.8628420 0.01992
NA
C17orf70 ovarian cancer 0.0199355 0.8628420 0.01994
NA
GCN1L1 ovarian cancer 0.0199355 0.8628420 0.01994
NA
PLA2G4E ovarian cancer 0.0199355 0.8628420 0.01994
NA
ST18 breast cancer 0.0199408 0.8628420 0.01994
NA
TYK2 breast cancer 0.0199408 0.8628420 0.01994
NA
CEP290 skin cancer 0.0199454 0.8628420 0.01995
NA
GLRA3 skin cancer 0.0199454 0.8628420 0.01995
NA
VWA1 skin cancer 0.0199454 0.8628420 0.01995
NA
RPL14 uterine cancer 0.0200600 0.8628420 0.02006
NA
CTNNB1 lung cancer 0.0201130 0.8628420 0.02011
NA
GTPBP4 colorectal cancer 0.0201324 0.8628420 0.02013
NA
FMNL3 lung cancer 0.0201348 0.8628420 0.02013
NA
TTC26 lung cancer 0.0201348 0.8628420 0.02013
NA
UGT8 lung cancer 0.0201348 0.8628420 0.02013
NA
XRCC5 lung cancer 0.0201348 0.8628420 0.02013
NA
LOXHD1 skin cancer 0.0204007 0.8628420 0.02040
NA
LPHN3 skin cancer 0.0204170 0.8628420 0.02042
NA
ZNF763 skin cancer 0.0204595 0.8628420 0.02046
NA
CCDC177 cancer 0.0205451 0.8628420 0.02055
NA
SI lymphoma 0.0205964 0.8628420 0.02060
NA
PCDHA8 lung cancer 0.0206282 0.8628420 0.02063
NA
PKHD1 colorectal cancer 0.0206563 0.8628420 0.02066
NA
ANKHD1 ovarian cancer 0.0206839 0.8628420 0.02068
NA
PGM5 ovarian cancer 0.0206839 0.8628420 0.02068
NA
NOTCH4 urinary bladder cancer 0.0207917 0.8628420 0.02079
NA
ZNF510 uterine cancer 0.0208252 0.8628420 0.02083
NA
KCNT2 skin cancer 0.0209061 0.8628420 0.02091
NA
GOLGA3 ovarian cancer 0.0209062 0.8628420 0.02091
NA
IFI44 ovarian cancer 0.0209062 0.8628420 0.02091
NA
MAP3K6 ovarian cancer 0.0209062 0.8628420 0.02091
NA
MYLK3 ovarian cancer 0.0209062 0.8628420 0.02091
NA
KRCC1 ovarian cancer 0.0209065 0.8628420 0.02091
NA
CHD8 uterine cancer 0.0209367 0.8628420 0.02094
NA
KCNQ5 skin cancer 0.0209734 0.8628420 0.02097
NA
NF1 ovarian cancer 0.0210427 0.8628420 0.02104
NA
BCAR3 lung cancer 0.0210544 0.8628420 0.02105
NA
DPYSL4 lung cancer 0.0210544 0.8628420 0.02105
NA
KRTAP10-9 lung cancer 0.0210544 0.8628420 0.02105
NA
PTPRF lung cancer 0.0210544 0.8628420 0.02105
NA
RRAGD lung cancer 0.0210544 0.8628420 0.02105
NA
SRPR lung cancer 0.0210544 0.8628420 0.02105
NA
ZNF221 lung cancer 0.0210544 0.8628420 0.02105
NA
ZNF330 lung cancer 0.0210544 0.8628420 0.02105
NA
OR1F1 lung cancer 0.0211477 0.8628420 0.02115
NA
TP53 breast cancer 0.0212205 0.8628420 0.02122
NA
ZNF331 lung cancer 0.0212801 0.8628420 0.02128
NA
DPY19L2 colorectal cancer 0.0212824 0.8628420 0.02128
NA
NADSYN1 colorectal cancer 0.0212824 0.8628420 0.02128
NA
ZNF667 colorectal cancer 0.0212824 0.8628420 0.02128
NA
FZD1 uterine cancer 0.0213911 0.8628420 0.02139
NA
PCDHGA4 uterine cancer 0.0213911 0.8628420 0.02139
NA
ASXL3 esophageal cancer 0.0214396 0.8628420 0.02144
NA
MUS81 urinary bladder cancer 0.0215026 0.8628420 0.02150
NA
CACNA1D ovarian cancer 0.0215696 0.8628420 0.02157
NA
ACTL8 central nervous system cancer 0.0215715 0.8628420 0.02157
NA
DTX2 central nervous system cancer 0.0215715 0.8628420 0.02157
NA
KIF18B urinary bladder cancer 0.0216302 0.8628420 0.02163
NA
NOTCH2 urinary bladder cancer 0.0216302 0.8628420 0.02163
NA
RICTOR kidney cancer 0.0216672 0.8628420 0.02167
NA
FBN3 colorectal cancer 0.0217945 0.8628420 0.02179
NA
MAP3K2 central nervous system cancer 0.0218317 0.8628420 0.02183
NA
ANXA5 uterine cancer 0.0218494 0.8628420 0.02185
NA
CACNG8 uterine cancer 0.0218494 0.8628420 0.02185
NA
CTSH uterine cancer 0.0218494 0.8628420 0.02185
NA
DNAJA3 uterine cancer 0.0218494 0.8628420 0.02185
NA
GNAL uterine cancer 0.0218494 0.8628420 0.02185
NA
NPSR1 uterine cancer 0.0218494 0.8628420 0.02185
NA
PDIA3 uterine cancer 0.0218494 0.8628420 0.02185
NA
ST7 uterine cancer 0.0218494 0.8628420 0.02185
NA
ZNF177 stomach cancer 0.0220095 0.8628420 0.02201
NA
ABCA8 lung cancer 0.0220285 0.8628420 0.02203
NA
PIK3R1 uterine cancer 0.0220770 0.8628420 0.02208
NA
CDC23 stomach cancer 0.0220927 0.8628420 0.02209
NA
CSMD2 stomach cancer 0.0220927 0.8628420 0.02209
NA
FMN1 stomach cancer 0.0220927 0.8628420 0.02209
NA
ARFGEF1 colorectal cancer 0.0220976 0.8628420 0.02210
NA
APC multiple myeloma 0.0221907 0.8628420 0.02219
NA
PLA2R1 liver cancer 0.0221907 0.8628420 0.02219
NA
USP6 lung cancer 0.0222081 0.8628420 0.02221
NA
BCAR1 skin cancer 0.0222172 0.8628420 0.02222
NA
CLPX skin cancer 0.0222172 0.8628420 0.02222
NA
PIGR skin cancer 0.0222172 0.8628420 0.02222
NA
SLC47A2 skin cancer 0.0222172 0.8628420 0.02222
NA
UGP2 skin cancer 0.0222172 0.8628420 0.02222
NA
DCAF8 central nervous system cancer 0.0222529 0.8628420 0.02225
NA
GABRA5 central nervous system cancer 0.0222745 0.8628420 0.02227
NA
MAP1A central nervous system cancer 0.0222745 0.8628420 0.02227
NA
NRAS central nervous system cancer 0.0222745 0.8628420 0.02227
NA
PAMR1 central nervous system cancer 0.0222745 0.8628420 0.02227
NA
TMEM260 central nervous system cancer 0.0222745 0.8628420 0.02227
NA
SMAD4 head and neck cancer 0.0223264 0.8628420 0.02233
NA
ARHGAP24 leukemia 0.0223811 0.8628420 0.02238
NA
LYST leukemia 0.0223811 0.8628420 0.02238
NA
SORBS1 leukemia 0.0223811 0.8628420 0.02238
NA
TPX2 leukemia 0.0223811 0.8628420 0.02238
NA
JAKMIP2 uterine cancer 0.0224023 0.8628420 0.02240
NA
C20orf194 uterine cancer 0.0224142 0.8628420 0.02241
NA
C6orf118 uterine cancer 0.0224142 0.8628420 0.02241
NA
GRAMD1A uterine cancer 0.0224142 0.8628420 0.02241
NA
PSPC1 uterine cancer 0.0224142 0.8628420 0.02241
NA
SKIV2L uterine cancer 0.0224142 0.8628420 0.02241
NA
SLC22A9 uterine cancer 0.0224142 0.8628420 0.02241
NA
TDP1 uterine cancer 0.0224142 0.8628420 0.02241
NA
USP33 uterine cancer 0.0224142 0.8628420 0.02241
NA
MYC lymphoma 0.0224379 0.8628420 0.02244
NA
CADPS2 colorectal cancer 0.0225063 0.8628420 0.02251
NA
PCM1 colorectal cancer 0.0225063 0.8628420 0.02251
NA
VPS16 uterine cancer 0.0225276 0.8628420 0.02253
NA
ANKRD13D skin cancer 0.0225628 0.8628420 0.02256
NA
HRAS skin cancer 0.0225628 0.8628420 0.02256
NA
IDUA skin cancer 0.0225628 0.8628420 0.02256
NA
MMP19 skin cancer 0.0225628 0.8628420 0.02256
NA
SCLT1 skin cancer 0.0225628 0.8628420 0.02256
NA
TEC skin cancer 0.0225628 0.8628420 0.02256
NA
ZBP1 skin cancer 0.0225628 0.8628420 0.02256
NA
ZNF623 skin cancer 0.0225628 0.8628420 0.02256
NA
ANKRD34C lung cancer 0.0225841 0.8628420 0.02258
NA
C14orf39 lung cancer 0.0225841 0.8628420 0.02258
NA
VCAN skin cancer 0.0225919 0.8628420 0.02259
NA
ZNF219 lung cancer 0.0226177 0.8628420 0.02262
NA
WDR19 colorectal cancer 0.0226230 0.8628420 0.02262
NA
FSIP2 ovarian cancer 0.0226982 0.8628420 0.02270
NA
NEBL uterine cancer 0.0227602 0.8628420 0.02276
NA
ALS2CL lung cancer 0.0228245 0.8628420 0.02282
NA
RARB lung cancer 0.0228245 0.8628420 0.02282
NA
ALX1 colorectal cancer 0.0228475 0.8628420 0.02285
NA
CNOT1 colorectal cancer 0.0228475 0.8628420 0.02285
NA
FER colorectal cancer 0.0228475 0.8628420 0.02285
NA
MDFIC colorectal cancer 0.0228475 0.8628420 0.02285
NA
NFRKB colorectal cancer 0.0228475 0.8628420 0.02285
NA
SLC12A6 colorectal cancer 0.0228475 0.8628420 0.02285
NA
SUPT7L colorectal cancer 0.0228475 0.8628420 0.02285
NA
TIE1 colorectal cancer 0.0228475 0.8628420 0.02285
NA
CAB39 colorectal cancer 0.0229034 0.8628420 0.02290
NA
ECD colorectal cancer 0.0229034 0.8628420 0.02290
NA
MOCOS colorectal cancer 0.0229034 0.8628420 0.02290
NA
PLEKHO1 colorectal cancer 0.0229034 0.8628420 0.02290
NA
SRGAP1 colorectal cancer 0.0229034 0.8628420 0.02290
NA
DOCK7 uterine cancer 0.0230355 0.8628420 0.02304
NA
MYH2 urinary bladder cancer 0.0230456 0.8628420 0.02305
NA
PHRF1 lung cancer 0.0230581 0.8628420 0.02306
NA
RALGAPA1 uterine cancer 0.0230976 0.8628420 0.02310
NA
DOCK8 uterine cancer 0.0231119 0.8628420 0.02311
NA
DGCR14 lung cancer 0.0231325 0.8628420 0.02313
NA
LARP4B lung cancer 0.0231325 0.8628420 0.02313
NA
NPTX2 lung cancer 0.0231325 0.8628420 0.02313
NA
ZNF572 lung cancer 0.0231325 0.8628420 0.02313
NA
KIAA1549L uterine cancer 0.0231364 0.8628420 0.02314
NA
MYH1 pancreatic cancer 0.0232100 0.8628420 0.02321
NA
FASN uterine cancer 0.0232155 0.8628420 0.02322
NA
COL7A1 uterine cancer 0.0232177 0.8628420 0.02322
NA
GBA2 uterine cancer 0.0232383 0.8628420 0.02324
NA
CPNE5 uterine cancer 0.0232528 0.8628420 0.02325
NA
CWC22 uterine cancer 0.0232528 0.8628420 0.02325
NA
EPB41L5 uterine cancer 0.0232528 0.8628420 0.02325
NA
PDGFRA uterine cancer 0.0232528 0.8628420 0.02325
NA
SENP2 uterine cancer 0.0232528 0.8628420 0.02325
NA
C7orf63 ovarian cancer 0.0232906 0.8628420 0.02329
NA
FCHO2 breast cancer 0.0232923 0.8628420 0.02329
NA
TUBB2A breast cancer 0.0232923 0.8628420 0.02329
NA
BAAT colorectal cancer 0.0233134 0.8628420 0.02331
NA
CDK7 colorectal cancer 0.0233134 0.8628420 0.02331
NA
CYP4V2 colorectal cancer 0.0233134 0.8628420 0.02331
NA
EIF3H colorectal cancer 0.0233134 0.8628420 0.02331
NA
FSCN2 colorectal cancer 0.0233134 0.8628420 0.02331
NA
HAX1 colorectal cancer 0.0233134 0.8628420 0.02331
NA
IRF2BP1 colorectal cancer 0.0233134 0.8628420 0.02331
NA
KCNJ6 colorectal cancer 0.0233134 0.8628420 0.02331
NA
NSUN6 colorectal cancer 0.0233134 0.8628420 0.02331
NA
PDZD3 colorectal cancer 0.0233134 0.8628420 0.02331
NA
PI4KB colorectal cancer 0.0233134 0.8628420 0.02331
NA
WDR46 colorectal cancer 0.0233134 0.8628420 0.02331
NA
KIAA1217 colorectal cancer 0.0233368 0.8628420 0.02334
NA
SH3D21 uterine cancer 0.0233796 0.8628420 0.02338
NA
STARD9 esophageal cancer 0.0234106 0.8628420 0.02341
NA
ZNF763 peripheral nervous system neoplasm 0.0234312 0.8628420 0.02343
NA
AFF3 colorectal cancer 0.0234640 0.8628420 0.02346
NA
ARMC5 colorectal cancer 0.0234640 0.8628420 0.02346
NA
SAMM50 colorectal cancer 0.0234915 0.8628420 0.02349
NA
TRIP10 colorectal cancer 0.0234915 0.8628420 0.02349
NA
PTPRZ1 uterine cancer 0.0235569 0.8628420 0.02356
NA
CEP170 uterine cancer 0.0235638 0.8628420 0.02356
NA
BRCA1 colorectal cancer 0.0237122 0.8628420 0.02371
NA
EXTL3 leukemia 0.0237385 0.8628420 0.02374
NA
FAM193B urinary bladder cancer 0.0237385 0.8628420 0.02374
NA
FIZ1 leukemia 0.0237385 0.8628420 0.02374
NA
LARP4B leukemia 0.0237385 0.8628420 0.02374
NA
MAS1 leukemia 0.0237385 0.8628420 0.02374
NA
MYH9 leukemia 0.0237385 0.8628420 0.02374
NA
TDRD1 urinary bladder cancer 0.0237385 0.8628420 0.02374
NA
TXNRD1 leukemia 0.0237385 0.8628420 0.02374
NA
ANXA4 breast cancer 0.0237414 0.8628420 0.02374
NA
C1S breast cancer 0.0237414 0.8628420 0.02374
NA
EVPL breast cancer 0.0237414 0.8628420 0.02374
NA
IGSF9 breast cancer 0.0237414 0.8628420 0.02374
NA
KRAS breast cancer 0.0237414 0.8628420 0.02374
NA
MAP10 breast cancer 0.0237414 0.8628420 0.02374
NA
NT5E breast cancer 0.0237414 0.8628420 0.02374
NA
OR51D1 breast cancer 0.0237414 0.8628420 0.02374
NA
TMC7 breast cancer 0.0237414 0.8628420 0.02374
NA
TRIML1 breast cancer 0.0237414 0.8628420 0.02374
NA
TRPC3 breast cancer 0.0237414 0.8628420 0.02374
NA
COBLL1 colorectal cancer 0.0240160 0.8628420 0.02402
NA
ASCC3 lung cancer 0.0240277 0.8628420 0.02403
NA
GABRB1 lung cancer 0.0240277 0.8628420 0.02403
NA
OR5AS1 lung cancer 0.0240277 0.8628420 0.02403
NA
FAT1 head and neck cancer 0.0240277 0.8628420 0.02403
NA
SUSD2 lung cancer 0.0240587 0.8628420 0.02406
NA
LHCGR skin cancer 0.0240855 0.8628420 0.02409
NA
SNX20 skin cancer 0.0240855 0.8628420 0.02409
NA
ABCC5 multiple myeloma 0.0240966 0.8628420 0.02410
NA
ZNF831 multiple myeloma 0.0240966 0.8628420 0.02410
NA
ZNF831 skin cancer 0.0241948 0.8628420 0.02419
NA
CRIM1 ovarian cancer 0.0241952 0.8628420 0.02420
NA
MAT2B uterine cancer 0.0243863 0.8628420 0.02439
NA
KIRREL lung cancer 0.0243872 0.8628420 0.02439
NA
LMO4 lung cancer 0.0243872 0.8628420 0.02439
NA
RAD21 lung cancer 0.0243872 0.8628420 0.02439
NA
SLC9A9 lung cancer 0.0243872 0.8628420 0.02439
NA
APPL2 uterine cancer 0.0243902 0.8628420 0.02439
NA
C11orf58 uterine cancer 0.0243902 0.8628420 0.02439
NA
CD1C uterine cancer 0.0243902 0.8628420 0.02439
NA
CLCA1 cancer 0.0243902 0.8628420 0.02439
NA
CYP20A1 uterine cancer 0.0243902 0.8628420 0.02439
NA
DLD uterine cancer 0.0243902 0.8628420 0.02439
NA
MKL2 uterine cancer 0.0243902 0.8628420 0.02439
NA
MLC1 uterine cancer 0.0243902 0.8628420 0.02439
NA
MTMR2 uterine cancer 0.0243902 0.8628420 0.02439
NA
NPLOC4 uterine cancer 0.0243902 0.8628420 0.02439
NA
P2RY2 uterine cancer 0.0243902 0.8628420 0.02439
NA
PARVG uterine cancer 0.0243902 0.8628420 0.02439
NA
PHF11 uterine cancer 0.0243902 0.8628420 0.02439
NA
PRAMEF10 uterine cancer 0.0243902 0.8628420 0.02439
NA
RANBP9 cancer 0.0243902 0.8628420 0.02439
NA
TRIM54 uterine cancer 0.0243902 0.8628420 0.02439
NA
TRIM65 uterine cancer 0.0243902 0.8628420 0.02439
NA
TTLL6 uterine cancer 0.0243902 0.8628420 0.02439
NA
ZNF124 uterine cancer 0.0243902 0.8628420 0.02439
NA
CNNM2 colorectal cancer 0.0244651 0.8628420 0.02447
NA
CCDC51 breast cancer 0.0246271 0.8628420 0.02463
NA
KIAA0196 breast cancer 0.0246271 0.8628420 0.02463
NA
NEDD4L breast cancer 0.0246271 0.8628420 0.02463
NA
NEK8 breast cancer 0.0246271 0.8628420 0.02463
NA
TCFL5 breast cancer 0.0246271 0.8628420 0.02463
NA
GALNS skin cancer 0.0246414 0.8628420 0.02464
NA
TRAK2 lung cancer 0.0246533 0.8628420 0.02465
NA
GLG1 uterine cancer 0.0246815 0.8628420 0.02468
NA
SDK1 lung cancer 0.0246874 0.8628420 0.02469
NA
SACS leukemia 0.0249901 0.8628420 0.02499
NA
PCLO esophageal cancer 0.0250148 0.8628420 0.02501
NA
POM121 colorectal cancer 0.0250989 0.8628420 0.02510
NA
KIF3A lung cancer 0.0251383 0.8628420 0.02514
NA
ARHGEF25 ovarian cancer 0.0251815 0.8628420 0.02518
NA
CLRN3 ovarian cancer 0.0251815 0.8628420 0.02518
NA
MYH6 ovarian cancer 0.0251815 0.8628420 0.02518
NA
RRP12 ovarian cancer 0.0251815 0.8628420 0.02518
NA
SDHA ovarian cancer 0.0251815 0.8628420 0.02518
NA
SLC1A3 ovarian cancer 0.0251815 0.8628420 0.02518
NA
XIRP2 ovarian cancer 0.0251815 0.8628420 0.02518
NA
HERC5 lung cancer 0.0251843 0.8628420 0.02518
NA
KLC3 lung cancer 0.0251843 0.8628420 0.02518
NA
NSFL1C lung cancer 0.0251843 0.8628420 0.02518
NA
R3HCC1L lung cancer 0.0251843 0.8628420 0.02518
NA
FBXO34 uterine cancer 0.0252550 0.8628420 0.02526
NA
EIF2AK3 kidney cancer 0.0252676 0.8628420 0.02527
NA
ASH1L stomach cancer 0.0252712 0.8628420 0.02527
NA
ITGAD head and neck cancer 0.0252712 0.8628420 0.02527
NA
KMT2E head and neck cancer 0.0252712 0.8628420 0.02527
NA
PIK3CA stomach cancer 0.0252712 0.8628420 0.02527
NA
VPS13D head and neck cancer 0.0252712 0.8628420 0.02527
NA
WDFY3 leukemia 0.0252750 0.8628420 0.02527
NA
FANCE pancreatic cancer 0.0253038 0.8628420 0.02530
NA
MYH3 pancreatic cancer 0.0253038 0.8628420 0.02530
NA
UNC5A pancreatic cancer 0.0253168 0.8628420 0.02532
NA
DAW1 lung cancer 0.0253864 0.8628420 0.02539
NA
DGKD lung cancer 0.0253864 0.8628420 0.02539
NA
FAM43A lung cancer 0.0253864 0.8628420 0.02539
NA
GGA1 lung cancer 0.0253864 0.8628420 0.02539
NA
KIAA1045 lung cancer 0.0253864 0.8628420 0.02539
NA
KRT9 lung cancer 0.0253864 0.8628420 0.02539
NA
MON2 lung cancer 0.0253864 0.8628420 0.02539
NA
MXD3 lung cancer 0.0253864 0.8628420 0.02539
NA
POGZ lung cancer 0.0253864 0.8628420 0.02539
NA
STOX1 lung cancer 0.0253864 0.8628420 0.02539
NA
ZNF697 lung cancer 0.0253864 0.8628420 0.02539
NA
DEAF1 central nervous system cancer 0.0253889 0.8628420 0.02539
NA
KIAA0319L central nervous system cancer 0.0253889 0.8628420 0.02539
NA
METTL14 central nervous system cancer 0.0253889 0.8628420 0.02539
NA
PUSL1 central nervous system cancer 0.0253889 0.8628420 0.02539
NA
CNOT1 lung cancer 0.0254122 0.8628420 0.02541
NA
REV3L colorectal cancer 0.0254282 0.8628420 0.02543
NA
CKS1B lymphoma 0.0254827 0.8628420 0.02548
NA
ANO6 lung cancer 0.0255133 0.8628420 0.02551
NA
HSPA1A lung cancer 0.0255594 0.8628420 0.02556
NA
CR1 colorectal cancer 0.0255810 0.8628420 0.02558
NA
OSBPL3 lung cancer 0.0256297 0.8628420 0.02563
NA
EMILIN1 kidney cancer 0.0256748 0.8628420 0.02567
NA
CLIP4 central nervous system cancer 0.0257091 0.8628420 0.02571
NA
GUCY1B3 central nervous system cancer 0.0257091 0.8628420 0.02571
NA
NLRP13 central nervous system cancer 0.0257091 0.8628420 0.02571
NA
PPP1R12A central nervous system cancer 0.0257091 0.8628420 0.02571
NA
RHPN2 central nervous system cancer 0.0257091 0.8628420 0.02571
NA
VWA3A central nervous system cancer 0.0257091 0.8628420 0.02571
NA
ZNF658 central nervous system cancer 0.0257091 0.8628420 0.02571
NA
CHRNA1 colorectal cancer 0.0257186 0.8628420 0.02572
NA
ISCA1 colorectal cancer 0.0257186 0.8628420 0.02572
NA
ZZZ3 colorectal cancer 0.0257186 0.8628420 0.02572
NA
SI lung cancer 0.0258291 0.8628420 0.02583
NA
RXFP2 colorectal cancer 0.0258373 0.8628420 0.02584
NA
DDX11 colorectal cancer 0.0258763 0.8628420 0.02588
NA
ACACA leukemia 0.0259015 0.8628420 0.02590
NA
ACSL3 leukemia 0.0259015 0.8628420 0.02590
NA
AGO3 leukemia 0.0259015 0.8628420 0.02590
NA
CLSPN leukemia 0.0259015 0.8628420 0.02590
NA
CUL2 leukemia 0.0259015 0.8628420 0.02590
NA
DOCK10 leukemia 0.0259015 0.8628420 0.02590
NA
EML6 leukemia 0.0259015 0.8628420 0.02590
NA
FAM83F leukemia 0.0259015 0.8628420 0.02590
NA
HEMK1 urinary bladder cancer 0.0259015 0.8628420 0.02590
NA
MLST8 leukemia 0.0259015 0.8628420 0.02590
NA
SPRYD3 leukemia 0.0259015 0.8628420 0.02590
NA
SRSF11 leukemia 0.0259015 0.8628420 0.02590
NA
TGOLN2 leukemia 0.0259015 0.8628420 0.02590
NA
ZBTB49 urinary bladder cancer 0.0259015 0.8628420 0.02590
NA
EXPH5 kidney cancer 0.0259435 0.8628420 0.02594
NA
LGR4 kidney cancer 0.0259435 0.8628420 0.02594
NA
ZNF792 kidney cancer 0.0259435 0.8628420 0.02594
NA
MUC4 pancreatic cancer 0.0259937 0.8628420 0.02599
NA
POC1A uterine cancer 0.0259991 0.8628420 0.02600
NA
SLCO1A2 lung cancer 0.0261852 0.8628420 0.02619
NA
KCNC2 uterine cancer 0.0262196 0.8628420 0.02622
NA
MICAL3 uterine cancer 0.0262196 0.8628420 0.02622
NA
RASGRF1 skin cancer 0.0262294 0.8628420 0.02623
NA
PRRC2B lymphoma 0.0262367 0.8628420 0.02624
NA
FAM19A2 lung cancer 0.0263138 0.8628420 0.02631
NA
NUAK2 lung cancer 0.0263138 0.8628420 0.02631
NA
FLNC esophageal cancer 0.0263188 0.8628420 0.02632
NA
NYNRIN esophageal cancer 0.0263188 0.8628420 0.02632
NA
WDR33 lung cancer 0.0263432 0.8628420 0.02634
NA
RRBP1 uterine cancer 0.0263705 0.8628420 0.02637
NA
KRT14 esophageal cancer 0.0263911 0.8628420 0.02639
NA
USP36 colorectal cancer 0.0264358 0.8628420 0.02644
NA
KANK4 colorectal cancer 0.0265411 0.8628420 0.02654
NA
AKR1B15 kidney cancer 0.0266040 0.8628420 0.02660
NA
ACE leukemia 0.0266603 0.8628420 0.02666
NA
ADD2 leukemia 0.0266603 0.8628420 0.02666
NA
APBB1 leukemia 0.0266603 0.8628420 0.02666
NA
ASCL4 urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
ATP5S leukemia 0.0266603 0.8628420 0.02666
NA
B3GAT1 leukemia 0.0266603 0.8628420 0.02666
NA
C1orf159 urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
CENPB leukemia 0.0266603 0.8628420 0.02666
NA
EFCAB5 urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
EPS8L2 leukemia 0.0266603 0.8628420 0.02666
NA
ERMAP leukemia 0.0266603 0.8628420 0.02666
NA
FEZ1 leukemia 0.0266603 0.8628420 0.02666
NA
GALNT16 leukemia 0.0266603 0.8628420 0.02666
NA
HIPK1 leukemia 0.0266603 0.8628420 0.02666
NA
KIAA1456 leukemia 0.0266603 0.8628420 0.02666
NA
KLHL24 leukemia 0.0266603 0.8628420 0.02666
NA
LRRN2 leukemia 0.0266603 0.8628420 0.02666
NA
MYBL2 leukemia 0.0266603 0.8628420 0.02666
NA
NBPF15 urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
PROM1 leukemia 0.0266603 0.8628420 0.02666
NA
PTEN urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
RASGRP1 urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
SPATA5 leukemia 0.0266603 0.8628420 0.02666
NA
SYNPO2L leukemia 0.0266603 0.8628420 0.02666
NA
TMCO4 urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
TSPAN32 urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
UBR1 leukemia 0.0266603 0.8628420 0.02666
NA
ZFHX2 urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
ZNF230 urinary bladder cancer 0.0266603 0.8628420 0.02666
NA
CFH colorectal cancer 0.0267006 0.8628420 0.02670
NA
NR1H4 lung cancer 0.0267419 0.8628420 0.02674
NA
LRRC15 lung cancer 0.0267489 0.8628420 0.02675
NA
PCDHB4 breast cancer 0.0267629 0.8628420 0.02676
NA
APC skin cancer 0.0269384 0.8628420 0.02694
NA
LY75 skin cancer 0.0269384 0.8628420 0.02694
NA
TCEB3B skin cancer 0.0269384 0.8628420 0.02694
NA
ABHD14A skin cancer 0.0269581 0.8628420 0.02696
NA
NOL10 skin cancer 0.0269581 0.8628420 0.02696
NA
SENP5 skin cancer 0.0269581 0.8628420 0.02696
NA
ACAN breast cancer 0.0269639 0.8628420 0.02696
NA
COL11A1 lung cancer 0.0269778 0.8628420 0.02698
NA
ATR lung cancer 0.0270447 0.8628420 0.02704
NA
BRINP3 lung cancer 0.0270777 0.8628420 0.02708
NA
ERBB3 lung cancer 0.0270777 0.8628420 0.02708
NA
ACE stomach cancer 0.0270901 0.8628420 0.02709
NA
AP5B1 ovarian cancer 0.0271254 0.8628420 0.02713
NA
CNTNAP4 ovarian cancer 0.0271254 0.8628420 0.02713
NA
ZBTB16 ovarian cancer 0.0271254 0.8628420 0.02713
NA
ZNF675 ovarian cancer 0.0271254 0.8628420 0.02713
NA
LRRK1 uterine cancer 0.0271976 0.8628420 0.02720
NA
LONRF2 lung cancer 0.0273096 0.8628420 0.02731
NA
KANK4 central nervous system cancer 0.0273262 0.8628420 0.02733
NA
TMCO4 central nervous system cancer 0.0273262 0.8628420 0.02733
NA
CD200 liver cancer 0.0273739 0.8628420 0.02737
NA
DOCK7 multiple myeloma 0.0273739 0.8628420 0.02737
NA
TAF1L multiple myeloma 0.0273739 0.8628420 0.02737
NA
RASAL2 uterine cancer 0.0274384 0.8628420 0.02744
NA
DIS3L2 lung cancer 0.0275353 0.8628420 0.02754
NA
FLNB ovarian cancer 0.0275425 0.8628420 0.02754
NA
RIMS2 ovarian cancer 0.0275580 0.8628420 0.02756
NA
THADA colorectal cancer 0.0276570 0.8628420 0.02766
NA
CYP26C1 uterine cancer 0.0277385 0.8628420 0.02774
NA
EDNRB uterine cancer 0.0277385 0.8628420 0.02774
NA
TTC14 kidney cancer 0.0277730 0.8628420 0.02777
NA
ACSBG2 lung cancer 0.0278279 0.8628420 0.02783
NA
CCDC96 lung cancer 0.0278279 0.8628420 0.02783
NA
EDARADD lung cancer 0.0278279 0.8628420 0.02783
NA
OR13J1 lung cancer 0.0278279 0.8628420 0.02783
NA
PLEKHB2 lung cancer 0.0278279 0.8628420 0.02783
NA
SLC22A12 lung cancer 0.0278279 0.8628420 0.02783
NA
TGOLN2 lung cancer 0.0278279 0.8628420 0.02783
NA
UTP3 lung cancer 0.0278279 0.8628420 0.02783
NA
LIG3 breast cancer 0.0278667 0.8628420 0.02787
NA
ACSS3 colorectal cancer 0.0278905 0.8628420 0.02789
NA
FBXO17 colorectal cancer 0.0278905 0.8628420 0.02789
NA
LTB colorectal cancer 0.0278905 0.8628420 0.02789
NA
PDGFD colorectal cancer 0.0278905 0.8628420 0.02789
NA
PHACTR3 colorectal cancer 0.0278905 0.8628420 0.02789
NA
PI4KA colorectal cancer 0.0278905 0.8628420 0.02789
NA
SGSM2 colorectal cancer 0.0278905 0.8628420 0.02789
NA
SLC37A1 colorectal cancer 0.0278905 0.8628420 0.02789
NA
TAF3 colorectal cancer 0.0278905 0.8628420 0.02789
NA
TRIP13 colorectal cancer 0.0278905 0.8628420 0.02789
NA
CARD10 uterine cancer 0.0279231 0.8628420 0.02792
NA
NR1H4 uterine cancer 0.0279601 0.8628420 0.02796
NA
GIN1 lung cancer 0.0281322 0.8628420 0.02813
NA
OR5W2 lung cancer 0.0281322 0.8628420 0.02813
NA
TRAM1L1 lung cancer 0.0281322 0.8628420 0.02813
NA
C9orf152 skin cancer 0.0281858 0.8628420 0.02819
NA
CSPP1 skin cancer 0.0281858 0.8628420 0.02819
NA
FGFR2 skin cancer 0.0281858 0.8628420 0.02819
NA
GYPE skin cancer 0.0281858 0.8628420 0.02819
NA
NDUFA11 skin cancer 0.0281858 0.8628420 0.02819
NA
NKAIN4 skin cancer 0.0281858 0.8628420 0.02819
NA
TAL1 skin cancer 0.0281858 0.8628420 0.02819
NA
ITPR1 urinary bladder cancer 0.0282157 0.8628420 0.02822
NA
BAP1 kidney cancer 0.0282577 0.8628420 0.02826
NA
TNKS1BP1 uterine cancer 0.0282636 0.8628420 0.02826
NA
ADCY3 uterine cancer 0.0283176 0.8628420 0.02832
NA
ATP6AP1L uterine cancer 0.0283176 0.8628420 0.02832
NA
EML1 uterine cancer 0.0283176 0.8628420 0.02832
NA
GIMAP6 uterine cancer 0.0283176 0.8628420 0.02832
NA
GTPBP4 uterine cancer 0.0283176 0.8628420 0.02832
NA
HLA-DRB1 uterine cancer 0.0283176 0.8628420 0.02832
NA
ITGB1BP1 uterine cancer 0.0283176 0.8628420 0.02832
NA
KRTAP10-6 cancer 0.0283176 0.8628420 0.02832
NA
MUC20 cancer 0.0283176 0.8628420 0.02832
NA
OR2T1 uterine cancer 0.0283176 0.8628420 0.02832
NA
OSBPL9 uterine cancer 0.0283176 0.8628420 0.02832
NA
SH2D1B uterine cancer 0.0283176 0.8628420 0.02832
NA
TMEM41B uterine cancer 0.0283176 0.8628420 0.02832
NA
ZNF195 cancer 0.0283176 0.8628420 0.02832
NA
ZNF419 uterine cancer 0.0283176 0.8628420 0.02832
NA
KCNJ4 lung cancer 0.0283705 0.8628420 0.02837
NA
LRRN2 lung cancer 0.0283705 0.8628420 0.02837
NA
SLC6A15 lung cancer 0.0283705 0.8628420 0.02837
NA
HELZ2 kidney cancer 0.0284858 0.8628420 0.02849
NA
MARK1 lung cancer 0.0285789 0.8628420 0.02858
NA
CNTN5 uterine cancer 0.0287186 0.8628420 0.02872
NA
LZTR1 uterine cancer 0.0287186 0.8628420 0.02872
NA
TOPAZ1 lung cancer 0.0287243 0.8628420 0.02872
NA
SLC2A10 breast cancer 0.0287627 0.8628420 0.02876
NA
TEX33 breast cancer 0.0287627 0.8628420 0.02876
NA
WIPI2 breast cancer 0.0287627 0.8628420 0.02876
NA
RNF43 uterine cancer 0.0288827 0.8628420 0.02888
NA
GOLGA2 breast cancer 0.0289322 0.8628420 0.02893
NA
OCA2 skin cancer 0.0289512 0.8628420 0.02895
NA
RBP3 skin cancer 0.0289512 0.8628420 0.02895
NA
SLITRK3 skin cancer 0.0289512 0.8628420 0.02895
NA
TYR skin cancer 0.0289512 0.8628420 0.02895
NA
ZNF10 skin cancer 0.0289512 0.8628420 0.02895
NA
NBEA colorectal cancer 0.0290192 0.8628420 0.02902
NA
MECOM lung cancer 0.0290485 0.8628420 0.02905
NA
CACYBP uterine cancer 0.0291743 0.8628420 0.02917
NA
NADSYN1 uterine cancer 0.0291743 0.8628420 0.02917
NA
OR10G7 uterine cancer 0.0291743 0.8628420 0.02917
NA
SYTL2 uterine cancer 0.0291743 0.8628420 0.02917
NA
ZSWIM8 uterine cancer 0.0291968 0.8628420 0.02920
NA
DNAH2 colorectal cancer 0.0292187 0.8628420 0.02922
NA
ANKRD30A esophageal cancer 0.0292725 0.8628420 0.02927
NA
BTAF1 esophageal cancer 0.0292725 0.8628420 0.02927
NA
CFH esophageal cancer 0.0292725 0.8628420 0.02927
NA
OSBPL8 esophageal cancer 0.0292725 0.8628420 0.02927
NA
ROS1 esophageal cancer 0.0292725 0.8628420 0.02927
NA
ZNF681 esophageal cancer 0.0292725 0.8628420 0.02927
NA
TRIOBP colorectal cancer 0.0293818 0.8628420 0.02938
NA
ADAD2 uterine cancer 0.0294387 0.8628420 0.02944
NA
ADH6 uterine cancer 0.0294387 0.8628420 0.02944
NA
APCDD1L cancer 0.0294387 0.8628420 0.02944
NA
BBS7 uterine cancer 0.0294387 0.8628420 0.02944
NA
BMP2K uterine cancer 0.0294387 0.8628420 0.02944
NA
BPIFA3 uterine cancer 0.0294387 0.8628420 0.02944
NA
BRAF cancer 0.0294387 0.8628420 0.02944
NA
CBFA2T2 uterine cancer 0.0294387 0.8628420 0.02944
NA
CCNJL uterine cancer 0.0294387 0.8628420 0.02944
NA
CD163 cancer 0.0294387 0.8628420 0.02944
NA
CREB3L4 uterine cancer 0.0294387 0.8628420 0.02944
NA
CTNNB1 cancer 0.0294387 0.8628420 0.02944
NA
DYNC1I2 cancer 0.0294387 0.8628420 0.02944
NA
ELANE cancer 0.0294387 0.8628420 0.02944
NA
FAM173A uterine cancer 0.0294387 0.8628420 0.02944
NA
FASLG uterine cancer 0.0294387 0.8628420 0.02944
NA
FPR3 uterine cancer 0.0294387 0.8628420 0.02944
NA
GALR2 uterine cancer 0.0294387 0.8628420 0.02944
NA
HBS1L uterine cancer 0.0294387 0.8628420 0.02944
NA
HESX1 uterine cancer 0.0294387 0.8628420 0.02944
NA
IFIT5 cancer 0.0294387 0.8628420 0.02944
NA
IL11RA uterine cancer 0.0294387 0.8628420 0.02944
NA
KCNK9 uterine cancer 0.0294387 0.8628420 0.02944
NA
KRTAP4-5 uterine cancer 0.0294387 0.8628420 0.02944
NA
LEFTY2 uterine cancer 0.0294387 0.8628420 0.02944
NA
LIPC uterine cancer 0.0294387 0.8628420 0.02944
NA
MIEF1 uterine cancer 0.0294387 0.8628420 0.02944
NA
NICN1 uterine cancer 0.0294387 0.8628420 0.02944
NA
OCEL1 uterine cancer 0.0294387 0.8628420 0.02944
NA
PCDHGB6 uterine cancer 0.0294387 0.8628420 0.02944
NA
PCGF6 uterine cancer 0.0294387 0.8628420 0.02944
NA
PDSS1 uterine cancer 0.0294387 0.8628420 0.02944
NA
PRIMPOL uterine cancer 0.0294387 0.8628420 0.02944
NA
PRL uterine cancer 0.0294387 0.8628420 0.02944
NA
PRSS23 uterine cancer 0.0294387 0.8628420 0.02944
NA
RBM48 uterine cancer 0.0294387 0.8628420 0.02944
NA
RPLP2 uterine cancer 0.0294387 0.8628420 0.02944
NA
SLC39A14 uterine cancer 0.0294387 0.8628420 0.02944
NA
SLX4IP uterine cancer 0.0294387 0.8628420 0.02944
NA
SPDYE3 uterine cancer 0.0294387 0.8628420 0.02944
NA
SYNDIG1 uterine cancer 0.0294387 0.8628420 0.02944
NA
TMEM62 cancer 0.0294387 0.8628420 0.02944
NA
TPSD1 uterine cancer 0.0294387 0.8628420 0.02944
NA
TTBK1 uterine cancer 0.0294387 0.8628420 0.02944
NA
TYK2 cancer 0.0294387 0.8628420 0.02944
NA
UBALD2 uterine cancer 0.0294387 0.8628420 0.02944
NA
VEPH1 uterine cancer 0.0294387 0.8628420 0.02944
NA
WDR48 uterine cancer 0.0294387 0.8628420 0.02944
NA
ADAM8 uterine cancer 0.0294749 0.8628420 0.02947
NA
CD248 uterine cancer 0.0294749 0.8628420 0.02947
NA
CTNS uterine cancer 0.0294749 0.8628420 0.02947
NA
FICD uterine cancer 0.0294749 0.8628420 0.02947
NA
LILRA6 uterine cancer 0.0294749 0.8628420 0.02947
NA
NEK7 uterine cancer 0.0294749 0.8628420 0.02947
NA
NFIC uterine cancer 0.0294749 0.8628420 0.02947
NA
SLC2A2 uterine cancer 0.0294749 0.8628420 0.02947
NA
TFR2 uterine cancer 0.0294749 0.8628420 0.02947
NA
WT1 uterine cancer 0.0294749 0.8628420 0.02947
NA
HSF4 uterine cancer 0.0294894 0.8628420 0.02949
NA
GTPBP2 uterine cancer 0.0295080 0.8628420 0.02951
NA
KIAA1211L uterine cancer 0.0295080 0.8628420 0.02951
NA
NYAP1 uterine cancer 0.0295080 0.8628420 0.02951
NA
SCN3A lung cancer 0.0295358 0.8628420 0.02954
NA
BAZ2B central nervous system cancer 0.0295480 0.8628420 0.02955
NA
ATP1A1 colorectal cancer 0.0295794 0.8628420 0.02958
NA
BCAN colorectal cancer 0.0295794 0.8628420 0.02958
NA
CCT4 colorectal cancer 0.0295794 0.8628420 0.02958
NA
COL28A1 colorectal cancer 0.0295794 0.8628420 0.02958
NA
CSTF3 colorectal cancer 0.0295794 0.8628420 0.02958
NA
DHFR colorectal cancer 0.0295794 0.8628420 0.02958
NA
EVI5L colorectal cancer 0.0295794 0.8628420 0.02958
NA
FZD5 colorectal cancer 0.0295794 0.8628420 0.02958
NA
KANK2 colorectal cancer 0.0295794 0.8628420 0.02958
NA
NCS1 colorectal cancer 0.0295794 0.8628420 0.02958
NA
OGFOD3 colorectal cancer 0.0295794 0.8628420 0.02958
NA
PCDHA5 colorectal cancer 0.0295794 0.8628420 0.02958
NA
PIK3R2 colorectal cancer 0.0295794 0.8628420 0.02958
NA
SLCO3A1 colorectal cancer 0.0295794 0.8628420 0.02958
NA
TCF3 colorectal cancer 0.0295794 0.8628420 0.02958
NA
DYRK1A ovarian cancer 0.0295871 0.8628420 0.02959
NA
SPATA2L ovarian cancer 0.0295871 0.8628420 0.02959
NA
ITGA8 central nervous system cancer 0.0295925 0.8628420 0.02959
NA
NFAT5 central nervous system cancer 0.0295925 0.8628420 0.02959
NA
SLC2A13 central nervous system cancer 0.0295925 0.8628420 0.02959
NA
ZNF181 central nervous system cancer 0.0295925 0.8628420 0.02959
NA
TRIM36 central nervous system cancer 0.0297327 0.8628420 0.02973
NA
MEFV uterine cancer 0.0297352 0.8628420 0.02974
NA
CENPE uterine cancer 0.0297997 0.8628420 0.02980
NA
EP300 urinary bladder cancer 0.0298928 0.8628420 0.02989
NA
ABCC3 leukemia 0.0299640 0.8628420 0.02996
NA
PALD1 leukemia 0.0299640 0.8628420 0.02996
NA
FUK lung cancer 0.0300251 0.8628420 0.03003
NA
PHGDH lung cancer 0.0300251 0.8628420 0.03003
NA
HMMR uterine cancer 0.0301129 0.8628420 0.03011
NA
TRPC1 uterine cancer 0.0301129 0.8628420 0.03011
NA
HERC2 leukemia 0.0301525 0.8628420 0.03015
NA
ATP5J lung cancer 0.0301543 0.8628420 0.03015
NA
DUSP22 lung cancer 0.0301543 0.8628420 0.03015
NA
NMUR2 lung cancer 0.0301543 0.8628420 0.03015
NA
USP20 lung cancer 0.0301543 0.8628420 0.03015
NA
ART3 ovarian cancer 0.0301937 0.8628420 0.03019
NA
C11orf49 ovarian cancer 0.0301937 0.8628420 0.03019
NA
CHD2 ovarian cancer 0.0301937 0.8628420 0.03019
NA
CNTNAP2 ovarian cancer 0.0301937 0.8628420 0.03019
NA
FER ovarian cancer 0.0301937 0.8628420 0.03019
NA
KIAA1324L ovarian cancer 0.0301937 0.8628420 0.03019
NA
MRPL22 ovarian cancer 0.0301937 0.8628420 0.03019
NA
POLG ovarian cancer 0.0301937 0.8628420 0.03019
NA
POLQ breast cancer 0.0301937 0.8628420 0.03019
NA
PRKD2 ovarian cancer 0.0301937 0.8628420 0.03019
NA
SPAG5 ovarian cancer 0.0301937 0.8628420 0.03019
NA
TAAR2 ovarian cancer 0.0301937 0.8628420 0.03019
NA
UBR2 ovarian cancer 0.0301937 0.8628420 0.03019
NA
ZNF133 ovarian cancer 0.0301937 0.8628420 0.03019
NA
BTN2A2 breast cancer 0.0302390 0.8628420 0.03024
NA
LRRC10 breast cancer 0.0302390 0.8628420 0.03024
NA
ZNF862 colorectal cancer 0.0302461 0.8628420 0.03025
NA
ARHGAP28 breast cancer 0.0303828 0.8628420 0.03038
NA
AUTS2 breast cancer 0.0303828 0.8628420 0.03038
NA
ENPEP breast cancer 0.0303828 0.8628420 0.03038
NA
LRP5 breast cancer 0.0303828 0.8628420 0.03038
NA
NBPF15 breast cancer 0.0303828 0.8628420 0.03038
NA
POLRMT breast cancer 0.0303828 0.8628420 0.03038
NA
TREML1 breast cancer 0.0303828 0.8628420 0.03038
NA
ARHGAP27 lung cancer 0.0304563 0.8628420 0.03046
NA
POTEC lung cancer 0.0304563 0.8628420 0.03046
NA
CHRNA1 lung cancer 0.0304692 0.8628420 0.03047
NA
EFNA3 lung cancer 0.0304692 0.8628420 0.03047
NA
KLK13 lung cancer 0.0304692 0.8628420 0.03047
NA
TBC1D14 lung cancer 0.0304692 0.8628420 0.03047
NA
TSPAN8 lung cancer 0.0304692 0.8628420 0.03047
NA
AMN multiple myeloma 0.0305521 0.8628420 0.03055
NA
CCDC146 multiple myeloma 0.0305521 0.8628420 0.03055
NA
CREBBP liver cancer 0.0305521 0.8628420 0.03055
NA
KRT19 bone cancer 0.0305521 0.8628420 0.03055
NA
NPB liver cancer 0.0305521 0.8628420 0.03055
NA
PIWIL3 multiple myeloma 0.0305521 0.8628420 0.03055
NA
POLG multiple myeloma 0.0305521 0.8628420 0.03055
NA
URB1 bone cancer 0.0305521 0.8628420 0.03055
NA
SLC22A8 lung cancer 0.0305642 0.8628420 0.03056
NA
TUSC3 lung cancer 0.0305642 0.8628420 0.03056
NA
MAPK10 central nervous system cancer 0.0306703 0.8628420 0.03067
NA
SELL central nervous system cancer 0.0306703 0.8628420 0.03067
NA
ARVCF leukemia 0.0307084 0.8628420 0.03071
NA
BEGAIN leukemia 0.0307084 0.8628420 0.03071
NA
CACNA1H leukemia 0.0307084 0.8628420 0.03071
NA
COL22A1 urinary bladder cancer 0.0307084 0.8628420 0.03071
NA
EXTL1 leukemia 0.0307084 0.8628420 0.03071
NA
FGFRL1 leukemia 0.0307084 0.8628420 0.03071
NA
NLRP3 leukemia 0.0307084 0.8628420 0.03071
NA
SIGLEC10 leukemia 0.0307084 0.8628420 0.03071
NA
SV2C urinary bladder cancer 0.0307084 0.8628420 0.03071
NA
TMTC2 urinary bladder cancer 0.0307084 0.8628420 0.03071
NA
WDR78 leukemia 0.0307084 0.8628420 0.03071
NA
LPHN2 lung cancer 0.0307454 0.8628420 0.03075
NA
CYP11B1 colorectal cancer 0.0307916 0.8628420 0.03079
NA
MYO7A colorectal cancer 0.0307916 0.8628420 0.03079
NA
KRT16 head and neck cancer 0.0308320 0.8628420 0.03083
NA
TESPA1 esophageal cancer 0.0308570 0.8628420 0.03086
NA
UBE2M esophageal cancer 0.0308570 0.8628420 0.03086
NA
ANKS3 colorectal cancer 0.0310929 0.8628420 0.03109
NA
BMPR1A colorectal cancer 0.0310929 0.8628420 0.03109
NA
ZRANB3 colorectal cancer 0.0310929 0.8628420 0.03109
NA
DPPA2 lung cancer 0.0311587 0.8628420 0.03116
NA
HIST1H1T central nervous system cancer 0.0311904 0.8628420 0.03119
NA
CSNK2A3 colorectal cancer 0.0312119 0.8628420 0.03121
NA
ZNF764 colorectal cancer 0.0312119 0.8628420 0.03121
NA
DYNC2H1 head and neck cancer 0.0312236 0.8628420 0.03122
NA
EXOC3L4 stomach cancer 0.0312294 0.8628420 0.03123
NA
NRG2 stomach cancer 0.0312294 0.8628420 0.03123
NA
ZNF326 head and neck cancer 0.0312294 0.8628420 0.03123
NA
PTPRB uterine cancer 0.0312715 0.8628420 0.03127
NA
XIRP1 colorectal cancer 0.0312835 0.8628420 0.03128
NA
FBXW10 leukemia 0.0312990 0.8628420 0.03130
NA
POLR1A liver cancer 0.0313538 0.8628420 0.03135
NA
SPEN multiple myeloma 0.0313538 0.8628420 0.03135
NA
ZNF804A multiple myeloma 0.0313538 0.8628420 0.03135
NA
CACNB2 uterine cancer 0.0313673 0.8628420 0.03137
NA
PKD1 lung cancer 0.0314173 0.8628420 0.03142
NA
EYA1 ovarian cancer 0.0314230 0.8628420 0.03142
NA
ACPT uterine cancer 0.0314807 0.8628420 0.03148
NA
AKT3 uterine cancer 0.0314807 0.8628420 0.03148
NA
HEXDC uterine cancer 0.0314807 0.8628420 0.03148
NA
MOB1B uterine cancer 0.0314807 0.8628420 0.03148
NA
PBXIP1 uterine cancer 0.0314807 0.8628420 0.03148
NA
PHC3 uterine cancer 0.0314807 0.8628420 0.03148
NA
OR6C75 ovarian cancer 0.0314933 0.8628420 0.03149
NA
TEK ovarian cancer 0.0314933 0.8628420 0.03149
NA
LPPR4 lung cancer 0.0314990 0.8628420 0.03150
NA
DNASE1L3 lung cancer 0.0315211 0.8628420 0.03152
NA
CNGA4 colorectal cancer 0.0315592 0.8628420 0.03156
NA
GEMIN5 colorectal cancer 0.0315592 0.8628420 0.03156
NA
PLA2G4D colorectal cancer 0.0315592 0.8628420 0.03156
NA
RAPGEF2 colorectal cancer 0.0315592 0.8628420 0.03156
NA
TBX3 colorectal cancer 0.0315592 0.8628420 0.03156
NA
ARHGAP5 uterine cancer 0.0315762 0.8628420 0.03158
NA
UNKL uterine cancer 0.0315762 0.8628420 0.03158
NA
DNAH10 central nervous system cancer 0.0316433 0.8628420 0.03164
NA
CCDC88A stomach cancer 0.0319476 0.8628420 0.03195
NA
GUCY1A3 stomach cancer 0.0319476 0.8628420 0.03195
NA
HSD17B12 head and neck cancer 0.0319476 0.8628420 0.03195
NA
ITIH3 stomach cancer 0.0319476 0.8628420 0.03195
NA
NUP155 head and neck cancer 0.0319476 0.8628420 0.03195
NA
PID1 stomach cancer 0.0319476 0.8628420 0.03195
NA
PLEKHG3 stomach cancer 0.0319476 0.8628420 0.03195
NA
SF3B2 stomach cancer 0.0319476 0.8628420 0.03195
NA
UFL1 stomach cancer 0.0319476 0.8628420 0.03195
NA
ZNF438 stomach cancer 0.0319476 0.8628420 0.03195
NA
CMTR1 lung cancer 0.0320263 0.8628420 0.03203
NA
OR4N5 lung cancer 0.0320263 0.8628420 0.03203
NA
ZNF177 colorectal cancer 0.0320522 0.8628420 0.03205
NA
SVIL ovarian cancer 0.0320534 0.8628420 0.03205
NA
ADAMTS16 multiple myeloma 0.0320740 0.8628420 0.03207
NA
APOA5 multiple myeloma 0.0320740 0.8628420 0.03207
NA
CTNNB1 liver cancer 0.0320740 0.8628420 0.03207
NA
DUSP22 multiple myeloma 0.0320740 0.8628420 0.03207
NA
LIMA1 multiple myeloma 0.0320740 0.8628420 0.03207
NA
LRRTM4 multiple myeloma 0.0320740 0.8628420 0.03207
NA
NOS3 liver cancer 0.0320740 0.8628420 0.03207
NA
OR2L3 liver cancer 0.0320740 0.8628420 0.03207
NA
PPP1R3A multiple myeloma 0.0320740 0.8628420 0.03207
NA
SLC45A1 bone cancer 0.0320740 0.8628420 0.03207
NA
TAB2 multiple myeloma 0.0320740 0.8628420 0.03207
NA
TRIM29 multiple myeloma 0.0320740 0.8628420 0.03207
NA
UNC13D bone cancer 0.0320740 0.8628420 0.03207
NA
WRAP73 liver cancer 0.0320740 0.8628420 0.03207
NA
ZNF528 multiple myeloma 0.0320740 0.8628420 0.03207
NA
ZP4 multiple myeloma 0.0320740 0.8628420 0.03207
NA
GPR98 lymphoma 0.0320887 0.8628420 0.03209
NA
NBEA lymphoma 0.0320887 0.8628420 0.03209
NA
SRF lymphoma 0.0320887 0.8628420 0.03209
NA
AKR7A2 skin cancer 0.0320913 0.8628420 0.03209
NA
PRR14L uterine cancer 0.0321163 0.8628420 0.03212
NA
MTA1 uterine cancer 0.0321306 0.8628420 0.03213
NA
NEDD4 uterine cancer 0.0321306 0.8628420 0.03213
NA
SLCO1B3 lung cancer 0.0322479 0.8628420 0.03225
NA
ADAMTS8 colorectal cancer 0.0322566 0.8628420 0.03226
NA
AIFM3 colorectal cancer 0.0322566 0.8628420 0.03226
NA
DDX49 colorectal cancer 0.0322566 0.8628420 0.03226
NA
HDAC7 colorectal cancer 0.0322566 0.8628420 0.03226
NA
PAQR8 colorectal cancer 0.0322566 0.8628420 0.03226
NA
EPS8L2 uterine cancer 0.0322605 0.8628420 0.03226
NA
GSN lung cancer 0.0322773 0.8628420 0.03228
NA
DPP10 lung cancer 0.0323050 0.8628420 0.03230
NA
TTC37 uterine cancer 0.0323430 0.8628420 0.03234
NA
MYEF2 lung cancer 0.0325118 0.8628420 0.03251
NA
GRM1 liver cancer 0.0326085 0.8628420 0.03261
NA
TDRD12 colorectal cancer 0.0328410 0.8628420 0.03284
NA
DENND4C esophageal cancer 0.0328974 0.8628420 0.03290
NA
LRRC36 lung cancer 0.0329021 0.8628420 0.03290
NA
VAV1 lung cancer 0.0329021 0.8628420 0.03290
NA
ACTN2 uterine cancer 0.0329694 0.8628420 0.03297
NA
EVA1C uterine cancer 0.0329694 0.8628420 0.03297
NA
IKZF3 uterine cancer 0.0329694 0.8628420 0.03297
NA
KATNAL1 uterine cancer 0.0329694 0.8628420 0.03297
NA
KIAA1147 uterine cancer 0.0329694 0.8628420 0.03297
NA
LSM2 uterine cancer 0.0329694 0.8628420 0.03297
NA
MAPK8 uterine cancer 0.0329694 0.8628420 0.03297
NA
NOC4L uterine cancer 0.0329694 0.8628420 0.03297
NA
PIGW uterine cancer 0.0329694 0.8628420 0.03297
NA
RUNDC3B uterine cancer 0.0329694 0.8628420 0.03297
NA
SDCCAG8 uterine cancer 0.0329694 0.8628420 0.03297
NA
SLC24A4 uterine cancer 0.0329694 0.8628420 0.03297
NA
SLC25A16 uterine cancer 0.0329694 0.8628420 0.03297
NA
SLC47A1 uterine cancer 0.0329694 0.8628420 0.03297
NA
SMARCC2 uterine cancer 0.0329694 0.8628420 0.03297
NA
SPATA6 uterine cancer 0.0329694 0.8628420 0.03297
NA
ZNF792 uterine cancer 0.0329694 0.8628420 0.03297
NA
ZNF572 lymphoma 0.0331652 0.8628420 0.03317
NA
CBX2 urinary bladder cancer 0.0331939 0.8628420 0.03319
NA
EIF2AK4 urinary bladder cancer 0.0331939 0.8628420 0.03319
NA
PRR14L leukemia 0.0331939 0.8628420 0.03319
NA
C2orf16 breast cancer 0.0331955 0.8628420 0.03320
NA
DLGAP3 uterine cancer 0.0332332 0.8628420 0.03323
NA
LSP1 pancreatic cancer 0.0332421 0.8628420 0.03324
NA
COL4A3 colorectal cancer 0.0332772 0.8628420 0.03328
NA
PLD5 uterine cancer 0.0333115 0.8628420 0.03331
NA
UTRN colorectal cancer 0.0333181 0.8628420 0.03332
NA
GLS lung cancer 0.0333231 0.8628420 0.03332
NA
SLC24A3 lung cancer 0.0333231 0.8628420 0.03332
NA
ZBTB26 lung cancer 0.0333231 0.8628420 0.03332
NA
ICA1L central nervous system cancer 0.0333618 0.8628420 0.03336
NA
BRPF1 pancreatic cancer 0.0333682 0.8628420 0.03337
NA
CDH18 pancreatic cancer 0.0333682 0.8628420 0.03337
NA
DMXL2 pancreatic cancer 0.0333682 0.8628420 0.03337
NA
LRRTM1 pancreatic cancer 0.0333682 0.8628420 0.03337
NA
MYH8 pancreatic cancer 0.0333682 0.8628420 0.03337
NA
ZNF716 pancreatic cancer 0.0333682 0.8628420 0.03337
NA
MYH9 colorectal cancer 0.0334091 0.8628420 0.03341
NA
SLCO1A2 uterine cancer 0.0334693 0.8628420 0.03347
NA
GAD2 uterine cancer 0.0335702 0.8628420 0.03357
NA
MICALL2 uterine cancer 0.0335702 0.8628420 0.03357
NA
TTC27 uterine cancer 0.0335702 0.8628420 0.03357
NA
COL6A1 esophageal cancer 0.0335935 0.8628420 0.03359
NA
MYH7 esophageal cancer 0.0335935 0.8628420 0.03359
NA
PRSS3 esophageal cancer 0.0335935 0.8628420 0.03359
NA
SCML4 esophageal cancer 0.0335935 0.8628420 0.03359
NA
SMIM11 esophageal cancer 0.0335935 0.8628420 0.03359
NA
ZBTB41 esophageal cancer 0.0335935 0.8628420 0.03359
NA
KCNH5 lung cancer 0.0336868 0.8628420 0.03369
NA
NOS1AP lung cancer 0.0336868 0.8628420 0.03369
NA
MEGF8 colorectal cancer 0.0337467 0.8628420 0.03375
NA
ASB16 head and neck cancer 0.0337522 0.8628420 0.03375
NA
CBFA2T3 stomach cancer 0.0337522 0.8628420 0.03375
NA
CEP95 stomach cancer 0.0337522 0.8628420 0.03375
NA
CPNE8 stomach cancer 0.0337522 0.8628420 0.03375
NA
CYP2C19 head and neck cancer 0.0337522 0.8628420 0.03375
NA
CYP4F2 head and neck cancer 0.0337522 0.8628420 0.03375
NA
DYNC1I2 stomach cancer 0.0337522 0.8628420 0.03375
NA
FUT1 stomach cancer 0.0337522 0.8628420 0.03375
NA
IFNAR1 head and neck cancer 0.0337522 0.8628420 0.03375
NA
ITIH2 stomach cancer 0.0337522 0.8628420 0.03375
NA
KIAA1211 stomach cancer 0.0337522 0.8628420 0.03375
NA
LGR6 stomach cancer 0.0337522 0.8628420 0.03375
NA
LRBA head and neck cancer 0.0337522 0.8628420 0.03375
NA
MPRIP stomach cancer 0.0337522 0.8628420 0.03375
NA
NAT10 stomach cancer 0.0337522 0.8628420 0.03375
NA
NRP1 stomach cancer 0.0337522 0.8628420 0.03375
NA
NYNRIN stomach cancer 0.0337522 0.8628420 0.03375
NA
POLN stomach cancer 0.0337522 0.8628420 0.03375
NA
PRRC2B head and neck cancer 0.0337522 0.8628420 0.03375
NA
SETDB1 stomach cancer 0.0337522 0.8628420 0.03375
NA
SOX13 stomach cancer 0.0337522 0.8628420 0.03375
NA
SPEN head and neck cancer 0.0337522 0.8628420 0.03375
NA
ZNF292 stomach cancer 0.0337522 0.8628420 0.03375
NA
HMCN1 peripheral nervous system neoplasm 0.0337888 0.8628420 0.03379
NA
HAND2 colorectal cancer 0.0338654 0.8628420 0.03387
NA
NTPCR colorectal cancer 0.0338654 0.8628420 0.03387
NA
PDPK1 colorectal cancer 0.0338654 0.8628420 0.03387
NA
PIAS1 colorectal cancer 0.0338654 0.8628420 0.03387
NA
U2SURP colorectal cancer 0.0338654 0.8628420 0.03387
NA
WIBG colorectal cancer 0.0338654 0.8628420 0.03387
NA
ASB1 central nervous system cancer 0.0339701 0.8628420 0.03397
NA
BRINP1 central nervous system cancer 0.0339701 0.8628420 0.03397
NA
CAMSAP3 central nervous system cancer 0.0339701 0.8628420 0.03397
NA
CEACAM1 central nervous system cancer 0.0339701 0.8628420 0.03397
NA
CTNNA2 central nervous system cancer 0.0339701 0.8628420 0.03397
NA
ITGAD central nervous system cancer 0.0339701 0.8628420 0.03397
NA
KRT3 central nervous system cancer 0.0339701 0.8628420 0.03397
NA
MYO15A central nervous system cancer 0.0339701 0.8628420 0.03397
NA
STC1 central nervous system cancer 0.0339701 0.8628420 0.03397
NA
SYBU central nervous system cancer 0.0339701 0.8628420 0.03397
NA
IFITM1 skin cancer 0.0339779 0.8628420 0.03398
NA
JSRP1 skin cancer 0.0339779 0.8628420 0.03398
NA
STARD5 skin cancer 0.0339779 0.8628420 0.03398
NA
ZNF85 skin cancer 0.0339779 0.8628420 0.03398
NA
CC2D2B uterine cancer 0.0339879 0.8628420 0.03399
NA
STK17A uterine cancer 0.0339879 0.8628420 0.03399
NA
IQUB lung cancer 0.0340955 0.8628420 0.03410
NA
CEP350 ovarian cancer 0.0341257 0.8628420 0.03413
NA
PCSK9 lung cancer 0.0341408 0.8628420 0.03414
NA
UBAP2 lung cancer 0.0341408 0.8628420 0.03414
NA
MAN2C1 ovarian cancer 0.0341850 0.8628420 0.03419
NA
ZNF716 ovarian cancer 0.0341850 0.8628420 0.03419
NA
UBXN4 lung cancer 0.0342726 0.8628420 0.03427
NA
MYH13 lung cancer 0.0342907 0.8628420 0.03429
NA
ZMYM6NB ovarian cancer 0.0343251 0.8628420 0.03433
NA
LTV1 central nervous system cancer 0.0343598 0.8628420 0.03436
NA
TRPM2 central nervous system cancer 0.0343598 0.8628420 0.03436
NA
BIRC6 colorectal cancer 0.0343825 0.8628420 0.03438
NA
DDX56 colorectal cancer 0.0345511 0.8628420 0.03455
NA
ATM central nervous system cancer 0.0345781 0.8628420 0.03458
NA
DDR1 kidney cancer 0.0346137 0.8628420 0.03461
NA
ENTHD2 kidney cancer 0.0346137 0.8628420 0.03461
NA
IL17RA kidney cancer 0.0346137 0.8628420 0.03461
NA
PROK2 kidney cancer 0.0346137 0.8628420 0.03461
NA
RPL22 kidney cancer 0.0346137 0.8628420 0.03461
NA
DAAM2 skin cancer 0.0346403 0.8628420 0.03464
NA
DACH1 skin cancer 0.0346403 0.8628420 0.03464
NA
POM121L2 skin cancer 0.0346403 0.8628420 0.03464
NA
PRICKLE1 skin cancer 0.0346403 0.8628420 0.03464
NA
PRRC2B skin cancer 0.0346403 0.8628420 0.03464
NA
SAFB skin cancer 0.0346403 0.8628420 0.03464
NA
VPS51 skin cancer 0.0346403 0.8628420 0.03464
NA
DNAH9 skin cancer 0.0347622 0.8628420 0.03476
NA
TRIP12 colorectal cancer 0.0347928 0.8628420 0.03479
NA
C16orf59 uterine cancer 0.0349429 0.8628420 0.03494
NA
DDX60L uterine cancer 0.0349429 0.8628420 0.03494
NA
CNTNAP5 skin cancer 0.0349702 0.8628420 0.03497
NA
APOL5 skin cancer 0.0349770 0.8628420 0.03498
NA
BTBD16 skin cancer 0.0349770 0.8628420 0.03498
NA
GTF2IRD1 skin cancer 0.0349770 0.8628420 0.03498
NA
IMPDH1 skin cancer 0.0349770 0.8628420 0.03498
NA
NRP2 skin cancer 0.0349770 0.8628420 0.03498
NA
PCDHA13 skin cancer 0.0349770 0.8628420 0.03498
NA
POTEG skin cancer 0.0349770 0.8628420 0.03498
NA
PROX1 skin cancer 0.0349770 0.8628420 0.03498
NA
SELP skin cancer 0.0349770 0.8628420 0.03498
NA
SNCG skin cancer 0.0349770 0.8628420 0.03498
NA
TTLL4 skin cancer 0.0349770 0.8628420 0.03498
NA
WRAP53 skin cancer 0.0349770 0.8628420 0.03498
NA
ZBTB9 skin cancer 0.0349770 0.8628420 0.03498
NA
C8A skin cancer 0.0350891 0.8628420 0.03509
NA
EMR2 uterine cancer 0.0350900 0.8628420 0.03509
NA
NUB1 uterine cancer 0.0350900 0.8628420 0.03509
NA
PMS2 uterine cancer 0.0350900 0.8628420 0.03509
NA
SAMD3 uterine cancer 0.0350900 0.8628420 0.03509
NA
SUV420H2 uterine cancer 0.0350900 0.8628420 0.03509
NA
TRIOBP uterine cancer 0.0351594 0.8628420 0.03516
NA
DSCAML1 uterine cancer 0.0352162 0.8628420 0.03522
NA
SPTAN1 urinary bladder cancer 0.0352397 0.8628420 0.03524
NA
MYO10 skin cancer 0.0352451 0.8628420 0.03525
NA
CCT5 leukemia 0.0352565 0.8628420 0.03526
NA
FUT10 leukemia 0.0352565 0.8628420 0.03526
NA
OC90 leukemia 0.0352565 0.8628420 0.03526
NA
SNAP91 leukemia 0.0352565 0.8628420 0.03526
NA
ZC3H7B leukemia 0.0352565 0.8628420 0.03526
NA
ZNF814 leukemia 0.0352565 0.8628420 0.03526
NA
AKR1B15 lung cancer 0.0352664 0.8628420 0.03527
NA
CCDC149 skin cancer 0.0352878 0.8628420 0.03529
NA
C1orf159 uterine cancer 0.0353098 0.8628420 0.03531
NA
SALL1 leukemia 0.0353164 0.8628420 0.03532
NA
CLSTN1 lung cancer 0.0353914 0.8628420 0.03539
NA
HMGXB4 lung cancer 0.0353914 0.8628420 0.03539
NA
PCDHGC5 lung cancer 0.0353914 0.8628420 0.03539
NA
CASKIN2 peripheral nervous system neoplasm 0.0355608 0.8628420 0.03556
NA
HOOK3 peripheral nervous system neoplasm 0.0355608 0.8628420 0.03556
NA
NEURL4 skin cancer 0.0356267 0.8628420 0.03563
NA
BRD1 uterine cancer 0.0356478 0.8628420 0.03565
NA
TYK2 uterine cancer 0.0356478 0.8628420 0.03565
NA
HSPG2 skin cancer 0.0356916 0.8628420 0.03569
NA
PCNT kidney cancer 0.0357181 0.8628420 0.03572
NA
RINL colorectal cancer 0.0357390 0.8628420 0.03574
NA
C2orf71 esophageal cancer 0.0357638 0.8628420 0.03576
NA
CADPS2 esophageal cancer 0.0357638 0.8628420 0.03576
NA
CHRM1 esophageal cancer 0.0357638 0.8628420 0.03576
NA
CREBBP esophageal cancer 0.0357638 0.8628420 0.03576
NA
DEPTOR esophageal cancer 0.0357638 0.8628420 0.03576
NA
DOK1 esophageal cancer 0.0357638 0.8628420 0.03576
NA
DOPEY2 esophageal cancer 0.0357638 0.8628420 0.03576
NA
FAM184A esophageal cancer 0.0357638 0.8628420 0.03576
NA
FOXM1 esophageal cancer 0.0357638 0.8628420 0.03576
NA
IGSF9B esophageal cancer 0.0357638 0.8628420 0.03576
NA
KCNB2 esophageal cancer 0.0357638 0.8628420 0.03576
NA
KIAA0355 esophageal cancer 0.0357638 0.8628420 0.03576
NA
LRRIQ3 esophageal cancer 0.0357638 0.8628420 0.03576
NA
MAN2B2 esophageal cancer 0.0357638 0.8628420 0.03576
NA
MS4A8 esophageal cancer 0.0357638 0.8628420 0.03576
NA
MYPN esophageal cancer 0.0357638 0.8628420 0.03576
NA
NRG3 esophageal cancer 0.0357638 0.8628420 0.03576
NA
OSBPL1A esophageal cancer 0.0357638 0.8628420 0.03576
NA
PCMTD2 esophageal cancer 0.0357638 0.8628420 0.03576
NA
RAPSN esophageal cancer 0.0357638 0.8628420 0.03576
NA
SZT2 esophageal cancer 0.0357638 0.8628420 0.03576
NA
ZNF597 esophageal cancer 0.0357638 0.8628420 0.03576
NA
ZNF177 leukemia 0.0358607 0.8628420 0.03586
NA
PROX1 lung cancer 0.0359365 0.8628420 0.03594
NA
MCOLN3 lung cancer 0.0359447 0.8628420 0.03594
NA
SHD lung cancer 0.0359447 0.8628420 0.03594
NA
TRPV1 lung cancer 0.0359447 0.8628420 0.03594
NA
ADAMTS13 leukemia 0.0360247 0.8628420 0.03602
NA
AMBRA1 leukemia 0.0360247 0.8628420 0.03602
NA
ARSG leukemia 0.0360247 0.8628420 0.03602
NA
COL10A1 leukemia 0.0360247 0.8628420 0.03602
NA
ELAC2 leukemia 0.0360247 0.8628420 0.03602
NA
ERCC6L2 urinary bladder cancer 0.0360247 0.8628420 0.03602
NA
EXT2 leukemia 0.0360247 0.8628420 0.03602
NA
FAM131B leukemia 0.0360247 0.8628420 0.03602
NA
FOXRED1 urinary bladder cancer 0.0360247 0.8628420 0.03602
NA
FRY leukemia 0.0360247 0.8628420 0.03602
NA
HPSE leukemia 0.0360247 0.8628420 0.03602
NA
KIAA1467 leukemia 0.0360247 0.8628420 0.03602
NA
KRAS leukemia 0.0360247 0.8628420 0.03602
NA
LOXL3 leukemia 0.0360247 0.8628420 0.03602
NA
NADK leukemia 0.0360247 0.8628420 0.03602
NA
NFKBIB leukemia 0.0360247 0.8628420 0.03602
NA
NR3C2 leukemia 0.0360247 0.8628420 0.03602
NA
PPM1H leukemia 0.0360247 0.8628420 0.03602
NA
RAB3D urinary bladder cancer 0.0360247 0.8628420 0.03602
NA
RASD2 leukemia 0.0360247 0.8628420 0.03602
NA
RBBP6 leukemia 0.0360247 0.8628420 0.03602
NA
SAFB leukemia 0.0360247 0.8628420 0.03602
NA
SATB1 urinary bladder cancer 0.0360247 0.8628420 0.03602
NA
SCYL1 leukemia 0.0360247 0.8628420 0.03602
NA
SMARCA2 urinary bladder cancer 0.0360247 0.8628420 0.03602
NA
STIL urinary bladder cancer 0.0360247 0.8628420 0.03602
NA
TAS2R5 leukemia 0.0360247 0.8628420 0.03602
NA
TRAF1 leukemia 0.0360247 0.8628420 0.03602
NA
TRDN urinary bladder cancer 0.0360247 0.8628420 0.03602
NA
TTC4 leukemia 0.0360247 0.8628420 0.03602
NA
UBR5 urinary bladder cancer 0.0360247 0.8628420 0.03602
NA
CDC37L1 colorectal cancer 0.0360283 0.8628420 0.03603
NA
EXO5 colorectal cancer 0.0360283 0.8628420 0.03603
NA
IER2 colorectal cancer 0.0360283 0.8628420 0.03603
NA
MLF1 colorectal cancer 0.0360283 0.8628420 0.03603
NA
PI4K2A colorectal cancer 0.0360283 0.8628420 0.03603
NA
SPO11 colorectal cancer 0.0360283 0.8628420 0.03603
NA
TMEM100 colorectal cancer 0.0360283 0.8628420 0.03603
NA
TTLL12 colorectal cancer 0.0360283 0.8628420 0.03603
NA
ASAP3 ovarian cancer 0.0360402 0.8628420 0.03604
NA
CCDC37 ovarian cancer 0.0360402 0.8628420 0.03604
NA
COL6A2 ovarian cancer 0.0360402 0.8628420 0.03604
NA
GTPBP1 ovarian cancer 0.0360402 0.8628420 0.03604
NA
JAKMIP3 breast cancer 0.0360402 0.8628420 0.03604
NA
NKAIN3 ovarian cancer 0.0360402 0.8628420 0.03604
NA
PI4KB ovarian cancer 0.0360402 0.8628420 0.03604
NA
PSD ovarian cancer 0.0360402 0.8628420 0.03604
NA
PVRL3 ovarian cancer 0.0360402 0.8628420 0.03604
NA
SEC16A ovarian cancer 0.0360402 0.8628420 0.03604
NA
ZNF765 ovarian cancer 0.0360402 0.8628420 0.03604
NA
DNAJC13 uterine cancer 0.0360406 0.8628420 0.03604
NA
PRSS3 pancreatic cancer 0.0361401 0.8628420 0.03614
NA
CSMD2 esophageal cancer 0.0361918 0.8628420 0.03619
NA
FILIP1 colorectal cancer 0.0363381 0.8628420 0.03634
NA
FANCA stomach cancer 0.0363586 0.8628420 0.03636
NA
HRNR head and neck cancer 0.0363586 0.8628420 0.03636
NA
MYO15A stomach cancer 0.0363586 0.8628420 0.03636
NA
ROS1 head and neck cancer 0.0363586 0.8628420 0.03636
NA
TMC6 stomach cancer 0.0363586 0.8628420 0.03636
NA
ACSM1 lung cancer 0.0363735 0.8628420 0.03637
NA
LRIT1 lung cancer 0.0363735 0.8628420 0.03637
NA
MSH3 lung cancer 0.0363735 0.8628420 0.03637
NA
AGGF1 lung cancer 0.0364026 0.8628420 0.03640
NA
CEP70 lung cancer 0.0364026 0.8628420 0.03640
NA
DHX35 lung cancer 0.0364026 0.8628420 0.03640
NA
F2RL1 lung cancer 0.0364026 0.8628420 0.03640
NA
KCNJ5 lung cancer 0.0364026 0.8628420 0.03640
NA
KIAA1586 lung cancer 0.0364026 0.8628420 0.03640
NA
LRRC1 lung cancer 0.0364026 0.8628420 0.03640
NA
OR51M1 lung cancer 0.0364026 0.8628420 0.03640
NA
PMS2 lung cancer 0.0364026 0.8628420 0.03640
NA
PNKD lung cancer 0.0364026 0.8628420 0.03640
NA
RAB36 lung cancer 0.0364026 0.8628420 0.03640
NA
WBSCR28 lung cancer 0.0364026 0.8628420 0.03640
NA
DOCK9 uterine cancer 0.0364089 0.8628420 0.03641
NA
IRF6 ovarian cancer 0.0364513 0.8628420 0.03645
NA
TOPAZ1 ovarian cancer 0.0364513 0.8628420 0.03645
NA
CACNA1I uterine cancer 0.0365415 0.8628420 0.03654
NA
DOPEY2 colorectal cancer 0.0365698 0.8628420 0.03657
NA
OTOP2 pancreatic cancer 0.0366730 0.8628420 0.03667
NA
ATP13A5 liver cancer 0.0367729 0.8628420 0.03677
NA
PDE4DIP colorectal cancer 0.0367872 0.8628420 0.03679
NA
ID1 lung cancer 0.0368112 0.8628420 0.03681
NA
LOXL4 lung cancer 0.0368112 0.8628420 0.03681
NA
SPDL1 lung cancer 0.0368112 0.8628420 0.03681
NA
YWHAZ breast cancer 0.0369163 0.8628420 0.03692
NA
FERMT2 central nervous system cancer 0.0370048 0.8628420 0.03700
NA
TPTE lung cancer 0.0371128 0.8628420 0.03711
NA
ZNF292 skin cancer 0.0371443 0.8628420 0.03714
NA
PATZ1 uterine cancer 0.0371593 0.8628420 0.03716
NA
ZNF490 uterine cancer 0.0371593 0.8628420 0.03716
NA
TAF2 breast cancer 0.0372136 0.8628420 0.03721
NA
AJAP1 colorectal cancer 0.0372425 0.8628420 0.03724
NA
APLP2 colorectal cancer 0.0372425 0.8628420 0.03724
NA
C15orf41 colorectal cancer 0.0372425 0.8628420 0.03724
NA
C16orf71 colorectal cancer 0.0372425 0.8628420 0.03724
NA
C17orf104 colorectal cancer 0.0372425 0.8628420 0.03724
NA
C8orf74 colorectal cancer 0.0372425 0.8628420 0.03724
NA
CCDC137 colorectal cancer 0.0372425 0.8628420 0.03724
NA
CCDC54 colorectal cancer 0.0372425 0.8628420 0.03724
NA
CCDC6 colorectal cancer 0.0372425 0.8628420 0.03724
NA
CCDC84 colorectal cancer 0.0372425 0.8628420 0.03724
NA
CSRNP3 colorectal cancer 0.0372425 0.8628420 0.03724
NA
DNAJC5B colorectal cancer 0.0372425 0.8628420 0.03724
NA
HOOK1 colorectal cancer 0.0372425 0.8628420 0.03724
NA
IL20RA colorectal cancer 0.0372425 0.8628420 0.03724
NA
IPO11 colorectal cancer 0.0372425 0.8628420 0.03724
NA
ITPKB colorectal cancer 0.0372425 0.8628420 0.03724
NA
LALBA colorectal cancer 0.0372425 0.8628420 0.03724
NA
LEMD1 colorectal cancer 0.0372425 0.8628420 0.03724
NA
LYPD6B colorectal cancer 0.0372425 0.8628420 0.03724
NA
MGMT colorectal cancer 0.0372425 0.8628420 0.03724
NA
NDST2 colorectal cancer 0.0372425 0.8628420 0.03724
NA
NPAS4 colorectal cancer 0.0372425 0.8628420 0.03724
NA
NR5A1 colorectal cancer 0.0372425 0.8628420 0.03724
NA
NRSN1 colorectal cancer 0.0372425 0.8628420 0.03724
NA
OAS2 colorectal cancer 0.0372425 0.8628420 0.03724
NA
OR6S1 colorectal cancer 0.0372425 0.8628420 0.03724
NA
P2RY2 colorectal cancer 0.0372425 0.8628420 0.03724
NA
PCK2 colorectal cancer 0.0372425 0.8628420 0.03724
NA
POLR2C colorectal cancer 0.0372425 0.8628420 0.03724
NA
PPAPDC2 colorectal cancer 0.0372425 0.8628420 0.03724
NA
PPM1G colorectal cancer 0.0372425 0.8628420 0.03724
NA
RAB38 colorectal cancer 0.0372425 0.8628420 0.03724
NA
RBFOX1 colorectal cancer 0.0372425 0.8628420 0.03724
NA
SEC16B colorectal cancer 0.0372425 0.8628420 0.03724
NA
ST3GAL3 colorectal cancer 0.0372425 0.8628420 0.03724
NA
TNNC2 colorectal cancer 0.0372425 0.8628420 0.03724
NA
TRIM64B colorectal cancer 0.0372425 0.8628420 0.03724
NA
VPS36 colorectal cancer 0.0372425 0.8628420 0.03724
NA
ZNF17 colorectal cancer 0.0372425 0.8628420 0.03724
NA
ZNF23 colorectal cancer 0.0372425 0.8628420 0.03724
NA
ZNF426 colorectal cancer 0.0372425 0.8628420 0.03724
NA
TCERG1 uterine cancer 0.0372530 0.8628420 0.03725
NA
CSMD1 skin cancer 0.0372754 0.8628420 0.03728
NA
IQSEC1 central nervous system cancer 0.0373358 0.8628420 0.03734
NA
NOB1 cancer 0.0373482 0.8628420 0.03735
NA
RAB11FIP5 uterine cancer 0.0373482 0.8628420 0.03735
NA
SCUBE3 uterine cancer 0.0373482 0.8628420 0.03735
NA
CHD9 lung cancer 0.0373606 0.8628420 0.03736
NA
ASIC1 colorectal cancer 0.0373701 0.8628420 0.03737
NA
BCAS3 colorectal cancer 0.0373701 0.8628420 0.03737
NA
SEZ6L colorectal cancer 0.0373701 0.8628420 0.03737
NA
SMC2 colorectal cancer 0.0373701 0.8628420 0.03737
NA
ZRANB1 colorectal cancer 0.0373701 0.8628420 0.03737
NA
DZIP3 multiple myeloma 0.0375182 0.8628420 0.03752
NA
FSCN3 colorectal cancer 0.0375189 0.8628420 0.03752
NA
LENG1 colorectal cancer 0.0375189 0.8628420 0.03752
NA
PCDHB2 colorectal cancer 0.0375189 0.8628420 0.03752
NA
SUPT16H colorectal cancer 0.0375189 0.8628420 0.03752
NA
C7orf62 lung cancer 0.0375324 0.8628420 0.03753
NA
ANKRD18A skin cancer 0.0376395 0.8628420 0.03764
NA
DMRT3 colorectal cancer 0.0377790 0.8628420 0.03778
NA
ANKRD31 lung cancer 0.0378119 0.8628420 0.03781
NA
SMC4 kidney cancer 0.0378881 0.8628420 0.03789
NA
ADAMTS9 lung cancer 0.0380397 0.8628420 0.03804
NA
C12orf60 lung cancer 0.0380397 0.8628420 0.03804
NA
MARCKS lung cancer 0.0380397 0.8628420 0.03804
NA
PDCD4 lung cancer 0.0380397 0.8628420 0.03804
NA
POLR3B lung cancer 0.0380397 0.8628420 0.03804
NA
HMGCR colorectal cancer 0.0381461 0.8628420 0.03815
NA
AGT peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
ATXN7L1 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
CAPN15 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
DCAF17 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
GBF1 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
GPR37 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
HEATR2 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
NRAS peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
NUAK2 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
RNF169 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
TRPM6 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
TTLL6 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
UNC13C peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
WDR87 peripheral nervous system neoplasm 0.0382144 0.8628420 0.03821
NA
COL9A1 ovarian cancer 0.0382678 0.8628420 0.03827
NA
ADAMTS18 colorectal cancer 0.0382761 0.8628420 0.03828
NA
NFASC uterine cancer 0.0383087 0.8628420 0.03831
NA
DNAJC2 uterine cancer 0.0383702 0.8628420 0.03837
NA
DYNC1I1 uterine cancer 0.0383702 0.8628420 0.03837
NA
FAM83A uterine cancer 0.0383702 0.8628420 0.03837
NA
FYN uterine cancer 0.0383702 0.8628420 0.03837
NA
GABRB3 uterine cancer 0.0383702 0.8628420 0.03837
NA
LPO uterine cancer 0.0383702 0.8628420 0.03837
NA
RUNX1T1 uterine cancer 0.0383702 0.8628420 0.03837
NA
NAT10 central nervous system cancer 0.0384222 0.8628420 0.03842
NA
CDH22 uterine cancer 0.0384496 0.8628420 0.03845
NA
FOXJ2 uterine cancer 0.0384496 0.8628420 0.03845
NA
FSHR uterine cancer 0.0384496 0.8628420 0.03845
NA
MICAL2 uterine cancer 0.0384496 0.8628420 0.03845
NA
RPAP1 uterine cancer 0.0384496 0.8628420 0.03845
NA
FAT1 uterine cancer 0.0384683 0.8628420 0.03847
NA
AEBP1 colorectal cancer 0.0384743 0.8628420 0.03847
NA
FLNC leukemia 0.0385137 0.8628420 0.03851
NA
AGAP3 uterine cancer 0.0385207 0.8628420 0.03852
NA
GNB2 uterine cancer 0.0385207 0.8628420 0.03852
NA
OTUD3 uterine cancer 0.0385207 0.8628420 0.03852
NA
SLC9A5 uterine cancer 0.0385207 0.8628420 0.03852
NA
TMEM150B uterine cancer 0.0385207 0.8628420 0.03852
NA
ACO2 breast cancer 0.0385612 0.8628420 0.03856
NA
CANT1 breast cancer 0.0385612 0.8628420 0.03856
NA
CAPNS1 breast cancer 0.0385612 0.8628420 0.03856
NA
CD109 breast cancer 0.0385612 0.8628420 0.03856
NA
CLIP3 breast cancer 0.0385612 0.8628420 0.03856
NA
DOCK2 breast cancer 0.0385612 0.8628420 0.03856
NA
DSCAM breast cancer 0.0385612 0.8628420 0.03856
NA
ITGAL breast cancer 0.0385612 0.8628420 0.03856
NA
ITGAV breast cancer 0.0385612 0.8628420 0.03856
NA
LRRC27 breast cancer 0.0385612 0.8628420 0.03856
NA
MAP3K19 breast cancer 0.0385612 0.8628420 0.03856
NA
NCKAP1L breast cancer 0.0385612 0.8628420 0.03856
NA
NET1 breast cancer 0.0385612 0.8628420 0.03856
NA
PHOSPHO2 breast cancer 0.0385612 0.8628420 0.03856
NA
SCNN1B breast cancer 0.0385612 0.8628420 0.03856
NA
SEZ6L breast cancer 0.0385612 0.8628420 0.03856
NA
ZSCAN22 breast cancer 0.0385612 0.8628420 0.03856
NA
PDE3A colorectal cancer 0.0386062 0.8628420 0.03861
NA
PPP1R9A colorectal cancer 0.0386062 0.8628420 0.03861
NA
MOV10L1 uterine cancer 0.0386689 0.8628420 0.03867
NA
ANKRD35 lung cancer 0.0387295 0.8628420 0.03873
NA
TMEM168 lung cancer 0.0387295 0.8628420 0.03873
NA
MYO1B uterine cancer 0.0387927 0.8628420 0.03879
NA
PDE6B uterine cancer 0.0388613 0.8628420 0.03886
NA
ANKRD30B head and neck cancer 0.0388645 0.8628420 0.03886
NA
AKAP1 central nervous system cancer 0.0388899 0.8628420 0.03889
NA
CABLES1 central nervous system cancer 0.0388899 0.8628420 0.03889
NA
CNTNAP5 central nervous system cancer 0.0388899 0.8628420 0.03889
NA
ELL central nervous system cancer 0.0388899 0.8628420 0.03889
NA
FLG2 central nervous system cancer 0.0388899 0.8628420 0.03889
NA
LRRC8E central nervous system cancer 0.0388899 0.8628420 0.03889
NA
MCPH1 central nervous system cancer 0.0388899 0.8628420 0.03889
NA
MYBL1 central nervous system cancer 0.0388899 0.8628420 0.03889
NA
MYO7A central nervous system cancer 0.0388899 0.8628420 0.03889
NA
PRR22 central nervous system cancer 0.0388899 0.8628420 0.03889
NA
TRPM1 central nervous system cancer 0.0388899 0.8628420 0.03889
NA
VWDE central nervous system cancer 0.0388899 0.8628420 0.03889
NA
WDR35 central nervous system cancer 0.0388899 0.8628420 0.03889
NA
CCDC110 uterine cancer 0.0392086 0.8628420 0.03921
NA
KDM3A uterine cancer 0.0392086 0.8628420 0.03921
NA
MAP2K3 uterine cancer 0.0392086 0.8628420 0.03921
NA
SLC26A7 uterine cancer 0.0392205 0.8628420 0.03922
NA
IFT140 leukemia 0.0393672 0.8628420 0.03937
NA
NRD1 leukemia 0.0393672 0.8628420 0.03937
NA
PAPLN leukemia 0.0393672 0.8628420 0.03937
NA
SOX4 lung cancer 0.0395082 0.8628420 0.03951
NA
CUBN leukemia 0.0396334 0.8628420 0.03963
NA
TENM4 urinary bladder cancer 0.0396334 0.8628420 0.03963
NA
BEGAIN lung cancer 0.0397214 0.8628420 0.03972
NA
CHUK lung cancer 0.0397214 0.8628420 0.03972
NA
CSPP1 lung cancer 0.0397214 0.8628420 0.03972
NA
CYP39A1 lung cancer 0.0397214 0.8628420 0.03972
NA
ENTPD2 lung cancer 0.0397214 0.8628420 0.03972
NA
FLCN lung cancer 0.0397214 0.8628420 0.03972
NA
INTS6 lung cancer 0.0397214 0.8628420 0.03972
NA
KREMEN2 lung cancer 0.0397214 0.8628420 0.03972
NA
LIM2 lung cancer 0.0397214 0.8628420 0.03972
NA
LRRFIP1 lung cancer 0.0397214 0.8628420 0.03972
NA
LRWD1 lung cancer 0.0397214 0.8628420 0.03972
NA
OXSM lung cancer 0.0397214 0.8628420 0.03972
NA
PDZK1 lung cancer 0.0397214 0.8628420 0.03972
NA
PHLPP1 lung cancer 0.0397214 0.8628420 0.03972
NA
PKM lung cancer 0.0397214 0.8628420 0.03972
NA
RHBDD3 lung cancer 0.0397214 0.8628420 0.03972
NA
CHRNA4 leukemia 0.0397512 0.8628420 0.03975
NA
FOXE1 leukemia 0.0397512 0.8628420 0.03975
NA
KDM4A urinary bladder cancer 0.0397512 0.8628420 0.03975
NA
OR4S2 urinary bladder cancer 0.0397512 0.8628420 0.03975
NA
POLR1B leukemia 0.0397512 0.8628420 0.03975
NA
SPTLC3 leukemia 0.0397512 0.8628420 0.03975
NA
NOTCH1 leukemia 0.0397833 0.8628420 0.03978
NA
GOLGA4 uterine cancer 0.0398821 0.8628420 0.03988
NA
CAPN15 central nervous system cancer 0.0399773 0.8628420 0.03998
NA
METTL22 pancreatic cancer 0.0399796 0.8628420 0.03998
NA
NEO1 uterine cancer 0.0400927 0.8628420 0.04009
NA
TLL2 colorectal cancer 0.0401697 0.8628420 0.04017
NA
FSBP skin cancer 0.0402433 0.8628420 0.04024
NA
KBTBD4 skin cancer 0.0402433 0.8628420 0.04024
NA
MYPOP skin cancer 0.0402433 0.8628420 0.04024
NA
NAALADL2 skin cancer 0.0402433 0.8628420 0.04024
NA
RSPH3 skin cancer 0.0402433 0.8628420 0.04024
NA
STK36 skin cancer 0.0402433 0.8628420 0.04024
NA
WIPI2 skin cancer 0.0402433 0.8628420 0.04024
NA
ZSWIM8 skin cancer 0.0402433 0.8628420 0.04024
NA
CCDC91 uterine cancer 0.0402767 0.8628420 0.04028
NA
PAFAH2 uterine cancer 0.0402767 0.8628420 0.04028
NA
SETD4 uterine cancer 0.0402767 0.8628420 0.04028
NA
TAF2 uterine cancer 0.0402767 0.8628420 0.04028
NA
ZNF808 uterine cancer 0.0402767 0.8628420 0.04028
NA
CAD urinary bladder cancer 0.0402920 0.8628420 0.04029
NA
CACNA1S skin cancer 0.0404041 0.8628420 0.04040
NA
SH2D3C skin cancer 0.0404041 0.8628420 0.04040
NA
KIF26B lung cancer 0.0404596 0.8628420 0.04046
NA
PIK3CA urinary bladder cancer 0.0405454 0.8628420 0.04055
NA
FSIP2 breast cancer 0.0405714 0.8628420 0.04057
NA
SBF2 breast cancer 0.0405714 0.8628420 0.04057
NA
IFT122 lung cancer 0.0405819 0.8628420 0.04058
NA
FMO5 central nervous system cancer 0.0407043 0.8628420 0.04070
NA
MYO15A uterine cancer 0.0407178 0.8628420 0.04072
NA
ALS2CR12 lung cancer 0.0408546 0.8628420 0.04085
NA
CDH6 lung cancer 0.0408546 0.8628420 0.04085
NA
FAM160B1 lung cancer 0.0408546 0.8628420 0.04085
NA
GRIK2 lung cancer 0.0408546 0.8628420 0.04085
NA
MX2 lung cancer 0.0408546 0.8628420 0.04085
NA
R3HDM1 lung cancer 0.0408546 0.8628420 0.04085
NA
SEMA7A lung cancer 0.0408546 0.8628420 0.04085
NA
ZNF311 lung cancer 0.0408546 0.8628420 0.04085
NA
XKR6 lung cancer 0.0408871 0.8628420 0.04089
NA
ANXA6 colorectal cancer 0.0409023 0.8628420 0.04090
NA
C11orf54 colorectal cancer 0.0409023 0.8628420 0.04090
NA
CD36 colorectal cancer 0.0409023 0.8628420 0.04090
NA
COG1 colorectal cancer 0.0409023 0.8628420 0.04090
NA
DHX9 colorectal cancer 0.0409023 0.8628420 0.04090
NA
EEA1 colorectal cancer 0.0409023 0.8628420 0.04090
NA
HAUS3 colorectal cancer 0.0409023 0.8628420 0.04090
NA
IFRD2 colorectal cancer 0.0409023 0.8628420 0.04090
NA
MYO1E colorectal cancer 0.0409023 0.8628420 0.04090
NA
NCDN colorectal cancer 0.0409023 0.8628420 0.04090
NA
NLRP2 colorectal cancer 0.0409023 0.8628420 0.04090
NA
SCN11A colorectal cancer 0.0409023 0.8628420 0.04090
NA
SLC4A4 colorectal cancer 0.0409023 0.8628420 0.04090
NA
VPS29 colorectal cancer 0.0409023 0.8628420 0.04090
NA
ZNF286B colorectal cancer 0.0409023 0.8628420 0.04090
NA
COL7A1 lymphoma 0.0409037 0.8628420 0.04090
NA
DCLRE1A lymphoma 0.0409037 0.8628420 0.04090
NA
ETV5 lymphoma 0.0409037 0.8628420 0.04090
NA
GAREML lymphoma 0.0409037 0.8628420 0.04090
NA
NEO1 lymphoma 0.0409037 0.8628420 0.04090
NA
PCM1 lymphoma 0.0409037 0.8628420 0.04090
NA
RNF113B lymphoma 0.0409037 0.8628420 0.04090
NA
AMER2 lung cancer 0.0409185 0.8628420 0.04092
NA
ANKRD28 skin cancer 0.0409511 0.8628420 0.04095
NA
MYO5B skin cancer 0.0409511 0.8628420 0.04095
NA
ALG10B colorectal cancer 0.0409647 0.8628420 0.04096
NA
PRKACB lung cancer 0.0409773 0.8628420 0.04098
NA
SOX17 leukemia 0.0409938 0.8628420 0.04099
NA
WDR87 leukemia 0.0409938 0.8628420 0.04099
NA
SCUBE2 colorectal cancer 0.0410595 0.8628420 0.04106
NA
ZNF92 colorectal cancer 0.0410595 0.8628420 0.04106
NA
FAM65A colorectal cancer 0.0411581 0.8628420 0.04116
NA
KCNQ5 colorectal cancer 0.0412081 0.8628420 0.04121
NA
EFR3A lung cancer 0.0412139 0.8628420 0.04121
NA
TNS3 lung cancer 0.0412139 0.8628420 0.04121
NA
IL15RA multiple myeloma 0.0412218 0.8628420 0.04122
NA
ANKRD32 skin cancer 0.0412580 0.8628420 0.04126
NA
DCHS1 skin cancer 0.0412580 0.8628420 0.04126
NA
EPB41L1 skin cancer 0.0412580 0.8628420 0.04126
NA
KRT5 skin cancer 0.0412580 0.8628420 0.04126
NA
SLC4A2 lung cancer 0.0413707 0.8628420 0.04137
NA
ACTN1 colorectal cancer 0.0413733 0.8628420 0.04137
NA
FAM47E uterine cancer 0.0413827 0.8628420 0.04138
NA
GATS cancer 0.0413827 0.8628420 0.04138
NA
SPTBN2 ovarian cancer 0.0414732 0.8628420 0.04147
NA
CAMSAP2 uterine cancer 0.0415801 0.8628420 0.04158
NA
RBM15 leukemia 0.0415926 0.8628420 0.04159
NA
CRIPAK ovarian cancer 0.0416058 0.8628420 0.04161
NA
LPHN2 ovarian cancer 0.0416058 0.8628420 0.04161
NA
PCOLCE ovarian cancer 0.0416058 0.8628420 0.04161
NA
PRAMEF12 pancreatic cancer 0.0416349 0.8628420 0.04163
NA
AAR2 uterine cancer 0.0416426 0.8628420 0.04164
NA
ADCK1 uterine cancer 0.0416426 0.8628420 0.04164
NA
ARHGDIG uterine cancer 0.0416426 0.8628420 0.04164
NA
CD302 uterine cancer 0.0416426 0.8628420 0.04164
NA
CD8A uterine cancer 0.0416426 0.8628420 0.04164
NA
CD93 uterine cancer 0.0416426 0.8628420 0.04164
NA
EMCN uterine cancer 0.0416426 0.8628420 0.04164
NA
EPX cancer 0.0416426 0.8628420 0.04164
NA
FAM129C uterine cancer 0.0416426 0.8628420 0.04164
NA
FAM174B uterine cancer 0.0416426 0.8628420 0.04164
NA
GPR126 cancer 0.0416426 0.8628420 0.04164
NA
HDAC1 uterine cancer 0.0416426 0.8628420 0.04164
NA
IGFALS uterine cancer 0.0416426 0.8628420 0.04164
NA
IMP3 uterine cancer 0.0416426 0.8628420 0.04164
NA
LARP6 uterine cancer 0.0416426 0.8628420 0.04164
NA
LCTL uterine cancer 0.0416426 0.8628420 0.04164
NA
NAT10 uterine cancer 0.0416426 0.8628420 0.04164
NA
NDUFB10 uterine cancer 0.0416426 0.8628420 0.04164
NA
NOTCH2 uterine cancer 0.0416426 0.8628420 0.04164
NA
OR5B17 uterine cancer 0.0416426 0.8628420 0.04164
NA
PDE12 uterine cancer 0.0416426 0.8628420 0.04164
NA
PGLS uterine cancer 0.0416426 0.8628420 0.04164
NA
POU4F2 uterine cancer 0.0416426 0.8628420 0.04164
NA
PUF60 uterine cancer 0.0416426 0.8628420 0.04164
NA
RND2 uterine cancer 0.0416426 0.8628420 0.04164
NA
RRNAD1 uterine cancer 0.0416426 0.8628420 0.04164
NA
SCN2A cancer 0.0416426 0.8628420 0.04164
NA
SF3B4 uterine cancer 0.0416426 0.8628420 0.04164
NA
SLC27A1 uterine cancer 0.0416426 0.8628420 0.04164
NA
SPATC1 cancer 0.0416426 0.8628420 0.04164
NA
SPHAR uterine cancer 0.0416426 0.8628420 0.04164
NA
SPP2 uterine cancer 0.0416426 0.8628420 0.04164
NA
SRSF6 uterine cancer 0.0416426 0.8628420 0.04164
NA
TAF8 cancer 0.0416426 0.8628420 0.04164
NA
WBSCR28 uterine cancer 0.0416426 0.8628420 0.04164
NA
ZNF140 uterine cancer 0.0416426 0.8628420 0.04164
NA
ZNF426 uterine cancer 0.0416426 0.8628420 0.04164
NA
ZNF543 uterine cancer 0.0416426 0.8628420 0.04164
NA
ARID1A colorectal cancer 0.0417917 0.8628420 0.04179
NA
BACH2 uterine cancer 0.0420436 0.8628420 0.04204
NA
CCDC67 uterine cancer 0.0420436 0.8628420 0.04204
NA
CYP19A1 uterine cancer 0.0420436 0.8628420 0.04204
NA
BAZ2B ovarian cancer 0.0420594 0.8628420 0.04206
NA
VPS13C ovarian cancer 0.0420594 0.8628420 0.04206
NA
HIVEP2 uterine cancer 0.0422470 0.8628420 0.04225
NA
RHOT2 uterine cancer 0.0424318 0.8628420 0.04243
NA
TNRC6C uterine cancer 0.0424318 0.8628420 0.04243
NA
CC2D2A leukemia 0.0424817 0.8628420 0.04248
NA
KIF18A colorectal cancer 0.0424980 0.8628420 0.04250
NA
TNIK uterine cancer 0.0426224 0.8628420 0.04262
NA
CYCS lung cancer 0.0426577 0.8628420 0.04266
NA
FCGBP peripheral nervous system neoplasm 0.0427315 0.8628420 0.04273
NA
F11R multiple myeloma 0.0427881 0.8628420 0.04279
NA
ADAM19 ovarian cancer 0.0428256 0.8628420 0.04283
NA
ATRN ovarian cancer 0.0428256 0.8628420 0.04283
NA
CLCA2 ovarian cancer 0.0428256 0.8628420 0.04283
NA
COL22A1 ovarian cancer 0.0428256 0.8628420 0.04283
NA
FLNC ovarian cancer 0.0428256 0.8628420 0.04283
NA
HSF4 ovarian cancer 0.0428256 0.8628420 0.04283
NA
KPRP ovarian cancer 0.0428256 0.8628420 0.04283
NA
PCDHGB4 ovarian cancer 0.0428256 0.8628420 0.04283
NA
RAPGEF6 ovarian cancer 0.0428256 0.8628420 0.04283
NA
SOX10 ovarian cancer 0.0428256 0.8628420 0.04283
NA
SPG21 ovarian cancer 0.0428256 0.8628420 0.04283
NA
SYT2 ovarian cancer 0.0428256 0.8628420 0.04283
NA
ZFP1 ovarian cancer 0.0428256 0.8628420 0.04283
NA
ACLY lung cancer 0.0428436 0.8628420 0.04284
NA
GTF3C4 lung cancer 0.0428436 0.8628420 0.04284
NA
SLIT2 lung cancer 0.0428841 0.8628420 0.04288
NA
PHF20 colorectal cancer 0.0429335 0.8628420 0.04293
NA
KALRN esophageal cancer 0.0429601 0.8628420 0.04296
NA
PIK3C3 esophageal cancer 0.0429722 0.8628420 0.04297
NA
IL17RA uterine cancer 0.0429795 0.8628420 0.04298
NA
CACNA1A stomach cancer 0.0430059 0.8628420 0.04301
NA
DNAH5 head and neck cancer 0.0430059 0.8628420 0.04301
NA
TNS3 head and neck cancer 0.0430059 0.8628420 0.04301
NA
RARS colorectal cancer 0.0430160 0.8628420 0.04302
NA
CDC6 skin cancer 0.0431187 0.8628420 0.04312
NA
DNM3 skin cancer 0.0431187 0.8628420 0.04312
NA
ESF1 skin cancer 0.0431187 0.8628420 0.04312
NA
HPN skin cancer 0.0431187 0.8628420 0.04312
NA
IL21R skin cancer 0.0431187 0.8628420 0.04312
NA
LIG4 skin cancer 0.0431187 0.8628420 0.04312
NA
OR52I2 skin cancer 0.0431187 0.8628420 0.04312
NA
PARK2 skin cancer 0.0431187 0.8628420 0.04312
NA
PDGFA skin cancer 0.0431187 0.8628420 0.04312
NA
PNLIPRP1 skin cancer 0.0431187 0.8628420 0.04312
NA
RNF43 skin cancer 0.0431187 0.8628420 0.04312
NA
SCUBE1 skin cancer 0.0431187 0.8628420 0.04312
NA
SPRYD3 skin cancer 0.0431187 0.8628420 0.04312
NA
ST6GALNAC4 skin cancer 0.0431187 0.8628420 0.04312
NA
TOM1 skin cancer 0.0431187 0.8628420 0.04312
NA
TPTE2 skin cancer 0.0431187 0.8628420 0.04312
NA
ULK4 skin cancer 0.0431187 0.8628420 0.04312
NA
MUC16 leukemia 0.0431610 0.8628420 0.04316
NA
ACVR2B lung cancer 0.0432936 0.8628420 0.04329
NA
ANKRD13D lung cancer 0.0432936 0.8628420 0.04329
NA
DIO3 lung cancer 0.0432936 0.8628420 0.04329
NA
HOXC6 lung cancer 0.0432936 0.8628420 0.04329
NA
KDM4D lung cancer 0.0432936 0.8628420 0.04329
NA
LRRC10 lung cancer 0.0432936 0.8628420 0.04329
NA
NOL10 lung cancer 0.0432936 0.8628420 0.04329
NA
NPFFR1 lung cancer 0.0432936 0.8628420 0.04329
NA
TAS2R9 lung cancer 0.0432936 0.8628420 0.04329
NA
TRIM24 lung cancer 0.0432936 0.8628420 0.04329
NA
UBE2M kidney cancer 0.0434857 0.8628420 0.04349
NA
ZNF358 kidney cancer 0.0434857 0.8628420 0.04349
NA
C1orf115 pancreatic cancer 0.0435376 0.8628420 0.04354
NA
GABRR2 pancreatic cancer 0.0435376 0.8628420 0.04354
NA
GNPTAB pancreatic cancer 0.0435376 0.8628420 0.04354
NA
MC5R pancreatic cancer 0.0435376 0.8628420 0.04354
NA
NOMO2 pancreatic cancer 0.0435376 0.8628420 0.04354
NA
PLXNA2 pancreatic cancer 0.0435376 0.8628420 0.04354
NA
SFXN1 pancreatic cancer 0.0435376 0.8628420 0.04354
NA
SPTB pancreatic cancer 0.0435376 0.8628420 0.04354
NA
ACACB stomach cancer 0.0435615 0.8628420 0.04356
NA
WDR17 lung cancer 0.0435692 0.8628420 0.04357
NA
KCNH8 uterine cancer 0.0435789 0.8628420 0.04358
NA
LRRC7 liver cancer 0.0435893 0.8628420 0.04359
NA
MATN4 multiple myeloma 0.0435893 0.8628420 0.04359
NA
NKTR bone cancer 0.0435893 0.8628420 0.04359
NA
PHRF1 multiple myeloma 0.0435893 0.8628420 0.04359
NA
PIEZO1 liver cancer 0.0435893 0.8628420 0.04359
NA
SPTBN5 multiple myeloma 0.0435893 0.8628420 0.04359
NA
BBOX1 head and neck cancer 0.0436525 0.8628420 0.04365
NA
PSMB8 stomach cancer 0.0436525 0.8628420 0.04365
NA
TMEM55A stomach cancer 0.0436525 0.8628420 0.04365
NA
STRIP2 uterine cancer 0.0436835 0.8628420 0.04368
NA
CHD8 liver cancer 0.0436906 0.8628420 0.04369
NA
DOCK2 colorectal cancer 0.0437585 0.8628420 0.04376
NA
HTR1E lung cancer 0.0438320 0.8628420 0.04383
NA
PDCD6IP lung cancer 0.0438320 0.8628420 0.04383
NA
SYCE1 lung cancer 0.0438320 0.8628420 0.04383
NA
AKR1C1 lung cancer 0.0438441 0.8628420 0.04384
NA
OR5M10 lung cancer 0.0438441 0.8628420 0.04384
NA
ZRANB2 lung cancer 0.0438441 0.8628420 0.04384
NA
CP lung cancer 0.0438672 0.8628420 0.04387
NA
SIGLEC12 lung cancer 0.0438672 0.8628420 0.04387
NA
NOC4L lung cancer 0.0438862 0.8628420 0.04389
NA
CNOT1 leukemia 0.0438890 0.8628420 0.04389
NA
PDE4D leukemia 0.0438890 0.8628420 0.04389
NA
SFRP2 leukemia 0.0438890 0.8628420 0.04389
NA
A2ML1 uterine cancer 0.0439236 0.8628420 0.04392
NA
SUSD2 uterine cancer 0.0439881 0.8628420 0.04399
NA
XKR4 uterine cancer 0.0439881 0.8628420 0.04399
NA
PKHD1L1 central nervous system cancer 0.0439990 0.8628420 0.04400
NA
PLEKHM3 central nervous system cancer 0.0439990 0.8628420 0.04400
NA
TEKT1 central nervous system cancer 0.0439990 0.8628420 0.04400
NA
RELN colorectal cancer 0.0439992 0.8628420 0.04400
NA
ALAS1 uterine cancer 0.0440110 0.8628420 0.04401
NA
ALKBH3 uterine cancer 0.0440110 0.8628420 0.04401
NA
ANKRD11 cancer 0.0440110 0.8628420 0.04401
NA
ARSB uterine cancer 0.0440110 0.8628420 0.04401
NA
C12orf60 uterine cancer 0.0440110 0.8628420 0.04401
NA
C9orf43 uterine cancer 0.0440110 0.8628420 0.04401
NA
CCDC147 uterine cancer 0.0440110 0.8628420 0.04401
NA
CD22 uterine cancer 0.0440110 0.8628420 0.04401
NA
DHRS12 uterine cancer 0.0440110 0.8628420 0.04401
NA
DPY19L3 uterine cancer 0.0440110 0.8628420 0.04401
NA
EPB41L4B uterine cancer 0.0440110 0.8628420 0.04401
NA
FAM53C uterine cancer 0.0440110 0.8628420 0.04401
NA
FASTK uterine cancer 0.0440110 0.8628420 0.04401
NA
FBXW8 uterine cancer 0.0440110 0.8628420 0.04401
NA
GDF3 uterine cancer 0.0440110 0.8628420 0.04401
NA
KRTAP10-2 uterine cancer 0.0440110 0.8628420 0.04401
NA
LMX1A uterine cancer 0.0440110 0.8628420 0.04401
NA
MFAP4 uterine cancer 0.0440110 0.8628420 0.04401
NA
NOL7 uterine cancer 0.0440110 0.8628420 0.04401
NA
OR52E8 uterine cancer 0.0440110 0.8628420 0.04401
NA
OR5T1 uterine cancer 0.0440110 0.8628420 0.04401
NA
OTUD4 uterine cancer 0.0440110 0.8628420 0.04401
NA
RGS19 uterine cancer 0.0440110 0.8628420 0.04401
NA
SCNN1G uterine cancer 0.0440110 0.8628420 0.04401
NA
SOX11 uterine cancer 0.0440110 0.8628420 0.04401
NA
TJAP1 uterine cancer 0.0440110 0.8628420 0.04401
NA
TTLL9 uterine cancer 0.0440110 0.8628420 0.04401
NA
USH1G uterine cancer 0.0440110 0.8628420 0.04401
NA
ZBTB39 uterine cancer 0.0440110 0.8628420 0.04401
NA
ZNF263 uterine cancer 0.0440110 0.8628420 0.04401
NA
XRN2 uterine cancer 0.0440453 0.8628420 0.04405
NA
GGNBP2 colorectal cancer 0.0440679 0.8628420 0.04407
NA
PITPNM2 colorectal cancer 0.0440679 0.8628420 0.04407
NA
TEP1 colorectal cancer 0.0440679 0.8628420 0.04407
NA
USP8 colorectal cancer 0.0440679 0.8628420 0.04407
NA
ZNF646 colorectal cancer 0.0440679 0.8628420 0.04407
NA
PLXNB1 uterine cancer 0.0440741 0.8628420 0.04407
NA
BTBD10 uterine cancer 0.0440784 0.8628420 0.04408
NA
COL8A1 uterine cancer 0.0440784 0.8628420 0.04408
NA
PCDHB7 uterine cancer 0.0440784 0.8628420 0.04408
NA
PPID uterine cancer 0.0440784 0.8628420 0.04408
NA
TBCK colorectal cancer 0.0442114 0.8628420 0.04421
NA
SIPA1L2 lung cancer 0.0442676 0.8628420 0.04427
NA
DOPEY1 colorectal cancer 0.0443188 0.8628420 0.04432
NA
ENGASE central nervous system cancer 0.0444022 0.8628420 0.04440
NA
FARSB central nervous system cancer 0.0444022 0.8628420 0.04440
NA
LYPLA2 central nervous system cancer 0.0444022 0.8628420 0.04440
NA
MAG central nervous system cancer 0.0444022 0.8628420 0.04440
NA
OR5D18 central nervous system cancer 0.0444022 0.8628420 0.04440
NA
PCDHB13 central nervous system cancer 0.0444022 0.8628420 0.04440
NA
PENK central nervous system cancer 0.0444022 0.8628420 0.04440
NA
TMEM63B central nervous system cancer 0.0444022 0.8628420 0.04440
NA
TTC16 central nervous system cancer 0.0444022 0.8628420 0.04440
NA
TXNRD1 central nervous system cancer 0.0444022 0.8628420 0.04440
NA
UBXN1 central nervous system cancer 0.0444022 0.8628420 0.04440
NA
MYBPC3 colorectal cancer 0.0444552 0.8628420 0.04446
NA
PTPRM colorectal cancer 0.0444552 0.8628420 0.04446
NA
BPHL lung cancer 0.0444926 0.8628420 0.04449
NA
KRT83 lung cancer 0.0444926 0.8628420 0.04449
NA
WDR53 lung cancer 0.0444926 0.8628420 0.04449
NA
MST1R leukemia 0.0445044 0.8628420 0.04450
NA
KIAA1462 kidney cancer 0.0445231 0.8628420 0.04452
NA
MAST2 kidney cancer 0.0445231 0.8628420 0.04452
NA
SHISA9 lung cancer 0.0447699 0.8628420 0.04477
NA
ZDHHC23 breast cancer 0.0447914 0.8628420 0.04479
NA
ACAP1 breast cancer 0.0448103 0.8628420 0.04481
NA
MX1 breast cancer 0.0448103 0.8628420 0.04481
NA
TMEM194A breast cancer 0.0448103 0.8628420 0.04481
NA
TET1 breast cancer 0.0448296 0.8628420 0.04483
NA
ATP8B1 colorectal cancer 0.0448793 0.8628420 0.04488
NA
PSD3 skin cancer 0.0449634 0.8628420 0.04496
NA
ST6GALNAC5 skin cancer 0.0449634 0.8628420 0.04496
NA
TLK1 skin cancer 0.0449634 0.8628420 0.04496
NA
ABCA4 lymphoma 0.0451269 0.8628420 0.04513
NA
CACNA1I lymphoma 0.0451269 0.8628420 0.04513
NA
CCDC116 lymphoma 0.0451269 0.8628420 0.04513
NA
CLUH lymphoma 0.0451269 0.8628420 0.04513
NA
GCC2 lymphoma 0.0451269 0.8628420 0.04513
NA
GNB1 lymphoma 0.0451269 0.8628420 0.04513
NA
LMAN1L lymphoma 0.0451269 0.8628420 0.04513
NA
LTB lymphoma 0.0451269 0.8628420 0.04513
NA
MAP1A lymphoma 0.0451269 0.8628420 0.04513
NA
MYH15 lymphoma 0.0451269 0.8628420 0.04513
NA
NRAS lymphoma 0.0451269 0.8628420 0.04513
NA
OTOF lymphoma 0.0451269 0.8628420 0.04513
NA
PIK3C2B lymphoma 0.0451269 0.8628420 0.04513
NA
SCN8A lymphoma 0.0451269 0.8628420 0.04513
NA
SMARCA5 lymphoma 0.0451269 0.8628420 0.04513
NA
TPRX1 lymphoma 0.0451269 0.8628420 0.04513
NA
ACO2 colorectal cancer 0.0452098 0.8628420 0.04521
NA
ALOX15 central nervous system cancer 0.0452804 0.8628420 0.04528
NA
FIGN liver cancer 0.0454011 0.8628420 0.04540
NA
C6orf132 uterine cancer 0.0454056 0.8628420 0.04541
NA
DNER uterine cancer 0.0454056 0.8628420 0.04541
NA
MVK uterine cancer 0.0454056 0.8628420 0.04541
NA
NBEA esophageal cancer 0.0455003 0.8628420 0.04550
NA
ACAP1 leukemia 0.0455861 0.8628420 0.04559
NA
ACAT1 urinary bladder cancer 0.0455861 0.8628420 0.04559
NA
CHD2 leukemia 0.0455861 0.8628420 0.04559
NA
CRYZL1 urinary bladder cancer 0.0455861 0.8628420 0.04559
NA
EP400 urinary bladder cancer 0.0455861 0.8628420 0.04559
NA
KRTAP5-11 leukemia 0.0455861 0.8628420 0.04559
NA
LRP10 leukemia 0.0455861 0.8628420 0.04559
NA
MAP2K7 leukemia 0.0455861 0.8628420 0.04559
NA
MAPK15 leukemia 0.0455861 0.8628420 0.04559
NA
POR leukemia 0.0455861 0.8628420 0.04559
NA
POSTN leukemia 0.0455861 0.8628420 0.04559
NA
RNF208 leukemia 0.0455861 0.8628420 0.04559
NA
RPS6KA4 leukemia 0.0455861 0.8628420 0.04559
NA
SPRN urinary bladder cancer 0.0455861 0.8628420 0.04559
NA
A2ML1 kidney cancer 0.0456472 0.8628420 0.04565
NA
ARAP3 kidney cancer 0.0456472 0.8628420 0.04565
NA
ATXN7 kidney cancer 0.0456472 0.8628420 0.04565
NA
CCDC137 kidney cancer 0.0456472 0.8628420 0.04565
NA
CLIC1 kidney cancer 0.0456472 0.8628420 0.04565
NA
LTN1 kidney cancer 0.0456472 0.8628420 0.04565
NA
MARVELD2 kidney cancer 0.0456472 0.8628420 0.04565
NA
MRC2 kidney cancer 0.0456472 0.8628420 0.04565
NA
PPP1R15B kidney cancer 0.0456472 0.8628420 0.04565
NA
REM1 kidney cancer 0.0456472 0.8628420 0.04565
NA
ZNF569 kidney cancer 0.0456472 0.8628420 0.04565
NA
CNTROB lung cancer 0.0456809 0.8628420 0.04568
NA
MUC16 kidney cancer 0.0457087 0.8628420 0.04571
NA
DZIP1L lung cancer 0.0457246 0.8628420 0.04572
NA
GSE1 lung cancer 0.0457829 0.8628420 0.04578
NA
TNFSF10 skin cancer 0.0459766 0.8628420 0.04598
NA
LRBA lung cancer 0.0459984 0.8628420 0.04600
NA
RMDN2 uterine cancer 0.0462058 0.8628420 0.04621
NA
SLAMF6 uterine cancer 0.0462058 0.8628420 0.04621
NA
TNS3 uterine cancer 0.0462058 0.8628420 0.04621
NA
NIPBL colorectal cancer 0.0462163 0.8628420 0.04622
NA
DNAH1 skin cancer 0.0463453 0.8628420 0.04635
NA
EBF1 skin cancer 0.0463453 0.8628420 0.04635
NA
TANC2 skin cancer 0.0463866 0.8628420 0.04639
NA
NF1 uterine cancer 0.0463914 0.8628420 0.04639
NA
ALMS1 ovarian cancer 0.0464280 0.8628420 0.04643
NA
TACC2 ovarian cancer 0.0464280 0.8628420 0.04643
NA
ATP6V0A4 uterine cancer 0.0464384 0.8628420 0.04644
NA
OLFM3 uterine cancer 0.0464384 0.8628420 0.04644
NA
SLC4A10 lung cancer 0.0464627 0.8628420 0.04646
NA
WDFY3 lung cancer 0.0464627 0.8628420 0.04646
NA
ABCA3 esophageal cancer 0.0465278 0.8628420 0.04653
NA
HS6ST1 esophageal cancer 0.0465278 0.8628420 0.04653
NA
MAP6 esophageal cancer 0.0465278 0.8628420 0.04653
NA
PRSS22 esophageal cancer 0.0465278 0.8628420 0.04653
NA
ZNF362 esophageal cancer 0.0465278 0.8628420 0.04653
NA
ACSF3 colorectal cancer 0.0465344 0.8628420 0.04653
NA
ADAM17 colorectal cancer 0.0465344 0.8628420 0.04653
NA
ARSG colorectal cancer 0.0465344 0.8628420 0.04653
NA
ATP6V1C1 colorectal cancer 0.0465344 0.8628420 0.04653
NA
BNC2 colorectal cancer 0.0465344 0.8628420 0.04653
NA
BTF3L4 colorectal cancer 0.0465344 0.8628420 0.04653
NA
C11orf21 colorectal cancer 0.0465344 0.8628420 0.04653
NA
CA12 colorectal cancer 0.0465344 0.8628420 0.04653
NA
CPSF3 colorectal cancer 0.0465344 0.8628420 0.04653
NA
CUEDC1 colorectal cancer 0.0465344 0.8628420 0.04653
NA
CYP2C19 colorectal cancer 0.0465344 0.8628420 0.04653
NA
DALRD3 colorectal cancer 0.0465344 0.8628420 0.04653
NA
DEGS1 colorectal cancer 0.0465344 0.8628420 0.04653
NA
FAM160A2 colorectal cancer 0.0465344 0.8628420 0.04653
NA
FLNB colorectal cancer 0.0465344 0.8628420 0.04653
NA
GNB2L1 colorectal cancer 0.0465344 0.8628420 0.04653
NA
HAUS1 colorectal cancer 0.0465344 0.8628420 0.04653
NA
IL27RA colorectal cancer 0.0465344 0.8628420 0.04653
NA
KIAA1324 colorectal cancer 0.0465344 0.8628420 0.04653
NA
KRT18 colorectal cancer 0.0465344 0.8628420 0.04653
NA
LIN28B colorectal cancer 0.0465344 0.8628420 0.04653
NA
LRP10 colorectal cancer 0.0465344 0.8628420 0.04653
NA
LSM1 colorectal cancer 0.0465344 0.8628420 0.04653
NA
MED20 colorectal cancer 0.0465344 0.8628420 0.04653
NA
NUTM2F colorectal cancer 0.0465344 0.8628420 0.04653
NA
OR2T10 colorectal cancer 0.0465344 0.8628420 0.04653
NA
OR5H1 colorectal cancer 0.0465344 0.8628420 0.04653
NA
PKD2 colorectal cancer 0.0465344 0.8628420 0.04653
NA
PLEKHS1 colorectal cancer 0.0465344 0.8628420 0.04653
NA
POLR3B colorectal cancer 0.0465344 0.8628420 0.04653
NA
PWP2 colorectal cancer 0.0465344 0.8628420 0.04653
NA
RNF31 colorectal cancer 0.0465344 0.8628420 0.04653
NA
SLC26A11 colorectal cancer 0.0465344 0.8628420 0.04653
NA
SMYD4 colorectal cancer 0.0465344 0.8628420 0.04653
NA
TEX30 colorectal cancer 0.0465344 0.8628420 0.04653
NA
TMC5 colorectal cancer 0.0465344 0.8628420 0.04653
NA
ZFR colorectal cancer 0.0465344 0.8628420 0.04653
NA
ZNF382 colorectal cancer 0.0465344 0.8628420 0.04653
NA
ZNF534 colorectal cancer 0.0465344 0.8628420 0.04653
NA
ZNF90 colorectal cancer 0.0465344 0.8628420 0.04653
NA
MARCH11 lung cancer 0.0465891 0.8628420 0.04659
NA
PIKFYVE lung cancer 0.0465891 0.8628420 0.04659
NA
PAPPA2 ovarian cancer 0.0465970 0.8628420 0.04660
NA
KCNB2 colorectal cancer 0.0468238 0.8628420 0.04682
NA
TESPA1 colorectal cancer 0.0468238 0.8628420 0.04682
NA
MKI67 kidney cancer 0.0468445 0.8628420 0.04684
NA
GIMAP8 uterine cancer 0.0469242 0.8628420 0.04692
NA
ZNF816 lung cancer 0.0470061 0.8628420 0.04701
NA
IPO4 lung cancer 0.0470163 0.8628420 0.04702
NA
LHX6 lung cancer 0.0470163 0.8628420 0.04702
NA
SRPK2 lung cancer 0.0470163 0.8628420 0.04702
NA
ZNF626 lung cancer 0.0470163 0.8628420 0.04702
NA
NINL uterine cancer 0.0470547 0.8628420 0.04705
NA
FAT1 esophageal cancer 0.0470926 0.8628420 0.04709
NA
PDZD2 esophageal cancer 0.0470926 0.8628420 0.04709
NA
ADAL lung cancer 0.0471334 0.8628420 0.04713
NA
AP1B1 lung cancer 0.0471334 0.8628420 0.04713
NA
APPBP2 lung cancer 0.0471334 0.8628420 0.04713
NA
C19orf38 lung cancer 0.0471334 0.8628420 0.04713
NA
CMA1 lung cancer 0.0471334 0.8628420 0.04713
NA
CPVL lung cancer 0.0471334 0.8628420 0.04713
NA
DENND4C lung cancer 0.0471334 0.8628420 0.04713
NA
ENTPD7 lung cancer 0.0471334 0.8628420 0.04713
NA
FAM49A lung cancer 0.0471334 0.8628420 0.04713
NA
KRTAP10-5 lung cancer 0.0471334 0.8628420 0.04713
NA
OR5H6 lung cancer 0.0471334 0.8628420 0.04713
NA
PIGW lung cancer 0.0471334 0.8628420 0.04713
NA
SSBP2 lung cancer 0.0471334 0.8628420 0.04713
NA
TCHP lung cancer 0.0471334 0.8628420 0.04713
NA
TNFRSF10A lung cancer 0.0471334 0.8628420 0.04713
NA
TUBA3D lung cancer 0.0471334 0.8628420 0.04713
NA
ZCCHC11 lung cancer 0.0471334 0.8628420 0.04713
NA
ZUFSP lung cancer 0.0471334 0.8628420 0.04713
NA
BCL9L multiple myeloma 0.0471767 0.8628420 0.04718
NA
C2orf16 multiple myeloma 0.0471767 0.8628420 0.04718
NA
DPEP2 liver cancer 0.0471767 0.8628420 0.04718
NA
DRD2 bone cancer 0.0471767 0.8628420 0.04718
NA
DSG1 bone cancer 0.0471767 0.8628420 0.04718
NA
FLT4 multiple myeloma 0.0471767 0.8628420 0.04718
NA
FRMPD2 liver cancer 0.0471767 0.8628420 0.04718
NA
IGSF9 bone cancer 0.0471767 0.8628420 0.04718
NA
MAF multiple myeloma 0.0471767 0.8628420 0.04718
NA
MARVELD3 liver cancer 0.0471767 0.8628420 0.04718
NA
MON2 bone cancer 0.0471767 0.8628420 0.04718
NA
MUC17 bone cancer 0.0471767 0.8628420 0.04718
NA
MYOM1 liver cancer 0.0471767 0.8628420 0.04718
NA
PCDHA1 bone cancer 0.0471767 0.8628420 0.04718
NA
RHNO1 multiple myeloma 0.0471767 0.8628420 0.04718
NA
SBF1 bone cancer 0.0471767 0.8628420 0.04718
NA
SEC14L3 bone cancer 0.0471767 0.8628420 0.04718
NA
SELE multiple myeloma 0.0471767 0.8628420 0.04718
NA
SLC39A5 multiple myeloma 0.0471767 0.8628420 0.04718
NA
SULT1C2 liver cancer 0.0471767 0.8628420 0.04718
NA
TECTA liver cancer 0.0471767 0.8628420 0.04718
NA
TMEM132D multiple myeloma 0.0471767 0.8628420 0.04718
NA
TNXB bone cancer 0.0471767 0.8628420 0.04718
NA
TXNRD1 bone cancer 0.0471767 0.8628420 0.04718
NA
WBSCR16 multiple myeloma 0.0471767 0.8628420 0.04718
NA
WBSCR28 liver cancer 0.0471767 0.8628420 0.04718
NA
YTHDC1 liver cancer 0.0471767 0.8628420 0.04718
NA
ZFAT liver cancer 0.0471767 0.8628420 0.04718
NA
ZNF253 multiple myeloma 0.0471767 0.8628420 0.04718
NA
ZNF768 liver cancer 0.0471767 0.8628420 0.04718
NA
PADI1 ovarian cancer 0.0474940 0.8628420 0.04749
NA
CLK4 uterine cancer 0.0475939 0.8628420 0.04759
NA
IFT172 uterine cancer 0.0476609 0.8628420 0.04766
NA
SNAPC4 colorectal cancer 0.0477287 0.8628420 0.04773
NA
SLC36A3 central nervous system cancer 0.0477802 0.8628420 0.04778
NA
UBE3A uterine cancer 0.0478213 0.8628420 0.04782
NA
TRIM50 lung cancer 0.0478227 0.8628420 0.04782
NA
ADAM15 leukemia 0.0480598 0.8628420 0.04806
NA
AK7 leukemia 0.0480598 0.8628420 0.04806
NA
BARD1 leukemia 0.0480598 0.8628420 0.04806
NA
CCDC65 leukemia 0.0480598 0.8628420 0.04806
NA
CCR10 leukemia 0.0480598 0.8628420 0.04806
NA
CENPT leukemia 0.0480598 0.8628420 0.04806
NA
COL1A1 leukemia 0.0480598 0.8628420 0.04806
NA
CSF3R leukemia 0.0480598 0.8628420 0.04806
NA
CSTF3 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
DHX38 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
DNAJB1 leukemia 0.0480598 0.8628420 0.04806
NA
DTNA urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
ESYT2 leukemia 0.0480598 0.8628420 0.04806
NA
FASTKD1 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
FOXG1 leukemia 0.0480598 0.8628420 0.04806
NA
GAB1 leukemia 0.0480598 0.8628420 0.04806
NA
GID4 leukemia 0.0480598 0.8628420 0.04806
NA
GPRIN1 leukemia 0.0480598 0.8628420 0.04806
NA
HIST1H1T leukemia 0.0480598 0.8628420 0.04806
NA
HRH2 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
IL4I1 leukemia 0.0480598 0.8628420 0.04806
NA
ITPRIPL1 leukemia 0.0480598 0.8628420 0.04806
NA
JARID2 leukemia 0.0480598 0.8628420 0.04806
NA
KDM4C leukemia 0.0480598 0.8628420 0.04806
NA
KIAA0825 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
LIM2 leukemia 0.0480598 0.8628420 0.04806
NA
MAP3K5 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
MAP4K3 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
MFSD5 leukemia 0.0480598 0.8628420 0.04806
NA
MSR1 leukemia 0.0480598 0.8628420 0.04806
NA
NOL4 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
NPAS4 leukemia 0.0480598 0.8628420 0.04806
NA
NXPE1 leukemia 0.0480598 0.8628420 0.04806
NA
OR5P3 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
P4HA1 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
PCDHGA8 leukemia 0.0480598 0.8628420 0.04806
NA
PHLDA2 leukemia 0.0480598 0.8628420 0.04806
NA
RAC3 leukemia 0.0480598 0.8628420 0.04806
NA
RPN1 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
SENP1 leukemia 0.0480598 0.8628420 0.04806
NA
SGK223 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
SLC30A4 leukemia 0.0480598 0.8628420 0.04806
NA
SORCS3 leukemia 0.0480598 0.8628420 0.04806
NA
STARD13 leukemia 0.0480598 0.8628420 0.04806
NA
STK3 leukemia 0.0480598 0.8628420 0.04806
NA
TBL1XR1 leukemia 0.0480598 0.8628420 0.04806
NA
TDRD1 leukemia 0.0480598 0.8628420 0.04806
NA
TGFB1 leukemia 0.0480598 0.8628420 0.04806
NA
TIMP4 leukemia 0.0480598 0.8628420 0.04806
NA
TMEM259 leukemia 0.0480598 0.8628420 0.04806
NA
TP63 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
TPO leukemia 0.0480598 0.8628420 0.04806
NA
TRPC4 urinary bladder cancer 0.0480598 0.8628420 0.04806
NA
TUBA3C leukemia 0.0480598 0.8628420 0.04806
NA
UGT8 leukemia 0.0480598 0.8628420 0.04806
NA
ZNF322 leukemia 0.0480598 0.8628420 0.04806
NA
ZNF541 leukemia 0.0480598 0.8628420 0.04806
NA
ZNF721 leukemia 0.0480598 0.8628420 0.04806
NA
KAT6B central nervous system cancer 0.0480810 0.8628420 0.04808
NA
ZNF763 breast cancer 0.0481780 0.8628420 0.04818
NA
PKN1 skin cancer 0.0481834 0.8628420 0.04818
NA
TCEB3 uterine cancer 0.0483537 0.8628420 0.04835
NA
CSMD2 uterine cancer 0.0483549 0.8628420 0.04835
NA
MYH14 central nervous system cancer 0.0483570 0.8628420 0.04836
NA
MTOR uterine cancer 0.0483980 0.8628420 0.04840
NA
OR2T2 lung cancer 0.0484279 0.8628420 0.04843
NA
URB2 uterine cancer 0.0484640 0.8628420 0.04846
NA
AATK breast cancer 0.0485396 0.8628420 0.04854
NA
ATP8B3 breast cancer 0.0485396 0.8628420 0.04854
NA
EXOC8 breast cancer 0.0485396 0.8628420 0.04854
NA
FAM160A2 breast cancer 0.0485396 0.8628420 0.04854
NA
FZD2 breast cancer 0.0485396 0.8628420 0.04854
NA
GP1BA breast cancer 0.0485396 0.8628420 0.04854
NA
LIAS breast cancer 0.0485396 0.8628420 0.04854
NA
MCF2L breast cancer 0.0485396 0.8628420 0.04854
NA
MIER1 breast cancer 0.0485396 0.8628420 0.04854
NA
OR51A2 breast cancer 0.0485396 0.8628420 0.04854
NA
PMPCA breast cancer 0.0485396 0.8628420 0.04854
NA
PPP6R2 breast cancer 0.0485396 0.8628420 0.04854
NA
PREX1 breast cancer 0.0485396 0.8628420 0.04854
NA
PXDNL breast cancer 0.0485396 0.8628420 0.04854
NA
PYGL breast cancer 0.0485396 0.8628420 0.04854
NA
RAB5A breast cancer 0.0485396 0.8628420 0.04854
NA
RAC1 breast cancer 0.0485396 0.8628420 0.04854
NA
SETD1B breast cancer 0.0485396 0.8628420 0.04854
NA
URGCP breast cancer 0.0485396 0.8628420 0.04854
NA
USP3 breast cancer 0.0485396 0.8628420 0.04854
NA
WNT5B breast cancer 0.0485396 0.8628420 0.04854
NA
NOTCH3 uterine cancer 0.0486060 0.8628420 0.04861
NA
SYNE1 stomach cancer 0.0486182 0.8628420 0.04862
NA
HSPA8 lung cancer 0.0486256 0.8628420 0.04863
NA
ACSS1 uterine cancer 0.0486717 0.8628420 0.04867
NA
FDXR uterine cancer 0.0486717 0.8628420 0.04867
NA
NBR1 uterine cancer 0.0486717 0.8628420 0.04867
NA
NFKBIZ uterine cancer 0.0486717 0.8628420 0.04867
NA
PAN3 uterine cancer 0.0486717 0.8628420 0.04867
NA
DNAH3 leukemia 0.0487266 0.8628420 0.04873
NA
SETD1B colorectal cancer 0.0487458 0.8628420 0.04875
NA
IFFO1 colorectal cancer 0.0488055 0.8628420 0.04881
NA
MAST4 lung cancer 0.0488533 0.8628420 0.04885
NA
PTH2R lung cancer 0.0488533 0.8628420 0.04885
NA
CAMK2B skin cancer 0.0489168 0.8628420 0.04892
NA
CCT6B skin cancer 0.0489168 0.8628420 0.04892
NA
MDGA1 skin cancer 0.0489168 0.8628420 0.04892
NA
NLRP14 skin cancer 0.0489168 0.8628420 0.04892
NA
UNC13D skin cancer 0.0489168 0.8628420 0.04892
NA
FLG2 lung cancer 0.0489732 0.8628420 0.04897
NA
NOD2 colorectal cancer 0.0489944 0.8628420 0.04899
NA
SAMD4A colorectal cancer 0.0489944 0.8628420 0.04899
NA
SEMA3E colorectal cancer 0.0489944 0.8628420 0.04899
NA
TMPRSS9 colorectal cancer 0.0489944 0.8628420 0.04899
NA
CLEC5A colorectal cancer 0.0491408 0.8628420 0.04914
NA
ERCC5 colorectal cancer 0.0491408 0.8628420 0.04914
NA
GRB10 colorectal cancer 0.0491408 0.8628420 0.04914
NA
KNOP1 colorectal cancer 0.0491408 0.8628420 0.04914
NA
LGI3 colorectal cancer 0.0491408 0.8628420 0.04914
NA
MERTK colorectal cancer 0.0491408 0.8628420 0.04914
NA
OR1M1 colorectal cancer 0.0491408 0.8628420 0.04914
NA
RBBP9 colorectal cancer 0.0491408 0.8628420 0.04914
NA
RGS3 colorectal cancer 0.0491408 0.8628420 0.04914
NA
SGIP1 colorectal cancer 0.0491408 0.8628420 0.04914
NA
SRSF6 colorectal cancer 0.0491408 0.8628420 0.04914
NA
TOR1AIP2 colorectal cancer 0.0491408 0.8628420 0.04914
NA
ZNF165 colorectal cancer 0.0491408 0.8628420 0.04914
NA
CD109 uterine cancer 0.0493634 0.8628420 0.04936
NA
AMACR uterine cancer 0.0494514 0.8628420 0.04945
NA
BPTF cancer 0.0494514 0.8628420 0.04945
NA
CCDC83 uterine cancer 0.0494514 0.8628420 0.04945
NA
HK1 uterine cancer 0.0494514 0.8628420 0.04945
NA
MCTP1 uterine cancer 0.0494514 0.8628420 0.04945
NA
MYZAP uterine cancer 0.0494514 0.8628420 0.04945
NA
SLC6A9 uterine cancer 0.0494514 0.8628420 0.04945
NA
SMG8 uterine cancer 0.0494514 0.8628420 0.04945
NA
TRAPPC10 uterine cancer 0.0494514 0.8628420 0.04945
NA
GATAD1 lung cancer 0.0494908 0.8628420 0.04949
NA
PALLD lung cancer 0.0494908 0.8628420 0.04949
NA
ZNRF3 lung cancer 0.0494908 0.8628420 0.04949
NA
GLI3 colorectal cancer 0.0495911 0.8628420 0.04959
NA
FAM209A colorectal cancer 0.0496715 0.8628420 0.04967
NA
GRK7 colorectal cancer 0.0496715 0.8628420 0.04967
NA
PIK3CB colorectal cancer 0.0496715 0.8628420 0.04967
NA
SETD2 colorectal cancer 0.0496715 0.8628420 0.04967
NA
CHUK pancreatic cancer 0.0496842 0.8628420 0.04968
NA
ABCA12 colorectal cancer 0.0496897 0.8628420 0.04969
NA
MYO9B colorectal cancer 0.0496897 0.8628420 0.04969
NA
SF3B2 leukemia 0.0497800 0.8628420 0.04978
NA
GTSE1 lung cancer 0.0498556 0.8628420 0.04986
NA
NYNRIN skin cancer 0.0498690 0.8628420 0.04987
NA
OR4S2 lung cancer 0.0498857 0.8628420 0.04989
NA
TRIP11 peripheral nervous system neoplasm 0.0499735 0.8628420 0.04997
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_lineage_allmut_nonsilent_plot <- ggplot(data = crispr_signif_allmut_nonsilent_lineage) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_lineage_allmut_nonsilent_plot

5.2.3 Deleterious and missense mutant vs. Other

crispr_signif_allmut_delmis_lineage <- compare_means(Score ~ Mutation_Status_DeleteriousMissense, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_allmut_delmis_lineage <- adj_signif(crispr_signif_allmut_delmis_lineage)
crispr_signif_allmut_delmis_lineage <- crispr_signif_allmut_delmis_lineage[order(crispr_signif_allmut_delmis_lineage$p),]
saveRDS(crispr_signif_allmut_delmis_lineage, "./data_munging/rds/crispr_signif_allmut_deleteriousmissens_lineage.rds")

# write.table(crispr_signif_allmut_delmis_lineage, file = "~/Desktop/crispr_signif_allmut_deleteriousmissense_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_allmut_delmis_lineage <- readRDS("./data_munging/rds/crispr_signif_allmut_deleteriousmissens_lineage.rds")

knitr::kable(filter(crispr_signif_allmut_delmis_lineage, p < 0.05)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing deleterious and missense mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing deleterious and missense mutant and other cell lines, p < 0.05 (BH-adjusted p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol group_general_lineage_name p p.adj p.format p.signif p.signif.adj
KRAS lung cancer 0.0000000 0.0000729 5.9e-10 **** ****
TP53 lung cancer 0.0000104 0.6484491 1.0e-05 **** NA
TP53 ovarian cancer 0.0001395 0.8627299 0.00014 *** NA
KRAS ovarian cancer 0.0001488 0.8627299 0.00015 *** NA
TP53 central nervous system cancer 0.0004398 0.8627299 0.00044 *** NA
NRAS leukemia 0.0005316 0.8627299 0.00053 *** NA
TP53 leukemia 0.0005388 0.8627299 0.00054 *** NA
NRAS skin cancer 0.0006117 0.8627299 0.00061 *** NA
TP53 skin cancer 0.0008277 0.8627299 0.00083 *** NA
PIK3CA ovarian cancer 0.0008371 0.8627299 0.00084 *** NA
DZANK1 breast cancer 0.0009819 0.8627299 0.00098 *** NA
PIK3CA breast cancer 0.0009842 0.8627299 0.00098 *** NA
KRAS colorectal cancer 0.0010547 0.8627299 0.00105 ** NA
UNC45B lung cancer 0.0011215 0.8627299 0.00112 ** NA
KRT17 breast cancer 0.0012972 0.8627299 0.00130 ** NA
GOLGA3 uterine cancer 0.0013666 0.8627299 0.00137 ** NA
NRAS multiple myeloma 0.0013756 0.8627299 0.00138 ** NA
GTF3C1 lung cancer 0.0013893 0.8627299 0.00139 ** NA
TICRR uterine cancer 0.0014839 0.8627299 0.00148 ** NA
ARID1A pancreatic cancer 0.0014920 0.8627299 0.00149 ** NA
HYOU1 colorectal cancer 0.0018107 0.8627299 0.00181 ** NA
USP34 breast cancer 0.0018820 0.8627299 0.00188 ** NA
MGA uterine cancer 0.0019495 0.8627299 0.00195 ** NA
SVOPL lung cancer 0.0019973 0.8627299 0.00200 ** NA
KMT2B stomach cancer 0.0022800 0.8627299 0.00228 ** NA
ARID1B ovarian cancer 0.0022924 0.8627299 0.00229 ** NA
TNRC6A lung cancer 0.0023744 0.8627299 0.00237 ** NA
SNX29 uterine cancer 0.0026104 0.8627299 0.00261 ** NA
KIF3B ovarian cancer 0.0026230 0.8627299 0.00262 ** NA
KMT2B breast cancer 0.0026433 0.8627299 0.00264 ** NA
GSPT1 colorectal cancer 0.0028115 0.8627299 0.00281 ** NA
AP1G2 breast cancer 0.0029835 0.8627299 0.00298 ** NA
ZNF264 colorectal cancer 0.0029879 0.8627299 0.00299 ** NA
ZNF141 central nervous system cancer 0.0031757 0.8627299 0.00318 ** NA
KMT2B ovarian cancer 0.0032684 0.8627299 0.00327 ** NA
KIAA0586 colorectal cancer 0.0032838 0.8627299 0.00328 ** NA
ANK2 colorectal cancer 0.0033597 0.8627299 0.00336 ** NA
RPS19BP1 multiple myeloma 0.0034613 0.8627299 0.00346 ** NA
TGS1 uterine cancer 0.0035864 0.8627299 0.00359 ** NA
COL2A1 leukemia 0.0036054 0.8627299 0.00361 ** NA
SLIT3 leukemia 0.0036054 0.8627299 0.00361 ** NA
TP53 colorectal cancer 0.0036994 0.8627299 0.00370 ** NA
HTR7 lung cancer 0.0037248 0.8627299 0.00372 ** NA
PAPPA uterine cancer 0.0037971 0.8627299 0.00380 ** NA
ZNF292 lung cancer 0.0038193 0.8627299 0.00382 ** NA
PTEN central nervous system cancer 0.0038648 0.8627299 0.00386 ** NA
PTEN ovarian cancer 0.0039517 0.8627299 0.00395 ** NA
KRAS stomach cancer 0.0040001 0.8627299 0.00400 ** NA
MTMR3 lung cancer 0.0041192 0.8627299 0.00412 ** NA
TSKS uterine cancer 0.0042550 0.8627299 0.00425 ** NA
PTEN uterine cancer 0.0042857 0.8627299 0.00429 ** NA
ARHGAP12 colorectal cancer 0.0042860 0.8627299 0.00429 ** NA
PAM uterine cancer 0.0043488 0.8627299 0.00435 ** NA
PDE10A uterine cancer 0.0043488 0.8627299 0.00435 ** NA
BRAF skin cancer 0.0043710 0.8627299 0.00437 ** NA
ECT2L central nervous system cancer 0.0044085 0.8627299 0.00441 ** NA
VHL kidney cancer 0.0046189 0.8627299 0.00462 ** NA
NCOR2 colorectal cancer 0.0046575 0.8627299 0.00466 ** NA
NLRP9 lung cancer 0.0046872 0.8627299 0.00469 ** NA
LRP4 uterine cancer 0.0046963 0.8627299 0.00470 ** NA
VAV3 lung cancer 0.0047769 0.8627299 0.00478 ** NA
NUP88 uterine cancer 0.0048888 0.8627299 0.00489 ** NA
LRRIQ1 central nervous system cancer 0.0049271 0.8627299 0.00493 ** NA
AXIN1 ovarian cancer 0.0050354 0.8627299 0.00504 ** NA
TNK2 uterine cancer 0.0050864 0.8627299 0.00509 ** NA
DIP2C kidney cancer 0.0052747 0.8627299 0.00527 ** NA
CTAGE15 lung cancer 0.0053375 0.8627299 0.00534 ** NA
LSP1 colorectal cancer 0.0053452 0.8627299 0.00535 ** NA
CORIN colorectal cancer 0.0054756 0.8627299 0.00548 ** NA
SETD2 kidney cancer 0.0056647 0.8627299 0.00566 ** NA
FNDC7 colorectal cancer 0.0057059 0.8627299 0.00571 ** NA
SKOR1 uterine cancer 0.0057795 0.8627299 0.00578 ** NA
HYDIN colorectal cancer 0.0057929 0.8627299 0.00579 ** NA
PARD3B uterine cancer 0.0059302 0.8627299 0.00593 ** NA
FNIP1 ovarian cancer 0.0060557 0.8627299 0.00606 ** NA
AP2A2 breast cancer 0.0061570 0.8627299 0.00616 ** NA
ASXL1 colorectal cancer 0.0061648 0.8627299 0.00616 ** NA
CCT8L2 colorectal cancer 0.0061648 0.8627299 0.00616 ** NA
MTMR14 colorectal cancer 0.0061648 0.8627299 0.00616 ** NA
TTC32 uterine cancer 0.0062881 0.8627299 0.00629 ** NA
NR4A1 lung cancer 0.0064934 0.8627299 0.00649 ** NA
SLC22A17 lung cancer 0.0064934 0.8627299 0.00649 ** NA
FAM208B colorectal cancer 0.0065065 0.8627299 0.00651 ** NA
ROCK1 colorectal cancer 0.0066106 0.8627299 0.00661 ** NA
ZNF521 colorectal cancer 0.0066975 0.8627299 0.00670 ** NA
RFWD3 lung cancer 0.0067488 0.8627299 0.00675 ** NA
TYRP1 lung cancer 0.0067488 0.8627299 0.00675 ** NA
ADRBK2 uterine cancer 0.0067676 0.8627299 0.00677 ** NA
DVL2 uterine cancer 0.0067676 0.8627299 0.00677 ** NA
EXOC8 uterine cancer 0.0067676 0.8627299 0.00677 ** NA
VPS51 pancreatic cancer 0.0067999 0.8627299 0.00680 ** NA
ITSN1 colorectal cancer 0.0069403 0.8627299 0.00694 ** NA
ZNF292 colorectal cancer 0.0069403 0.8627299 0.00694 ** NA
OR5M8 colorectal cancer 0.0070184 0.8627299 0.00702 ** NA
C10orf76 ovarian cancer 0.0070773 0.8627299 0.00708 ** NA
DDX11 lung cancer 0.0070952 0.8627299 0.00710 ** NA
KMT2C multiple myeloma 0.0071541 0.8627299 0.00715 ** NA
MYH6 uterine cancer 0.0071786 0.8627299 0.00718 ** NA
SURF6 uterine cancer 0.0073058 0.8627299 0.00731 ** NA
PIK3CA colorectal cancer 0.0073288 0.8627299 0.00733 ** NA
GLP2R lung cancer 0.0073425 0.8627299 0.00734 ** NA
C1orf86 leukemia 0.0073710 0.8627299 0.00737 ** NA
TEX10 ovarian cancer 0.0075601 0.8627299 0.00756 ** NA
ALPK3 ovarian cancer 0.0076300 0.8627299 0.00763 ** NA
MYOM3 lung cancer 0.0076435 0.8627299 0.00764 ** NA
ALPPL2 ovarian cancer 0.0077480 0.8627299 0.00775 ** NA
TP53 kidney cancer 0.0077589 0.8627299 0.00776 ** NA
PNPLA5 colorectal cancer 0.0077740 0.8627299 0.00777 ** NA
PTPRN2 colorectal cancer 0.0078299 0.8627299 0.00783 ** NA
PTGFRN lung cancer 0.0078691 0.8627299 0.00787 ** NA
PCDH10 uterine cancer 0.0078925 0.8627299 0.00789 ** NA
ANKRD23 colorectal cancer 0.0078965 0.8627299 0.00790 ** NA
RB1 central nervous system cancer 0.0079424 0.8627299 0.00794 ** NA
HERC1 skin cancer 0.0079501 0.8627299 0.00795 ** NA
SCFD1 colorectal cancer 0.0079828 0.8627299 0.00798 ** NA
C12orf4 uterine cancer 0.0080215 0.8627299 0.00802 ** NA
EGFLAM lung cancer 0.0081906 0.8627299 0.00819 ** NA
SPRED1 lung cancer 0.0084512 0.8627299 0.00845 ** NA
MROH1 pancreatic cancer 0.0084519 0.8627299 0.00845 ** NA
SBF2 lung cancer 0.0084541 0.8627299 0.00845 ** NA
EFCAB5 ovarian cancer 0.0084624 0.8627299 0.00846 ** NA
C6orf211 uterine cancer 0.0085754 0.8627299 0.00858 ** NA
CSNK1D uterine cancer 0.0085754 0.8627299 0.00858 ** NA
FAM110A uterine cancer 0.0085754 0.8627299 0.00858 ** NA
MICAL1 uterine cancer 0.0085754 0.8627299 0.00858 ** NA
MORF4L1 uterine cancer 0.0085754 0.8627299 0.00858 ** NA
RIOK2 uterine cancer 0.0085754 0.8627299 0.00858 ** NA
GAA colorectal cancer 0.0085960 0.8627299 0.00860 ** NA
KIAA1107 colorectal cancer 0.0085960 0.8627299 0.00860 ** NA
ZNF536 skin cancer 0.0086987 0.8627299 0.00870 ** NA
RPS6KA2 uterine cancer 0.0087779 0.8627299 0.00878 ** NA
TPR lung cancer 0.0088831 0.8627299 0.00888 ** NA
SHANK1 central nervous system cancer 0.0088878 0.8627299 0.00889 ** NA
TECRL lung cancer 0.0089331 0.8627299 0.00893 ** NA
CLEC9A liver cancer 0.0090085 0.8627299 0.00901 ** NA
SVEP1 skin cancer 0.0090238 0.8627299 0.00902 ** NA
COX4I1 lung cancer 0.0091372 0.8627299 0.00914 ** NA
DPYSL5 uterine cancer 0.0091517 0.8627299 0.00915 ** NA
FAM189A1 uterine cancer 0.0091517 0.8627299 0.00915 ** NA
IRX6 uterine cancer 0.0091517 0.8627299 0.00915 ** NA
XKR9 uterine cancer 0.0091517 0.8627299 0.00915 ** NA
KIAA0922 lung cancer 0.0091532 0.8627299 0.00915 ** NA
TTF1 lung cancer 0.0092125 0.8627299 0.00921 ** NA
SYNE1 lung cancer 0.0092324 0.8627299 0.00923 ** NA
TBC1D10B uterine cancer 0.0092568 0.8627299 0.00926 ** NA
DNAJC8 uterine cancer 0.0092717 0.8627299 0.00927 ** NA
PKDCC uterine cancer 0.0092717 0.8627299 0.00927 ** NA
TCF3 uterine cancer 0.0092717 0.8627299 0.00927 ** NA
ZNF207 uterine cancer 0.0093098 0.8627299 0.00931 ** NA
RASIP1 colorectal cancer 0.0093199 0.8627299 0.00932 ** NA
AP5B1 uterine cancer 0.0093215 0.8627299 0.00932 ** NA
RAD50 leukemia 0.0094090 0.8627299 0.00941 ** NA
DNAH5 colorectal cancer 0.0095928 0.8627299 0.00959 ** NA
TJP3 head and neck cancer 0.0096224 0.8627299 0.00962 ** NA
NRP2 colorectal cancer 0.0096226 0.8627299 0.00962 ** NA
INTS4 uterine cancer 0.0096407 0.8627299 0.00964 ** NA
TCHH liver cancer 0.0096613 0.8627299 0.00966 ** NA
TTF1 leukemia 0.0097690 0.8627299 0.00977 ** NA
ZNF343 lung cancer 0.0098486 0.8627299 0.00985 ** NA
LILRB2 leukemia 0.0098632 0.8627299 0.00986 ** NA
ZNF469 uterine cancer 0.0099581 0.8627299 0.00996 ** NA
IPO4 uterine cancer 0.0099688 0.8627299 0.00997 ** NA
TET3 ovarian cancer 0.0100008 0.8627299 0.01000
NA
USP21 ovarian cancer 0.0100008 0.8627299 0.01000
NA
SP140L lung cancer 0.0100344 0.8627299 0.01003
NA
TBC1D9 colorectal cancer 0.0100658 0.8627299 0.01007
NA
SPTBN5 central nervous system cancer 0.0100977 0.8627299 0.01010
NA
ELAC2 lung cancer 0.0102227 0.8627299 0.01022
NA
LGSN uterine cancer 0.0103804 0.8627299 0.01038
NA
ZNF581 leukemia 0.0103818 0.8627299 0.01038
NA
ARID1A skin cancer 0.0104238 0.8627299 0.01042
NA
SLC22A9 skin cancer 0.0104238 0.8627299 0.01042
NA
UNC13B skin cancer 0.0104238 0.8627299 0.01042
NA
TRIOBP colorectal cancer 0.0104464 0.8627299 0.01045
NA
B4GALNT3 colorectal cancer 0.0104834 0.8627299 0.01048
NA
SCN10A pancreatic cancer 0.0104889 0.8627299 0.01049
NA
SUGP1 lung cancer 0.0105193 0.8627299 0.01052
NA
DNAH11 uterine cancer 0.0107248 0.8627299 0.01072
NA
SEMA4G uterine cancer 0.0108615 0.8627299 0.01086
NA
CD180 lung cancer 0.0109209 0.8627299 0.01092
NA
MYH13 central nervous system cancer 0.0112036 0.8627299 0.01120
NA
DDC uterine cancer 0.0112169 0.8627299 0.01122
NA
ITGB4 lung cancer 0.0112630 0.8627299 0.01126
NA
RBM39 uterine cancer 0.0113320 0.8627299 0.01133
NA
PIK3CA head and neck cancer 0.0115400 0.8627299 0.01154
NA
SLC22A17 stomach cancer 0.0115400 0.8627299 0.01154
NA
KLHL18 colorectal cancer 0.0115434 0.8627299 0.01154
NA
ZNF132 colorectal cancer 0.0115434 0.8627299 0.01154
NA
VPS13D colorectal cancer 0.0117450 0.8627299 0.01174
NA
ARHGEF10L ovarian cancer 0.0117835 0.8627299 0.01178
NA
DHX36 uterine cancer 0.0118194 0.8627299 0.01182
NA
EIF2D uterine cancer 0.0118466 0.8627299 0.01185
NA
LIG3 cancer 0.0118466 0.8627299 0.01185
NA
SLC24A5 uterine cancer 0.0118466 0.8627299 0.01185
NA
LRRC24 lung cancer 0.0118764 0.8627299 0.01188
NA
PFAS lung cancer 0.0118764 0.8627299 0.01188
NA
IL27RA esophageal cancer 0.0119719 0.8627299 0.01197
NA
USP6NL bone cancer 0.0120377 0.8627299 0.01204
NA
UBASH3B uterine cancer 0.0121489 0.8627299 0.01215
NA
CLSPN colorectal cancer 0.0121613 0.8627299 0.01216
NA
COG6 colorectal cancer 0.0121613 0.8627299 0.01216
NA
KIAA0319L colorectal cancer 0.0121613 0.8627299 0.01216
NA
KLHL12 colorectal cancer 0.0121613 0.8627299 0.01216
NA
TSGA10 colorectal cancer 0.0121613 0.8627299 0.01216
NA
TPR ovarian cancer 0.0122681 0.8627299 0.01227
NA
EXO1 lung cancer 0.0122948 0.8627299 0.01229
NA
ATP13A5 uterine cancer 0.0123809 0.8627299 0.01238
NA
MTMR12 uterine cancer 0.0123944 0.8627299 0.01239
NA
GRIN1 uterine cancer 0.0125718 0.8627299 0.01257
NA
HELB uterine cancer 0.0126206 0.8627299 0.01262
NA
ZNF454 uterine cancer 0.0126206 0.8627299 0.01262
NA
SCN4A colorectal cancer 0.0127308 0.8627299 0.01273
NA
ABCC3 skin cancer 0.0128117 0.8627299 0.01281
NA
ABCC6 lung cancer 0.0128413 0.8627299 0.01284
NA
ZNF827 lung cancer 0.0128413 0.8627299 0.01284
NA
BRAF breast cancer 0.0128473 0.8627299 0.01285
NA
C6orf223 uterine cancer 0.0128512 0.8627299 0.01285
NA
SRP68 uterine cancer 0.0128512 0.8627299 0.01285
NA
TMPPE uterine cancer 0.0128512 0.8627299 0.01285
NA
CHRM3 lung cancer 0.0129054 0.8627299 0.01291
NA
DGKQ lung cancer 0.0129054 0.8627299 0.01291
NA
PSKH2 lung cancer 0.0129054 0.8627299 0.01291
NA
HLA-G lung cancer 0.0129294 0.8627299 0.01293
NA
ECT2 lung cancer 0.0132161 0.8627299 0.01322
NA
SORCS3 uterine cancer 0.0132719 0.8627299 0.01327
NA
IQGAP1 skin cancer 0.0134888 0.8627299 0.01349
NA
PPP3R1 skin cancer 0.0134888 0.8627299 0.01349
NA
PCDHGA2 colorectal cancer 0.0136086 0.8627299 0.01361
NA
NOS3 colorectal cancer 0.0137107 0.8627299 0.01371
NA
HEATR1 lung cancer 0.0137738 0.8627299 0.01377
NA
UGGT2 leukemia 0.0137795 0.8627299 0.01378
NA
ATP2B4 leukemia 0.0138033 0.8627299 0.01380
NA
SETBP1 colorectal cancer 0.0138037 0.8627299 0.01380
NA
ZNF136 uterine cancer 0.0138645 0.8627299 0.01386
NA
KIF26A colorectal cancer 0.0139045 0.8627299 0.01390
NA
VPS41 colorectal cancer 0.0139045 0.8627299 0.01390
NA
RFPL4B central nervous system cancer 0.0139274 0.8627299 0.01393
NA
PDE1A lung cancer 0.0140124 0.8627299 0.01401
NA
SAMD11 lung cancer 0.0140124 0.8627299 0.01401
NA
SIGLEC7 lung cancer 0.0140124 0.8627299 0.01401
NA
OXCT1 uterine cancer 0.0140391 0.8627299 0.01404
NA
CAGE1 uterine cancer 0.0141081 0.8627299 0.01411
NA
IQUB uterine cancer 0.0142430 0.8627299 0.01424
NA
ZBTB41 colorectal cancer 0.0142761 0.8627299 0.01428
NA
ITIH1 uterine cancer 0.0143762 0.8627299 0.01438
NA
SMCR8 uterine cancer 0.0144732 0.8627299 0.01447
NA
TP53 urinary bladder cancer 0.0146235 0.8627299 0.01462
NA
JAG2 central nervous system cancer 0.0149192 0.8627299 0.01492
NA
GFRA3 colorectal cancer 0.0150873 0.8627299 0.01509
NA
RFXANK colorectal cancer 0.0150873 0.8627299 0.01509
NA
SEC22A colorectal cancer 0.0150873 0.8627299 0.01509
NA
VASN colorectal cancer 0.0150873 0.8627299 0.01509
NA
IL17RD colorectal cancer 0.0151103 0.8627299 0.01511
NA
NOS1 lung cancer 0.0151398 0.8627299 0.01514
NA
SOX30 lung cancer 0.0152024 0.8627299 0.01520
NA
ZC3H18 uterine cancer 0.0152235 0.8627299 0.01522
NA
KIAA1731 ovarian cancer 0.0154482 0.8627299 0.01545
NA
KNDC1 liver cancer 0.0154514 0.8627299 0.01545
NA
NNT lung cancer 0.0154639 0.8627299 0.01546
NA
JMJD1C kidney cancer 0.0155331 0.8627299 0.01553
NA
CRISP3 lung cancer 0.0155759 0.8627299 0.01558
NA
WDR11 lung cancer 0.0156454 0.8627299 0.01565
NA
ANKRD55 colorectal cancer 0.0157625 0.8627299 0.01576
NA
ATP8A2 colorectal cancer 0.0157625 0.8627299 0.01576
NA
CARS colorectal cancer 0.0157625 0.8627299 0.01576
NA
PLEKHG4B uterine cancer 0.0158232 0.8627299 0.01582
NA
SLK uterine cancer 0.0158232 0.8627299 0.01582
NA
C14orf39 uterine cancer 0.0158941 0.8627299 0.01589
NA
PCDHGA3 uterine cancer 0.0158941 0.8627299 0.01589
NA
NTRK1 uterine cancer 0.0160319 0.8627299 0.01603
NA
PIK3CG uterine cancer 0.0160319 0.8627299 0.01603
NA
BRD4 lymphoma 0.0160440 0.8627299 0.01604
NA
DDX59 lymphoma 0.0160440 0.8627299 0.01604
NA
CEP290 colorectal cancer 0.0160938 0.8627299 0.01609
NA
BSDC1 uterine cancer 0.0161801 0.8627299 0.01618
NA
COMP uterine cancer 0.0161801 0.8627299 0.01618
NA
ACSBG1 lung cancer 0.0162285 0.8627299 0.01623
NA
ZZZ3 uterine cancer 0.0162966 0.8627299 0.01630
NA
SMG1 esophageal cancer 0.0163951 0.8627299 0.01640
NA
CFTR colorectal cancer 0.0164072 0.8627299 0.01641
NA
MIS18BP1 colorectal cancer 0.0164072 0.8627299 0.01641
NA
PTPRE colorectal cancer 0.0164072 0.8627299 0.01641
NA
SREK1 colorectal cancer 0.0164072 0.8627299 0.01641
NA
NBAS skin cancer 0.0164406 0.8627299 0.01644
NA
CYTH4 lung cancer 0.0164805 0.8627299 0.01648
NA
ITGA2 lung cancer 0.0164805 0.8627299 0.01648
NA
TP53 uterine cancer 0.0165330 0.8627299 0.01653
NA
PDGFRA colorectal cancer 0.0165448 0.8627299 0.01654
NA
TOP2A colorectal cancer 0.0165482 0.8627299 0.01655
NA
CLEC4F skin cancer 0.0165842 0.8627299 0.01658
NA
KRT19 urinary bladder cancer 0.0166681 0.8627299 0.01667
NA
PLEC head and neck cancer 0.0166707 0.8627299 0.01667
NA
ASAP2 uterine cancer 0.0166803 0.8627299 0.01668
NA
SLFN12L uterine cancer 0.0166803 0.8627299 0.01668
NA
KNTC1 uterine cancer 0.0166884 0.8627299 0.01669
NA
POLE uterine cancer 0.0166884 0.8627299 0.01669
NA
MPO leukemia 0.0167340 0.8627299 0.01673
NA
ZC3H13 urinary bladder cancer 0.0167340 0.8627299 0.01673
NA
CHD2 uterine cancer 0.0168725 0.8627299 0.01687
NA
TRAM1L1 central nervous system cancer 0.0169020 0.8627299 0.01690
NA
CCDC77 uterine cancer 0.0169268 0.8627299 0.01693
NA
BRAF ovarian cancer 0.0170103 0.8627299 0.01701
NA
HSF1 ovarian cancer 0.0170103 0.8627299 0.01701
NA
SMC1B ovarian cancer 0.0170103 0.8627299 0.01701
NA
ZNF592 head and neck cancer 0.0172390 0.8627299 0.01724
NA
ST5 uterine cancer 0.0172718 0.8627299 0.01727
NA
PHYH lung cancer 0.0173326 0.8627299 0.01733
NA
ZCCHC24 lung cancer 0.0173326 0.8627299 0.01733
NA
GATS ovarian cancer 0.0173464 0.8627299 0.01735
NA
PPP2R5B bone cancer 0.0173572 0.8627299 0.01736
NA
DNAH6 colorectal cancer 0.0173625 0.8627299 0.01736
NA
KRTAP19-6 lung cancer 0.0173813 0.8627299 0.01738
NA
RERGL lung cancer 0.0173813 0.8627299 0.01738
NA
SLC46A2 lung cancer 0.0173813 0.8627299 0.01738
NA
SLC6A18 lung cancer 0.0173813 0.8627299 0.01738
NA
TOMM40 lung cancer 0.0173813 0.8627299 0.01738
NA
GNL3 colorectal cancer 0.0174434 0.8627299 0.01744
NA
OR51I2 colorectal cancer 0.0174434 0.8627299 0.01744
NA
PUF60 colorectal cancer 0.0174434 0.8627299 0.01744
NA
ZBBX colorectal cancer 0.0174434 0.8627299 0.01744
NA
RYR3 central nervous system cancer 0.0175113 0.8627299 0.01751
NA
DCAF8 lung cancer 0.0175301 0.8627299 0.01753
NA
ATRNL1 lung cancer 0.0175487 0.8627299 0.01755
NA
DAGLA leukemia 0.0175662 0.8627299 0.01757
NA
SEPT14 lung cancer 0.0176723 0.8627299 0.01767
NA
FCRL3 skin cancer 0.0177061 0.8627299 0.01771
NA
ADAM17 uterine cancer 0.0178172 0.8627299 0.01782
NA
BMPER uterine cancer 0.0178172 0.8627299 0.01782
NA
C11orf57 uterine cancer 0.0178172 0.8627299 0.01782
NA
DCUN1D4 uterine cancer 0.0178172 0.8627299 0.01782
NA
FRMD4B uterine cancer 0.0178172 0.8627299 0.01782
NA
GALK1 uterine cancer 0.0178172 0.8627299 0.01782
NA
HABP4 uterine cancer 0.0178172 0.8627299 0.01782
NA
SPHK2 uterine cancer 0.0178172 0.8627299 0.01782
NA
SRPR uterine cancer 0.0178172 0.8627299 0.01782
NA
TIMD4 uterine cancer 0.0178172 0.8627299 0.01782
NA
ARHGDIB lung cancer 0.0178521 0.8627299 0.01785
NA
LACRT lung cancer 0.0178521 0.8627299 0.01785
NA
TSHZ2 lung cancer 0.0178521 0.8627299 0.01785
NA
NAA60 skin cancer 0.0179741 0.8627299 0.01797
NA
IPCEF1 uterine cancer 0.0179937 0.8627299 0.01799
NA
STT3B uterine cancer 0.0179937 0.8627299 0.01799
NA
FBXO46 colorectal cancer 0.0180867 0.8627299 0.01809
NA
MAN1B1 uterine cancer 0.0181827 0.8627299 0.01818
NA
NUP62 uterine cancer 0.0181827 0.8627299 0.01818
NA
TUBGCP5 uterine cancer 0.0181827 0.8627299 0.01818
NA
CEP192 leukemia 0.0181845 0.8627299 0.01818
NA
ERF leukemia 0.0181845 0.8627299 0.01818
NA
LY75 leukemia 0.0181845 0.8627299 0.01818
NA
NRAS lung cancer 0.0182610 0.8627299 0.01826
NA
EXOC1 uterine cancer 0.0183476 0.8627299 0.01835
NA
TOPAZ1 uterine cancer 0.0184163 0.8627299 0.01842
NA
COMP colorectal cancer 0.0186163 0.8627299 0.01862
NA
ENTPD4 colorectal cancer 0.0186163 0.8627299 0.01862
NA
NLRP14 colorectal cancer 0.0186163 0.8627299 0.01862
NA
WDR3 colorectal cancer 0.0187002 0.8627299 0.01870
NA
OPTN uterine cancer 0.0187215 0.8627299 0.01872
NA
TMPRSS4 uterine cancer 0.0187215 0.8627299 0.01872
NA
CASZ1 skin cancer 0.0187389 0.8627299 0.01874
NA
LHX8 lung cancer 0.0187985 0.8627299 0.01880
NA
OR10W1 lung cancer 0.0187985 0.8627299 0.01880
NA
TXNDC16 lung cancer 0.0188103 0.8627299 0.01881
NA
CENPK uterine cancer 0.0188289 0.8627299 0.01883
NA
SPAG17 uterine cancer 0.0189001 0.8627299 0.01890
NA
ATP13A5 lymphoma 0.0189035 0.8627299 0.01890
NA
TCHH kidney cancer 0.0189394 0.8627299 0.01894
NA
ZBTB3 lung cancer 0.0189829 0.8627299 0.01898
NA
CDKN2A pancreatic cancer 0.0190032 0.8627299 0.01900
NA
RBM15 leukemia 0.0190450 0.8627299 0.01904
NA
MYO3B central nervous system cancer 0.0191124 0.8627299 0.01911
NA
LPCAT2 lung cancer 0.0191409 0.8627299 0.01914
NA
PIP5KL1 lung cancer 0.0191409 0.8627299 0.01914
NA
PLIN4 skin cancer 0.0191460 0.8627299 0.01915
NA
ABCB11 colorectal cancer 0.0191531 0.8627299 0.01915
NA
BAZ2B kidney cancer 0.0192345 0.8627299 0.01923
NA
ANGEL2 central nervous system cancer 0.0192461 0.8627299 0.01925
NA
ANKRD36 central nervous system cancer 0.0192461 0.8627299 0.01925
NA
DTNB central nervous system cancer 0.0192461 0.8627299 0.01925
NA
FLNB central nervous system cancer 0.0192461 0.8627299 0.01925
NA
SLC35A5 central nervous system cancer 0.0192461 0.8627299 0.01925
NA
SYNJ2 central nervous system cancer 0.0192461 0.8627299 0.01925
NA
LRGUK colorectal cancer 0.0192474 0.8627299 0.01925
NA
MRVI1 colorectal cancer 0.0192474 0.8627299 0.01925
NA
NFIA colorectal cancer 0.0192474 0.8627299 0.01925
NA
PLOD1 colorectal cancer 0.0192474 0.8627299 0.01925
NA
GOLGA6L9 central nervous system cancer 0.0192773 0.8627299 0.01928
NA
NCAPD2 colorectal cancer 0.0192795 0.8627299 0.01928
NA
UNC80 leukemia 0.0192996 0.8627299 0.01930
NA
OR4N2 lung cancer 0.0193226 0.8627299 0.01932
NA
SLC6A17 lung cancer 0.0193226 0.8627299 0.01932
NA
ZNF213 lung cancer 0.0193226 0.8627299 0.01932
NA
MKI67 skin cancer 0.0194253 0.8627299 0.01943
NA
FMN2 esophageal cancer 0.0195175 0.8627299 0.01952
NA
CEP250 esophageal cancer 0.0196244 0.8627299 0.01962
NA
ANKRD11 central nervous system cancer 0.0196394 0.8627299 0.01964
NA
PUS10 uterine cancer 0.0196882 0.8627299 0.01969
NA
PCDHGB1 liver cancer 0.0196896 0.8627299 0.01969
NA
FUT5 colorectal cancer 0.0198845 0.8627299 0.01988
NA
FAM135B uterine cancer 0.0199102 0.8627299 0.01991
NA
ABCA6 lung cancer 0.0199212 0.8627299 0.01992
NA
C17orf70 ovarian cancer 0.0199355 0.8627299 0.01994
NA
GCN1L1 ovarian cancer 0.0199355 0.8627299 0.01994
NA
PLA2G4E ovarian cancer 0.0199355 0.8627299 0.01994
NA
TYK2 breast cancer 0.0199408 0.8627299 0.01994
NA
CEP290 skin cancer 0.0199454 0.8627299 0.01995
NA
GLRA3 skin cancer 0.0199454 0.8627299 0.01995
NA
VWA1 skin cancer 0.0199454 0.8627299 0.01995
NA
CTNNB1 lung cancer 0.0201130 0.8627299 0.02011
NA
GTPBP4 colorectal cancer 0.0201324 0.8627299 0.02013
NA
FMNL3 lung cancer 0.0201348 0.8627299 0.02013
NA
TTC26 lung cancer 0.0201348 0.8627299 0.02013
NA
UGT8 lung cancer 0.0201348 0.8627299 0.02013
NA
LOXHD1 skin cancer 0.0204007 0.8627299 0.02040
NA
LPHN3 skin cancer 0.0204170 0.8627299 0.02042
NA
ZNF763 skin cancer 0.0204595 0.8627299 0.02046
NA
CCDC177 cancer 0.0205451 0.8627299 0.02055
NA
SI lymphoma 0.0205964 0.8627299 0.02060
NA
PCDHA8 lung cancer 0.0206282 0.8627299 0.02063
NA
PKHD1 colorectal cancer 0.0206563 0.8627299 0.02066
NA
ANKHD1 ovarian cancer 0.0206839 0.8627299 0.02068
NA
PGM5 ovarian cancer 0.0206839 0.8627299 0.02068
NA
NOTCH4 urinary bladder cancer 0.0207917 0.8627299 0.02079
NA
ZNF510 uterine cancer 0.0208252 0.8627299 0.02083
NA
KCNT2 skin cancer 0.0209061 0.8627299 0.02091
NA
GOLGA3 ovarian cancer 0.0209062 0.8627299 0.02091
NA
IFI44 ovarian cancer 0.0209062 0.8627299 0.02091
NA
MAP3K6 ovarian cancer 0.0209062 0.8627299 0.02091
NA
MYLK3 ovarian cancer 0.0209062 0.8627299 0.02091
NA
KRCC1 ovarian cancer 0.0209065 0.8627299 0.02091
NA
KCNQ5 skin cancer 0.0209734 0.8627299 0.02097
NA
NF1 ovarian cancer 0.0210427 0.8627299 0.02104
NA
BCAR3 lung cancer 0.0210544 0.8627299 0.02105
NA
KRTAP10-9 lung cancer 0.0210544 0.8627299 0.02105
NA
PTPRF lung cancer 0.0210544 0.8627299 0.02105
NA
RRAGD lung cancer 0.0210544 0.8627299 0.02105
NA
SRPR lung cancer 0.0210544 0.8627299 0.02105
NA
ZNF221 lung cancer 0.0210544 0.8627299 0.02105
NA
ZNF330 lung cancer 0.0210544 0.8627299 0.02105
NA
OR1F1 lung cancer 0.0211477 0.8627299 0.02115
NA
TP53 breast cancer 0.0212205 0.8627299 0.02122
NA
ZNF331 lung cancer 0.0212801 0.8627299 0.02128
NA
DPY19L2 colorectal cancer 0.0212824 0.8627299 0.02128
NA
NADSYN1 colorectal cancer 0.0212824 0.8627299 0.02128
NA
ZNF667 colorectal cancer 0.0212824 0.8627299 0.02128
NA
FZD1 uterine cancer 0.0213911 0.8627299 0.02139
NA
PCDHGA4 uterine cancer 0.0213911 0.8627299 0.02139
NA
ASXL3 esophageal cancer 0.0214396 0.8627299 0.02144
NA
THSD7A lung cancer 0.0214835 0.8627299 0.02148
NA
MUS81 urinary bladder cancer 0.0215026 0.8627299 0.02150
NA
CACNA1D ovarian cancer 0.0215696 0.8627299 0.02157
NA
ACTL8 central nervous system cancer 0.0215715 0.8627299 0.02157
NA
DTX2 central nervous system cancer 0.0215715 0.8627299 0.02157
NA
KIF18B urinary bladder cancer 0.0216302 0.8627299 0.02163
NA
NOTCH2 urinary bladder cancer 0.0216302 0.8627299 0.02163
NA
RICTOR kidney cancer 0.0216672 0.8627299 0.02167
NA
FBN3 colorectal cancer 0.0217945 0.8627299 0.02179
NA
MAP3K2 central nervous system cancer 0.0218317 0.8627299 0.02183
NA
ANXA5 uterine cancer 0.0218494 0.8627299 0.02185
NA
CACNG8 uterine cancer 0.0218494 0.8627299 0.02185
NA
CTSH uterine cancer 0.0218494 0.8627299 0.02185
NA
DNAJA3 uterine cancer 0.0218494 0.8627299 0.02185
NA
GNAL uterine cancer 0.0218494 0.8627299 0.02185
NA
NPSR1 uterine cancer 0.0218494 0.8627299 0.02185
NA
PDIA3 uterine cancer 0.0218494 0.8627299 0.02185
NA
ST7 uterine cancer 0.0218494 0.8627299 0.02185
NA
ZNF177 stomach cancer 0.0220095 0.8627299 0.02201
NA
ABCA8 lung cancer 0.0220285 0.8627299 0.02203
NA
CSMD2 stomach cancer 0.0220927 0.8627299 0.02209
NA
FMN1 stomach cancer 0.0220927 0.8627299 0.02209
NA
ARFGEF1 colorectal cancer 0.0220976 0.8627299 0.02210
NA
APC multiple myeloma 0.0221907 0.8627299 0.02219
NA
PLA2R1 liver cancer 0.0221907 0.8627299 0.02219
NA
USP6 lung cancer 0.0222081 0.8627299 0.02221
NA
BCAR1 skin cancer 0.0222172 0.8627299 0.02222
NA
CLPX skin cancer 0.0222172 0.8627299 0.02222
NA
PIGR skin cancer 0.0222172 0.8627299 0.02222
NA
SLC47A2 skin cancer 0.0222172 0.8627299 0.02222
NA
UGP2 skin cancer 0.0222172 0.8627299 0.02222
NA
DCAF8 central nervous system cancer 0.0222529 0.8627299 0.02225
NA
GABRA5 central nervous system cancer 0.0222745 0.8627299 0.02227
NA
MAP1A central nervous system cancer 0.0222745 0.8627299 0.02227
NA
NRAS central nervous system cancer 0.0222745 0.8627299 0.02227
NA
PAMR1 central nervous system cancer 0.0222745 0.8627299 0.02227
NA
TMEM260 central nervous system cancer 0.0222745 0.8627299 0.02227
NA
SMAD4 head and neck cancer 0.0223264 0.8627299 0.02233
NA
ARHGAP24 leukemia 0.0223811 0.8627299 0.02238
NA
LYST leukemia 0.0223811 0.8627299 0.02238
NA
SORBS1 leukemia 0.0223811 0.8627299 0.02238
NA
TPX2 leukemia 0.0223811 0.8627299 0.02238
NA
JAKMIP2 uterine cancer 0.0224023 0.8627299 0.02240
NA
C20orf194 uterine cancer 0.0224142 0.8627299 0.02241
NA
C6orf118 uterine cancer 0.0224142 0.8627299 0.02241
NA
GRAMD1A uterine cancer 0.0224142 0.8627299 0.02241
NA
PSPC1 uterine cancer 0.0224142 0.8627299 0.02241
NA
SKIV2L uterine cancer 0.0224142 0.8627299 0.02241
NA
SLC22A9 uterine cancer 0.0224142 0.8627299 0.02241
NA
TDP1 uterine cancer 0.0224142 0.8627299 0.02241
NA
USP33 uterine cancer 0.0224142 0.8627299 0.02241
NA
CADPS2 colorectal cancer 0.0225063 0.8627299 0.02251
NA
PCM1 colorectal cancer 0.0225063 0.8627299 0.02251
NA
VPS16 uterine cancer 0.0225276 0.8627299 0.02253
NA
ANKRD13D skin cancer 0.0225628 0.8627299 0.02256
NA
HRAS skin cancer 0.0225628 0.8627299 0.02256
NA
IDUA skin cancer 0.0225628 0.8627299 0.02256
NA
MMP19 skin cancer 0.0225628 0.8627299 0.02256
NA
SCLT1 skin cancer 0.0225628 0.8627299 0.02256
NA
TEC skin cancer 0.0225628 0.8627299 0.02256
NA
ZBP1 skin cancer 0.0225628 0.8627299 0.02256
NA
ZNF623 skin cancer 0.0225628 0.8627299 0.02256
NA
ANKRD34C lung cancer 0.0225841 0.8627299 0.02258
NA
C14orf39 lung cancer 0.0225841 0.8627299 0.02258
NA
VCAN skin cancer 0.0225919 0.8627299 0.02259
NA
ZNF219 lung cancer 0.0226177 0.8627299 0.02262
NA
WDR19 colorectal cancer 0.0226230 0.8627299 0.02262
NA
FSIP2 ovarian cancer 0.0226982 0.8627299 0.02270
NA
NEBL uterine cancer 0.0227602 0.8627299 0.02276
NA
ALS2CL lung cancer 0.0228245 0.8627299 0.02282
NA
RARB lung cancer 0.0228245 0.8627299 0.02282
NA
ALX1 colorectal cancer 0.0228475 0.8627299 0.02285
NA
CNOT1 colorectal cancer 0.0228475 0.8627299 0.02285
NA
FER colorectal cancer 0.0228475 0.8627299 0.02285
NA
MDFIC colorectal cancer 0.0228475 0.8627299 0.02285
NA
NFRKB colorectal cancer 0.0228475 0.8627299 0.02285
NA
SLC12A6 colorectal cancer 0.0228475 0.8627299 0.02285
NA
SUPT7L colorectal cancer 0.0228475 0.8627299 0.02285
NA
TIE1 colorectal cancer 0.0228475 0.8627299 0.02285
NA
CAB39 colorectal cancer 0.0229034 0.8627299 0.02290
NA
ECD colorectal cancer 0.0229034 0.8627299 0.02290
NA
MOCOS colorectal cancer 0.0229034 0.8627299 0.02290
NA
PLEKHO1 colorectal cancer 0.0229034 0.8627299 0.02290
NA
SRGAP1 colorectal cancer 0.0229034 0.8627299 0.02290
NA
DOCK7 uterine cancer 0.0230355 0.8627299 0.02304
NA
MYH2 urinary bladder cancer 0.0230456 0.8627299 0.02305
NA
PHRF1 lung cancer 0.0230581 0.8627299 0.02306
NA
RALGAPA1 uterine cancer 0.0230976 0.8627299 0.02310
NA
DOCK8 uterine cancer 0.0231119 0.8627299 0.02311
NA
DGCR14 lung cancer 0.0231325 0.8627299 0.02313
NA
LARP4B lung cancer 0.0231325 0.8627299 0.02313
NA
NPTX2 lung cancer 0.0231325 0.8627299 0.02313
NA
ZNF572 lung cancer 0.0231325 0.8627299 0.02313
NA
KIAA1549L uterine cancer 0.0231364 0.8627299 0.02314
NA
MYH1 pancreatic cancer 0.0232100 0.8627299 0.02321
NA
FASN uterine cancer 0.0232155 0.8627299 0.02322
NA
COL7A1 uterine cancer 0.0232177 0.8627299 0.02322
NA
GBA2 uterine cancer 0.0232383 0.8627299 0.02324
NA
CPNE5 uterine cancer 0.0232528 0.8627299 0.02325
NA
CWC22 uterine cancer 0.0232528 0.8627299 0.02325
NA
EPB41L5 uterine cancer 0.0232528 0.8627299 0.02325
NA
PDGFRA uterine cancer 0.0232528 0.8627299 0.02325
NA
SENP2 uterine cancer 0.0232528 0.8627299 0.02325
NA
C7orf63 ovarian cancer 0.0232906 0.8627299 0.02329
NA
FCHO2 breast cancer 0.0232923 0.8627299 0.02329
NA
BAAT colorectal cancer 0.0233134 0.8627299 0.02331
NA
CDK7 colorectal cancer 0.0233134 0.8627299 0.02331
NA
CYP4V2 colorectal cancer 0.0233134 0.8627299 0.02331
NA
EIF3H colorectal cancer 0.0233134 0.8627299 0.02331
NA
FSCN2 colorectal cancer 0.0233134 0.8627299 0.02331
NA
HAX1 colorectal cancer 0.0233134 0.8627299 0.02331
NA
IRF2BP1 colorectal cancer 0.0233134 0.8627299 0.02331
NA
KCNJ6 colorectal cancer 0.0233134 0.8627299 0.02331
NA
NSUN6 colorectal cancer 0.0233134 0.8627299 0.02331
NA
PDZD3 colorectal cancer 0.0233134 0.8627299 0.02331
NA
PI4KB colorectal cancer 0.0233134 0.8627299 0.02331
NA
WDR46 colorectal cancer 0.0233134 0.8627299 0.02331
NA
KIAA1217 colorectal cancer 0.0233368 0.8627299 0.02334
NA
SH3D21 uterine cancer 0.0233796 0.8627299 0.02338
NA
STARD9 esophageal cancer 0.0234106 0.8627299 0.02341
NA
ZNF763 peripheral nervous system neoplasm 0.0234312 0.8627299 0.02343
NA
AFF3 colorectal cancer 0.0234640 0.8627299 0.02346
NA
ARMC5 colorectal cancer 0.0234640 0.8627299 0.02346
NA
SAMM50 colorectal cancer 0.0234915 0.8627299 0.02349
NA
PTPRZ1 uterine cancer 0.0235569 0.8627299 0.02356
NA
CEP170 uterine cancer 0.0235638 0.8627299 0.02356
NA
BRCA1 colorectal cancer 0.0237122 0.8627299 0.02371
NA
EXTL3 leukemia 0.0237385 0.8627299 0.02374
NA
FAM193B urinary bladder cancer 0.0237385 0.8627299 0.02374
NA
FIZ1 leukemia 0.0237385 0.8627299 0.02374
NA
LARP4B leukemia 0.0237385 0.8627299 0.02374
NA
MAS1 leukemia 0.0237385 0.8627299 0.02374
NA
MYH9 leukemia 0.0237385 0.8627299 0.02374
NA
TDRD1 urinary bladder cancer 0.0237385 0.8627299 0.02374
NA
TXNRD1 leukemia 0.0237385 0.8627299 0.02374
NA
ANXA4 breast cancer 0.0237414 0.8627299 0.02374
NA
C1S breast cancer 0.0237414 0.8627299 0.02374
NA
EVPL breast cancer 0.0237414 0.8627299 0.02374
NA
IGSF9 breast cancer 0.0237414 0.8627299 0.02374
NA
KRAS breast cancer 0.0237414 0.8627299 0.02374
NA
MAP10 breast cancer 0.0237414 0.8627299 0.02374
NA
NT5E breast cancer 0.0237414 0.8627299 0.02374
NA
OR51D1 breast cancer 0.0237414 0.8627299 0.02374
NA
TMC7 breast cancer 0.0237414 0.8627299 0.02374
NA
TRIML1 breast cancer 0.0237414 0.8627299 0.02374
NA
TRPC3 breast cancer 0.0237414 0.8627299 0.02374
NA
COBLL1 colorectal cancer 0.0240160 0.8627299 0.02402
NA
ASCC3 lung cancer 0.0240277 0.8627299 0.02403
NA
GABRB1 lung cancer 0.0240277 0.8627299 0.02403
NA
OR5AS1 lung cancer 0.0240277 0.8627299 0.02403
NA
FAT1 head and neck cancer 0.0240277 0.8627299 0.02403
NA
SUSD2 lung cancer 0.0240587 0.8627299 0.02406
NA
LHCGR skin cancer 0.0240855 0.8627299 0.02409
NA
SNX20 skin cancer 0.0240855 0.8627299 0.02409
NA
ABCC5 multiple myeloma 0.0240966 0.8627299 0.02410
NA
ZNF831 multiple myeloma 0.0240966 0.8627299 0.02410
NA
ZNF831 skin cancer 0.0241948 0.8627299 0.02419
NA
CRIM1 ovarian cancer 0.0241952 0.8627299 0.02420
NA
MAT2B uterine cancer 0.0243863 0.8627299 0.02439
NA
KIRREL lung cancer 0.0243872 0.8627299 0.02439
NA
LMO4 lung cancer 0.0243872 0.8627299 0.02439
NA
RAD21 lung cancer 0.0243872 0.8627299 0.02439
NA
SLC9A9 lung cancer 0.0243872 0.8627299 0.02439
NA
APPL2 uterine cancer 0.0243902 0.8627299 0.02439
NA
C11orf58 uterine cancer 0.0243902 0.8627299 0.02439
NA
CD1C uterine cancer 0.0243902 0.8627299 0.02439
NA
CLCA1 cancer 0.0243902 0.8627299 0.02439
NA
CYP20A1 uterine cancer 0.0243902 0.8627299 0.02439
NA
DLD uterine cancer 0.0243902 0.8627299 0.02439
NA
MKL2 uterine cancer 0.0243902 0.8627299 0.02439
NA
MLC1 uterine cancer 0.0243902 0.8627299 0.02439
NA
MTMR2 uterine cancer 0.0243902 0.8627299 0.02439
NA
NPLOC4 uterine cancer 0.0243902 0.8627299 0.02439
NA
P2RY2 uterine cancer 0.0243902 0.8627299 0.02439
NA
PARVG uterine cancer 0.0243902 0.8627299 0.02439
NA
PHF11 uterine cancer 0.0243902 0.8627299 0.02439
NA
PRAMEF10 uterine cancer 0.0243902 0.8627299 0.02439
NA
RANBP9 cancer 0.0243902 0.8627299 0.02439
NA
TRIM54 uterine cancer 0.0243902 0.8627299 0.02439
NA
TRIM65 uterine cancer 0.0243902 0.8627299 0.02439
NA
TTLL6 uterine cancer 0.0243902 0.8627299 0.02439
NA
ZNF124 uterine cancer 0.0243902 0.8627299 0.02439
NA
CNNM2 colorectal cancer 0.0244651 0.8627299 0.02447
NA
ZNF785 leukemia 0.0245157 0.8627299 0.02452
NA
CCDC51 breast cancer 0.0246271 0.8627299 0.02463
NA
KIAA0196 breast cancer 0.0246271 0.8627299 0.02463
NA
NEDD4L breast cancer 0.0246271 0.8627299 0.02463
NA
NEK8 breast cancer 0.0246271 0.8627299 0.02463
NA
TCFL5 breast cancer 0.0246271 0.8627299 0.02463
NA
GALNS skin cancer 0.0246414 0.8627299 0.02464
NA
TRAK2 lung cancer 0.0246533 0.8627299 0.02465
NA
GLG1 uterine cancer 0.0246815 0.8627299 0.02468
NA
SDK1 lung cancer 0.0246874 0.8627299 0.02469
NA
SACS leukemia 0.0249901 0.8627299 0.02499
NA
PCLO esophageal cancer 0.0250148 0.8627299 0.02501
NA
POM121 colorectal cancer 0.0250989 0.8627299 0.02510
NA
KIF3A lung cancer 0.0251383 0.8627299 0.02514
NA
ARHGEF25 ovarian cancer 0.0251815 0.8627299 0.02518
NA
CLRN3 ovarian cancer 0.0251815 0.8627299 0.02518
NA
MYH6 ovarian cancer 0.0251815 0.8627299 0.02518
NA
RRP12 ovarian cancer 0.0251815 0.8627299 0.02518
NA
SDHA ovarian cancer 0.0251815 0.8627299 0.02518
NA
SLC1A3 ovarian cancer 0.0251815 0.8627299 0.02518
NA
XIRP2 ovarian cancer 0.0251815 0.8627299 0.02518
NA
HERC5 lung cancer 0.0251843 0.8627299 0.02518
NA
KLC3 lung cancer 0.0251843 0.8627299 0.02518
NA
NSFL1C lung cancer 0.0251843 0.8627299 0.02518
NA
FBXO34 uterine cancer 0.0252550 0.8627299 0.02526
NA
EIF2AK3 kidney cancer 0.0252676 0.8627299 0.02527
NA
ASH1L stomach cancer 0.0252712 0.8627299 0.02527
NA
KMT2E head and neck cancer 0.0252712 0.8627299 0.02527
NA
PIK3CA stomach cancer 0.0252712 0.8627299 0.02527
NA
VPS13D head and neck cancer 0.0252712 0.8627299 0.02527
NA
WDFY3 leukemia 0.0252750 0.8627299 0.02527
NA
FANCE pancreatic cancer 0.0253038 0.8627299 0.02530
NA
MYH3 pancreatic cancer 0.0253038 0.8627299 0.02530
NA
UNC5A pancreatic cancer 0.0253168 0.8627299 0.02532
NA
DAW1 lung cancer 0.0253864 0.8627299 0.02539
NA
DGKD lung cancer 0.0253864 0.8627299 0.02539
NA
FAM43A lung cancer 0.0253864 0.8627299 0.02539
NA
GGA1 lung cancer 0.0253864 0.8627299 0.02539
NA
KRT9 lung cancer 0.0253864 0.8627299 0.02539
NA
MON2 lung cancer 0.0253864 0.8627299 0.02539
NA
MXD3 lung cancer 0.0253864 0.8627299 0.02539
NA
POGZ lung cancer 0.0253864 0.8627299 0.02539
NA
STOX1 lung cancer 0.0253864 0.8627299 0.02539
NA
DEAF1 central nervous system cancer 0.0253889 0.8627299 0.02539
NA
KIAA0319L central nervous system cancer 0.0253889 0.8627299 0.02539
NA
METTL14 central nervous system cancer 0.0253889 0.8627299 0.02539
NA
PUSL1 central nervous system cancer 0.0253889 0.8627299 0.02539
NA
CNOT1 lung cancer 0.0254122 0.8627299 0.02541
NA
REV3L colorectal cancer 0.0254282 0.8627299 0.02543
NA
ANO6 lung cancer 0.0255133 0.8627299 0.02551
NA
HSPA1A lung cancer 0.0255594 0.8627299 0.02556
NA
CR1 colorectal cancer 0.0255810 0.8627299 0.02558
NA
OSBPL3 lung cancer 0.0256297 0.8627299 0.02563
NA
MAML2 uterine cancer 0.0256397 0.8627299 0.02564
NA
EMILIN1 kidney cancer 0.0256748 0.8627299 0.02567
NA
CHD8 uterine cancer 0.0256926 0.8627299 0.02569
NA
CLIP4 central nervous system cancer 0.0257091 0.8627299 0.02571
NA
GUCY1B3 central nervous system cancer 0.0257091 0.8627299 0.02571
NA
NLRP13 central nervous system cancer 0.0257091 0.8627299 0.02571
NA
PPP1R12A central nervous system cancer 0.0257091 0.8627299 0.02571
NA
RHPN2 central nervous system cancer 0.0257091 0.8627299 0.02571
NA
VWA3A central nervous system cancer 0.0257091 0.8627299 0.02571
NA
ZNF658 central nervous system cancer 0.0257091 0.8627299 0.02571
NA
CHRNA1 colorectal cancer 0.0257186 0.8627299 0.02572
NA
ISCA1 colorectal cancer 0.0257186 0.8627299 0.02572
NA
ZZZ3 colorectal cancer 0.0257186 0.8627299 0.02572
NA
SI lung cancer 0.0258291 0.8627299 0.02583
NA
RXFP2 colorectal cancer 0.0258373 0.8627299 0.02584
NA
DDX11 colorectal cancer 0.0258763 0.8627299 0.02588
NA
ACSL3 leukemia 0.0259015 0.8627299 0.02590
NA
AGO3 leukemia 0.0259015 0.8627299 0.02590
NA
CLSPN leukemia 0.0259015 0.8627299 0.02590
NA
CUL2 leukemia 0.0259015 0.8627299 0.02590
NA
DOCK10 leukemia 0.0259015 0.8627299 0.02590
NA
EML6 leukemia 0.0259015 0.8627299 0.02590
NA
FAM83F leukemia 0.0259015 0.8627299 0.02590
NA
HEMK1 urinary bladder cancer 0.0259015 0.8627299 0.02590
NA
MLST8 leukemia 0.0259015 0.8627299 0.02590
NA
SRSF11 leukemia 0.0259015 0.8627299 0.02590
NA
TGOLN2 leukemia 0.0259015 0.8627299 0.02590
NA
ZBTB49 urinary bladder cancer 0.0259015 0.8627299 0.02590
NA
ZEB1 uterine cancer 0.0259140 0.8627299 0.02591
NA
EXPH5 kidney cancer 0.0259435 0.8627299 0.02594
NA
LGR4 kidney cancer 0.0259435 0.8627299 0.02594
NA
ZNF792 kidney cancer 0.0259435 0.8627299 0.02594
NA
MUC4 pancreatic cancer 0.0259937 0.8627299 0.02599
NA
SLCO1A2 lung cancer 0.0261852 0.8627299 0.02619
NA
HMGCR colorectal cancer 0.0261925 0.8627299 0.02619
NA
KCNC2 uterine cancer 0.0262196 0.8627299 0.02622
NA
MICAL3 uterine cancer 0.0262196 0.8627299 0.02622
NA
RASGRF1 skin cancer 0.0262294 0.8627299 0.02623
NA
PRRC2B lymphoma 0.0262367 0.8627299 0.02624
NA
ART5 lung cancer 0.0263138 0.8627299 0.02631
NA
FAM19A2 lung cancer 0.0263138 0.8627299 0.02631
NA
NUAK2 lung cancer 0.0263138 0.8627299 0.02631
NA
FLNC esophageal cancer 0.0263188 0.8627299 0.02632
NA
NYNRIN esophageal cancer 0.0263188 0.8627299 0.02632
NA
WDR33 lung cancer 0.0263432 0.8627299 0.02634
NA
RRBP1 uterine cancer 0.0263705 0.8627299 0.02637
NA
KRT14 esophageal cancer 0.0263911 0.8627299 0.02639
NA
USP36 colorectal cancer 0.0264358 0.8627299 0.02644
NA
KANK4 colorectal cancer 0.0265411 0.8627299 0.02654
NA
ACE leukemia 0.0266603 0.8627299 0.02666
NA
ADD2 leukemia 0.0266603 0.8627299 0.02666
NA
APBB1 leukemia 0.0266603 0.8627299 0.02666
NA
ASCL4 urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
ATP5S leukemia 0.0266603 0.8627299 0.02666
NA
B3GAT1 leukemia 0.0266603 0.8627299 0.02666
NA
C1orf159 urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
CENPB leukemia 0.0266603 0.8627299 0.02666
NA
EFCAB5 urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
EPS8L2 leukemia 0.0266603 0.8627299 0.02666
NA
ERMAP leukemia 0.0266603 0.8627299 0.02666
NA
FEZ1 leukemia 0.0266603 0.8627299 0.02666
NA
GALNT16 leukemia 0.0266603 0.8627299 0.02666
NA
HIPK1 leukemia 0.0266603 0.8627299 0.02666
NA
KIAA1456 leukemia 0.0266603 0.8627299 0.02666
NA
KLHL24 leukemia 0.0266603 0.8627299 0.02666
NA
LRRN2 leukemia 0.0266603 0.8627299 0.02666
NA
MYBL2 leukemia 0.0266603 0.8627299 0.02666
NA
NBPF15 urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
PROM1 leukemia 0.0266603 0.8627299 0.02666
NA
PTEN urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
RASGRP1 urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
SPATA5 leukemia 0.0266603 0.8627299 0.02666
NA
SYNPO2L leukemia 0.0266603 0.8627299 0.02666
NA
TMCO4 urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
TSPAN32 urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
UBR1 leukemia 0.0266603 0.8627299 0.02666
NA
ZFHX2 urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
ZNF230 urinary bladder cancer 0.0266603 0.8627299 0.02666
NA
CFH colorectal cancer 0.0267006 0.8627299 0.02670
NA
NR1H4 lung cancer 0.0267419 0.8627299 0.02674
NA
LRRC15 lung cancer 0.0267489 0.8627299 0.02675
NA
PCDHB4 breast cancer 0.0267629 0.8627299 0.02676
NA
APC skin cancer 0.0269384 0.8627299 0.02694
NA
LY75 skin cancer 0.0269384 0.8627299 0.02694
NA
TCEB3B skin cancer 0.0269384 0.8627299 0.02694
NA
ABHD14A skin cancer 0.0269581 0.8627299 0.02696
NA
NOL10 skin cancer 0.0269581 0.8627299 0.02696
NA
SENP5 skin cancer 0.0269581 0.8627299 0.02696
NA
ACAN breast cancer 0.0269639 0.8627299 0.02696
NA
COL11A1 lung cancer 0.0269778 0.8627299 0.02698
NA
ATR lung cancer 0.0270447 0.8627299 0.02704
NA
BRINP3 lung cancer 0.0270777 0.8627299 0.02708
NA
CNTNAP4 ovarian cancer 0.0271254 0.8627299 0.02713
NA
ZBTB16 ovarian cancer 0.0271254 0.8627299 0.02713
NA
ZNF675 ovarian cancer 0.0271254 0.8627299 0.02713
NA
LRRK1 uterine cancer 0.0271976 0.8627299 0.02720
NA
LONRF2 lung cancer 0.0273096 0.8627299 0.02731
NA
KANK4 central nervous system cancer 0.0273262 0.8627299 0.02733
NA
TMCO4 central nervous system cancer 0.0273262 0.8627299 0.02733
NA
CD200 liver cancer 0.0273739 0.8627299 0.02737
NA
DOCK7 multiple myeloma 0.0273739 0.8627299 0.02737
NA
TAF1L multiple myeloma 0.0273739 0.8627299 0.02737
NA
DIS3L2 lung cancer 0.0275353 0.8627299 0.02754
NA
FLNB ovarian cancer 0.0275425 0.8627299 0.02754
NA
RIMS2 ovarian cancer 0.0275580 0.8627299 0.02756
NA
THADA colorectal cancer 0.0276570 0.8627299 0.02766
NA
CYP26C1 uterine cancer 0.0277385 0.8627299 0.02774
NA
EDNRB uterine cancer 0.0277385 0.8627299 0.02774
NA
TTC14 kidney cancer 0.0277730 0.8627299 0.02777
NA
ACSBG2 lung cancer 0.0278279 0.8627299 0.02783
NA
CCDC96 lung cancer 0.0278279 0.8627299 0.02783
NA
EDARADD lung cancer 0.0278279 0.8627299 0.02783
NA
OR13J1 lung cancer 0.0278279 0.8627299 0.02783
NA
PLEKHB2 lung cancer 0.0278279 0.8627299 0.02783
NA
SLC22A12 lung cancer 0.0278279 0.8627299 0.02783
NA
TGOLN2 lung cancer 0.0278279 0.8627299 0.02783
NA
UTP3 lung cancer 0.0278279 0.8627299 0.02783
NA
LIG3 breast cancer 0.0278667 0.8627299 0.02787
NA
ACSS3 colorectal cancer 0.0278905 0.8627299 0.02789
NA
FBXO17 colorectal cancer 0.0278905 0.8627299 0.02789
NA
LTB colorectal cancer 0.0278905 0.8627299 0.02789
NA
PDGFD colorectal cancer 0.0278905 0.8627299 0.02789
NA
PHACTR3 colorectal cancer 0.0278905 0.8627299 0.02789
NA
PI4KA colorectal cancer 0.0278905 0.8627299 0.02789
NA
SGSM2 colorectal cancer 0.0278905 0.8627299 0.02789
NA
SLC37A1 colorectal cancer 0.0278905 0.8627299 0.02789
NA
TAF3 colorectal cancer 0.0278905 0.8627299 0.02789
NA
TRIP13 colorectal cancer 0.0278905 0.8627299 0.02789
NA
CARD10 uterine cancer 0.0279231 0.8627299 0.02792
NA
NR1H4 uterine cancer 0.0279601 0.8627299 0.02796
NA
GIN1 lung cancer 0.0281322 0.8627299 0.02813
NA
OR5W2 lung cancer 0.0281322 0.8627299 0.02813
NA
TRAM1L1 lung cancer 0.0281322 0.8627299 0.02813
NA
C9orf152 skin cancer 0.0281858 0.8627299 0.02819
NA
CSPP1 skin cancer 0.0281858 0.8627299 0.02819
NA
FGFR2 skin cancer 0.0281858 0.8627299 0.02819
NA
GYPE skin cancer 0.0281858 0.8627299 0.02819
NA
NDUFA11 skin cancer 0.0281858 0.8627299 0.02819
NA
NKAIN4 skin cancer 0.0281858 0.8627299 0.02819
NA
TAL1 skin cancer 0.0281858 0.8627299 0.02819
NA
ITPR1 urinary bladder cancer 0.0282157 0.8627299 0.02822
NA
BAP1 kidney cancer 0.0282577 0.8627299 0.02826
NA
TNKS1BP1 uterine cancer 0.0282636 0.8627299 0.02826
NA
ADCY3 uterine cancer 0.0283176 0.8627299 0.02832
NA
ATP6AP1L uterine cancer 0.0283176 0.8627299 0.02832
NA
EML1 uterine cancer 0.0283176 0.8627299 0.02832
NA
GIMAP6 uterine cancer 0.0283176 0.8627299 0.02832
NA
GTPBP4 uterine cancer 0.0283176 0.8627299 0.02832
NA
HLA-DRB1 uterine cancer 0.0283176 0.8627299 0.02832
NA
ITGB1BP1 uterine cancer 0.0283176 0.8627299 0.02832
NA
KRTAP10-6 cancer 0.0283176 0.8627299 0.02832
NA
MUC20 cancer 0.0283176 0.8627299 0.02832
NA
OR2T1 uterine cancer 0.0283176 0.8627299 0.02832
NA
SH2D1B uterine cancer 0.0283176 0.8627299 0.02832
NA
TMEM41B uterine cancer 0.0283176 0.8627299 0.02832
NA
ZNF195 cancer 0.0283176 0.8627299 0.02832
NA
ZNF419 uterine cancer 0.0283176 0.8627299 0.02832
NA
KCNJ4 lung cancer 0.0283705 0.8627299 0.02837
NA
LRRN2 lung cancer 0.0283705 0.8627299 0.02837
NA
SLC6A15 lung cancer 0.0283705 0.8627299 0.02837
NA
SLX4 lung cancer 0.0283705 0.8627299 0.02837
NA
XRCC5 lung cancer 0.0283705 0.8627299 0.02837
NA
HELZ2 kidney cancer 0.0284858 0.8627299 0.02849
NA
MARK1 lung cancer 0.0285789 0.8627299 0.02858
NA
CNTN5 uterine cancer 0.0287186 0.8627299 0.02872
NA
LZTR1 uterine cancer 0.0287186 0.8627299 0.02872
NA
TOPAZ1 lung cancer 0.0287243 0.8627299 0.02872
NA
SLC2A10 breast cancer 0.0287627 0.8627299 0.02876
NA
TEX33 breast cancer 0.0287627 0.8627299 0.02876
NA
WIPI2 breast cancer 0.0287627 0.8627299 0.02876
NA
RNF43 uterine cancer 0.0288827 0.8627299 0.02888
NA
GOLGA2 breast cancer 0.0289322 0.8627299 0.02893
NA
OCA2 skin cancer 0.0289512 0.8627299 0.02895
NA
RBP3 skin cancer 0.0289512 0.8627299 0.02895
NA
SLITRK3 skin cancer 0.0289512 0.8627299 0.02895
NA
ZNF10 skin cancer 0.0289512 0.8627299 0.02895
NA
NBEA colorectal cancer 0.0290192 0.8627299 0.02902
NA
MECOM lung cancer 0.0290485 0.8627299 0.02905
NA
CACYBP uterine cancer 0.0291743 0.8627299 0.02917
NA
NADSYN1 uterine cancer 0.0291743 0.8627299 0.02917
NA
OR10G7 uterine cancer 0.0291743 0.8627299 0.02917
NA
SYTL2 uterine cancer 0.0291743 0.8627299 0.02917
NA
ZSWIM8 uterine cancer 0.0291968 0.8627299 0.02920
NA
DNAH2 colorectal cancer 0.0292187 0.8627299 0.02922
NA
ANKRD30A esophageal cancer 0.0292725 0.8627299 0.02927
NA
BTAF1 esophageal cancer 0.0292725 0.8627299 0.02927
NA
CFH esophageal cancer 0.0292725 0.8627299 0.02927
NA
OSBPL8 esophageal cancer 0.0292725 0.8627299 0.02927
NA
ROS1 esophageal cancer 0.0292725 0.8627299 0.02927
NA
ZNF681 esophageal cancer 0.0292725 0.8627299 0.02927
NA
ADAD2 uterine cancer 0.0294387 0.8627299 0.02944
NA
ADH6 uterine cancer 0.0294387 0.8627299 0.02944
NA
APCDD1L cancer 0.0294387 0.8627299 0.02944
NA
BBS7 uterine cancer 0.0294387 0.8627299 0.02944
NA
BMP2K uterine cancer 0.0294387 0.8627299 0.02944
NA
BPIFA3 uterine cancer 0.0294387 0.8627299 0.02944
NA
BRAF cancer 0.0294387 0.8627299 0.02944
NA
CBFA2T2 uterine cancer 0.0294387 0.8627299 0.02944
NA
CCNJL uterine cancer 0.0294387 0.8627299 0.02944
NA
CD163 cancer 0.0294387 0.8627299 0.02944
NA
CTNNB1 cancer 0.0294387 0.8627299 0.02944
NA
DYNC1I2 cancer 0.0294387 0.8627299 0.02944
NA
ELANE cancer 0.0294387 0.8627299 0.02944
NA
ERGIC2 uterine cancer 0.0294387 0.8627299 0.02944
NA
FAM173A uterine cancer 0.0294387 0.8627299 0.02944
NA
FASLG uterine cancer 0.0294387 0.8627299 0.02944
NA
FPR3 uterine cancer 0.0294387 0.8627299 0.02944
NA
GALR2 uterine cancer 0.0294387 0.8627299 0.02944
NA
HBS1L uterine cancer 0.0294387 0.8627299 0.02944
NA
HESX1 uterine cancer 0.0294387 0.8627299 0.02944
NA
IL11RA uterine cancer 0.0294387 0.8627299 0.02944
NA
KCNK9 uterine cancer 0.0294387 0.8627299 0.02944
NA
KRTAP4-5 uterine cancer 0.0294387 0.8627299 0.02944
NA
LEFTY2 uterine cancer 0.0294387 0.8627299 0.02944
NA
LIPC uterine cancer 0.0294387 0.8627299 0.02944
NA
MIEF1 uterine cancer 0.0294387 0.8627299 0.02944
NA
NICN1 uterine cancer 0.0294387 0.8627299 0.02944
NA
OCEL1 uterine cancer 0.0294387 0.8627299 0.02944
NA
PCDHGB6 uterine cancer 0.0294387 0.8627299 0.02944
NA
PCGF6 uterine cancer 0.0294387 0.8627299 0.02944
NA
PDSS1 uterine cancer 0.0294387 0.8627299 0.02944
NA
PRIMPOL uterine cancer 0.0294387 0.8627299 0.02944
NA
PRL uterine cancer 0.0294387 0.8627299 0.02944
NA
PRSS23 uterine cancer 0.0294387 0.8627299 0.02944
NA
RBM48 uterine cancer 0.0294387 0.8627299 0.02944
NA
RPLP2 uterine cancer 0.0294387 0.8627299 0.02944
NA
SLC39A14 uterine cancer 0.0294387 0.8627299 0.02944
NA
SLX4IP uterine cancer 0.0294387 0.8627299 0.02944
NA
SPDYE3 uterine cancer 0.0294387 0.8627299 0.02944
NA
TMEM62 cancer 0.0294387 0.8627299 0.02944
NA
TPSD1 uterine cancer 0.0294387 0.8627299 0.02944
NA
TTBK1 uterine cancer 0.0294387 0.8627299 0.02944
NA
TYK2 cancer 0.0294387 0.8627299 0.02944
NA
UBALD2 uterine cancer 0.0294387 0.8627299 0.02944
NA
VEPH1 uterine cancer 0.0294387 0.8627299 0.02944
NA
WDR48 uterine cancer 0.0294387 0.8627299 0.02944
NA
ADAM8 uterine cancer 0.0294749 0.8627299 0.02947
NA
CD248 uterine cancer 0.0294749 0.8627299 0.02947
NA
CTNS uterine cancer 0.0294749 0.8627299 0.02947
NA
FICD uterine cancer 0.0294749 0.8627299 0.02947
NA
LILRA6 uterine cancer 0.0294749 0.8627299 0.02947
NA
NEK7 uterine cancer 0.0294749 0.8627299 0.02947
NA
NFIC uterine cancer 0.0294749 0.8627299 0.02947
NA
SLC2A2 uterine cancer 0.0294749 0.8627299 0.02947
NA
TFR2 uterine cancer 0.0294749 0.8627299 0.02947
NA
WT1 uterine cancer 0.0294749 0.8627299 0.02947
NA
HSF4 uterine cancer 0.0294894 0.8627299 0.02949
NA
GTPBP2 uterine cancer 0.0295080 0.8627299 0.02951
NA
KIAA1211L uterine cancer 0.0295080 0.8627299 0.02951
NA
NYAP1 uterine cancer 0.0295080 0.8627299 0.02951
NA
SCN3A lung cancer 0.0295358 0.8627299 0.02954
NA
BAZ2B central nervous system cancer 0.0295480 0.8627299 0.02955
NA
ATP1A1 colorectal cancer 0.0295794 0.8627299 0.02958
NA
BCAN colorectal cancer 0.0295794 0.8627299 0.02958
NA
CCT4 colorectal cancer 0.0295794 0.8627299 0.02958
NA
COL28A1 colorectal cancer 0.0295794 0.8627299 0.02958
NA
CSTF3 colorectal cancer 0.0295794 0.8627299 0.02958
NA
DHFR colorectal cancer 0.0295794 0.8627299 0.02958
NA
EVI5L colorectal cancer 0.0295794 0.8627299 0.02958
NA
FZD5 colorectal cancer 0.0295794 0.8627299 0.02958
NA
HABP2 colorectal cancer 0.0295794 0.8627299 0.02958
NA
KANK2 colorectal cancer 0.0295794 0.8627299 0.02958
NA
NCS1 colorectal cancer 0.0295794 0.8627299 0.02958
NA
OGFOD3 colorectal cancer 0.0295794 0.8627299 0.02958
NA
PCDHA5 colorectal cancer 0.0295794 0.8627299 0.02958
NA
PIK3R2 colorectal cancer 0.0295794 0.8627299 0.02958
NA
SLCO3A1 colorectal cancer 0.0295794 0.8627299 0.02958
NA
TCF3 colorectal cancer 0.0295794 0.8627299 0.02958
NA
DYRK1A ovarian cancer 0.0295871 0.8627299 0.02959
NA
KIAA1522 ovarian cancer 0.0295871 0.8627299 0.02959
NA
SPATA2L ovarian cancer 0.0295871 0.8627299 0.02959
NA
ITGA8 central nervous system cancer 0.0295925 0.8627299 0.02959
NA
NFAT5 central nervous system cancer 0.0295925 0.8627299 0.02959
NA
SLC2A13 central nervous system cancer 0.0295925 0.8627299 0.02959
NA
ZNF181 central nervous system cancer 0.0295925 0.8627299 0.02959
NA
TRIM36 central nervous system cancer 0.0297327 0.8627299 0.02973
NA
MEFV uterine cancer 0.0297352 0.8627299 0.02974
NA
CENPE uterine cancer 0.0297997 0.8627299 0.02980
NA
EP300 urinary bladder cancer 0.0298928 0.8627299 0.02989
NA
ABCC3 leukemia 0.0299640 0.8627299 0.02996
NA
PALD1 leukemia 0.0299640 0.8627299 0.02996
NA
FUK lung cancer 0.0300251 0.8627299 0.03003
NA
PHGDH lung cancer 0.0300251 0.8627299 0.03003
NA
HMMR uterine cancer 0.0301129 0.8627299 0.03011
NA
TRPC1 uterine cancer 0.0301129 0.8627299 0.03011
NA
HERC2 leukemia 0.0301525 0.8627299 0.03015
NA
ATP5J lung cancer 0.0301543 0.8627299 0.03015
NA
DUSP22 lung cancer 0.0301543 0.8627299 0.03015
NA
NMUR2 lung cancer 0.0301543 0.8627299 0.03015
NA
USP20 lung cancer 0.0301543 0.8627299 0.03015
NA
ART3 ovarian cancer 0.0301937 0.8627299 0.03019
NA
C11orf49 ovarian cancer 0.0301937 0.8627299 0.03019
NA
CNTNAP2 ovarian cancer 0.0301937 0.8627299 0.03019
NA
FER ovarian cancer 0.0301937 0.8627299 0.03019
NA
KIAA1324L ovarian cancer 0.0301937 0.8627299 0.03019
NA
MRPL22 ovarian cancer 0.0301937 0.8627299 0.03019
NA
POLG ovarian cancer 0.0301937 0.8627299 0.03019
NA
POLQ breast cancer 0.0301937 0.8627299 0.03019
NA
PRKD2 ovarian cancer 0.0301937 0.8627299 0.03019
NA
SPAG5 ovarian cancer 0.0301937 0.8627299 0.03019
NA
TAAR2 ovarian cancer 0.0301937 0.8627299 0.03019
NA
UBR2 ovarian cancer 0.0301937 0.8627299 0.03019
NA
ZNF133 ovarian cancer 0.0301937 0.8627299 0.03019
NA
BTN2A2 breast cancer 0.0302390 0.8627299 0.03024
NA
LRRC10 breast cancer 0.0302390 0.8627299 0.03024
NA
ZNF862 colorectal cancer 0.0302461 0.8627299 0.03025
NA
ARHGAP28 breast cancer 0.0303828 0.8627299 0.03038
NA
AUTS2 breast cancer 0.0303828 0.8627299 0.03038
NA
ENPEP breast cancer 0.0303828 0.8627299 0.03038
NA
LRP5 breast cancer 0.0303828 0.8627299 0.03038
NA
NBPF15 breast cancer 0.0303828 0.8627299 0.03038
NA
POLRMT breast cancer 0.0303828 0.8627299 0.03038
NA
TREML1 breast cancer 0.0303828 0.8627299 0.03038
NA
ARHGAP27 lung cancer 0.0304563 0.8627299 0.03046
NA
POTEC lung cancer 0.0304563 0.8627299 0.03046
NA
CHRNA1 lung cancer 0.0304692 0.8627299 0.03047
NA
EFNA3 lung cancer 0.0304692 0.8627299 0.03047
NA
KLK13 lung cancer 0.0304692 0.8627299 0.03047
NA
TBC1D14 lung cancer 0.0304692 0.8627299 0.03047
NA
TSPAN8 lung cancer 0.0304692 0.8627299 0.03047
NA
AMN multiple myeloma 0.0305521 0.8627299 0.03055
NA
CCDC146 multiple myeloma 0.0305521 0.8627299 0.03055
NA
CREBBP liver cancer 0.0305521 0.8627299 0.03055
NA
KRT19 bone cancer 0.0305521 0.8627299 0.03055
NA
NPB liver cancer 0.0305521 0.8627299 0.03055
NA
PIWIL3 multiple myeloma 0.0305521 0.8627299 0.03055
NA
URB1 bone cancer 0.0305521 0.8627299 0.03055
NA
TUSC3 lung cancer 0.0305642 0.8627299 0.03056
NA
MAPK10 central nervous system cancer 0.0306703 0.8627299 0.03067
NA
SELL central nervous system cancer 0.0306703 0.8627299 0.03067
NA
ARVCF leukemia 0.0307084 0.8627299 0.03071
NA
BEGAIN leukemia 0.0307084 0.8627299 0.03071
NA
CACNA1H leukemia 0.0307084 0.8627299 0.03071
NA
COL22A1 urinary bladder cancer 0.0307084 0.8627299 0.03071
NA
EXTL1 leukemia 0.0307084 0.8627299 0.03071
NA
FGFRL1 leukemia 0.0307084 0.8627299 0.03071
NA
NLRP3 leukemia 0.0307084 0.8627299 0.03071
NA
SIGLEC10 leukemia 0.0307084 0.8627299 0.03071
NA
SV2C urinary bladder cancer 0.0307084 0.8627299 0.03071
NA
TMTC2 urinary bladder cancer 0.0307084 0.8627299 0.03071
NA
WDR78 leukemia 0.0307084 0.8627299 0.03071
NA
LPHN2 lung cancer 0.0307454 0.8627299 0.03075
NA
CYP11B1 colorectal cancer 0.0307916 0.8627299 0.03079
NA
MYO7A colorectal cancer 0.0307916 0.8627299 0.03079
NA
TESPA1 esophageal cancer 0.0308570 0.8627299 0.03086
NA
UBE2M esophageal cancer 0.0308570 0.8627299 0.03086
NA
CELSR1 uterine cancer 0.0310736 0.8627299 0.03107
NA
ANKS3 colorectal cancer 0.0310929 0.8627299 0.03109
NA
BMPR1A colorectal cancer 0.0310929 0.8627299 0.03109
NA
ZRANB3 colorectal cancer 0.0310929 0.8627299 0.03109
NA
DPPA2 lung cancer 0.0311587 0.8627299 0.03116
NA
HIST1H1T central nervous system cancer 0.0311904 0.8627299 0.03119
NA
CSNK2A3 colorectal cancer 0.0312119 0.8627299 0.03121
NA
ZNF764 colorectal cancer 0.0312119 0.8627299 0.03121
NA
DYNC2H1 head and neck cancer 0.0312236 0.8627299 0.03122
NA
EXOC3L4 stomach cancer 0.0312294 0.8627299 0.03123
NA
NRG2 stomach cancer 0.0312294 0.8627299 0.03123
NA
ZNF326 head and neck cancer 0.0312294 0.8627299 0.03123
NA
PTPRB uterine cancer 0.0312715 0.8627299 0.03127
NA
XIRP1 colorectal cancer 0.0312835 0.8627299 0.03128
NA
FBXW10 leukemia 0.0312990 0.8627299 0.03130
NA
POLR1A liver cancer 0.0313538 0.8627299 0.03135
NA
SPEN multiple myeloma 0.0313538 0.8627299 0.03135
NA
ZNF804A multiple myeloma 0.0313538 0.8627299 0.03135
NA
CACNB2 uterine cancer 0.0313673 0.8627299 0.03137
NA
PKD1 lung cancer 0.0314173 0.8627299 0.03142
NA
EYA1 ovarian cancer 0.0314230 0.8627299 0.03142
NA
ACPT uterine cancer 0.0314807 0.8627299 0.03148
NA
AKT3 uterine cancer 0.0314807 0.8627299 0.03148
NA
HEXDC uterine cancer 0.0314807 0.8627299 0.03148
NA
MOB1B uterine cancer 0.0314807 0.8627299 0.03148
NA
PHC3 uterine cancer 0.0314807 0.8627299 0.03148
NA
OR6C75 ovarian cancer 0.0314933 0.8627299 0.03149
NA
TEK ovarian cancer 0.0314933 0.8627299 0.03149
NA
LPPR4 lung cancer 0.0314990 0.8627299 0.03150
NA
DNASE1L3 lung cancer 0.0315211 0.8627299 0.03152
NA
CNGA4 colorectal cancer 0.0315592 0.8627299 0.03156
NA
GEMIN5 colorectal cancer 0.0315592 0.8627299 0.03156
NA
PLA2G4D colorectal cancer 0.0315592 0.8627299 0.03156
NA
RAPGEF2 colorectal cancer 0.0315592 0.8627299 0.03156
NA
TBX3 colorectal cancer 0.0315592 0.8627299 0.03156
NA
ARHGAP5 uterine cancer 0.0315762 0.8627299 0.03158
NA
UNKL uterine cancer 0.0315762 0.8627299 0.03158
NA
DNAH10 central nervous system cancer 0.0316433 0.8627299 0.03164
NA
CCDC88A stomach cancer 0.0319476 0.8627299 0.03195
NA
CDC23 stomach cancer 0.0319476 0.8627299 0.03195
NA
GUCY1A3 stomach cancer 0.0319476 0.8627299 0.03195
NA
HSD17B12 head and neck cancer 0.0319476 0.8627299 0.03195
NA
ITIH3 stomach cancer 0.0319476 0.8627299 0.03195
NA
NUP155 head and neck cancer 0.0319476 0.8627299 0.03195
NA
PID1 stomach cancer 0.0319476 0.8627299 0.03195
NA
PLEKHG3 stomach cancer 0.0319476 0.8627299 0.03195
NA
SF3B2 stomach cancer 0.0319476 0.8627299 0.03195
NA
UFL1 stomach cancer 0.0319476 0.8627299 0.03195
NA
ZNF438 stomach cancer 0.0319476 0.8627299 0.03195
NA
CMTR1 lung cancer 0.0320263 0.8627299 0.03203
NA
ERBB3 lung cancer 0.0320263 0.8627299 0.03203
NA
OR4N5 lung cancer 0.0320263 0.8627299 0.03203
NA
ZNF177 colorectal cancer 0.0320522 0.8627299 0.03205
NA
SVIL ovarian cancer 0.0320534 0.8627299 0.03205
NA
APOA5 multiple myeloma 0.0320740 0.8627299 0.03207
NA
CTNNB1 liver cancer 0.0320740 0.8627299 0.03207
NA
DUSP22 multiple myeloma 0.0320740 0.8627299 0.03207
NA
LIMA1 multiple myeloma 0.0320740 0.8627299 0.03207
NA
LRRTM4 multiple myeloma 0.0320740 0.8627299 0.03207
NA
NOS3 liver cancer 0.0320740 0.8627299 0.03207
NA
OR2L3 liver cancer 0.0320740 0.8627299 0.03207
NA
PPP1R3A multiple myeloma 0.0320740 0.8627299 0.03207
NA
SLC45A1 bone cancer 0.0320740 0.8627299 0.03207
NA
TAB2 multiple myeloma 0.0320740 0.8627299 0.03207
NA
TRIM29 multiple myeloma 0.0320740 0.8627299 0.03207
NA
UNC13D bone cancer 0.0320740 0.8627299 0.03207
NA
WRAP73 liver cancer 0.0320740 0.8627299 0.03207
NA
ZNF528 multiple myeloma 0.0320740 0.8627299 0.03207
NA
ZP4 multiple myeloma 0.0320740 0.8627299 0.03207
NA
GPR98 lymphoma 0.0320887 0.8627299 0.03209
NA
NBEA lymphoma 0.0320887 0.8627299 0.03209
NA
SRF lymphoma 0.0320887 0.8627299 0.03209
NA
AKR7A2 skin cancer 0.0320913 0.8627299 0.03209
NA
PRR14L uterine cancer 0.0321163 0.8627299 0.03212
NA
MTA1 uterine cancer 0.0321306 0.8627299 0.03213
NA
NEDD4 uterine cancer 0.0321306 0.8627299 0.03213
NA
SLCO1B3 lung cancer 0.0322479 0.8627299 0.03225
NA
ADAMTS8 colorectal cancer 0.0322566 0.8627299 0.03226
NA
AIFM3 colorectal cancer 0.0322566 0.8627299 0.03226
NA
DDX49 colorectal cancer 0.0322566 0.8627299 0.03226
NA
HDAC7 colorectal cancer 0.0322566 0.8627299 0.03226
NA
PAQR8 colorectal cancer 0.0322566 0.8627299 0.03226
NA
EPS8L2 uterine cancer 0.0322605 0.8627299 0.03226
NA
GSN lung cancer 0.0322773 0.8627299 0.03228
NA
DPP10 lung cancer 0.0323050 0.8627299 0.03230
NA
TTC37 uterine cancer 0.0323430 0.8627299 0.03234
NA
MYEF2 lung cancer 0.0325118 0.8627299 0.03251
NA
GRM1 liver cancer 0.0326085 0.8627299 0.03261
NA
TDRD12 colorectal cancer 0.0328410 0.8627299 0.03284
NA
DENND4C esophageal cancer 0.0328974 0.8627299 0.03290
NA
LRRC36 lung cancer 0.0329021 0.8627299 0.03290
NA
VAV1 lung cancer 0.0329021 0.8627299 0.03290
NA
ACTN2 uterine cancer 0.0329694 0.8627299 0.03297
NA
EVA1C uterine cancer 0.0329694 0.8627299 0.03297
NA
IKZF3 uterine cancer 0.0329694 0.8627299 0.03297
NA
KATNAL1 uterine cancer 0.0329694 0.8627299 0.03297
NA
KIAA1147 uterine cancer 0.0329694 0.8627299 0.03297
NA
LSM2 uterine cancer 0.0329694 0.8627299 0.03297
NA
MAPK8 uterine cancer 0.0329694 0.8627299 0.03297
NA
NOC4L uterine cancer 0.0329694 0.8627299 0.03297
NA
PIGW uterine cancer 0.0329694 0.8627299 0.03297
NA
RUNDC3B uterine cancer 0.0329694 0.8627299 0.03297
NA
SDCCAG8 uterine cancer 0.0329694 0.8627299 0.03297
NA
SLC24A4 uterine cancer 0.0329694 0.8627299 0.03297
NA
SLC25A16 uterine cancer 0.0329694 0.8627299 0.03297
NA
SLC47A1 uterine cancer 0.0329694 0.8627299 0.03297
NA
SMARCC2 uterine cancer 0.0329694 0.8627299 0.03297
NA
SPATA6 uterine cancer 0.0329694 0.8627299 0.03297
NA
ZNF792 uterine cancer 0.0329694 0.8627299 0.03297
NA
ZNF572 lymphoma 0.0331652 0.8627299 0.03317
NA
CBX2 urinary bladder cancer 0.0331939 0.8627299 0.03319
NA
EIF2AK4 urinary bladder cancer 0.0331939 0.8627299 0.03319
NA
PRR14L leukemia 0.0331939 0.8627299 0.03319
NA
C2orf16 breast cancer 0.0331955 0.8627299 0.03320
NA
LSP1 pancreatic cancer 0.0332421 0.8627299 0.03324
NA
COL4A3 colorectal cancer 0.0332772 0.8627299 0.03328
NA
PLD5 uterine cancer 0.0333115 0.8627299 0.03331
NA
UTRN colorectal cancer 0.0333181 0.8627299 0.03332
NA
GLS lung cancer 0.0333231 0.8627299 0.03332
NA
SLC24A3 lung cancer 0.0333231 0.8627299 0.03332
NA
ZBTB26 lung cancer 0.0333231 0.8627299 0.03332
NA
ICA1L central nervous system cancer 0.0333618 0.8627299 0.03336
NA
BRPF1 pancreatic cancer 0.0333682 0.8627299 0.03337
NA
CDH18 pancreatic cancer 0.0333682 0.8627299 0.03337
NA
DMXL2 pancreatic cancer 0.0333682 0.8627299 0.03337
NA
LRRTM1 pancreatic cancer 0.0333682 0.8627299 0.03337
NA
MYH8 pancreatic cancer 0.0333682 0.8627299 0.03337
NA
ZNF716 pancreatic cancer 0.0333682 0.8627299 0.03337
NA
SLCO1A2 uterine cancer 0.0334693 0.8627299 0.03347
NA
GAD2 uterine cancer 0.0335702 0.8627299 0.03357
NA
MICALL2 uterine cancer 0.0335702 0.8627299 0.03357
NA
TTC27 uterine cancer 0.0335702 0.8627299 0.03357
NA
COL6A1 esophageal cancer 0.0335935 0.8627299 0.03359
NA
MYH7 esophageal cancer 0.0335935 0.8627299 0.03359
NA
PRSS3 esophageal cancer 0.0335935 0.8627299 0.03359
NA
SCML4 esophageal cancer 0.0335935 0.8627299 0.03359
NA
SMIM11 esophageal cancer 0.0335935 0.8627299 0.03359
NA
ZBTB41 esophageal cancer 0.0335935 0.8627299 0.03359
NA
KCNH5 lung cancer 0.0336868 0.8627299 0.03369
NA
NOS1AP lung cancer 0.0336868 0.8627299 0.03369
NA
MEGF8 colorectal cancer 0.0337467 0.8627299 0.03375
NA
ASB16 head and neck cancer 0.0337522 0.8627299 0.03375
NA
CBFA2T3 stomach cancer 0.0337522 0.8627299 0.03375
NA
CEP95 stomach cancer 0.0337522 0.8627299 0.03375
NA
CPNE8 stomach cancer 0.0337522 0.8627299 0.03375
NA
CYP2C19 head and neck cancer 0.0337522 0.8627299 0.03375
NA
CYP4F2 head and neck cancer 0.0337522 0.8627299 0.03375
NA
FUT1 stomach cancer 0.0337522 0.8627299 0.03375
NA
ITIH2 stomach cancer 0.0337522 0.8627299 0.03375
NA
KIAA1211 stomach cancer 0.0337522 0.8627299 0.03375
NA
LGR6 stomach cancer 0.0337522 0.8627299 0.03375
NA
LRBA head and neck cancer 0.0337522 0.8627299 0.03375
NA
MPRIP stomach cancer 0.0337522 0.8627299 0.03375
NA
NAT10 stomach cancer 0.0337522 0.8627299 0.03375
NA
NRP1 stomach cancer 0.0337522 0.8627299 0.03375
NA
NYNRIN stomach cancer 0.0337522 0.8627299 0.03375
NA
POLN stomach cancer 0.0337522 0.8627299 0.03375
NA
PRRC2B head and neck cancer 0.0337522 0.8627299 0.03375
NA
SETDB1 stomach cancer 0.0337522 0.8627299 0.03375
NA
SOX13 stomach cancer 0.0337522 0.8627299 0.03375
NA
SPEN head and neck cancer 0.0337522 0.8627299 0.03375
NA
ZNF292 stomach cancer 0.0337522 0.8627299 0.03375
NA
HMCN1 peripheral nervous system neoplasm 0.0337888 0.8627299 0.03379
NA
HAND2 colorectal cancer 0.0338654 0.8627299 0.03387
NA
NTPCR colorectal cancer 0.0338654 0.8627299 0.03387
NA
PDPK1 colorectal cancer 0.0338654 0.8627299 0.03387
NA
PIAS1 colorectal cancer 0.0338654 0.8627299 0.03387
NA
U2SURP colorectal cancer 0.0338654 0.8627299 0.03387
NA
ASB1 central nervous system cancer 0.0339701 0.8627299 0.03397
NA
BRINP1 central nervous system cancer 0.0339701 0.8627299 0.03397
NA
CAMSAP3 central nervous system cancer 0.0339701 0.8627299 0.03397
NA
CEACAM1 central nervous system cancer 0.0339701 0.8627299 0.03397
NA
CTNNA2 central nervous system cancer 0.0339701 0.8627299 0.03397
NA
ITGAD central nervous system cancer 0.0339701 0.8627299 0.03397
NA
KRT3 central nervous system cancer 0.0339701 0.8627299 0.03397
NA
MYO15A central nervous system cancer 0.0339701 0.8627299 0.03397
NA
STC1 central nervous system cancer 0.0339701 0.8627299 0.03397
NA
SYBU central nervous system cancer 0.0339701 0.8627299 0.03397
NA
IFITM1 skin cancer 0.0339779 0.8627299 0.03398
NA
JSRP1 skin cancer 0.0339779 0.8627299 0.03398
NA
ZNF85 skin cancer 0.0339779 0.8627299 0.03398
NA
CC2D2B uterine cancer 0.0339879 0.8627299 0.03399
NA
STK17A uterine cancer 0.0339879 0.8627299 0.03399
NA
ITPKB lung cancer 0.0340946 0.8627299 0.03409
NA
IQUB lung cancer 0.0340955 0.8627299 0.03410
NA
CEP350 ovarian cancer 0.0341257 0.8627299 0.03413
NA
PCSK9 lung cancer 0.0341408 0.8627299 0.03414
NA
UBAP2 lung cancer 0.0341408 0.8627299 0.03414
NA
MAN2C1 ovarian cancer 0.0341850 0.8627299 0.03419
NA
ZNF716 ovarian cancer 0.0341850 0.8627299 0.03419
NA
UBXN4 lung cancer 0.0342726 0.8627299 0.03427
NA
MYH13 lung cancer 0.0342907 0.8627299 0.03429
NA
FAM160B1 ovarian cancer 0.0343251 0.8627299 0.03433
NA
ZMYM6NB ovarian cancer 0.0343251 0.8627299 0.03433
NA
LTV1 central nervous system cancer 0.0343598 0.8627299 0.03436
NA
TRPM2 central nervous system cancer 0.0343598 0.8627299 0.03436
NA
BIRC6 colorectal cancer 0.0343825 0.8627299 0.03438
NA
DDX56 colorectal cancer 0.0345511 0.8627299 0.03455
NA
ATM central nervous system cancer 0.0345781 0.8627299 0.03458
NA
C3 kidney cancer 0.0346137 0.8627299 0.03461
NA
DDR1 kidney cancer 0.0346137 0.8627299 0.03461
NA
ENTHD2 kidney cancer 0.0346137 0.8627299 0.03461
NA
IL17RA kidney cancer 0.0346137 0.8627299 0.03461
NA
RPL22 kidney cancer 0.0346137 0.8627299 0.03461
NA
DAAM2 skin cancer 0.0346403 0.8627299 0.03464
NA
DACH1 skin cancer 0.0346403 0.8627299 0.03464
NA
POM121L2 skin cancer 0.0346403 0.8627299 0.03464
NA
PRICKLE1 skin cancer 0.0346403 0.8627299 0.03464
NA
PRRC2B skin cancer 0.0346403 0.8627299 0.03464
NA
SAFB skin cancer 0.0346403 0.8627299 0.03464
NA
VPS51 skin cancer 0.0346403 0.8627299 0.03464
NA
DNAH9 skin cancer 0.0347622 0.8627299 0.03476
NA
TRIP12 colorectal cancer 0.0347928 0.8627299 0.03479
NA
C16orf59 uterine cancer 0.0349429 0.8627299 0.03494
NA
DDX60L uterine cancer 0.0349429 0.8627299 0.03494
NA
CNTNAP5 skin cancer 0.0349702 0.8627299 0.03497
NA
APOL5 skin cancer 0.0349770 0.8627299 0.03498
NA
BTBD16 skin cancer 0.0349770 0.8627299 0.03498
NA
GTF2IRD1 skin cancer 0.0349770 0.8627299 0.03498
NA
IMPDH1 skin cancer 0.0349770 0.8627299 0.03498
NA
PCDHA13 skin cancer 0.0349770 0.8627299 0.03498
NA
POTEG skin cancer 0.0349770 0.8627299 0.03498
NA
PROX1 skin cancer 0.0349770 0.8627299 0.03498
NA
SELP skin cancer 0.0349770 0.8627299 0.03498
NA
SNCG skin cancer 0.0349770 0.8627299 0.03498
NA
TTLL4 skin cancer 0.0349770 0.8627299 0.03498
NA
WRAP53 skin cancer 0.0349770 0.8627299 0.03498
NA
ZBTB9 skin cancer 0.0349770 0.8627299 0.03498
NA
C8A skin cancer 0.0350891 0.8627299 0.03509
NA
EMR2 uterine cancer 0.0350900 0.8627299 0.03509
NA
NUB1 uterine cancer 0.0350900 0.8627299 0.03509
NA
PMS2 uterine cancer 0.0350900 0.8627299 0.03509
NA
SAMD3 uterine cancer 0.0350900 0.8627299 0.03509
NA
SUV420H2 uterine cancer 0.0350900 0.8627299 0.03509
NA
TRIOBP uterine cancer 0.0351594 0.8627299 0.03516
NA
DSCAML1 uterine cancer 0.0352162 0.8627299 0.03522
NA
SPTAN1 urinary bladder cancer 0.0352397 0.8627299 0.03524
NA
MYO10 skin cancer 0.0352451 0.8627299 0.03525
NA
CCT5 leukemia 0.0352565 0.8627299 0.03526
NA
FUT10 leukemia 0.0352565 0.8627299 0.03526
NA
OC90 leukemia 0.0352565 0.8627299 0.03526
NA
SNAP91 leukemia 0.0352565 0.8627299 0.03526
NA
CCDC149 skin cancer 0.0352878 0.8627299 0.03529
NA
C1orf159 uterine cancer 0.0353098 0.8627299 0.03531
NA
SALL1 leukemia 0.0353164 0.8627299 0.03532
NA
NF1 peripheral nervous system neoplasm 0.0353557 0.8627299 0.03536
NA
HMGXB4 lung cancer 0.0353914 0.8627299 0.03539
NA
PCDHGC5 lung cancer 0.0353914 0.8627299 0.03539
NA
CASKIN2 peripheral nervous system neoplasm 0.0355608 0.8627299 0.03556
NA
HOOK3 peripheral nervous system neoplasm 0.0355608 0.8627299 0.03556
NA
NEURL4 skin cancer 0.0356267 0.8627299 0.03563
NA
BRD1 uterine cancer 0.0356478 0.8627299 0.03565
NA
TYK2 uterine cancer 0.0356478 0.8627299 0.03565
NA
HSPG2 skin cancer 0.0356916 0.8627299 0.03569
NA
PCNT kidney cancer 0.0357181 0.8627299 0.03572
NA
RINL colorectal cancer 0.0357390 0.8627299 0.03574
NA
C2orf71 esophageal cancer 0.0357638 0.8627299 0.03576
NA
CADPS2 esophageal cancer 0.0357638 0.8627299 0.03576
NA
CHD8 esophageal cancer 0.0357638 0.8627299 0.03576
NA
CHRM1 esophageal cancer 0.0357638 0.8627299 0.03576
NA
CREBBP esophageal cancer 0.0357638 0.8627299 0.03576
NA
DEPTOR esophageal cancer 0.0357638 0.8627299 0.03576
NA
DOK1 esophageal cancer 0.0357638 0.8627299 0.03576
NA
DOPEY2 esophageal cancer 0.0357638 0.8627299 0.03576
NA
FAM184A esophageal cancer 0.0357638 0.8627299 0.03576
NA
FOXM1 esophageal cancer 0.0357638 0.8627299 0.03576
NA
IGSF9B esophageal cancer 0.0357638 0.8627299 0.03576
NA
KCNB2 esophageal cancer 0.0357638 0.8627299 0.03576
NA
KIAA0355 esophageal cancer 0.0357638 0.8627299 0.03576
NA
LRRIQ3 esophageal cancer 0.0357638 0.8627299 0.03576
NA
MAN2B2 esophageal cancer 0.0357638 0.8627299 0.03576
NA
MS4A8 esophageal cancer 0.0357638 0.8627299 0.03576
NA
MYPN esophageal cancer 0.0357638 0.8627299 0.03576
NA
NRG3 esophageal cancer 0.0357638 0.8627299 0.03576
NA
OSBPL1A esophageal cancer 0.0357638 0.8627299 0.03576
NA
PCMTD2 esophageal cancer 0.0357638 0.8627299 0.03576
NA
RAPSN esophageal cancer 0.0357638 0.8627299 0.03576
NA
SZT2 esophageal cancer 0.0357638 0.8627299 0.03576
NA
ZNF597 esophageal cancer 0.0357638 0.8627299 0.03576
NA
ZNF177 leukemia 0.0358607 0.8627299 0.03586
NA
PROX1 lung cancer 0.0359365 0.8627299 0.03594
NA
MCOLN3 lung cancer 0.0359447 0.8627299 0.03594
NA
SHD lung cancer 0.0359447 0.8627299 0.03594
NA
TRPV1 lung cancer 0.0359447 0.8627299 0.03594
NA
ADAMTS13 leukemia 0.0360247 0.8627299 0.03602
NA
AMBRA1 leukemia 0.0360247 0.8627299 0.03602
NA
ARSG leukemia 0.0360247 0.8627299 0.03602
NA
COL10A1 leukemia 0.0360247 0.8627299 0.03602
NA
ERCC6L2 urinary bladder cancer 0.0360247 0.8627299 0.03602
NA
EXT2 leukemia 0.0360247 0.8627299 0.03602
NA
FAM131B leukemia 0.0360247 0.8627299 0.03602
NA
FOXRED1 urinary bladder cancer 0.0360247 0.8627299 0.03602
NA
FRY leukemia 0.0360247 0.8627299 0.03602
NA
HPSE leukemia 0.0360247 0.8627299 0.03602
NA
KIAA1467 leukemia 0.0360247 0.8627299 0.03602
NA
KRAS leukemia 0.0360247 0.8627299 0.03602
NA
LOXL3 leukemia 0.0360247 0.8627299 0.03602
NA
NADK leukemia 0.0360247 0.8627299 0.03602
NA
NFKBIB leukemia 0.0360247 0.8627299 0.03602
NA
NR3C2 leukemia 0.0360247 0.8627299 0.03602
NA
PPM1H leukemia 0.0360247 0.8627299 0.03602
NA
RAB3D urinary bladder cancer 0.0360247 0.8627299 0.03602
NA
RASD2 leukemia 0.0360247 0.8627299 0.03602
NA
RBBP6 leukemia 0.0360247 0.8627299 0.03602
NA
SAFB leukemia 0.0360247 0.8627299 0.03602
NA
SATB1 urinary bladder cancer 0.0360247 0.8627299 0.03602
NA
SCYL1 leukemia 0.0360247 0.8627299 0.03602
NA
SMARCA2 urinary bladder cancer 0.0360247 0.8627299 0.03602
NA
STIL urinary bladder cancer 0.0360247 0.8627299 0.03602
NA
TAS2R5 leukemia 0.0360247 0.8627299 0.03602
NA
TRAF1 leukemia 0.0360247 0.8627299 0.03602
NA
TRDN urinary bladder cancer 0.0360247 0.8627299 0.03602
NA
TTC4 leukemia 0.0360247 0.8627299 0.03602
NA
UBR5 urinary bladder cancer 0.0360247 0.8627299 0.03602
NA
CDC37L1 colorectal cancer 0.0360283 0.8627299 0.03603
NA
EXO5 colorectal cancer 0.0360283 0.8627299 0.03603
NA
IER2 colorectal cancer 0.0360283 0.8627299 0.03603
NA
MLF1 colorectal cancer 0.0360283 0.8627299 0.03603
NA
PI4K2A colorectal cancer 0.0360283 0.8627299 0.03603
NA
SPO11 colorectal cancer 0.0360283 0.8627299 0.03603
NA
TMEM100 colorectal cancer 0.0360283 0.8627299 0.03603
NA
ASAP3 ovarian cancer 0.0360402 0.8627299 0.03604
NA
COL6A2 ovarian cancer 0.0360402 0.8627299 0.03604
NA
GTPBP1 ovarian cancer 0.0360402 0.8627299 0.03604
NA
JAKMIP3 breast cancer 0.0360402 0.8627299 0.03604
NA
NKAIN3 ovarian cancer 0.0360402 0.8627299 0.03604
NA
PI4KB ovarian cancer 0.0360402 0.8627299 0.03604
NA
PSD ovarian cancer 0.0360402 0.8627299 0.03604
NA
PVRL3 ovarian cancer 0.0360402 0.8627299 0.03604
NA
SEC16A ovarian cancer 0.0360402 0.8627299 0.03604
NA
ZNF765 ovarian cancer 0.0360402 0.8627299 0.03604
NA
DNAJC13 uterine cancer 0.0360406 0.8627299 0.03604
NA
PRSS3 pancreatic cancer 0.0361401 0.8627299 0.03614
NA
CSMD2 esophageal cancer 0.0361918 0.8627299 0.03619
NA
FILIP1 colorectal cancer 0.0363381 0.8627299 0.03634
NA
FANCA stomach cancer 0.0363586 0.8627299 0.03636
NA
HRNR head and neck cancer 0.0363586 0.8627299 0.03636
NA
MYO15A stomach cancer 0.0363586 0.8627299 0.03636
NA
ROS1 head and neck cancer 0.0363586 0.8627299 0.03636
NA
TMC6 stomach cancer 0.0363586 0.8627299 0.03636
NA
ACSM1 lung cancer 0.0363735 0.8627299 0.03637
NA
LRIT1 lung cancer 0.0363735 0.8627299 0.03637
NA
MSH3 lung cancer 0.0363735 0.8627299 0.03637
NA
AGGF1 lung cancer 0.0364026 0.8627299 0.03640
NA
CEP70 lung cancer 0.0364026 0.8627299 0.03640
NA
DHX35 lung cancer 0.0364026 0.8627299 0.03640
NA
F2RL1 lung cancer 0.0364026 0.8627299 0.03640
NA
KCNJ5 lung cancer 0.0364026 0.8627299 0.03640
NA
KIAA1586 lung cancer 0.0364026 0.8627299 0.03640
NA
LRRC1 lung cancer 0.0364026 0.8627299 0.03640
NA
OR51M1 lung cancer 0.0364026 0.8627299 0.03640
NA
PMS2 lung cancer 0.0364026 0.8627299 0.03640
NA
PNKD lung cancer 0.0364026 0.8627299 0.03640
NA
RAB36 lung cancer 0.0364026 0.8627299 0.03640
NA
WBSCR28 lung cancer 0.0364026 0.8627299 0.03640
NA
DOCK9 uterine cancer 0.0364089 0.8627299 0.03641
NA
IRF6 ovarian cancer 0.0364513 0.8627299 0.03645
NA
TOPAZ1 ovarian cancer 0.0364513 0.8627299 0.03645
NA
CACNA1I uterine cancer 0.0365415 0.8627299 0.03654
NA
DOPEY2 colorectal cancer 0.0365698 0.8627299 0.03657
NA
OTOP2 pancreatic cancer 0.0366730 0.8627299 0.03667
NA
PIK3R1 ovarian cancer 0.0366841 0.8627299 0.03668
NA
ATP13A5 liver cancer 0.0367729 0.8627299 0.03677
NA
PDE4DIP colorectal cancer 0.0367872 0.8627299 0.03679
NA
ID1 lung cancer 0.0368112 0.8627299 0.03681
NA
LOXL4 lung cancer 0.0368112 0.8627299 0.03681
NA
SPDL1 lung cancer 0.0368112 0.8627299 0.03681
NA
YWHAZ breast cancer 0.0369163 0.8627299 0.03692
NA
FERMT2 central nervous system cancer 0.0370048 0.8627299 0.03700
NA
TPTE lung cancer 0.0371128 0.8627299 0.03711
NA
ZNF292 skin cancer 0.0371443 0.8627299 0.03714
NA
PATZ1 uterine cancer 0.0371593 0.8627299 0.03716
NA
ZNF490 uterine cancer 0.0371593 0.8627299 0.03716
NA
TAF2 breast cancer 0.0372136 0.8627299 0.03721
NA
AJAP1 colorectal cancer 0.0372425 0.8627299 0.03724
NA
APLP2 colorectal cancer 0.0372425 0.8627299 0.03724
NA
C15orf41 colorectal cancer 0.0372425 0.8627299 0.03724
NA
C16orf71 colorectal cancer 0.0372425 0.8627299 0.03724
NA
C17orf104 colorectal cancer 0.0372425 0.8627299 0.03724
NA
C8orf74 colorectal cancer 0.0372425 0.8627299 0.03724
NA
CCDC137 colorectal cancer 0.0372425 0.8627299 0.03724
NA
CCDC54 colorectal cancer 0.0372425 0.8627299 0.03724
NA
CCDC6 colorectal cancer 0.0372425 0.8627299 0.03724
NA
CCDC84 colorectal cancer 0.0372425 0.8627299 0.03724
NA
CSRNP3 colorectal cancer 0.0372425 0.8627299 0.03724
NA
DNAJC5B colorectal cancer 0.0372425 0.8627299 0.03724
NA
HOOK1 colorectal cancer 0.0372425 0.8627299 0.03724
NA
IL20RA colorectal cancer 0.0372425 0.8627299 0.03724
NA
IPO11 colorectal cancer 0.0372425 0.8627299 0.03724
NA
ITPKB colorectal cancer 0.0372425 0.8627299 0.03724
NA
LALBA colorectal cancer 0.0372425 0.8627299 0.03724
NA
LEMD1 colorectal cancer 0.0372425 0.8627299 0.03724
NA
LYPD6B colorectal cancer 0.0372425 0.8627299 0.03724
NA
MGMT colorectal cancer 0.0372425 0.8627299 0.03724
NA
NDST2 colorectal cancer 0.0372425 0.8627299 0.03724
NA
NPAS4 colorectal cancer 0.0372425 0.8627299 0.03724
NA
NR5A1 colorectal cancer 0.0372425 0.8627299 0.03724
NA
NRSN1 colorectal cancer 0.0372425 0.8627299 0.03724
NA
OAS2 colorectal cancer 0.0372425 0.8627299 0.03724
NA
OR6S1 colorectal cancer 0.0372425 0.8627299 0.03724
NA
P2RY2 colorectal cancer 0.0372425 0.8627299 0.03724
NA
PCK2 colorectal cancer 0.0372425 0.8627299 0.03724
NA
POLR2C colorectal cancer 0.0372425 0.8627299 0.03724
NA
PPAPDC2 colorectal cancer 0.0372425 0.8627299 0.03724
NA
RAB38 colorectal cancer 0.0372425 0.8627299 0.03724
NA
RBFOX1 colorectal cancer 0.0372425 0.8627299 0.03724
NA
SEC16B colorectal cancer 0.0372425 0.8627299 0.03724
NA
ST3GAL3 colorectal cancer 0.0372425 0.8627299 0.03724
NA
TNNC2 colorectal cancer 0.0372425 0.8627299 0.03724
NA
TRIM64B colorectal cancer 0.0372425 0.8627299 0.03724
NA
VPS36 colorectal cancer 0.0372425 0.8627299 0.03724
NA
ZNF17 colorectal cancer 0.0372425 0.8627299 0.03724
NA
ZNF23 colorectal cancer 0.0372425 0.8627299 0.03724
NA
ZNF426 colorectal cancer 0.0372425 0.8627299 0.03724
NA
TCERG1 uterine cancer 0.0372530 0.8627299 0.03725
NA
CSMD1 skin cancer 0.0372754 0.8627299 0.03728
NA
IQSEC1 central nervous system cancer 0.0373358 0.8627299 0.03734
NA
NOB1 cancer 0.0373482 0.8627299 0.03735
NA
RAB11FIP5 uterine cancer 0.0373482 0.8627299 0.03735
NA
SCUBE3 uterine cancer 0.0373482 0.8627299 0.03735
NA
CHD9 lung cancer 0.0373606 0.8627299 0.03736
NA
ASIC1 colorectal cancer 0.0373701 0.8627299 0.03737
NA
BCAS3 colorectal cancer 0.0373701 0.8627299 0.03737
NA
SMC2 colorectal cancer 0.0373701 0.8627299 0.03737
NA
ZRANB1 colorectal cancer 0.0373701 0.8627299 0.03737
NA
DZIP3 multiple myeloma 0.0375182 0.8627299 0.03752
NA
FSCN3 colorectal cancer 0.0375189 0.8627299 0.03752
NA
LENG1 colorectal cancer 0.0375189 0.8627299 0.03752
NA
PCDHB2 colorectal cancer 0.0375189 0.8627299 0.03752
NA
SUPT16H colorectal cancer 0.0375189 0.8627299 0.03752
NA
C7orf62 lung cancer 0.0375324 0.8627299 0.03753
NA
ANKRD18A skin cancer 0.0376395 0.8627299 0.03764
NA
DMRT3 colorectal cancer 0.0377790 0.8627299 0.03778
NA
ANKRD31 lung cancer 0.0378119 0.8627299 0.03781
NA
ADAMTS9 lung cancer 0.0380397 0.8627299 0.03804
NA
C12orf60 lung cancer 0.0380397 0.8627299 0.03804
NA
MARCKS lung cancer 0.0380397 0.8627299 0.03804
NA
PDCD4 lung cancer 0.0380397 0.8627299 0.03804
NA
POLR3B lung cancer 0.0380397 0.8627299 0.03804
NA
AGT peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
ATXN7L1 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
CAPN15 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
DCAF17 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
GBF1 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
GPR37 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
HEATR2 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
NRAS peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
NUAK2 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
TRPM6 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
TTLL6 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
UNC13C peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
WDR87 peripheral nervous system neoplasm 0.0382144 0.8627299 0.03821
NA
COL9A1 ovarian cancer 0.0382678 0.8627299 0.03827
NA
ADAMTS18 colorectal cancer 0.0382761 0.8627299 0.03828
NA
RANBP2 colorectal cancer 0.0382761 0.8627299 0.03828
NA
NFASC uterine cancer 0.0383087 0.8627299 0.03831
NA
DNAJC2 uterine cancer 0.0383702 0.8627299 0.03837
NA
DYNC1I1 uterine cancer 0.0383702 0.8627299 0.03837
NA
FAM83A uterine cancer 0.0383702 0.8627299 0.03837
NA
FYN uterine cancer 0.0383702 0.8627299 0.03837
NA
GABRB3 uterine cancer 0.0383702 0.8627299 0.03837
NA
LPO uterine cancer 0.0383702 0.8627299 0.03837
NA
RUNX1T1 uterine cancer 0.0383702 0.8627299 0.03837
NA
NAT10 central nervous system cancer 0.0384222 0.8627299 0.03842
NA
CDH22 uterine cancer 0.0384496 0.8627299 0.03845
NA
FOXJ2 uterine cancer 0.0384496 0.8627299 0.03845
NA
FSHR uterine cancer 0.0384496 0.8627299 0.03845
NA
MICAL2 uterine cancer 0.0384496 0.8627299 0.03845
NA
RPAP1 uterine cancer 0.0384496 0.8627299 0.03845
NA
FAT1 uterine cancer 0.0384683 0.8627299 0.03847
NA
AEBP1 colorectal cancer 0.0384743 0.8627299 0.03847
NA
FLNC leukemia 0.0385137 0.8627299 0.03851
NA
AGAP3 uterine cancer 0.0385207 0.8627299 0.03852
NA
GNB2 uterine cancer 0.0385207 0.8627299 0.03852
NA
OTUD3 uterine cancer 0.0385207 0.8627299 0.03852
NA
SLC9A5 uterine cancer 0.0385207 0.8627299 0.03852
NA
TMEM150B uterine cancer 0.0385207 0.8627299 0.03852
NA
ACO2 breast cancer 0.0385612 0.8627299 0.03856
NA
CANT1 breast cancer 0.0385612 0.8627299 0.03856
NA
CAPNS1 breast cancer 0.0385612 0.8627299 0.03856
NA
CD109 breast cancer 0.0385612 0.8627299 0.03856
NA
CLIP3 breast cancer 0.0385612 0.8627299 0.03856
NA
DOCK2 breast cancer 0.0385612 0.8627299 0.03856
NA
DSCAM breast cancer 0.0385612 0.8627299 0.03856
NA
ITGAL breast cancer 0.0385612 0.8627299 0.03856
NA
ITGAV breast cancer 0.0385612 0.8627299 0.03856
NA
LRRC27 breast cancer 0.0385612 0.8627299 0.03856
NA
MAP3K19 breast cancer 0.0385612 0.8627299 0.03856
NA
NCKAP1L breast cancer 0.0385612 0.8627299 0.03856
NA
NET1 breast cancer 0.0385612 0.8627299 0.03856
NA
PHOSPHO2 breast cancer 0.0385612 0.8627299 0.03856
NA
SCNN1B breast cancer 0.0385612 0.8627299 0.03856
NA
SEZ6L breast cancer 0.0385612 0.8627299 0.03856
NA
ZSCAN22 breast cancer 0.0385612 0.8627299 0.03856
NA
PDE3A colorectal cancer 0.0386062 0.8627299 0.03861
NA
PPP1R9A colorectal cancer 0.0386062 0.8627299 0.03861
NA
MOV10L1 uterine cancer 0.0386689 0.8627299 0.03867
NA
ANKRD35 lung cancer 0.0387295 0.8627299 0.03873
NA
TMEM168 lung cancer 0.0387295 0.8627299 0.03873
NA
MYO1B uterine cancer 0.0387927 0.8627299 0.03879
NA
PDE6B uterine cancer 0.0388613 0.8627299 0.03886
NA
ANKRD30B head and neck cancer 0.0388645 0.8627299 0.03886
NA
AKAP1 central nervous system cancer 0.0388899 0.8627299 0.03889
NA
CABLES1 central nervous system cancer 0.0388899 0.8627299 0.03889
NA
CNTNAP5 central nervous system cancer 0.0388899 0.8627299 0.03889
NA
ELL central nervous system cancer 0.0388899 0.8627299 0.03889
NA
FLG2 central nervous system cancer 0.0388899 0.8627299 0.03889
NA
LRRC8E central nervous system cancer 0.0388899 0.8627299 0.03889
NA
MCPH1 central nervous system cancer 0.0388899 0.8627299 0.03889
NA
MYBL1 central nervous system cancer 0.0388899 0.8627299 0.03889
NA
PRR22 central nervous system cancer 0.0388899 0.8627299 0.03889
NA
VWDE central nervous system cancer 0.0388899 0.8627299 0.03889
NA
WDR35 central nervous system cancer 0.0388899 0.8627299 0.03889
NA
CCDC110 uterine cancer 0.0392086 0.8627299 0.03921
NA
KDM3A uterine cancer 0.0392086 0.8627299 0.03921
NA
MAP2K3 uterine cancer 0.0392086 0.8627299 0.03921
NA
SLC26A7 uterine cancer 0.0392205 0.8627299 0.03922
NA
IFT140 leukemia 0.0393672 0.8627299 0.03937
NA
NRD1 leukemia 0.0393672 0.8627299 0.03937
NA
PAPLN leukemia 0.0393672 0.8627299 0.03937
NA
CUBN leukemia 0.0396334 0.8627299 0.03963
NA
TENM4 urinary bladder cancer 0.0396334 0.8627299 0.03963
NA
BEGAIN lung cancer 0.0397214 0.8627299 0.03972
NA
CHUK lung cancer 0.0397214 0.8627299 0.03972
NA
CSPP1 lung cancer 0.0397214 0.8627299 0.03972
NA
CYP39A1 lung cancer 0.0397214 0.8627299 0.03972
NA
ENTPD2 lung cancer 0.0397214 0.8627299 0.03972
NA
FLCN lung cancer 0.0397214 0.8627299 0.03972
NA
INTS6 lung cancer 0.0397214 0.8627299 0.03972
NA
KREMEN2 lung cancer 0.0397214 0.8627299 0.03972
NA
LIM2 lung cancer 0.0397214 0.8627299 0.03972
NA
LRRFIP1 lung cancer 0.0397214 0.8627299 0.03972
NA
LRWD1 lung cancer 0.0397214 0.8627299 0.03972
NA
OXSM lung cancer 0.0397214 0.8627299 0.03972
NA
PDZK1 lung cancer 0.0397214 0.8627299 0.03972
NA
PHLPP1 lung cancer 0.0397214 0.8627299 0.03972
NA
PKM lung cancer 0.0397214 0.8627299 0.03972
NA
RHBDD3 lung cancer 0.0397214 0.8627299 0.03972
NA
CHRNA4 leukemia 0.0397512 0.8627299 0.03975
NA
FOXE1 leukemia 0.0397512 0.8627299 0.03975
NA
KDM4A urinary bladder cancer 0.0397512 0.8627299 0.03975
NA
OR4S2 urinary bladder cancer 0.0397512 0.8627299 0.03975
NA
POLR1B leukemia 0.0397512 0.8627299 0.03975
NA
SPTLC3 leukemia 0.0397512 0.8627299 0.03975
NA
NOTCH1 leukemia 0.0397833 0.8627299 0.03978
NA
GOLGA4 uterine cancer 0.0398821 0.8627299 0.03988
NA
METTL22 pancreatic cancer 0.0399796 0.8627299 0.03998
NA
NEO1 uterine cancer 0.0400927 0.8627299 0.04009
NA
TLL2 colorectal cancer 0.0401697 0.8627299 0.04017
NA
FSBP skin cancer 0.0402433 0.8627299 0.04024
NA
KBTBD4 skin cancer 0.0402433 0.8627299 0.04024
NA
MYPOP skin cancer 0.0402433 0.8627299 0.04024
NA
NAALADL2 skin cancer 0.0402433 0.8627299 0.04024
NA
RSPH3 skin cancer 0.0402433 0.8627299 0.04024
NA
STK36 skin cancer 0.0402433 0.8627299 0.04024
NA
WIPI2 skin cancer 0.0402433 0.8627299 0.04024
NA
ZSWIM8 skin cancer 0.0402433 0.8627299 0.04024
NA
CCDC91 uterine cancer 0.0402767 0.8627299 0.04028
NA
PAFAH2 uterine cancer 0.0402767 0.8627299 0.04028
NA
SETD4 uterine cancer 0.0402767 0.8627299 0.04028
NA
TAF2 uterine cancer 0.0402767 0.8627299 0.04028
NA
ZNF808 uterine cancer 0.0402767 0.8627299 0.04028
NA
CAD urinary bladder cancer 0.0402920 0.8627299 0.04029
NA
CACNA1S skin cancer 0.0404041 0.8627299 0.04040
NA
SH2D3C skin cancer 0.0404041 0.8627299 0.04040
NA
KIF26B lung cancer 0.0404596 0.8627299 0.04046
NA
PIK3CA urinary bladder cancer 0.0405454 0.8627299 0.04055
NA
FSIP2 breast cancer 0.0405714 0.8627299 0.04057
NA
SBF2 breast cancer 0.0405714 0.8627299 0.04057
NA
KRT16 head and neck cancer 0.0406873 0.8627299 0.04069
NA
FMO5 central nervous system cancer 0.0407043 0.8627299 0.04070
NA
MYO15A uterine cancer 0.0407178 0.8627299 0.04072
NA
ALS2CR12 lung cancer 0.0408546 0.8627299 0.04085
NA
CDH6 lung cancer 0.0408546 0.8627299 0.04085
NA
FAM160B1 lung cancer 0.0408546 0.8627299 0.04085
NA
GRIK2 lung cancer 0.0408546 0.8627299 0.04085
NA
MX2 lung cancer 0.0408546 0.8627299 0.04085
NA
R3HDM1 lung cancer 0.0408546 0.8627299 0.04085
NA
SEMA7A lung cancer 0.0408546 0.8627299 0.04085
NA
ZNF311 lung cancer 0.0408546 0.8627299 0.04085
NA
XKR6 lung cancer 0.0408871 0.8627299 0.04089
NA
ANXA6 colorectal cancer 0.0409023 0.8627299 0.04090
NA
C11orf54 colorectal cancer 0.0409023 0.8627299 0.04090
NA
CD36 colorectal cancer 0.0409023 0.8627299 0.04090
NA
COG1 colorectal cancer 0.0409023 0.8627299 0.04090
NA
DHX9 colorectal cancer 0.0409023 0.8627299 0.04090
NA
EEA1 colorectal cancer 0.0409023 0.8627299 0.04090
NA
HAUS3 colorectal cancer 0.0409023 0.8627299 0.04090
NA
IFRD2 colorectal cancer 0.0409023 0.8627299 0.04090
NA
MYO1E colorectal cancer 0.0409023 0.8627299 0.04090
NA
NCDN colorectal cancer 0.0409023 0.8627299 0.04090
NA
NLRP2 colorectal cancer 0.0409023 0.8627299 0.04090
NA
SCN11A colorectal cancer 0.0409023 0.8627299 0.04090
NA
SEZ6L colorectal cancer 0.0409023 0.8627299 0.04090
NA
SLC4A4 colorectal cancer 0.0409023 0.8627299 0.04090
NA
VPS29 colorectal cancer 0.0409023 0.8627299 0.04090
NA
ZNF286B colorectal cancer 0.0409023 0.8627299 0.04090
NA
COL7A1 lymphoma 0.0409037 0.8627299 0.04090
NA
DCLRE1A lymphoma 0.0409037 0.8627299 0.04090
NA
ETV5 lymphoma 0.0409037 0.8627299 0.04090
NA
GAREML lymphoma 0.0409037 0.8627299 0.04090
NA
NEO1 lymphoma 0.0409037 0.8627299 0.04090
NA
PCM1 lymphoma 0.0409037 0.8627299 0.04090
NA
RNF113B lymphoma 0.0409037 0.8627299 0.04090
NA
AMER2 lung cancer 0.0409185 0.8627299 0.04092
NA
ANKRD28 skin cancer 0.0409511 0.8627299 0.04095
NA
MYO5B skin cancer 0.0409511 0.8627299 0.04095
NA
ALG10B colorectal cancer 0.0409647 0.8627299 0.04096
NA
PRKACB lung cancer 0.0409773 0.8627299 0.04098
NA
SOX17 leukemia 0.0409938 0.8627299 0.04099
NA
WDR87 leukemia 0.0409938 0.8627299 0.04099
NA
SCUBE2 colorectal cancer 0.0410595 0.8627299 0.04106
NA
ZNF92 colorectal cancer 0.0410595 0.8627299 0.04106
NA
FAM65A colorectal cancer 0.0411581 0.8627299 0.04116
NA
KCNQ5 colorectal cancer 0.0412081 0.8627299 0.04121
NA
EFR3A lung cancer 0.0412139 0.8627299 0.04121
NA
TNS3 lung cancer 0.0412139 0.8627299 0.04121
NA
IL15RA multiple myeloma 0.0412218 0.8627299 0.04122
NA
ANKRD32 skin cancer 0.0412580 0.8627299 0.04126
NA
DCHS1 skin cancer 0.0412580 0.8627299 0.04126
NA
EPB41L1 skin cancer 0.0412580 0.8627299 0.04126
NA
KRT5 skin cancer 0.0412580 0.8627299 0.04126
NA
SLC4A2 lung cancer 0.0413707 0.8627299 0.04137
NA
ACTN1 colorectal cancer 0.0413733 0.8627299 0.04137
NA
SBF1 colorectal cancer 0.0413733 0.8627299 0.04137
NA
FAM47E uterine cancer 0.0413827 0.8627299 0.04138
NA
GATS cancer 0.0413827 0.8627299 0.04138
NA
SPTBN2 ovarian cancer 0.0414732 0.8627299 0.04147
NA
CAMSAP2 uterine cancer 0.0415801 0.8627299 0.04158
NA
MYO1C uterine cancer 0.0415801 0.8627299 0.04158
NA
CRIPAK ovarian cancer 0.0416058 0.8627299 0.04161
NA
LPHN2 ovarian cancer 0.0416058 0.8627299 0.04161
NA
PCOLCE ovarian cancer 0.0416058 0.8627299 0.04161
NA
PRAMEF12 pancreatic cancer 0.0416349 0.8627299 0.04163
NA
AAR2 uterine cancer 0.0416426 0.8627299 0.04164
NA
ADCK1 uterine cancer 0.0416426 0.8627299 0.04164
NA
ARHGDIG uterine cancer 0.0416426 0.8627299 0.04164
NA
CD302 uterine cancer 0.0416426 0.8627299 0.04164
NA
CD8A uterine cancer 0.0416426 0.8627299 0.04164
NA
CD93 uterine cancer 0.0416426 0.8627299 0.04164
NA
EMCN uterine cancer 0.0416426 0.8627299 0.04164
NA
EPX cancer 0.0416426 0.8627299 0.04164
NA
FAM129C uterine cancer 0.0416426 0.8627299 0.04164
NA
FAM174B uterine cancer 0.0416426 0.8627299 0.04164
NA
FBXO32 uterine cancer 0.0416426 0.8627299 0.04164
NA
GPR126 cancer 0.0416426 0.8627299 0.04164
NA
IGFALS uterine cancer 0.0416426 0.8627299 0.04164
NA
IMP3 uterine cancer 0.0416426 0.8627299 0.04164
NA
LARP6 uterine cancer 0.0416426 0.8627299 0.04164
NA
LCTL uterine cancer 0.0416426 0.8627299 0.04164
NA
NAT10 uterine cancer 0.0416426 0.8627299 0.04164
NA
NDUFB10 uterine cancer 0.0416426 0.8627299 0.04164
NA
NOTCH2 uterine cancer 0.0416426 0.8627299 0.04164
NA
OR5B17 uterine cancer 0.0416426 0.8627299 0.04164
NA
PDE12 uterine cancer 0.0416426 0.8627299 0.04164
NA
PGLS uterine cancer 0.0416426 0.8627299 0.04164
NA
POU4F2 uterine cancer 0.0416426 0.8627299 0.04164
NA
PUF60 uterine cancer 0.0416426 0.8627299 0.04164
NA
RND2 uterine cancer 0.0416426 0.8627299 0.04164
NA
RRNAD1 uterine cancer 0.0416426 0.8627299 0.04164
NA
SCN2A cancer 0.0416426 0.8627299 0.04164
NA
SF3B4 uterine cancer 0.0416426 0.8627299 0.04164
NA
SHF uterine cancer 0.0416426 0.8627299 0.04164
NA
SLC27A1 uterine cancer 0.0416426 0.8627299 0.04164
NA
SPATC1 cancer 0.0416426 0.8627299 0.04164
NA
SPHAR uterine cancer 0.0416426 0.8627299 0.04164
NA
SPP2 uterine cancer 0.0416426 0.8627299 0.04164
NA
SRSF6 uterine cancer 0.0416426 0.8627299 0.04164
NA
TAF8 cancer 0.0416426 0.8627299 0.04164
NA
WBSCR28 uterine cancer 0.0416426 0.8627299 0.04164
NA
ZNF140 uterine cancer 0.0416426 0.8627299 0.04164
NA
ZNF426 uterine cancer 0.0416426 0.8627299 0.04164
NA
ZNF543 uterine cancer 0.0416426 0.8627299 0.04164
NA
ARID1A colorectal cancer 0.0417917 0.8627299 0.04179
NA
BACH2 uterine cancer 0.0420436 0.8627299 0.04204
NA
CCDC67 uterine cancer 0.0420436 0.8627299 0.04204
NA
CYP19A1 uterine cancer 0.0420436 0.8627299 0.04204
NA
BAZ2B ovarian cancer 0.0420594 0.8627299 0.04206
NA
VPS13C ovarian cancer 0.0420594 0.8627299 0.04206
NA
HIVEP2 uterine cancer 0.0422470 0.8627299 0.04225
NA
RHOT2 uterine cancer 0.0424318 0.8627299 0.04243
NA
TNRC6C uterine cancer 0.0424318 0.8627299 0.04243
NA
CC2D2A leukemia 0.0424817 0.8627299 0.04248
NA
KIF18A colorectal cancer 0.0424980 0.8627299 0.04250
NA
TNIK uterine cancer 0.0426224 0.8627299 0.04262
NA
CYCS lung cancer 0.0426577 0.8627299 0.04266
NA
FCGBP peripheral nervous system neoplasm 0.0427315 0.8627299 0.04273
NA
F11R multiple myeloma 0.0427881 0.8627299 0.04279
NA
ADAM19 ovarian cancer 0.0428256 0.8627299 0.04283
NA
ATRN ovarian cancer 0.0428256 0.8627299 0.04283
NA
COL22A1 ovarian cancer 0.0428256 0.8627299 0.04283
NA
FLNC ovarian cancer 0.0428256 0.8627299 0.04283
NA
HSF4 ovarian cancer 0.0428256 0.8627299 0.04283
NA
KPRP ovarian cancer 0.0428256 0.8627299 0.04283
NA
PCDHGB4 ovarian cancer 0.0428256 0.8627299 0.04283
NA
RAPGEF6 ovarian cancer 0.0428256 0.8627299 0.04283
NA
SPG21 ovarian cancer 0.0428256 0.8627299 0.04283
NA
SYT2 ovarian cancer 0.0428256 0.8627299 0.04283
NA
ZFP1 ovarian cancer 0.0428256 0.8627299 0.04283
NA
ACLY lung cancer 0.0428436 0.8627299 0.04284
NA
GTF3C4 lung cancer 0.0428436 0.8627299 0.04284
NA
SLIT2 lung cancer 0.0428841 0.8627299 0.04288
NA
PHF20 colorectal cancer 0.0429335 0.8627299 0.04293
NA
KALRN esophageal cancer 0.0429601 0.8627299 0.04296
NA
PIK3C3 esophageal cancer 0.0429722 0.8627299 0.04297
NA
IL17RA uterine cancer 0.0429795 0.8627299 0.04298
NA
CACNA1A stomach cancer 0.0430059 0.8627299 0.04301
NA
DNAH5 head and neck cancer 0.0430059 0.8627299 0.04301
NA
TNS3 head and neck cancer 0.0430059 0.8627299 0.04301
NA
RARS colorectal cancer 0.0430160 0.8627299 0.04302
NA
CDC6 skin cancer 0.0431187 0.8627299 0.04312
NA
DNM3 skin cancer 0.0431187 0.8627299 0.04312
NA
ESF1 skin cancer 0.0431187 0.8627299 0.04312
NA
HPN skin cancer 0.0431187 0.8627299 0.04312
NA
IL21R skin cancer 0.0431187 0.8627299 0.04312
NA
LIG4 skin cancer 0.0431187 0.8627299 0.04312
NA
OR52I2 skin cancer 0.0431187 0.8627299 0.04312
NA
PARK2 skin cancer 0.0431187 0.8627299 0.04312
NA
PDGFA skin cancer 0.0431187 0.8627299 0.04312
NA
PNLIPRP1 skin cancer 0.0431187 0.8627299 0.04312
NA
RNF43 skin cancer 0.0431187 0.8627299 0.04312
NA
SCUBE1 skin cancer 0.0431187 0.8627299 0.04312
NA
SPRYD3 skin cancer 0.0431187 0.8627299 0.04312
NA
ST6GALNAC4 skin cancer 0.0431187 0.8627299 0.04312
NA
TOM1 skin cancer 0.0431187 0.8627299 0.04312
NA
TPTE2 skin cancer 0.0431187 0.8627299 0.04312
NA
ULK4 skin cancer 0.0431187 0.8627299 0.04312
NA
MUC16 leukemia 0.0431610 0.8627299 0.04316
NA
ACVR2B lung cancer 0.0432936 0.8627299 0.04329
NA
ANKRD13D lung cancer 0.0432936 0.8627299 0.04329
NA
DIO3 lung cancer 0.0432936 0.8627299 0.04329
NA
HOXC6 lung cancer 0.0432936 0.8627299 0.04329
NA
KDM4D lung cancer 0.0432936 0.8627299 0.04329
NA
LRRC10 lung cancer 0.0432936 0.8627299 0.04329
NA
NEDD4L lung cancer 0.0432936 0.8627299 0.04329
NA
NOL10 lung cancer 0.0432936 0.8627299 0.04329
NA
NPFFR1 lung cancer 0.0432936 0.8627299 0.04329
NA
TAS2R9 lung cancer 0.0432936 0.8627299 0.04329
NA
TRIM24 lung cancer 0.0432936 0.8627299 0.04329
NA
ZNF358 kidney cancer 0.0434857 0.8627299 0.04349
NA
C1orf115 pancreatic cancer 0.0435376 0.8627299 0.04354
NA
GABRR2 pancreatic cancer 0.0435376 0.8627299 0.04354
NA
GNPTAB pancreatic cancer 0.0435376 0.8627299 0.04354
NA
MC5R pancreatic cancer 0.0435376 0.8627299 0.04354
NA
NOMO2 pancreatic cancer 0.0435376 0.8627299 0.04354
NA
PLXNA2 pancreatic cancer 0.0435376 0.8627299 0.04354
NA
SFXN1 pancreatic cancer 0.0435376 0.8627299 0.04354
NA
SPTB pancreatic cancer 0.0435376 0.8627299 0.04354
NA
ACACB stomach cancer 0.0435615 0.8627299 0.04356
NA
WDR17 lung cancer 0.0435692 0.8627299 0.04357
NA
KCNH8 uterine cancer 0.0435789 0.8627299 0.04358
NA
LRRC7 liver cancer 0.0435893 0.8627299 0.04359
NA
MATN4 multiple myeloma 0.0435893 0.8627299 0.04359
NA
NKTR bone cancer 0.0435893 0.8627299 0.04359
NA
PHRF1 multiple myeloma 0.0435893 0.8627299 0.04359
NA
PIEZO1 liver cancer 0.0435893 0.8627299 0.04359
NA
SPTBN5 multiple myeloma 0.0435893 0.8627299 0.04359
NA
BBOX1 head and neck cancer 0.0436525 0.8627299 0.04365
NA
PSMB8 stomach cancer 0.0436525 0.8627299 0.04365
NA
TMEM55A stomach cancer 0.0436525 0.8627299 0.04365
NA
STRIP2 uterine cancer 0.0436835 0.8627299 0.04368
NA
CHD8 liver cancer 0.0436906 0.8627299 0.04369
NA
DOCK2 colorectal cancer 0.0437585 0.8627299 0.04376
NA
HTR1E lung cancer 0.0438320 0.8627299 0.04383
NA
PDCD6IP lung cancer 0.0438320 0.8627299 0.04383
NA
SYCE1 lung cancer 0.0438320 0.8627299 0.04383
NA
AKR1C1 lung cancer 0.0438441 0.8627299 0.04384
NA
OR5M10 lung cancer 0.0438441 0.8627299 0.04384
NA
ZRANB2 lung cancer 0.0438441 0.8627299 0.04384
NA
CP lung cancer 0.0438672 0.8627299 0.04387
NA
SIGLEC12 lung cancer 0.0438672 0.8627299 0.04387
NA
NOC4L lung cancer 0.0438862 0.8627299 0.04389
NA
CNOT1 leukemia 0.0438890 0.8627299 0.04389
NA
PDE4D leukemia 0.0438890 0.8627299 0.04389
NA
SFRP2 leukemia 0.0438890 0.8627299 0.04389
NA
A2ML1 uterine cancer 0.0439236 0.8627299 0.04392
NA
SUSD2 uterine cancer 0.0439881 0.8627299 0.04399
NA
XKR4 uterine cancer 0.0439881 0.8627299 0.04399
NA
PKHD1L1 central nervous system cancer 0.0439990 0.8627299 0.04400
NA
PLEKHM3 central nervous system cancer 0.0439990 0.8627299 0.04400
NA
TEKT1 central nervous system cancer 0.0439990 0.8627299 0.04400
NA
RELN colorectal cancer 0.0439992 0.8627299 0.04400
NA
ALAS1 uterine cancer 0.0440110 0.8627299 0.04401
NA
ALKBH3 uterine cancer 0.0440110 0.8627299 0.04401
NA
ANKRD11 cancer 0.0440110 0.8627299 0.04401
NA
ARSB uterine cancer 0.0440110 0.8627299 0.04401
NA
C12orf60 uterine cancer 0.0440110 0.8627299 0.04401
NA
C9orf43 uterine cancer 0.0440110 0.8627299 0.04401
NA
CCDC147 uterine cancer 0.0440110 0.8627299 0.04401
NA
CD22 uterine cancer 0.0440110 0.8627299 0.04401
NA
DHRS12 uterine cancer 0.0440110 0.8627299 0.04401
NA
DPY19L3 uterine cancer 0.0440110 0.8627299 0.04401
NA
EPB41L4B uterine cancer 0.0440110 0.8627299 0.04401
NA
FAM53C uterine cancer 0.0440110 0.8627299 0.04401
NA
FASTK uterine cancer 0.0440110 0.8627299 0.04401
NA
FBXW8 uterine cancer 0.0440110 0.8627299 0.04401
NA
GDF3 uterine cancer 0.0440110 0.8627299 0.04401
NA
KRTAP10-2 uterine cancer 0.0440110 0.8627299 0.04401
NA
LMX1A uterine cancer 0.0440110 0.8627299 0.04401
NA
MFAP4 uterine cancer 0.0440110 0.8627299 0.04401
NA
NOL7 uterine cancer 0.0440110 0.8627299 0.04401
NA
OR52E8 uterine cancer 0.0440110 0.8627299 0.04401
NA
OR5T1 uterine cancer 0.0440110 0.8627299 0.04401
NA
OTUD4 uterine cancer 0.0440110 0.8627299 0.04401
NA
RGS19 uterine cancer 0.0440110 0.8627299 0.04401
NA
SCNN1G uterine cancer 0.0440110 0.8627299 0.04401
NA
SOX11 uterine cancer 0.0440110 0.8627299 0.04401
NA
TJAP1 uterine cancer 0.0440110 0.8627299 0.04401
NA
TTLL9 uterine cancer 0.0440110 0.8627299 0.04401
NA
USH1G uterine cancer 0.0440110 0.8627299 0.04401
NA
ZBTB39 uterine cancer 0.0440110 0.8627299 0.04401
NA
ZNF263 uterine cancer 0.0440110 0.8627299 0.04401
NA
XRN2 uterine cancer 0.0440453 0.8627299 0.04405
NA
GGNBP2 colorectal cancer 0.0440679 0.8627299 0.04407
NA
PITPNM2 colorectal cancer 0.0440679 0.8627299 0.04407
NA
TEP1 colorectal cancer 0.0440679 0.8627299 0.04407
NA
USP8 colorectal cancer 0.0440679 0.8627299 0.04407
NA
ZNF646 colorectal cancer 0.0440679 0.8627299 0.04407
NA
PLXNB1 uterine cancer 0.0440741 0.8627299 0.04407
NA
BTBD10 uterine cancer 0.0440784 0.8627299 0.04408
NA
COL8A1 uterine cancer 0.0440784 0.8627299 0.04408
NA
PCDHB7 uterine cancer 0.0440784 0.8627299 0.04408
NA
PPID uterine cancer 0.0440784 0.8627299 0.04408
NA
TBCK colorectal cancer 0.0442114 0.8627299 0.04421
NA
SIPA1L2 lung cancer 0.0442676 0.8627299 0.04427
NA
DOPEY1 colorectal cancer 0.0443188 0.8627299 0.04432
NA
ENGASE central nervous system cancer 0.0444022 0.8627299 0.04440
NA
FARSB central nervous system cancer 0.0444022 0.8627299 0.04440
NA
LYPLA2 central nervous system cancer 0.0444022 0.8627299 0.04440
NA
MAG central nervous system cancer 0.0444022 0.8627299 0.04440
NA
OR5D18 central nervous system cancer 0.0444022 0.8627299 0.04440
NA
PCDHB13 central nervous system cancer 0.0444022 0.8627299 0.04440
NA
PENK central nervous system cancer 0.0444022 0.8627299 0.04440
NA
TMEM63B central nervous system cancer 0.0444022 0.8627299 0.04440
NA
TTC16 central nervous system cancer 0.0444022 0.8627299 0.04440
NA
TXNRD1 central nervous system cancer 0.0444022 0.8627299 0.04440
NA
UBXN1 central nervous system cancer 0.0444022 0.8627299 0.04440
NA
ZNF267 central nervous system cancer 0.0444022 0.8627299 0.04440
NA
PTPRM colorectal cancer 0.0444552 0.8627299 0.04446
NA
BPHL lung cancer 0.0444926 0.8627299 0.04449
NA
KRT83 lung cancer 0.0444926 0.8627299 0.04449
NA
WDR53 lung cancer 0.0444926 0.8627299 0.04449
NA
MST1R leukemia 0.0445044 0.8627299 0.04450
NA
MAST2 kidney cancer 0.0445231 0.8627299 0.04452
NA
SHISA9 lung cancer 0.0447699 0.8627299 0.04477
NA
ZDHHC23 breast cancer 0.0447914 0.8627299 0.04479
NA
ACAP1 breast cancer 0.0448103 0.8627299 0.04481
NA
MX1 breast cancer 0.0448103 0.8627299 0.04481
NA
TMEM194A breast cancer 0.0448103 0.8627299 0.04481
NA
TET1 breast cancer 0.0448296 0.8627299 0.04483
NA
PHF3 colorectal cancer 0.0448793 0.8627299 0.04488
NA
PSD3 skin cancer 0.0449634 0.8627299 0.04496
NA
ST6GALNAC5 skin cancer 0.0449634 0.8627299 0.04496
NA
TLK1 skin cancer 0.0449634 0.8627299 0.04496
NA
ABCA4 lymphoma 0.0451269 0.8627299 0.04513
NA
CACNA1I lymphoma 0.0451269 0.8627299 0.04513
NA
CCDC116 lymphoma 0.0451269 0.8627299 0.04513
NA
CLUH lymphoma 0.0451269 0.8627299 0.04513
NA
GCC2 lymphoma 0.0451269 0.8627299 0.04513
NA
GNB1 lymphoma 0.0451269 0.8627299 0.04513
NA
LMAN1L lymphoma 0.0451269 0.8627299 0.04513
NA
LTB lymphoma 0.0451269 0.8627299 0.04513
NA
MAP1A lymphoma 0.0451269 0.8627299 0.04513
NA
MYH15 lymphoma 0.0451269 0.8627299 0.04513
NA
NRAS lymphoma 0.0451269 0.8627299 0.04513
NA
OTOF lymphoma 0.0451269 0.8627299 0.04513
NA
PIK3C2B lymphoma 0.0451269 0.8627299 0.04513
NA
SCN8A lymphoma 0.0451269 0.8627299 0.04513
NA
SMARCA5 lymphoma 0.0451269 0.8627299 0.04513
NA
TPRX1 lymphoma 0.0451269 0.8627299 0.04513
NA
ACO2 colorectal cancer 0.0452098 0.8627299 0.04521
NA
ALOX15 central nervous system cancer 0.0452804 0.8627299 0.04528
NA
FIGN liver cancer 0.0454011 0.8627299 0.04540
NA
C6orf132 uterine cancer 0.0454056 0.8627299 0.04541
NA
DNER uterine cancer 0.0454056 0.8627299 0.04541
NA
MVK uterine cancer 0.0454056 0.8627299 0.04541
NA
NBEA esophageal cancer 0.0455003 0.8627299 0.04550
NA
ACAP1 leukemia 0.0455861 0.8627299 0.04559
NA
ACAT1 urinary bladder cancer 0.0455861 0.8627299 0.04559
NA
CHD2 leukemia 0.0455861 0.8627299 0.04559
NA
CRYZL1 urinary bladder cancer 0.0455861 0.8627299 0.04559
NA
EP400 urinary bladder cancer 0.0455861 0.8627299 0.04559
NA
KRTAP5-11 leukemia 0.0455861 0.8627299 0.04559
NA
LRP10 leukemia 0.0455861 0.8627299 0.04559
NA
MAP2K7 leukemia 0.0455861 0.8627299 0.04559
NA
MAPK15 leukemia 0.0455861 0.8627299 0.04559
NA
POR leukemia 0.0455861 0.8627299 0.04559
NA
POSTN leukemia 0.0455861 0.8627299 0.04559
NA
RNF208 leukemia 0.0455861 0.8627299 0.04559
NA
RPS6KA4 leukemia 0.0455861 0.8627299 0.04559
NA
A2ML1 kidney cancer 0.0456472 0.8627299 0.04565
NA
ARAP3 kidney cancer 0.0456472 0.8627299 0.04565
NA
ATXN7 kidney cancer 0.0456472 0.8627299 0.04565
NA
CCDC137 kidney cancer 0.0456472 0.8627299 0.04565
NA
CLIC1 kidney cancer 0.0456472 0.8627299 0.04565
NA
LTN1 kidney cancer 0.0456472 0.8627299 0.04565
NA
MARVELD2 kidney cancer 0.0456472 0.8627299 0.04565
NA
MRC2 kidney cancer 0.0456472 0.8627299 0.04565
NA
PPP1R15B kidney cancer 0.0456472 0.8627299 0.04565
NA
REM1 kidney cancer 0.0456472 0.8627299 0.04565
NA
ZNF569 kidney cancer 0.0456472 0.8627299 0.04565
NA
CNTROB lung cancer 0.0456809 0.8627299 0.04568
NA
MUC16 kidney cancer 0.0457087 0.8627299 0.04571
NA
DZIP1L lung cancer 0.0457246 0.8627299 0.04572
NA
GSE1 lung cancer 0.0457829 0.8627299 0.04578
NA
TNFSF10 skin cancer 0.0459766 0.8627299 0.04598
NA
LRBA lung cancer 0.0459984 0.8627299 0.04600
NA
RMDN2 uterine cancer 0.0462058 0.8627299 0.04621
NA
SLAMF6 uterine cancer 0.0462058 0.8627299 0.04621
NA
TNS3 uterine cancer 0.0462058 0.8627299 0.04621
NA
NIPBL colorectal cancer 0.0462163 0.8627299 0.04622
NA
DNAH1 skin cancer 0.0463453 0.8627299 0.04635
NA
EBF1 skin cancer 0.0463453 0.8627299 0.04635
NA
TANC2 skin cancer 0.0463866 0.8627299 0.04639
NA
NF1 uterine cancer 0.0463914 0.8627299 0.04639
NA
ALMS1 ovarian cancer 0.0464280 0.8627299 0.04643
NA
TACC2 ovarian cancer 0.0464280 0.8627299 0.04643
NA
ATP6V0A4 uterine cancer 0.0464384 0.8627299 0.04644
NA
OLFM3 uterine cancer 0.0464384 0.8627299 0.04644
NA
SLC4A10 lung cancer 0.0464627 0.8627299 0.04646
NA
WDFY3 lung cancer 0.0464627 0.8627299 0.04646
NA
ABCA3 esophageal cancer 0.0465278 0.8627299 0.04653
NA
HS6ST1 esophageal cancer 0.0465278 0.8627299 0.04653
NA
MAP6 esophageal cancer 0.0465278 0.8627299 0.04653
NA
PRSS22 esophageal cancer 0.0465278 0.8627299 0.04653
NA
ZNF362 esophageal cancer 0.0465278 0.8627299 0.04653
NA
ACSF3 colorectal cancer 0.0465344 0.8627299 0.04653
NA
ADAM17 colorectal cancer 0.0465344 0.8627299 0.04653
NA
ARSG colorectal cancer 0.0465344 0.8627299 0.04653
NA
ATP6V1C1 colorectal cancer 0.0465344 0.8627299 0.04653
NA
BNC2 colorectal cancer 0.0465344 0.8627299 0.04653
NA
BTF3L4 colorectal cancer 0.0465344 0.8627299 0.04653
NA
C11orf21 colorectal cancer 0.0465344 0.8627299 0.04653
NA
CA12 colorectal cancer 0.0465344 0.8627299 0.04653
NA
CPSF3 colorectal cancer 0.0465344 0.8627299 0.04653
NA
CUEDC1 colorectal cancer 0.0465344 0.8627299 0.04653
NA
CYP2C19 colorectal cancer 0.0465344 0.8627299 0.04653
NA
DALRD3 colorectal cancer 0.0465344 0.8627299 0.04653
NA
DEGS1 colorectal cancer 0.0465344 0.8627299 0.04653
NA
FAM160A2 colorectal cancer 0.0465344 0.8627299 0.04653
NA
FLNB colorectal cancer 0.0465344 0.8627299 0.04653
NA
HAUS1 colorectal cancer 0.0465344 0.8627299 0.04653
NA
IL27RA colorectal cancer 0.0465344 0.8627299 0.04653
NA
KIAA1324 colorectal cancer 0.0465344 0.8627299 0.04653
NA
KRT18 colorectal cancer 0.0465344 0.8627299 0.04653
NA
LIN28B colorectal cancer 0.0465344 0.8627299 0.04653
NA
LRP10 colorectal cancer 0.0465344 0.8627299 0.04653
NA
LSM1 colorectal cancer 0.0465344 0.8627299 0.04653
NA
MED20 colorectal cancer 0.0465344 0.8627299 0.04653
NA
NUTM2F colorectal cancer 0.0465344 0.8627299 0.04653
NA
OR2T10 colorectal cancer 0.0465344 0.8627299 0.04653
NA
OR5H1 colorectal cancer 0.0465344 0.8627299 0.04653
NA
PKD2 colorectal cancer 0.0465344 0.8627299 0.04653
NA
PLEKHS1 colorectal cancer 0.0465344 0.8627299 0.04653
NA
POLR3B colorectal cancer 0.0465344 0.8627299 0.04653
NA
PWP2 colorectal cancer 0.0465344 0.8627299 0.04653
NA
RNF31 colorectal cancer 0.0465344 0.8627299 0.04653
NA
SLC26A11 colorectal cancer 0.0465344 0.8627299 0.04653
NA
SMYD4 colorectal cancer 0.0465344 0.8627299 0.04653
NA
TEX30 colorectal cancer 0.0465344 0.8627299 0.04653
NA
TMC5 colorectal cancer 0.0465344 0.8627299 0.04653
NA
ZFR colorectal cancer 0.0465344 0.8627299 0.04653
NA
ZNF382 colorectal cancer 0.0465344 0.8627299 0.04653
NA
ZNF534 colorectal cancer 0.0465344 0.8627299 0.04653
NA
ZNF90 colorectal cancer 0.0465344 0.8627299 0.04653
NA
MARCH11 lung cancer 0.0465891 0.8627299 0.04659
NA
PIKFYVE lung cancer 0.0465891 0.8627299 0.04659
NA
PAPPA2 ovarian cancer 0.0465970 0.8627299 0.04660
NA
KCNB2 colorectal cancer 0.0468238 0.8627299 0.04682
NA
TESPA1 colorectal cancer 0.0468238 0.8627299 0.04682
NA
MKI67 kidney cancer 0.0468445 0.8627299 0.04684
NA
GIMAP8 uterine cancer 0.0469242 0.8627299 0.04692
NA
ZNF816 lung cancer 0.0470061 0.8627299 0.04701
NA
IPO4 lung cancer 0.0470163 0.8627299 0.04702
NA
LHX6 lung cancer 0.0470163 0.8627299 0.04702
NA
SRPK2 lung cancer 0.0470163 0.8627299 0.04702
NA
ZNF626 lung cancer 0.0470163 0.8627299 0.04702
NA
NINL uterine cancer 0.0470547 0.8627299 0.04705
NA
FAT1 esophageal cancer 0.0470926 0.8627299 0.04709
NA
PDZD2 esophageal cancer 0.0470926 0.8627299 0.04709
NA
ADAL lung cancer 0.0471334 0.8627299 0.04713
NA
AP1B1 lung cancer 0.0471334 0.8627299 0.04713
NA
APPBP2 lung cancer 0.0471334 0.8627299 0.04713
NA
C19orf38 lung cancer 0.0471334 0.8627299 0.04713
NA
CMA1 lung cancer 0.0471334 0.8627299 0.04713
NA
CPVL lung cancer 0.0471334 0.8627299 0.04713
NA
DENND4C lung cancer 0.0471334 0.8627299 0.04713
NA
ENTPD7 lung cancer 0.0471334 0.8627299 0.04713
NA
FAM49A lung cancer 0.0471334 0.8627299 0.04713
NA
GPR37L1 lung cancer 0.0471334 0.8627299 0.04713
NA
KRTAP10-5 lung cancer 0.0471334 0.8627299 0.04713
NA
PIGW lung cancer 0.0471334 0.8627299 0.04713
NA
SSBP2 lung cancer 0.0471334 0.8627299 0.04713
NA
TCHP lung cancer 0.0471334 0.8627299 0.04713
NA
TMEM67 lung cancer 0.0471334 0.8627299 0.04713
NA
TNFRSF10A lung cancer 0.0471334 0.8627299 0.04713
NA
TUBA3D lung cancer 0.0471334 0.8627299 0.04713
NA
ZCCHC11 lung cancer 0.0471334 0.8627299 0.04713
NA
ZUFSP lung cancer 0.0471334 0.8627299 0.04713
NA
BCL9L multiple myeloma 0.0471767 0.8627299 0.04718
NA
C2orf16 multiple myeloma 0.0471767 0.8627299 0.04718
NA
DPEP2 liver cancer 0.0471767 0.8627299 0.04718
NA
DRD2 bone cancer 0.0471767 0.8627299 0.04718
NA
DSG1 bone cancer 0.0471767 0.8627299 0.04718
NA
FLT4 multiple myeloma 0.0471767 0.8627299 0.04718
NA
FRMPD2 liver cancer 0.0471767 0.8627299 0.04718
NA
IGSF9 bone cancer 0.0471767 0.8627299 0.04718
NA
MAF multiple myeloma 0.0471767 0.8627299 0.04718
NA
MARVELD3 liver cancer 0.0471767 0.8627299 0.04718
NA
MON2 bone cancer 0.0471767 0.8627299 0.04718
NA
MUC17 bone cancer 0.0471767 0.8627299 0.04718
NA
MYOM1 liver cancer 0.0471767 0.8627299 0.04718
NA
PCDHA1 bone cancer 0.0471767 0.8627299 0.04718
NA
RHNO1 multiple myeloma 0.0471767 0.8627299 0.04718
NA
SBF1 bone cancer 0.0471767 0.8627299 0.04718
NA
SEC14L3 bone cancer 0.0471767 0.8627299 0.04718
NA
SELE multiple myeloma 0.0471767 0.8627299 0.04718
NA
SLC39A5 multiple myeloma 0.0471767 0.8627299 0.04718
NA
SULT1C2 liver cancer 0.0471767 0.8627299 0.04718
NA
TECTA liver cancer 0.0471767 0.8627299 0.04718
NA
TMEM132D multiple myeloma 0.0471767 0.8627299 0.04718
NA
TNXB bone cancer 0.0471767 0.8627299 0.04718
NA
TXNRD1 bone cancer 0.0471767 0.8627299 0.04718
NA
WBSCR16 multiple myeloma 0.0471767 0.8627299 0.04718
NA
WBSCR28 liver cancer 0.0471767 0.8627299 0.04718
NA
YTHDC1 liver cancer 0.0471767 0.8627299 0.04718
NA
ZFAT liver cancer 0.0471767 0.8627299 0.04718
NA
ZNF253 multiple myeloma 0.0471767 0.8627299 0.04718
NA
ZNF768 liver cancer 0.0471767 0.8627299 0.04718
NA
PADI1 ovarian cancer 0.0474940 0.8627299 0.04749
NA
CLK4 uterine cancer 0.0475939 0.8627299 0.04759
NA
IFT172 uterine cancer 0.0476609 0.8627299 0.04766
NA
SNAPC4 colorectal cancer 0.0477287 0.8627299 0.04773
NA
SLC36A3 central nervous system cancer 0.0477802 0.8627299 0.04778
NA
UBE3A uterine cancer 0.0478213 0.8627299 0.04782
NA
TRIM50 lung cancer 0.0478227 0.8627299 0.04782
NA
DENND4B uterine cancer 0.0480312 0.8627299 0.04803
NA
ADAM15 leukemia 0.0480598 0.8627299 0.04806
NA
AK7 leukemia 0.0480598 0.8627299 0.04806
NA
BARD1 leukemia 0.0480598 0.8627299 0.04806
NA
CCDC65 leukemia 0.0480598 0.8627299 0.04806
NA
CCR10 leukemia 0.0480598 0.8627299 0.04806
NA
CENPT leukemia 0.0480598 0.8627299 0.04806
NA
COL1A1 leukemia 0.0480598 0.8627299 0.04806
NA
CSF3R leukemia 0.0480598 0.8627299 0.04806
NA
CSTF3 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
DHX38 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
DNAJB1 leukemia 0.0480598 0.8627299 0.04806
NA
DTNA urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
ESYT2 leukemia 0.0480598 0.8627299 0.04806
NA
FASTKD1 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
FOXG1 leukemia 0.0480598 0.8627299 0.04806
NA
GAB1 leukemia 0.0480598 0.8627299 0.04806
NA
GID4 leukemia 0.0480598 0.8627299 0.04806
NA
GPRIN1 leukemia 0.0480598 0.8627299 0.04806
NA
HIST1H1T leukemia 0.0480598 0.8627299 0.04806
NA
HRH2 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
IL4I1 leukemia 0.0480598 0.8627299 0.04806
NA
ITPRIPL1 leukemia 0.0480598 0.8627299 0.04806
NA
JARID2 leukemia 0.0480598 0.8627299 0.04806
NA
KDM4C leukemia 0.0480598 0.8627299 0.04806
NA
KIAA0825 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
LIM2 leukemia 0.0480598 0.8627299 0.04806
NA
MAP3K5 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
MAP4K3 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
MFSD5 leukemia 0.0480598 0.8627299 0.04806
NA
MSR1 leukemia 0.0480598 0.8627299 0.04806
NA
NOL4 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
NPAS4 leukemia 0.0480598 0.8627299 0.04806
NA
NXPE1 leukemia 0.0480598 0.8627299 0.04806
NA
OR5P3 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
P4HA1 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
PCDHGA8 leukemia 0.0480598 0.8627299 0.04806
NA
PHLDA2 leukemia 0.0480598 0.8627299 0.04806
NA
PPP1R13L urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
RPN1 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
SENP1 leukemia 0.0480598 0.8627299 0.04806
NA
SGK223 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
SLC30A4 leukemia 0.0480598 0.8627299 0.04806
NA
SORCS3 leukemia 0.0480598 0.8627299 0.04806
NA
STARD13 leukemia 0.0480598 0.8627299 0.04806
NA
STK3 leukemia 0.0480598 0.8627299 0.04806
NA
TBL1XR1 leukemia 0.0480598 0.8627299 0.04806
NA
TDRD1 leukemia 0.0480598 0.8627299 0.04806
NA
TGFB1 leukemia 0.0480598 0.8627299 0.04806
NA
TIMP4 leukemia 0.0480598 0.8627299 0.04806
NA
TMEM259 leukemia 0.0480598 0.8627299 0.04806
NA
TPO leukemia 0.0480598 0.8627299 0.04806
NA
TRPC4 urinary bladder cancer 0.0480598 0.8627299 0.04806
NA
TUBA3C leukemia 0.0480598 0.8627299 0.04806
NA
UGT8 leukemia 0.0480598 0.8627299 0.04806
NA
ZNF322 leukemia 0.0480598 0.8627299 0.04806
NA
ZNF541 leukemia 0.0480598 0.8627299 0.04806
NA
ZNF721 leukemia 0.0480598 0.8627299 0.04806
NA
KAT6B central nervous system cancer 0.0480810 0.8627299 0.04808
NA
ZNF763 breast cancer 0.0481780 0.8627299 0.04818
NA
PKN1 skin cancer 0.0481834 0.8627299 0.04818
NA
CSMD2 uterine cancer 0.0483549 0.8627299 0.04835
NA
MYH14 central nervous system cancer 0.0483570 0.8627299 0.04836
NA
MTOR uterine cancer 0.0483980 0.8627299 0.04840
NA
OR2T2 lung cancer 0.0484279 0.8627299 0.04843
NA
URB2 uterine cancer 0.0484640 0.8627299 0.04846
NA
AATK breast cancer 0.0485396 0.8627299 0.04854
NA
ATP8B3 breast cancer 0.0485396 0.8627299 0.04854
NA
EXOC8 breast cancer 0.0485396 0.8627299 0.04854
NA
FAM160A2 breast cancer 0.0485396 0.8627299 0.04854
NA
FZD2 breast cancer 0.0485396 0.8627299 0.04854
NA
GP1BA breast cancer 0.0485396 0.8627299 0.04854
NA
LIAS breast cancer 0.0485396 0.8627299 0.04854
NA
MCF2L breast cancer 0.0485396 0.8627299 0.04854
NA
MIER1 breast cancer 0.0485396 0.8627299 0.04854
NA
OR51A2 breast cancer 0.0485396 0.8627299 0.04854
NA
PLD2 breast cancer 0.0485396 0.8627299 0.04854
NA
PMPCA breast cancer 0.0485396 0.8627299 0.04854
NA
PPP6R2 breast cancer 0.0485396 0.8627299 0.04854
NA
PREX1 breast cancer 0.0485396 0.8627299 0.04854
NA
PXDNL breast cancer 0.0485396 0.8627299 0.04854
NA
PYGL breast cancer 0.0485396 0.8627299 0.04854
NA
RAB5A breast cancer 0.0485396 0.8627299 0.04854
NA
RAC1 breast cancer 0.0485396 0.8627299 0.04854
NA
SETD1B breast cancer 0.0485396 0.8627299 0.04854
NA
URGCP breast cancer 0.0485396 0.8627299 0.04854
NA
USP3 breast cancer 0.0485396 0.8627299 0.04854
NA
WNT5B breast cancer 0.0485396 0.8627299 0.04854
NA
NOTCH3 uterine cancer 0.0486060 0.8627299 0.04861
NA
SYNE1 stomach cancer 0.0486182 0.8627299 0.04862
NA
HSPA8 lung cancer 0.0486256 0.8627299 0.04863
NA
ACSS1 uterine cancer 0.0486717 0.8627299 0.04867
NA
FDXR uterine cancer 0.0486717 0.8627299 0.04867
NA
NBR1 uterine cancer 0.0486717 0.8627299 0.04867
NA
NFKBIZ uterine cancer 0.0486717 0.8627299 0.04867
NA
PAN3 uterine cancer 0.0486717 0.8627299 0.04867
NA
DNAH3 leukemia 0.0487266 0.8627299 0.04873
NA
SETD1B colorectal cancer 0.0487458 0.8627299 0.04875
NA
IFFO1 colorectal cancer 0.0488055 0.8627299 0.04881
NA
MAST4 lung cancer 0.0488533 0.8627299 0.04885
NA
PTH2R lung cancer 0.0488533 0.8627299 0.04885
NA
CAMK2B skin cancer 0.0489168 0.8627299 0.04892
NA
CCT6B skin cancer 0.0489168 0.8627299 0.04892
NA
MDGA1 skin cancer 0.0489168 0.8627299 0.04892
NA
NLRP14 skin cancer 0.0489168 0.8627299 0.04892
NA
UNC13D skin cancer 0.0489168 0.8627299 0.04892
NA
FLG2 lung cancer 0.0489732 0.8627299 0.04897
NA
NOD2 colorectal cancer 0.0489944 0.8627299 0.04899
NA
SAMD4A colorectal cancer 0.0489944 0.8627299 0.04899
NA
SEMA3E colorectal cancer 0.0489944 0.8627299 0.04899
NA
TMPRSS9 colorectal cancer 0.0489944 0.8627299 0.04899
NA
CLEC5A colorectal cancer 0.0491408 0.8627299 0.04914
NA
ERCC5 colorectal cancer 0.0491408 0.8627299 0.04914
NA
GRB10 colorectal cancer 0.0491408 0.8627299 0.04914
NA
KNOP1 colorectal cancer 0.0491408 0.8627299 0.04914
NA
LGI3 colorectal cancer 0.0491408 0.8627299 0.04914
NA
MERTK colorectal cancer 0.0491408 0.8627299 0.04914
NA
OR1M1 colorectal cancer 0.0491408 0.8627299 0.04914
NA
RBBP9 colorectal cancer 0.0491408 0.8627299 0.04914
NA
RGS3 colorectal cancer 0.0491408 0.8627299 0.04914
NA
SGIP1 colorectal cancer 0.0491408 0.8627299 0.04914
NA
SRSF6 colorectal cancer 0.0491408 0.8627299 0.04914
NA
TOR1AIP2 colorectal cancer 0.0491408 0.8627299 0.04914
NA
ZNF165 colorectal cancer 0.0491408 0.8627299 0.04914
NA
CD109 uterine cancer 0.0493634 0.8627299 0.04936
NA
AMACR uterine cancer 0.0494514 0.8627299 0.04945
NA
BPTF cancer 0.0494514 0.8627299 0.04945
NA
CCDC83 uterine cancer 0.0494514 0.8627299 0.04945
NA
HK1 uterine cancer 0.0494514 0.8627299 0.04945
NA
MCTP1 uterine cancer 0.0494514 0.8627299 0.04945
NA
MYZAP uterine cancer 0.0494514 0.8627299 0.04945
NA
SLC6A9 uterine cancer 0.0494514 0.8627299 0.04945
NA
SMG8 uterine cancer 0.0494514 0.8627299 0.04945
NA
TRAPPC10 uterine cancer 0.0494514 0.8627299 0.04945
NA
GATAD1 lung cancer 0.0494908 0.8627299 0.04949
NA
PALLD lung cancer 0.0494908 0.8627299 0.04949
NA
ZNRF3 lung cancer 0.0494908 0.8627299 0.04949
NA
GLI3 colorectal cancer 0.0495911 0.8627299 0.04959
NA
MYH9 colorectal cancer 0.0495911 0.8627299 0.04959
NA
FAM209A colorectal cancer 0.0496715 0.8627299 0.04967
NA
GRK7 colorectal cancer 0.0496715 0.8627299 0.04967
NA
PIK3CB colorectal cancer 0.0496715 0.8627299 0.04967
NA
SETD2 colorectal cancer 0.0496715 0.8627299 0.04967
NA
CHUK pancreatic cancer 0.0496842 0.8627299 0.04968
NA
ABCA12 colorectal cancer 0.0496897 0.8627299 0.04969
NA
MYO9B colorectal cancer 0.0496897 0.8627299 0.04969
NA
SF3B2 leukemia 0.0497800 0.8627299 0.04978
NA
MYO7B lung cancer 0.0498087 0.8627299 0.04981
NA
GTSE1 lung cancer 0.0498556 0.8627299 0.04986
NA
NYNRIN skin cancer 0.0498690 0.8627299 0.04987
NA
OR4S2 lung cancer 0.0498857 0.8627299 0.04989
NA
TRIP11 peripheral nervous system neoplasm 0.0499735 0.8627299 0.04997
NA
Note:
Wilcoxon test Benjamini-Hochberg-corrected p-values:
: p <= 0.05
: p <= 0.01
: p <= 0.001
****: p <= 0.0001 
wilcox_lineage_allmut_delmis_plot <- ggplot(data = crispr_signif_allmut_delmis_lineage) +
  geom_histogram(aes(x = p, fill = "chartreuse4"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  geom_histogram(aes(x = p.adj, fill = "darkslategray3"), breaks = seq(0, 1, by = 0.025), color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_fill_manual(name = "P-values", values = c("chartreuse4" = "chartreuse4", "darkslategray3" = "darkslategray3"), labels = c("Unadjusted", "BH-adjusted")) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1), legend.position = c(0.1, 0.85)) +
  labs(x = "BH-adjusted p-values", y = "Frequency")
wilcox_lineage_allmut_delmis_plot

6 Heatmaps

6.1 Data management

The mutation status portion of these heatmaps was made using deleterious and missense mutations as “mutant” and all others as “other.”

Make and save heatmap data matrices:

# Set up heatmap data
chm_scores <- t(crispr)
colnames(chm_scores) <- chm_scores[1, ]
chm_scores <- chm_scores[-1, ]
chm_rows <- rownames(chm_scores)
chm_cols <- colnames(chm_scores)
chm_scores <- apply(chm_scores, 2, as.double)
chm_scores <- apply(chm_scores, 2, function(x) (x - mean(x)) / var(x))
colnames(chm_scores) <- chm_cols
rownames(chm_scores) <- chm_rows
saveRDS(chm_scores, "./data_munging/rds/crispr_heatmap_scores.rds")

# Make full grid for genomic features
crispr_grid_ccls <- unique(crispr_data$Broad_ID)
crispr_grid_genes <- unique(crispr_data$Hugo_Symbol)
crispr_grid <- expand.grid("Broad_ID" = crispr_grid_ccls, "Hugo_Symbol" = crispr_grid_genes)

# Gene expression
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))[, c("Hugo_Symbol", "Broad_ID", "RPKM")]
ge_filt$RPKM <- log2(ge_filt$RPKM + 0.0001)
chm_ge_grid <- merge(crispr_grid, ge_filt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
chm_ge <- reshape(chm_ge_grid, idvar = "Hugo_Symbol", timevar = "Broad_ID", direction = "wide")
chm_ge_rows <- chm_ge$Hugo_Symbol
chm_ge$Hugo_Symbol <- NULL
chm_ge_cols <- colnames(chm_ge) %>% gsub("RPKM.", "", .)
chm_ge <- apply(chm_ge, 2, as.double)
chm_ge <- apply(chm_ge, 2, function(x) (x - mean(x, na.rm = TRUE)) / var(x, na.rm = TRUE))
rownames(chm_ge) <- chm_ge_rows
colnames(chm_ge) <- chm_ge_cols
saveRDS(chm_ge, "./data_munging/rds/crispr_heatmap_ge.rds")

# Mutation status
chm_mut_grid <- merge(crispr_grid, maf_df[, c("Broad_ID", "Hugo_Symbol", "Mutation_Status")], by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
chm_mut_grid$Mutation_Status <- ifelse(is.na(chm_mut_grid$Mutation_Status), "Other", chm_mut_grid$Mutation_Status)
chm_mut_grid$Mutation_Status <- ifelse(chm_mut_grid$Mutation_Status == "Other", 0, 1)
chm_mut <- reshape(chm_mut_grid, idvar = "Hugo_Symbol", timevar = "Broad_ID", direction = "wide")
chm_mut_rows <- chm_mut$Hugo_Symbol
chm_mut$Hugo_Symbol <- NULL
chm_mut_cols <- colnames(chm_mut) %>% gsub("Mutation_Status.", "", .)
chm_mut <- matrix(as.numeric(unlist(chm_mut)), nrow = nrow(chm_mut))
rownames(chm_mut) <- chm_mut_rows
colnames(chm_mut) <- chm_mut_cols
saveRDS(chm_mut, "./data_munging/rds/crispr_heatmap_mut.rds")

# Copy number
cn_filt <- filter(cn_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))
chm_cn_grid <- merge(crispr_grid, cn_melt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
chm_cn <- reshape(chm_cn_grid, idvar = "Hugo_Symbol", timevar = "Broad_ID", direction = "wide")
chm_cn_rows <- chm_cn$Hugo_Symbol
chm_cn$Hugo_Symbol <- NULL
chm_cn_cols <- colnames(chm_cn) %>% gsub("Copy_Number.", "", .)
chm_cn <- apply(chm_cn, 2, as.double)
chm_cn <- apply(chm_cn, 2, function(x) (x - mean(x, na.rm = TRUE)) / var(x, na.rm = TRUE))
rownames(chm_cn) <- chm_cn_rows
colnames(chm_cn) <- chm_cn_cols
saveRDS(chm_cn, "./data_munging/rds/crispr_heatmap_cn.rds")

Load heatmap matrices:

chm_scores <- readRDS("./data_munging/rds/crispr_heatmap_scores.rds")
chm_ge <- readRDS("./data_munging/rds/crispr_heatmap_ge.rds")
chm_mut <- readRDS("./data_munging/rds/crispr_heatmap_mut.rds")
chm_cn <- readRDS("./data_munging/rds/crispr_heatmap_cn.rds")

# Metadata anotation dataframe
chm_annot <- merge(merge(data.frame("Broad_ID" = crispr$Broad_ID), crispr_meta[, c("Broad_ID", "cell_line_SSMD", "cas9_activity", "culture_type", "primary_tissue")], by = "Broad_ID", all.x = TRUE), ccl_info[, c("Broad_ID", "Primary.Disease", "Gender", "Source")], by = "Broad_ID", all.x = TRUE)
rownames(chm_annot) <- chm_annot$Broad_ID
chm_annot$Broad_ID <- NULL
colnames(chm_annot) <- c("Cell_Line_SSMD", "Cas9_Activity", "Culture_Type", "Primary_Tissue", "Primary_Disease", "Gender", "Source")
chm_annot$Cell_Line_SSMD <- as.numeric(chm_annot$Cell_Line_SSMD)
chm_annot$Cas9_Activity <- as.numeric(chm_annot$Cas9_Activity)

6.2 All genes, no omics

chm_annot_list <- HeatmapAnnotation(df = chm_annot, annotation_legend_param = list(
  Cell_Line_SSMD = list(title = "Cell Line SSMD", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Cas9_Activity = list(title = "Cas9 Activity", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Culture_Type = list(title = "Culture Type", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Culture Type", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Tissue = list(title = "Primary Tissue", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary_Tissue", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Disease = list(title = "Primary Disease", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary Disease", title_position = "topleft", grid_height = unit(0.3, "in")),
  Gender = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), grid_height = unit(0.3, "in")),
  Source = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Source", title_position = "topleft", grid_height = unit(0.3, "in"))))

chm_all_plot <- Heatmap(chm_scores, name = "CERES Score",
        bottom_annotation = chm_annot_list,
        bottom_annotation_height = unit(5, "in"),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        row_title = "Genes", column_title = "Cancer Cell Lines",
        col = colorRamp2(c(min(chm_scores), 0, max(chm_scores)), c("purple4", "white", "seagreen4")),
        na_col = "black",
        row_title_gp = gpar(fontsize = 30, fontface = "bold"),
        row_names_gp = gpar(fontsize = 5),
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_names_gp = gpar(fontsize = 5),
        row_dend_reorder = TRUE,
        column_dend_reorder = TRUE,
        clustering_distance_rows = "euclidean",
        clustering_distance_columns = "euclidean",
        clustering_method_rows = "complete",
        clustering_method_columns = "complete",
        column_dend_height = unit(2, "in"),
        row_dend_width = unit(4, "in"),
        width = 3)

pdf("./plots_18Q3/crispr_heatmap_euclidean_all.pdf", width = 50, height = 50, paper = "special")
draw(chm_all_plot, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

png("./plots_18Q3/crispr_heatmap_euclidean_all.png", width = 50, height = 50, units = "in", res = 96)
draw(chm_all_plot, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

6.3 CGC genes

Code for heatmap of CGC-filtered genes only

6.3.1 Euclidean distance

chm_scores_cgc <- subset(chm_scores, rownames(chm_scores) %in% cgc$Hugo_Symbol)
chm_ge_cgc <- subset(chm_ge, rownames(chm_ge) %in% cgc$Hugo_Symbol)
chm_mut_cgc <- subset(chm_mut, rownames(chm_mut) %in% cgc$Hugo_Symbol)
chm_cn_cgc <- subset(chm_cn, rownames(chm_cn) %in% cgc$Hugo_Symbol)

chm_annot_list <- HeatmapAnnotation(df = chm_annot, annotation_legend_param = list(
  Cell_Line_SSMD = list(title = "Cell Line SSMD", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Cas9_Activity = list(title = "Cas9 Activity", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Culture_Type = list(title = "Culture Type", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Culture Type", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Tissue = list(title = "Primary Tissue", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary_Tissue", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Disease = list(title = "Primary Disease", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary Disease", title_position = "topleft", grid_height = unit(0.3, "in")),
  Gender = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), grid_height = unit(0.3, "in")),
  Source = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Source", title_position = "topleft", grid_height = unit(0.3, "in"))))

chm_plot_cgc <- Heatmap(chm_scores_cgc, name = "CERES Score",
        bottom_annotation = chm_annot_list,
        bottom_annotation_height = unit(5, "in"),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        row_title = "Genes", column_title = "Cancer Cell Lines",
        col = colorRamp2(c(min(chm_scores_cgc), 0, max(chm_scores_cgc)), c("purple4", "white", "seagreen4")),
        na_col = "black",
        row_title_gp = gpar(fontsize = 30, fontface = "bold"),
        row_names_gp = gpar(fontsize = 5),
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_names_gp = gpar(fontsize = 5),
        row_dend_reorder = TRUE,
        column_dend_reorder = TRUE,
        clustering_distance_rows = "euclidean",
        clustering_distance_columns = "euclidean",
        clustering_method_rows = "complete",
        clustering_method_columns = "complete",
        column_dend_height = unit(2, "in"),
        row_dend_width = unit(4, "in"),
        width = 3)

chm_plot_cgc_cols <- colnames(chm_scores_cgc)[unlist(column_order(chm_plot_cgc))]
chm_plot_cgc_rows <- rownames(chm_scores_cgc)[unlist(row_order(chm_plot_cgc))]

chm_ge_plot_cgc <- Heatmap(chm_ge_cgc, name = "Gene Expression",
        col = colorRamp2(c(min(chm_ge_cgc[!is.na(chm_ge_cgc)]), 0, max(chm_ge_cgc[!is.na(chm_ge_cgc)])), c("dodgerblue4", "white", "firebrick4")),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        na_col = "black",
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Gene Expression",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)
chm_cn_plot_cgc <- Heatmap(chm_cn_cgc, name = "Copy Number",
        col = colorRamp2(c(min(chm_cn_cgc[!is.na(chm_cn_cgc)]), 0, max(chm_cn_cgc[!is.na(chm_cn_cgc)])), c("white", "thistle2", "mediumorchid4")),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        na_col = "black",
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Copy Number",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)
chm_mut_plot_cgc <- Heatmap(chm_mut_cgc, name = "Mutation Status",
        na_col = "black",
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), at = c(0, 1), labels = c("Other", "Mutant"), title_position = "topcenter", grid_height = unit(0.3, "in")),
        col = c("cyan3", "darkorchid"),
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Mutation Status",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)

chm_all_plot_cgc <- chm_plot_cgc + chm_ge_plot_cgc + chm_cn_plot_cgc + chm_mut_plot_cgc

pdf("./plots_18Q3/crispr_heatmap_euclidean_all_cgc.pdf", width = 50, height = 50, paper = "special")
draw(chm_all_plot_cgc, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

png("./plots_18Q3/crispr_heatmap_euclidean_all_cgc.png", width = 50, height = 50, units = "in", res = 96)
draw(chm_all_plot_cgc, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

6.3.2 Pearson correlation

chm_scores_cgc <- subset(chm_scores, rownames(chm_scores) %in% cgc$Hugo_Symbol)
chm_ge_cgc <- subset(chm_ge, rownames(chm_ge) %in% cgc$Hugo_Symbol)
chm_mut_cgc <- subset(chm_mut, rownames(chm_mut) %in% cgc$Hugo_Symbol)
chm_cn_cgc <- subset(chm_cn, rownames(chm_cn) %in% cgc$Hugo_Symbol)

chm_annot_list <- HeatmapAnnotation(df = chm_annot, annotation_legend_param = list(
  Cell_Line_SSMD = list(title = "Cell Line SSMD", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Cas9_Activity = list(title = "Cas9 Activity", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
  Culture_Type = list(title = "Culture Type", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Culture Type", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Tissue = list(title = "Primary Tissue", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary_Tissue", title_position = "topleft", grid_height = unit(0.3, "in")),
  Primary_Disease = list(title = "Primary Disease", title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Primary Disease", title_position = "topleft", grid_height = unit(0.3, "in")),
  Gender = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), grid_height = unit(0.3, "in")),
  Source = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), nrow = 8, title = "Source", title_position = "topleft", grid_height = unit(0.3, "in"))))

chm_plot_cgc <- Heatmap(chm_scores_cgc, name = "CERES Score",
        bottom_annotation = chm_annot_list,
        bottom_annotation_height = unit(5, "in"),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        row_title = "Genes", column_title = "Cancer Cell Lines",
        col = colorRamp2(c(min(chm_scores_cgc), 0, max(chm_scores_cgc)), c("purple4", "white", "seagreen4")),
        na_col = "black",
        row_title_gp = gpar(fontsize = 30, fontface = "bold"),
        row_names_gp = gpar(fontsize = 5),
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_names_gp = gpar(fontsize = 5),
        row_dend_reorder = TRUE,
        column_dend_reorder = TRUE,
        clustering_distance_rows = "pearson",
        clustering_distance_columns = "pearson",
        clustering_method_rows = "complete",
        clustering_method_columns = "complete",
        column_dend_height = unit(2, "in"),
        row_dend_width = unit(4, "in"),
        width = 3)

chm_plot_cgc_cols <- colnames(chm_scores_cgc)[unlist(column_order(chm_plot_cgc))]
chm_plot_cgc_rows <- rownames(chm_scores_cgc)[unlist(row_order(chm_plot_cgc))]

chm_ge_plot_cgc <- Heatmap(chm_ge_cgc, name = "Gene Expression",
        col = colorRamp2(c(min(chm_ge_cgc[!is.na(chm_ge_cgc)]), 0, max(chm_ge_cgc[!is.na(chm_ge_cgc)])), c("dodgerblue4", "white", "firebrick4")),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        na_col = "black",
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Gene Expression",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)
chm_cn_plot_cgc <- Heatmap(chm_cn_cgc, name = "Copy Number",
        col = colorRamp2(c(min(chm_cn_cgc[!is.na(chm_cn_cgc)]), 0, max(chm_cn_cgc[!is.na(chm_cn_cgc)])), c("white", "thistle2", "mediumorchid4")),
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), title_position = "topcenter", legend_height = unit(2, "in")),
        na_col = "black",
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Copy Number",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)
chm_mut_plot_cgc <- Heatmap(chm_mut_cgc, name = "Mutation Status",
        na_col = "black",
        heatmap_legend_param = list(title_gp = gpar(fontsize = 20), labels_gp = gpar(fontsize = 15), at = c(0, 1), labels = c("Other", "Mutant"), title_position = "topcenter", grid_height = unit(0.3, "in")),
        col = c("cyan3", "darkorchid"),
        cluster_rows = FALSE, cluster_columns = FALSE,
        row_names_gp = gpar(fontsize = 5), show_column_names = FALSE,
        column_title = "Mutation Status",
        column_title_gp = gpar(fontsize = 30, fontface = "bold"),
        column_order = chm_plot_cgc_cols,
        row_order = chm_plot_cgc_rows,
        width = 1)

chm_all_plot_cgc <- chm_plot_cgc + chm_ge_plot_cgc + chm_cn_plot_cgc + chm_mut_plot_cgc

pdf("./plots_18Q3/crispr_heatmap_pearson_all_cgc.pdf", width = 50, height = 50, paper = "special")
draw(chm_all_plot_cgc, heatmap_legend_side = "bottom", annotation_legend_side = "bottom")
seekViewport("annotation_Cell_Line_SSMD")
grid.text("Cell Line SSMD", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Cas9_Activity")
grid.text("Cas9 Activity", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Culture_Type")
grid.text("Culture Type", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Tissue")
grid.text("Primary Tissue", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Primary_Disease")
grid.text("Primary Disease", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Gender")
grid.text("Gender", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
seekViewport("annotation_Source")
grid.text("Source", unit(1, "npc") + unit(1, "mm"), 0.5, gp = gpar(fontsize = 15), default.units = "npc", just = "left")
dev.off()

7 Per-gene plots

7.1 Grouped plots

Plot code:

crispr_data_cgc <- filter(crispr_data, Hugo_Symbol %in% cgc$Hugo_Symbol)
crispr_all_genes <- unique(crispr_data_cgc$Hugo_Symbol)
crispr_all_groups <- lapply(crispr_all_genes, makeCRISPRgrob)
crispr_all_groups_paths <- paste0(crispr_all_genes, "_crispr_grouped.png")
pwalk(list(crispr_all_groups_paths, crispr_all_groups), ggsave, path = "./plots_18Q3/crispr_grouped_plots_cgc", dpi = 300, width = 12, height = 12, units = "in")

Data management:

crispr_all_bygene <- paste0(list.files("./plots_18Q3/crispr_grouped_plots_cgc", full.names = TRUE))
names(crispr_all_bygene) <- str_replace_all(crispr_all_bygene, c("_crispr_grouped.png" = "", "./plots_18Q3/crispr_grouped_plots_cgc/" = ""))
crispr_bygene_order <- c(intersect(crispr_signif$Hugo_Symbol, names(crispr_all_bygene)), setdiff(names(crispr_all_bygene), crispr_signif$Hugo_Symbol))
crispr_all_bygene <- crispr_all_bygene[match(crispr_bygene_order, names(crispr_all_bygene))]
bsselect(crispr_all_bygene, type = "img", selected = "KRAS", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)

7.2 Sorted lineage plots

Plot code:

crispr_data_cgc <- filter(crispr_data, Hugo_Symbol %in% cgc$Hugo_Symbol)
crispr_all_genes <- unique(crispr_data_cgc$Hugo_Symbol)
crispr_all_lins <- lapply(crispr_all_genes, makeCRISPRlinplot)
crispr_all_lins_paths <- paste0(crispr_all_genes, "_crispr_lineage.png")
pwalk(list(crispr_all_lins_paths, crispr_all_lins), ggsave, path = "./plots_18Q3/crispr_lineage_plots_cgc", dpi = 300, width = 12, height = 12, units = "in")

Data management:

crispr_all_bygene <- paste0(list.files("./plots_18Q3/crispr_lineage_plots_cgc", full.names = TRUE))
names(crispr_all_bygene) <- str_replace_all(crispr_all_bygene, c("_crispr_lineage.png" = "", "./plots_18Q3/crispr_lineage_plots_cgc/" = ""))
crispr_bygene_order <- c(intersect(crispr_signif$Hugo_Symbol, names(crispr_all_bygene)), setdiff(names(crispr_all_bygene), crispr_signif$Hugo_Symbol))
crispr_all_bygene <- crispr_all_bygene[match(crispr_bygene_order, names(crispr_all_bygene))]
bsselect(crispr_all_bygene, type = "img", selected = "KRAS", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)

7.3 Sorted tissue plots

Plot code:

crispr_data_cgc <- filter(crispr_data, Hugo_Symbol %in% cgc$Hugo_Symbol)
crispr_all_genes <- unique(crispr_data_cgc$Hugo_Symbol)
crispr_all_lins <- lapply(crispr_all_genes, makeCRISPRtissueplot)
crispr_all_lins_paths <- paste0(crispr_all_genes, "_crispr_tissue.png")
pwalk(list(crispr_all_lins_paths, crispr_all_lins), ggsave, path = "./plots_18Q3/crispr_tissue_plots_cgc", dpi = 300, width = 12, height = 12, units = "in")

Data management:

crispr_all_bygene <- paste0(list.files("./plots_18Q3/crispr_tissue_plots_cgc", full.names = TRUE))
names(crispr_all_bygene) <- str_replace_all(crispr_all_bygene, c("_crispr_tissue.png" = "", "./plots_18Q3/crispr_tissue_plots_cgc/" = ""))
crispr_bygene_order <- c(intersect(crispr_signif$Hugo_Symbol, names(crispr_all_bygene)), setdiff(names(crispr_all_bygene), crispr_signif$Hugo_Symbol))
crispr_all_bygene <- crispr_all_bygene[match(crispr_bygene_order, names(crispr_all_bygene))]
bsselect(crispr_all_bygene, type = "img", selected = "KRAS", live_search = TRUE, show_tick = TRUE, height = 300, frame_height = 275)

8 Report #2

8.1 Metadata

tissue_summ <- crispr_meta %>% group_by(primary_tissue) %>% tally()
disease_summ <- ccl_info %>% group_by(Primary.Disease) %>% tally()
ggplot(data = tissue_summ) + 
  aes(x = 0, y = n, fill = primary_tissue, label = primary_tissue) +
  geom_histogram(color = "black", stat = "identity") +
  geom_text(position = position_stack(vjust = 0.5)) +
  scale_y_continuous(breaks = seq(0, 500, by = 25), labels = seq(0, 500, by = 25)) +
  coord_cartesian(ylim = c(0, 500)) +
  theme(legend.position = "none", axis.text.x = element_blank(), axis.ticks.x = element_blank(), axis.title.x = element_blank()) +
  labs(y = "Count")

8.2 Scores

Distribution of scores across cell lines and primary tissues. Each data point represents a single cell line.

ceres_summ <- crispr_data %>% group_by(primary_tissue) %>% summarize(Max = max(Score),
                                                                     Min = min(Score))
score_summ_plot <- ggplot(data = crispr_data, aes(x = primary_tissue, color = primary_tissue)) +
  geom_boxplot(mapping = aes(y = Score), outlier.shape = NA) +
  geom_point(data = ceres_summ, mapping = aes(x = primary_tissue, y = Min)) +
  geom_point(data = ceres_summ, mapping = aes(x = primary_tissue, y = Max)) +
  scale_y_continuous(breaks = seq(-4, 6, by = 1), labels = seq(-4, 6, by = 1)) +
  theme(axis.text.x = element_text(angle = 30, hjust = 1), legend.position = "none") +
  labs(x = "Primary Tissue", y = "CERES Score")
score_summ_plot

# ggsave(filename = "./plots_18Q3/crispr/ceres_score_summ_plot.pdf", plot = score_summ_plot, width = 12, height = 4, device = "pdf")

8.3 Mutations

maf_df_filt <- filter(maf_df, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol))
# maf_summ_filt <- maf_df_filt %>% group_by(Mutation_Status) %>% tally()
# maf_summ_filt$Percent <- format(round(maf_summ_filt$n / sum(maf_summ_filt$n) * 100, 4), nsmall = 2)
# maf_summ_filt$Percent <- as.numeric(as.character(maf_summ_filt$Percent))

Distribution of mutations across cell lines and primary tissues. Each data point represents a single cell line.

maf_ccl_annot <- merge(maf_df %>% group_by(Broad_ID) %>% tally(), crispr_meta, by = "Broad_ID", all.y = TRUE)

maf_ccl_annot_plot <- ggplot(data = maf_ccl_annot, aes(x = primary_tissue, y = n, color = primary_tissue)) +
  geom_boxplot(outlier.shape = NA, fill = NA) +
  geom_jitter(alpha = 0.7, size = 1, position = position_jitter(w = 0.25)) +
  scale_y_continuous(breaks = seq(0, 9000, by = 1000), labels = seq(0, 9000, by = 1000)) +
  theme(axis.ticks.x = element_blank(), axis.title.x = element_blank(), axis.text.x = element_blank(), legend.position = "none") +
  labs(x = "Primary Tissue", y = "Number of Mutations")
maf_ccl_annot_plot

# ggsave(filename = "./plots_18Q3/crispr/maf_ccl_annot_plot.pdf", plot = maf_ccl_annot_plot, width = 12, height = 4, device = "pdf")
# ggsave(filename = "./plots_18Q3/crispr/score_mut_summ.pdf", plot = grid.draw(rbind(ggplotGrob(maf_ccl_annot_plot), ggplotGrob(score_summ_plot), size = "first")), width = 12, height = 8, device = "pdf")
maf_gene_annot <- maf_df_filt %>% group_by(Hugo_Symbol) %>% tally()

ggplot(data = maf_gene_annot, aes(x = n)) +
  geom_histogram(breaks = seq(0, 600, by = 20), fill = "darkslategray3", color = "black", alpha = 0.7) +
  coord_cartesian(ylim = c(0, 13000)) +
  scale_y_continuous(breaks = seq(0, 13500, by = 500), labels = formatC(seq(0, 13500, by = 500), format = "d")) +
  scale_x_continuous(breaks = seq(0, 600, by = 20), labels = seq(0, 600, by = 20)) +
  theme(axis.text.x = element_text(angle = 45, hjust = 1)) +
  stat_bin(breaks = seq(0, 600, by = 20), geom = "text", colour = "black", size = 2.5, aes(label = ..count..), vjust = -0.2, angle = 45, hjust = -0.1) +
  labs(x = "Number of Mutations", y = "Frequency", title = paste0("Distribution of mutational load for ", length(unique(maf_gene_annot$Hugo_Symbol)), " genes in the CCLE MAF file across all ", length(unique(crispr_ccl$Broad_ID)), " cell lines in the CRISPR screen"))

8.4 Dependency probabilities

drop_prob_100 <- ggplot(data = crispr_data, aes(x = Dep_Prob)) +
  geom_histogram(breaks = seq(0, 1, by = 0.05), fill = "darkslategray3", color = "black", alpha = 0.7) +
  scale_x_continuous(breaks = seq(0, 1, by = 0.05), labels = seq(0, 1, by = 0.05)) +
  scale_y_continuous(breaks = seq(0, 5500000, by = 500000), labels = formatC(seq(0, 5500000, by = 500000), format = "d")) +
  stat_bin(breaks = seq(0, 1, by = 0.05), geom = "text", colour = "black", size = 3.5, aes(label = ..count..), vjust = -1) +
  labs(title = "Distribution of all dependency probabilities", x = "Probability of Real Dependency", y = "Frequency")

dep_prob_5 <- ggplot(data = filter(crispr_data, Dep_Prob >= 0.95), aes(x = Dep_Prob)) +
  geom_histogram(mapping = aes(fill = primary_tissue), breaks = seq(0.95, 1, by = 0.005), color = "black") +
  scale_y_continuous(breaks = seq(0, 60000, by = 10000), labels = formatC(seq(0, 60000, by = 10000), format = "d")) +
  theme(legend.position = "bottom") +
  guides(fill = guide_legend(nrow = 4, byrow = FALSE)) +
  stat_bin(breaks = seq(0.95, 1, by = 0.005), geom = "text", color = "black", size = 3.5, aes(label = ..count..), vjust = -1) +
  labs(title = "Distribution of all dependency probabilities > 0.95", x = "Probability of Real Dependency", y = "Frequency", fill = "Primary Tissue")

8.5 Per-gene plots

sig_genes <- c("KRAS", "TP53", "NRAS", "BRAF", "PIK3CA", "PTEN", "CTNNB1")
crispr_sig_genes <- filter(crispr_data, Hugo_Symbol %in% sig_genes)
crispr_sig_genes$Hugo_Symbol <- factor(crispr_sig_genes$Hugo_Symbol, levels = c("KRAS", "TP53", "NRAS", "BRAF", "PIK3CA", "PTEN", "CTNNB1"))

crispr_color <- as.character(crispr_sig_genes$Color)
names(crispr_color) <- crispr_sig_genes$Mutation_Status

# Mutation status
plot_mut <- ggplot(data = crispr_sig_genes, aes(x = Mutation_Status, y = Score, color = Mutation_Status)) +
  geom_boxplot(outlier.shape = NA) +
  geom_jitter(alpha = 0.3, size = 0.7, position = position_jitter(w = 0.05)) +
  facet_wrap(~ Hugo_Symbol, nrow = 7, scales = "free_y") +
  scale_color_manual(values = crispr_color) +
  geom_hline(yintercept = 0, linetype = 2, lwd = 0.3) +
  theme_light() +
  theme(legend.position = "none") +
  labs(x = "Mutation Status", y = "CERES Score",
       title = "Mutation Status")
# plot_mut

# Copy number
plot_cn <- ggplot(data = crispr_sig_genes, aes(x = Copy_Number, y = Score, color = Mutation_Status)) +
  geom_point(size = 0.5, alpha = 0.5) +
  geom_smooth(method = "lm", size = 0.5) +
  scale_color_manual(values = crispr_color) +
  facet_wrap(~ Hugo_Symbol, nrow = 7, scales = "free") +
  stat_cor(method = "pearson", show.legend = FALSE, label.x.npc = "right", label.y.npc = "top") +
  theme_light() +
  theme(legend.position = "none", axis.title.y = element_blank()) +
  labs(y = "CERES Score", color = "Mutation Status",
       x = "Theoretical Copy number", title = "Copy Number")
# plot_cn

# Gene expression
plot_ge <- ggplot(data = crispr_sig_genes, aes(x = RPKM_log2, y = Score, color = Mutation_Status)) +
  geom_point(size = 0.5, alpha = 0.5) +
  geom_smooth(method = "lm", size = 0.5) +
  facet_wrap(~ Hugo_Symbol, nrow = 7, scales = "free_y") +
  scale_color_manual(values = crispr_color) +
  stat_cor(method = "pearson", show.legend = FALSE, label.x.npc = "left", label.y.npc = "top") +
  theme_light() +
  theme(legend.position = "none", axis.title.y = element_blank()) +
  labs(y = "CERES Score", color = "Mutation Status",
       x = "Gene Expression [log2(RPKM)]",
       title = "Gene Expression")
# plot_ge

# ggsave(filename = "./plots_18Q3/crispr/omics_sig_genes.pdf", plot = grid.draw(cbind(ggplotGrob(plot_mut), ggplotGrob(plot_ge), ggplotGrob(plot_cn), size = "last")), width = 15, height = 18, device = "pdf")

9 shRNA

9.1 Data and annotations

DepMap cell line metadata:

# From figshare
shrna_meta <- read.delim("./data_munging/sample_info_18Q3_shrna.csv", sep = ",", header = TRUE, na.strings = c("", NA))
colnames(shrna_meta)[1] <- "CCLE_Name"

The Achilles shRNA DEMETER score data was pulled from the CTD2 Data Portal (Tsherniak et al 2017).

shrna <- read.table("./data_munging/D2_combined_gene_dep_scores.csv.gz", sep = ",", header = TRUE, check.names = FALSE)
colnames(shrna)[1] <- "Hugo_Symbol"
# Remove Entrez gene IDs from gene names
shrna$Hugo_Symbol <- gsub(" .*", "", shrna$Hugo_Symbol)

# Melt shRNA dataset for merging
shrna_melt <- melt(shrna , id.vars = "Hugo_Symbol", measure.vars = colnames(shrna)[2:ncol(shrna)], variable.name = "CCLE_Name", value.name = "Score")
shrna_melt <- drop_na(shrna_melt)

Merge annotation data:

# Merge cell line metadata
shrna_melt <- merge(shrna_melt, ccl_info, by = "CCLE_Name", all.x = TRUE)
shrna_melt <- merge(shrna_melt, shrna_meta, by = "CCLE_Name", all.x = TRUE)

# Merge mutation annotations
shrna_muts <- merge(shrna_melt, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
shrna_muts <- shrna_muts %>% mutate(Mutation_Status = if_else(is.na(Mutation_Status), "Other", Mutation_Status))
shrna_muts$Hugo_Symbol <- factor(shrna_muts$Hugo_Symbol)

# Summarize number of mutant and Other cell lines
shrna_muts_summ <- shrna_muts %>% group_by(Hugo_Symbol) %>%
  summarize(N_Other = sum(Mutation_Status == "Other"),
            N_Mutant = sum(Mutation_Status == "Mutant"))

# Merge test results back into full dataset, which restores information lost in the summarization
shrna_data <- merge(shrna_muts_summ, shrna_muts, by = "Hugo_Symbol")

# Add Color column
shrna_data$Color <- ifelse(shrna_data$Mutation_Status == "Other", "cyan3", "darkorchid")
shrna_data$Color <- factor(shrna_data$Color)

# Cell line lineages
shrna_data <- merge(shrna_data, ccl_converter, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
levels(shrna_data$lineage_name) <- sort(levels(shrna_data$lineage_name), decreasing = TRUE)

# Copy number
shrna_data <- merge(shrna_data, cn_melt, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)

# Gene expression (RPKM)
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(shrna_data$Hugo_Symbol))
shrna_data <- merge(shrna_data, ge_filt, by = c("Hugo_Symbol", "Broad_ID", "CCLE_Name"), all.x = TRUE)

saveRDS(shrna_data, "./../crispr_lineages_giant_files/shrna_data_18Q3.rds", compress = "xz")
shrna_data <- readRDS("./../crispr_lineages_giant_files/shrna_data_18Q3.rds")
shrna_ccl <- data.frame("Broad_ID" = shrna_data$Broad_ID)

9.2 Wilcoxon tests

9.2.1 Grouped by gene

shrna_signif <- compare_means(Score ~ Mutation_Status, group.by = c("Hugo_Symbol"), data = shrna_data, method = "wilcox.test", p.adjust.method = "BH")
shrna_signif <- adj_signif(shrna_signif)
shrna_signif <- shrna_signif[order(shrna_signif$p),]
saveRDS(shrna_signif, "./data_munging/rds/shrna_signif.rds")
shrna_signif <- readRDS("./data_munging/rds/shrna_signif.rds")

knitr::kable(filter(shrna_signif, p < 0.05)[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "shRNA Screen: Wilcoxon Test Results Comparing Mutant and Other Cell Lines, p < 0.1  (Benjamini-Hochberg-corrected p-values: * p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% footnote(general = "Wilcoxon test Benjamini-Hochberg-corrected p-values:\n*: p <= 0.05\n**: p <= 0.01\n***: p <= 0.001\n****: p <= 0.0001") %>% scroll_box(width = "900px", height = "450px")

9.2.2 Grouped by gene and lineage

shrna_signif_lineage <- compare_means(Score ~ Mutation_Status, group.by = c("Hugo_Symbol", "lineage_name"), data = shrna_data, method = "wilcox.test", p.adjust.method = "BH")
shrna_signif_lineage <- adj_signif(shrna_signif_lineage)
shrna_signif_lineage <- mutate(shrna_signif_lineage, lineage_name = reorder(lineage_name, p.adj, mean))
saveRDS(shrna_signif_lineage, "./../crispr_lineages_giant_files/shrna_signif_lineage.rds")
shrna_signif_lineage <- readRDS("./../crispr_lineages_giant_files/shrna_signif_lineage.rds")

10 References

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., … Garraway, L. A. (2012). The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 483(7391), 603–607. https://doi.org/10.1038/nature11003

Broad Institute Cancer Dependency Map; Cancer Data Science (2018): Cancer Dependency Map, CRISPR Avana dataset 18Q3 (Avana_public_18Q3). figshare. Fileset. doi:10.6084/m9.figshare.6931364.v1

Consortium, T. C. C. L. E., & Consortium, T. G. of D. S. in C. (2015). Pharmacogenomic agreement between two cancer cell line data sets. Nature, 528(7580), 84–87. https://doi.org/10.1038/nature15736

Data Science, Cancer (2018): DEMETER2 data. figshare. Fileset. doi:10.6084/m9.figshare.6025238.v2

Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E. W., Donovan, K. F., … Root, D. E. (2016). Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nature Biotechnology, 34(2), 184–191. https://doi.org/10.1038/nbt.3437

Meyers, R. M., Bryan, J. G., McFarland, J. M., Weir, B. A., Sizemore, A. E., Xu, H., … Tsherniak, A. (2017). Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature Genetics, 49(12), 1779–1784. https://doi.org/10.1038/ng.3984

McFarland, J. M., Ho, Z. V., Kugener, G., Dempster, J. M., Montgomery, P. G., Bryan, J. G., … Tsherniak, A. (2018). Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. https://doi.org/10.1101/305656

11 Session information

print(sessionInfo())
## R version 3.5.0 (2018-04-23)
## Platform: x86_64-apple-darwin15.6.0 (64-bit)
## Running under: macOS High Sierra 10.13.6
## 
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRlapack.dylib
## 
## locale:
## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
## 
## attached base packages:
## [1] grid      parallel  stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] bindrcpp_0.2.2        circlize_0.4.4        ComplexHeatmap_1.18.1
##  [4] bsselectR_0.1.0       caret_6.0-80          lattice_0.20-35      
##  [7] reshape2_1.4.3        devtools_1.13.6       glmnet_2.0-16        
## [10] foreach_1.4.4         Matrix_1.2-14         broom_0.5.0          
## [13] gridExtra_2.3         kableExtra_0.9.0      matrixStats_0.54.0   
## [16] forcats_0.3.0         stringr_1.3.1         dplyr_0.7.6          
## [19] purrr_0.2.5           readr_1.1.1           tidyr_0.8.1          
## [22] tibble_1.4.2          tidyverse_1.2.1       plyr_1.8.4           
## [25] CePa_0.6              data.table_1.11.4     rowr_1.1.3           
## [28] ggsignif_0.4.0        ggpubr_0.1.7.999      magrittr_1.5         
## [31] ggplot2_3.0.0         NMF_0.21.0            Biobase_2.40.0       
## [34] BiocGenerics_0.26.0   cluster_2.0.7-1       rngtools_1.3.1       
## [37] pkgmaker_0.27         registry_0.5         
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.3-2    rjson_0.2.20        class_7.3-14       
##  [4] rprojroot_1.3-2     GlobalOptions_0.1.0 pls_2.6-0          
##  [7] rstudioapi_0.7      DRR_0.0.3           fansi_0.2.3        
## [10] prodlim_2018.04.18  lubridate_1.7.4     xml2_1.2.0         
## [13] splines_3.5.0       codetools_0.2-15    doParallel_1.0.11  
## [16] robustbase_0.93-1.1 knitr_1.20          RcppRoll_0.3.0     
## [19] jsonlite_1.5        gridBase_0.4-7      ddalpha_1.3.4      
## [22] kernlab_0.9-26      sfsmisc_1.1-2       graph_1.58.0       
## [25] compiler_3.5.0      httr_1.3.1          backports_1.1.2    
## [28] assertthat_0.2.0    lazyeval_0.2.1      cli_1.0.0          
## [31] htmltools_0.3.6     tools_3.5.0         igraph_1.2.1       
## [34] gtable_0.2.0        glue_1.3.0          Rcpp_0.12.18       
## [37] cellranger_1.1.0    nlme_3.1-137        iterators_1.0.10   
## [40] timeDate_3043.102   gower_0.1.2         rvest_0.3.2        
## [43] DEoptimR_1.0-8      MASS_7.3-50         scales_0.5.0       
## [46] ipred_0.9-6         hms_0.4.2           RColorBrewer_1.1-2 
## [49] yaml_2.1.19         memoise_1.1.0       rpart_4.1-13       
## [52] stringi_1.2.4       highr_0.7           bibtex_0.4.2       
## [55] shape_1.4.4         lava_1.6.2          geometry_0.3-6     
## [58] rlang_0.2.1         pkgconfig_2.0.1     evaluate_0.11      
## [61] bindr_0.1.1         labeling_0.3        htmlwidgets_1.2    
## [64] recipes_0.1.3       CVST_0.2-2          tidyselect_0.2.4   
## [67] R6_2.2.2            dimRed_0.1.0        pillar_1.3.0       
## [70] haven_1.1.2         withr_2.1.2         nnet_7.3-12        
## [73] survival_2.42-6     abind_1.4-5         modelr_0.1.2       
## [76] crayon_1.3.4        utf8_1.1.4          rmarkdown_1.10     
## [79] GetoptLong_0.1.7    readxl_1.1.0        Rgraphviz_2.24.0   
## [82] ModelMetrics_1.1.0  digest_0.6.15       xtable_1.8-2       
## [85] stats4_3.5.0        munsell_0.5.0       viridisLite_0.3.0  
## [88] magic_1.5-8